SI1499729T1 - Derivati encima ki inducira nf-kappab njihova priprava in uporaba - Google Patents

Derivati encima ki inducira nf-kappab njihova priprava in uporaba

Info

Publication number
SI1499729T1
SI1499729T1 SI200332055T SI200332055T SI1499729T1 SI 1499729 T1 SI1499729 T1 SI 1499729T1 SI 200332055 T SI200332055 T SI 200332055T SI 200332055 T SI200332055 T SI 200332055T SI 1499729 T1 SI1499729 T1 SI 1499729T1
Authority
SI
Slovenia
Prior art keywords
derivatives
preparation
inducing enzyme
kappab
kappab inducing
Prior art date
Application number
SI200332055T
Other languages
English (en)
Inventor
David Wallach
Parameswaran Ramakrishnan
Taisia Shmushkovich
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL14921702A external-priority patent/IL149217A0/xx
Priority claimed from IL15218302A external-priority patent/IL152183A0/xx
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of SI1499729T1 publication Critical patent/SI1499729T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
SI200332055T 2002-04-18 2003-04-15 Derivati encima ki inducira nf-kappab njihova priprava in uporaba SI1499729T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IL14921702A IL149217A0 (en) 2002-04-18 2002-04-18 Derivatives of the il-2 receptor gamma chain, their preparation and use
IL15218302A IL152183A0 (en) 2002-10-08 2002-10-08 Derivatives of the il-2 receptor gamma chain, their preparation and use
EP03746399A EP1499729B9 (en) 2002-04-18 2003-04-15 Derivatives of the nf-kappab inducing enzyme, their preparation and use
PCT/IL2003/000317 WO2003087380A1 (en) 2002-04-18 2003-04-15 Derivatives of the nf-kappab inducing enzyme, their preparation and use

Publications (1)

Publication Number Publication Date
SI1499729T1 true SI1499729T1 (sl) 2011-11-30

Family

ID=29252551

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200332055T SI1499729T1 (sl) 2002-04-18 2003-04-15 Derivati encima ki inducira nf-kappab njihova priprava in uporaba

Country Status (13)

Country Link
US (3) US8330026B2 (sl)
EP (2) EP1499724B1 (sl)
JP (2) JP4435575B2 (sl)
AR (2) AR039646A1 (sl)
AT (1) ATE521707T1 (sl)
AU (2) AU2003222415B2 (sl)
CA (2) CA2482387C (sl)
CY (1) CY1111864T1 (sl)
DK (1) DK1499729T5 (sl)
ES (1) ES2415331T3 (sl)
PT (1) PT1499729E (sl)
SI (1) SI1499729T1 (sl)
WO (2) WO2003087380A1 (sl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL158287A0 (en) 2003-10-07 2004-05-12 Yeda Res & Dev Antibodies to nik, their preparation and use
CA2547459C (en) 2003-11-30 2013-10-08 Yeda Research And Development Co. Ltd Modulators of nik-siva complex formation for treating immune disorders
US8034773B2 (en) * 2004-02-05 2011-10-11 Arizona Biomedical Research Commission Immunostimulatory compositions and uses thereof
IL166006A0 (en) * 2004-12-27 2006-01-15 Yeda Res & Dev Pharmaceutical compositions for treating diseases associated with nf-kb activity
US8663309B2 (en) 2007-09-26 2014-03-04 Trivascular, Inc. Asymmetric stent apparatus and method
US8066755B2 (en) 2007-09-26 2011-11-29 Trivascular, Inc. System and method of pivoted stent deployment
US8226701B2 (en) 2007-09-26 2012-07-24 Trivascular, Inc. Stent and delivery system for deployment thereof
WO2009046372A2 (en) * 2007-10-04 2009-04-09 Trivascular2, Inc. Modular vascular graft for low profile percutaneous delivery
US8083789B2 (en) 2007-11-16 2011-12-27 Trivascular, Inc. Securement assembly and method for expandable endovascular device
US8328861B2 (en) 2007-11-16 2012-12-11 Trivascular, Inc. Delivery system and method for bifurcated graft
US8992595B2 (en) 2012-04-04 2015-03-31 Trivascular, Inc. Durable stent graft with tapered struts and stable delivery methods and devices
US9498363B2 (en) 2012-04-06 2016-11-22 Trivascular, Inc. Delivery catheter for endovascular device
LT3401402T (lt) * 2012-06-08 2020-12-28 Alkermes Pharma Ireland Limited Ligandai, modifikuoti cirkuliarinės permutacijos pagalba, kaip agonistai ir antagonistai
WO2018152371A1 (en) * 2017-02-15 2018-08-23 Fred Hutchinson Cancer Research Center In vivo gene therapy for immune deficiencies
EP3609519A4 (en) * 2017-04-11 2021-03-31 University of Maryland, Baltimore COMPOSITIONS AND METHODS FOR TREATING INFLAMMATION AND CANCER

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US510259A (en) * 1893-12-05 Pavement
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
JP3255699B2 (ja) 1992-04-23 2002-02-12 味の素株式会社 ヒトＩＬ−２レセプターγ鎖分子
US7070972B1 (en) * 1995-01-13 2006-07-04 The United States Of America As Represented By The Department Of Health And Human Services Janus family kinases and identification of immune modulators
UA71889C2 (uk) * 1996-04-02 2005-01-17 Йєда Рісерч Енд Дівелопмент Ко. Лтд. Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування
EP2305027B1 (en) 1996-12-03 2014-07-02 Amgen Fremont Inc. Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom
US5843721A (en) 1997-07-03 1998-12-01 Tularik Inc. Nucleic acids encoding human NIK protein
NZ514414A (en) 1999-03-04 2004-02-27 Praecis Pharm Inc Modulators of beta-amyloid peptide aggregation comprising D-amino acids

Also Published As

Publication number Publication date
CA2482718A1 (en) 2003-10-23
AU2003226607C1 (en) 2011-02-24
CA2482387C (en) 2015-03-03
JP4435575B2 (ja) 2010-03-17
JP2005530491A (ja) 2005-10-13
CY1111864T1 (el) 2015-11-04
US7416730B2 (en) 2008-08-26
JP2005525113A (ja) 2005-08-25
US20050272633A1 (en) 2005-12-08
AU2003222415B2 (en) 2009-02-05
CA2482387A1 (en) 2003-10-23
AU2003226607A1 (en) 2003-10-27
ES2415331T3 (es) 2013-07-25
EP1499724A1 (en) 2005-01-26
EP1499729A1 (en) 2005-01-26
AU2003226607B2 (en) 2009-02-05
EP1499729B1 (en) 2011-08-24
PT1499729E (pt) 2011-09-06
EP1499729B9 (en) 2012-03-14
AU2003222415A1 (en) 2003-10-27
WO2003087374A1 (en) 2003-10-23
US20050287144A1 (en) 2005-12-29
JP4435574B2 (ja) 2010-03-17
DK1499729T5 (da) 2011-12-05
DK1499729T3 (da) 2011-10-03
EP1499724B1 (en) 2013-05-22
WO2003087380A1 (en) 2003-10-23
US8330026B2 (en) 2012-12-11
AR039646A1 (es) 2005-03-02
US8048847B2 (en) 2011-11-01
ATE521707T1 (de) 2011-09-15
WO2003087374A9 (en) 2005-01-27
CA2482718C (en) 2014-08-19
AR039645A1 (es) 2005-03-02
US20090042796A1 (en) 2009-02-12

Similar Documents

Publication Publication Date Title
HK1044545A1 (zh) 貝他分泌酶組合物及其方法
AU2003284808A8 (en) The derivatives of pyridone and the use of them
MXPA03006010A (es) Derivados de arilamina sustituida y metodos de uso.
EP1546112A4 (en) IMIDAZOLOPYRIDINE AND METHOD FOR THE PRODUCTION AND USE THEREOF
IL176478A0 (en) Derivatives of 1-piperazine- and 1-homopiperazine-carboxylates, preparation method thereof and use of same as inhibitors of the faah enzyme
EP1465615A4 (en) TRICYCLIC BISENONE DERIVATIVES AND METHODS OF USE
AU2003266321A1 (en) Tetrahydropyrimidine-2-one derivatives and their uses
IL164249A0 (en) Acyl-3-carboxphenylurea derivatives, processes forpreparing them and their use
MXPA03006260A (es) Derivados de amina sustituidos y metodos de uso.
HK1076110A1 (en) Piperazinylacylpiperidine derivatives, their preparation and therapeutic use thereof
PT1499729E (pt) Derivados da enzima de indução de nf-kappab, sua preparação e utilização
HK1081954A1 (en) Novel 1,4-diazabicycloalkane derivatives, their preparation and use
IL163868A0 (en) Hermiasterlin derivatives and uses thereof
AU2003224747A1 (en) Technetium-labeled rotenone derivatives, and methods of use thereof
PT1525193E (pt) Derivados do acilaminotiazole e sua utilização como inibidores de beta amilóide
HK1074444A1 (en) Acyloxypyrrolidine derivatives, preparation and therapeutic use thereof
PL1786759T3 (pl) Nowe pochodne 3,5-seko-4-norcholestanowe i ich zastosowanie
AU2003235506A8 (en) Targeted enzymes and methods of making and using targeted enzymes.
AU2003297612A8 (en) 2-substituted-3-propenamide derivatives and methods of using the same
AU2003206872A1 (en) Derivatives of (1-benzyl-piperidine-4-yl)-diphenyl-methanol and their use as pesticide
EP1517879A4 (en) AMINOALKYLPHENOLS AND METHODS OF USE AND MANUFACTURE
AU2002302551A1 (en) Flavone synthase i enzymes and the use thereof
AU2003260566A1 (en) Phenyl-furan or phenyl-thiophene derivatives, their preparation and their use as medicine
EP1499338A4 (en) 7-HYDROXY-16ALPHA-FLUORO-5-ANDROSENES-17-ONE AND 7-HYDROXY-16ALPHA-FLUORO-5-ANDROSTAN-17-ONE AND THEIR DERIVATIVES
AU2003300607A8 (en) Mannuronan c5-epimerases of brown algae, methods of obtaining same and use thereof