ES2929579T3 - Tratamiento terapéutico de enfermedades cutáneas con microorganismos cutáneos comensales recombinantes - Google Patents
Tratamiento terapéutico de enfermedades cutáneas con microorganismos cutáneos comensales recombinantes Download PDFInfo
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- ES2929579T3 ES2929579T3 ES15799765T ES15799765T ES2929579T3 ES 2929579 T3 ES2929579 T3 ES 2929579T3 ES 15799765 T ES15799765 T ES 15799765T ES 15799765 T ES15799765 T ES 15799765T ES 2929579 T3 ES2929579 T3 ES 2929579T3
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- 239000004408 titanium dioxide Substances 0.000 description 1
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- 229960001727 tretinoin Drugs 0.000 description 1
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- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- 229960002117 triamcinolone acetonide Drugs 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- UEVAMYPIMMOEFW-UHFFFAOYSA-N trolamine salicylate Chemical compound OCCN(CCO)CCO.OC(=O)C1=CC=CC=C1O UEVAMYPIMMOEFW-UHFFFAOYSA-N 0.000 description 1
- 229940030300 trolamine salicylate Drugs 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
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- WZVWUSABZGIQJZ-UHFFFAOYSA-N z2-tocopherol Chemical compound OC1=C(C)C=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C WZVWUSABZGIQJZ-UHFFFAOYSA-N 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 229960001296 zinc oxide Drugs 0.000 description 1
- 229940043810 zinc pyrithione Drugs 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Marine Sciences & Fisheries (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Rehabilitation Therapy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462005652P | 2014-05-30 | 2014-05-30 | |
| US201462005558P | 2014-05-30 | 2014-05-30 | |
| PCT/US2015/032972 WO2015184134A1 (en) | 2014-05-30 | 2015-05-28 | Therapeutic tratment of skin disease with recombinant commensal skin microorganisms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2929579T3 true ES2929579T3 (es) | 2022-11-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES15799765T Active ES2929579T3 (es) | 2014-05-30 | 2015-05-28 | Tratamiento terapéutico de enfermedades cutáneas con microorganismos cutáneos comensales recombinantes |
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| Country | Link |
|---|---|
| US (3) | US10702558B2 (enExample) |
| EP (2) | EP4144756A1 (enExample) |
| JP (2) | JP6810028B2 (enExample) |
| CA (1) | CA2979079A1 (enExample) |
| ES (1) | ES2929579T3 (enExample) |
| MA (1) | MA40057A (enExample) |
| WO (1) | WO2015184134A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP4144756A1 (en) | 2014-05-30 | 2023-03-08 | Azitra, Inc. | Therapeutic treatment of skin disease with recombinant commensal skin microorganisms |
| AU2017254684A1 (en) | 2016-04-21 | 2018-12-06 | Weiss Bioscience, Inc. | Compositions and methods for treatment of skin disorders |
| JP2020527357A (ja) * | 2017-06-16 | 2020-09-10 | アジトラ インコーポレーテッド | Ｌｅｋｔｉ発現組換え微生物を用いたネザートン症候群の処置のための組成物および方法 |
| EP3675884A4 (en) * | 2017-08-31 | 2021-08-11 | The Regents of the University of California | MOLECULAR BACTERIOTHERAPY TO CONTROL ENZYMATIC ACTIVITY OF THE SKIN |
| WO2019050898A1 (en) * | 2017-09-05 | 2019-03-14 | Azitra Inc | METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY SKIN DISEASE |
| JP7460531B2 (ja) | 2017-12-05 | 2024-04-02 | バイオピーエルエックス，インコーポレイティド | 微生物感染を防ぐための方法および組成物 |
| JP7121969B2 (ja) * | 2018-02-23 | 2022-08-19 | 株式会社北里コーポレーション | 培養液保護用液状物 |
| AU2019249249B2 (en) | 2018-04-05 | 2025-03-13 | Azitra Inc | Methods and compositions for treating skin disease with recombinant microorganisms |
| AU2019203692B2 (en) * | 2018-08-30 | 2024-12-12 | Kenvue Brands Llc | Topical composition containing glycerin and yeast extract |
| US20210395775A1 (en) * | 2018-09-26 | 2021-12-23 | Krystal Biotech, Inc. | Compositions and methods for the treatment of skin diseases |
| WO2020076770A1 (en) * | 2018-10-08 | 2020-04-16 | Yale University | Selective binding and aggregation of human keratin in the skin barrier using human filaggrin subdomains sd67 and sd150 |
| EP3880241A4 (en) * | 2018-11-16 | 2022-08-17 | Azitra, Inc. | AUXOTROPHIC STRAINS OF STAPHYLOCOCCUS BACTERIA |
| CZ308231B6 (cs) * | 2019-02-11 | 2020-03-11 | BiomCare s.r.o. | Kombinované několikastupňové mikrobiální přípravky a způsob jejich aplikace |
| CA3136115A1 (en) * | 2019-04-05 | 2020-10-08 | Azitra Inc | Methods and compositions for treating atopic dermatitis with recombinant microorganisms |
| US20220362358A1 (en) * | 2019-06-19 | 2022-11-17 | Chan Zuckerberg Biohub, Inc. | Bacteria-engineered to elicit antigen-specific t-cells |
| KR20220133262A (ko) * | 2020-01-29 | 2022-10-04 | 더 잭슨 래보라토리 | 박테리아 혼합물 |
| WO2022087065A1 (en) * | 2020-10-21 | 2022-04-28 | The Jackson Laboratory | Antimicrobial biosensors |
| EP4274435A1 (en) * | 2021-01-05 | 2023-11-15 | Lactobio A/S | Strains, compositions and methods of use |
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| JPH0637384B2 (ja) * | 1985-09-21 | 1994-05-18 | 株式会社資生堂 | 皮膚化粧料 |
| US4659774A (en) | 1985-11-01 | 1987-04-21 | American Hoechst Corporation | Support for solid-phase oligonucleotide synthesis |
| DE4221255C2 (de) | 1992-06-26 | 1994-09-15 | Lancaster Group Ag | Phospholipide enthaltendes Kosmetikum |
| DE4221268C2 (de) | 1992-06-26 | 1997-06-12 | Lancaster Group Ag | Verwendung eines Dermatikums zur Unterstützung des Sauerstofftransportes in der Haut |
| US20120295952A1 (en) * | 2009-09-25 | 2012-11-22 | Curna, Inc. | Treatment of filaggrin (flg) related diseases by modulation of flg expression and activity |
| AU2010321784B2 (en) | 2009-11-23 | 2014-04-24 | Research Development Foundation | Recombinant filaggrin polypeptides for cell importation |
| US20130078275A1 (en) * | 2010-05-25 | 2013-03-28 | The Board Of Trustees Of The University Of Illinois | Novel systems, vectors, and methods for delivery of biomolecules to eukaryotic cells |
| US9234204B2 (en) * | 2012-08-07 | 2016-01-12 | TopGeniX, Inc. | Topical composition comprising transformed bacteria expressing a compound of interest |
| KR101491240B1 (ko) | 2013-03-15 | 2015-02-11 | 현대자동차주식회사 | 인비저블 슬라이딩 도어 링크 구조 |
| EP4144756A1 (en) | 2014-05-30 | 2023-03-08 | Azitra, Inc. | Therapeutic treatment of skin disease with recombinant commensal skin microorganisms |
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2015
- 2015-05-28 EP EP22182996.3A patent/EP4144756A1/en active Pending
- 2015-05-28 WO PCT/US2015/032972 patent/WO2015184134A1/en not_active Ceased
- 2015-05-28 EP EP15799765.1A patent/EP3148569B1/en active Active
- 2015-05-28 CA CA2979079A patent/CA2979079A1/en active Pending
- 2015-05-28 US US15/312,441 patent/US10702558B2/en active Active
- 2015-05-28 MA MA040057A patent/MA40057A/fr unknown
- 2015-05-28 JP JP2017515014A patent/JP6810028B2/ja active Active
- 2015-05-28 ES ES15799765T patent/ES2929579T3/es active Active
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2020
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- 2020-12-10 JP JP2020205127A patent/JP2021038271A/ja active Pending
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2024
- 2024-06-06 US US18/735,645 patent/US20250009810A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MA40057A (fr) | 2015-12-03 |
| US20210379120A1 (en) | 2021-12-09 |
| US20250009810A1 (en) | 2025-01-09 |
| JP2017518370A (ja) | 2017-07-06 |
| EP3148569A1 (en) | 2017-04-05 |
| JP6810028B2 (ja) | 2021-01-06 |
| EP4144756A1 (en) | 2023-03-08 |
| WO2015184134A1 (en) | 2015-12-03 |
| CA2979079A1 (en) | 2015-12-03 |
| US10702558B2 (en) | 2020-07-07 |
| EP3148569B1 (en) | 2022-07-06 |
| EP3148569A4 (en) | 2017-11-22 |
| US12036248B2 (en) | 2024-07-16 |
| US20180161380A1 (en) | 2018-06-14 |
| JP2021038271A (ja) | 2021-03-11 |
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