PL2229440T3 - Rekombinowane białka elastazy, sposoby ich wytwarzania oraz ich zastosowanie - Google Patents

Rekombinowane białka elastazy, sposoby ich wytwarzania oraz ich zastosowanie

Info

Publication number
PL2229440T3
PL2229440T3 PL08861467T PL08861467T PL2229440T3 PL 2229440 T3 PL2229440 T3 PL 2229440T3 PL 08861467 T PL08861467 T PL 08861467T PL 08861467 T PL08861467 T PL 08861467T PL 2229440 T3 PL2229440 T3 PL 2229440T3
Authority
PL
Poland
Prior art keywords
manufacturing
methods
elastase proteins
recombinant elastase
recombinant
Prior art date
Application number
PL08861467T
Other languages
English (en)
Inventor
F Nicholas Franano
Kimberly Bland
Marco D Wong
Bee C Ding
Original Assignee
Proteon Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteon Therapeutics Inc filed Critical Proteon Therapeutics Inc
Publication of PL2229440T3 publication Critical patent/PL2229440T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6448Elastases, e.g. pancreatic elastase (3.4.21.36); leukocyte elastase (3.4.31.37)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/486Elastase (3.4.21.36 or 3.4.21.37)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/50Fusion polypeptide containing protease site
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21036Pancreatic elastase (3.4.21.36)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21037Leukocyte elastase (3.4.21.37), i.e. neutrophil-elastase
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
PL08861467T 2007-12-04 2008-12-04 Rekombinowane białka elastazy, sposoby ich wytwarzania oraz ich zastosowanie PL2229440T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US99231907P 2007-12-04 2007-12-04
US12/327,809 US8501449B2 (en) 2007-12-04 2008-12-03 Recombinant elastase proteins and methods of manufacturing and use thereof
PCT/US2008/085559 WO2009079220A2 (en) 2007-12-04 2008-12-04 Recombinant elastase proteins and methods of manufacturing and use thereof
EP08861467.2A EP2229440B9 (en) 2007-12-04 2008-12-04 Recombinant elastase proteins and methods of manufacturing and use thereof

Publications (1)

Publication Number Publication Date
PL2229440T3 true PL2229440T3 (pl) 2014-07-31

Family

ID=40344763

Family Applications (2)

Application Number Title Priority Date Filing Date
PL13181046T PL2666854T3 (pl) 2007-12-04 2008-12-04 Rekombinowane białka elastazy i sposoby ich otrzymywania i zastosowania
PL08861467T PL2229440T3 (pl) 2007-12-04 2008-12-04 Rekombinowane białka elastazy, sposoby ich wytwarzania oraz ich zastosowanie

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL13181046T PL2666854T3 (pl) 2007-12-04 2008-12-04 Rekombinowane białka elastazy i sposoby ich otrzymywania i zastosowania

Country Status (26)

Country Link
US (14) US8501449B2 (pl)
EP (3) EP3176262A1 (pl)
JP (3) JP5829808B2 (pl)
KR (3) KR101732190B1 (pl)
CN (4) CN109893647A (pl)
AR (1) AR069584A1 (pl)
AU (1) AU2008338743B2 (pl)
BR (1) BRPI0819977A2 (pl)
CA (1) CA2707051C (pl)
CY (2) CY1114724T1 (pl)
DK (2) DK2666854T3 (pl)
ES (2) ES2627066T3 (pl)
HK (1) HK1148772A1 (pl)
HR (2) HRP20131135T1 (pl)
HU (1) HUE032739T2 (pl)
IL (2) IL206157A (pl)
LT (1) LT2666854T (pl)
MX (2) MX2010006211A (pl)
NZ (2) NZ601592A (pl)
PL (2) PL2666854T3 (pl)
PT (2) PT2229440E (pl)
RS (2) RS55982B1 (pl)
RU (1) RU2611200C2 (pl)
SI (2) SI2229440T1 (pl)
TW (2) TWI619726B (pl)
WO (1) WO2009079220A2 (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8501449B2 (en) 2007-12-04 2013-08-06 Proteon Therapeutics, Inc. Recombinant elastase proteins and methods of manufacturing and use thereof
CN102250863B (zh) * 2011-04-29 2012-12-05 天津金斯坦生物科技有限公司 基因重组人中性粒细胞弹性蛋白酶及其制备方法和该弹性蛋白酶的医药用途
US10202630B2 (en) * 2013-03-15 2019-02-12 Alderbio Holdings Llc Temperature shift for high yield expression of polypeptides in yeast and other transformed cells
EP3597664A3 (en) * 2013-03-15 2020-03-11 Alder Biopharmaceuticals, Inc. Temperature shift for high yield expression of polypeptides in yeast and other transformed cells
KR102618002B1 (ko) * 2017-03-10 2023-12-27 볼트 쓰레즈, 인크. 재조합 단백질을 고분비 수율로 생산하기 위한 조성물 및 방법
EP4065167A4 (en) * 2019-11-26 2024-03-27 Childrens Hospital Med Ct INHIBITION OF CELA-1 FOR THE TREATMENT OF PULMONARY DISEASE
EP4090758A1 (en) * 2020-01-14 2022-11-23 Basf Se Method for producing recombinant protein in yeast cells
EP4199948A1 (en) * 2020-08-18 2023-06-28 Onchilles Pharma, Inc. Modified serine protease proproteins
IL300080A (en) * 2020-08-18 2023-03-01 Onchilles Pharma Inc Processed porcine pancreatic elastase proteins

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2508408A (en) 1943-10-11 1950-05-23 Sidney H Liebson Averaging indicator
US2546308A (en) 1948-12-29 1951-03-27 Kahler John Floor marking device
US5212068A (en) * 1985-04-05 1993-05-18 Sankyo Company Limited Human pancreatic elastase
DE3751873T2 (de) 1986-04-09 1997-02-13 Genzyme Corp Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
US5162205A (en) 1986-04-26 1992-11-10 Sankyo Company, Limited Human pancreatic elastase I
JPH0673456B2 (ja) * 1986-04-26 1994-09-21 三共株式会社 ヒト・膵臓エラスタ−ゼ▲i▼
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
US5543302A (en) 1988-05-27 1996-08-06 Solvay Enzymes, Inc. Proteases of altered stability to autolytic degradation
DK105489D0 (da) 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid
ES2090297T5 (es) 1989-11-06 2005-03-01 Cell Genesys, Inc. Produccion de proteinas que utilizan recombinacion homologa.
GB8927722D0 (en) 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
NZ236819A (en) 1990-02-03 1993-07-27 Max Planck Gesellschaft Enzymatic cleavage of fusion proteins; fusion proteins; recombinant dna and pharmaceutical compositions
US5503333A (en) 1993-06-23 1996-04-02 Laventure; David Duster extension tube system with dust collecting region and tube cleaner and method of using the same
ATE226642T1 (de) 1994-07-07 2002-11-15 Tno Modifizierte proenzyme als substrate für proteolische enzyme
US5955072A (en) 1994-07-13 1999-09-21 Sankyo Company, Limited Expression systems utilizing autolyzing fusion proteins and a reducing polypeptide
US7531325B2 (en) 1997-04-25 2009-05-12 Sembiosys Genetics Inc. Method for cleavage of fusion proteins
US20030207402A1 (en) 1997-08-22 2003-11-06 Erhard Kopetzki Autocatalytically activatable zymogenic precursors of proteases and their use
GB9817909D0 (en) 1998-08-17 1998-10-14 Zeneca Ltd DNA constructs
GB9908458D0 (en) 1999-04-13 1999-06-09 Queen Mary & Westfield College Enzyme
WO2000068363A2 (en) 1999-05-05 2000-11-16 Genentech, Inc. Elastase variants and substrates
US7001892B1 (en) * 1999-06-11 2006-02-21 Purdue Research Foundation Pharmaceutical materials and methods for their preparation and use
US7063838B1 (en) 1999-09-24 2006-06-20 Proteon Therapeutics Llc Methods for treating an artery or vein in a human subject
ES2534938T3 (es) * 1999-09-24 2015-04-30 Proteon Therapeutics, Inc. Una elastasa para abrir conductos biológicos obstruidos
US7351549B2 (en) 2000-01-24 2008-04-01 Polymun Scientific Immunbiologische Forschung Gmbh Method for the manufacture of recombinant trypsin
EP1266035A4 (en) 2000-02-24 2003-09-17 Phylos Inc IMPROVED METHODS OF PRODUCING CATAYTIC PROTEINS
US20040142325A1 (en) * 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
US20060189941A1 (en) 2002-01-22 2006-08-24 Mercator Medsystems, Inc. Methods and kits for volumetric distribution of pharmaceutical agents via the vascular adventitia and microcirculation
EP1624786A4 (en) 2003-02-20 2011-07-13 Proteon Therapeutics Inc METHOD FOR THE TREATMENT AND PREVENTION OF ILLNESSES OF BIOLOGICAL CHANNELS
US7571008B2 (en) 2003-08-18 2009-08-04 Medtronic, Inc. System and apparatus for remote activation of implantable medical devices
ES2427046T3 (es) * 2004-06-21 2013-10-28 Galapagos N.V. Métodos y medios para el tratamiento de la osteoartritis
JP2008513517A (ja) 2004-09-22 2008-05-01 プロテオン セラペウチクス インコーポレーテッド 生物学的導管の疾患の治療方法及び予防方法
RU2299070C2 (ru) * 2005-02-08 2007-05-20 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Фармацевтическая композиция для лечения заболевания вен и способ ее получения
US20060193824A1 (en) 2005-02-28 2006-08-31 Rubin Bruce K Methods for the treatment of infectious and inflammatory airway diseases
CN1769424A (zh) * 2005-09-20 2006-05-10 浙江大学 一种芽孢杆菌菌株及其用途
US8211428B2 (en) * 2006-07-05 2012-07-03 Torrey Pines Institute For Molecular Studies Protease screening methods and proteases identified thereby
US8501449B2 (en) * 2007-12-04 2013-08-06 Proteon Therapeutics, Inc. Recombinant elastase proteins and methods of manufacturing and use thereof
JP5811483B2 (ja) * 2008-04-03 2015-11-11 シービー バイオテクノロジーズ インコーポレイテッド 多数の標的の増幅のためのアンプリコンレスキューマルチプレックスポリメラーゼ連鎖反応

Also Published As

Publication number Publication date
US9057060B2 (en) 2015-06-16
EP2229440A2 (en) 2010-09-22
DK2666854T3 (da) 2017-05-22
AU2008338743A1 (en) 2009-06-25
US20160319267A1 (en) 2016-11-03
WO2009079220A3 (en) 2009-08-06
EP2666854A1 (en) 2013-11-27
RU2611200C2 (ru) 2017-02-21
CY1118930T1 (el) 2018-01-10
US20180208918A1 (en) 2018-07-26
CA2707051A1 (en) 2009-06-25
EP2229440B1 (en) 2013-08-28
HUE032739T2 (en) 2017-10-30
CA2707051C (en) 2019-05-21
TW201643188A (zh) 2016-12-16
AU2008338743B2 (en) 2015-02-19
BRPI0819977A2 (pt) 2020-08-18
CN101918547A (zh) 2010-12-15
MX2010006211A (es) 2010-10-25
NZ585866A (en) 2012-09-28
US20150166974A1 (en) 2015-06-18
TW200938219A (en) 2009-09-16
NZ601592A (en) 2014-02-28
EP3176262A1 (en) 2017-06-07
SI2666854T1 (sl) 2017-06-30
US20180273928A1 (en) 2018-09-27
KR101824350B1 (ko) 2018-01-31
KR101732190B1 (ko) 2017-05-04
RS53083B (en) 2014-06-30
IL206157A (en) 2013-07-31
CN104711243A (zh) 2015-06-17
CN103952388B (zh) 2017-10-03
HRP20131135T1 (hr) 2014-01-03
JP5829808B2 (ja) 2015-12-09
US20160243205A1 (en) 2016-08-25
CN104711243B (zh) 2019-06-11
US20180155703A1 (en) 2018-06-07
US8501449B2 (en) 2013-08-06
JP2017104114A (ja) 2017-06-15
ES2436783T3 (es) 2014-01-07
IL206157A0 (en) 2010-12-30
US20190062718A1 (en) 2019-02-28
US20130336956A1 (en) 2013-12-19
CN103952388A (zh) 2014-07-30
IL226771A0 (en) 2013-07-31
HK1148772A1 (en) 2011-09-16
US20110081705A1 (en) 2011-04-07
SI2229440T1 (sl) 2013-12-31
JP6084653B2 (ja) 2017-02-22
RS55982B1 (sr) 2017-09-29
JP2015172056A (ja) 2015-10-01
PL2666854T3 (pl) 2017-08-31
KR20100120639A (ko) 2010-11-16
PT2666854T (pt) 2017-06-28
PT2229440E (pt) 2013-11-11
TWI577385B (zh) 2017-04-11
KR20180011860A (ko) 2018-02-02
AR069584A1 (es) 2010-02-03
CY1114724T1 (el) 2016-10-05
US10308924B2 (en) 2019-06-04
US20190010476A1 (en) 2019-01-10
EP2666854B1 (en) 2017-03-15
HRP20170755T1 (hr) 2017-07-28
CN109893647A (zh) 2019-06-18
RU2010127232A (ru) 2012-01-10
JP2011505164A (ja) 2011-02-24
US20110008315A1 (en) 2011-01-13
US20090162343A1 (en) 2009-06-25
MX341317B (es) 2016-08-15
US10301612B2 (en) 2019-05-28
EP2229440B9 (en) 2013-11-13
CN101918547B (zh) 2015-01-14
LT2666854T (lt) 2017-06-12
US20200208132A1 (en) 2020-07-02
US20150329846A1 (en) 2015-11-19
US20150322420A9 (en) 2015-11-12
DK2229440T3 (da) 2013-12-09
KR20160095184A (ko) 2016-08-10
TWI619726B (zh) 2018-04-01
ES2627066T3 (es) 2017-07-26
WO2009079220A2 (en) 2009-06-25

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