JP2014509841A - 癌を治療するための組成物および方法 - Google Patents

癌を治療するための組成物および方法 Download PDF

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JP2014509841A
JP2014509841A JP2013550567A JP2013550567A JP2014509841A JP 2014509841 A JP2014509841 A JP 2014509841A JP 2013550567 A JP2013550567 A JP 2013550567A JP 2013550567 A JP2013550567 A JP 2013550567A JP 2014509841 A JP2014509841 A JP 2014509841A
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cells
acid sequence
car
nucleic acid
cell
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JP2014509841A5 (enExample
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ダニエル ジェイ． パウエル
ジョージ クーコス
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ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
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    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/59—Reproductive system, e.g. uterus, ovaries, cervix or testes
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor

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JP2013550567A 2011-01-18 2012-01-18 癌を治療するための組成物および方法 Pending JP2014509841A (ja)

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US201161433731P 2011-01-18 2011-01-18
US61/433,731 2011-01-18
PCT/US2012/021738 WO2012099973A2 (en) 2011-01-18 2012-01-18 Compositions and methods for treating cancer

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JP2014509841A5 JP2014509841A5 (enExample) 2015-03-05

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US (4) US9402865B2 (enExample)
EP (1) EP2665521A4 (enExample)
JP (1) JP2014509841A (enExample)
KR (1) KR20140004174A (enExample)
CN (1) CN103442768A (enExample)
AU (1) AU2012207356A1 (enExample)
BR (1) BR112013018311A2 (enExample)
CA (2) CA2824997C (enExample)
EA (1) EA201391059A1 (enExample)
IL (1) IL227429A0 (enExample)
MX (1) MX2013008376A (enExample)
SG (1) SG192010A1 (enExample)
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Cited By (9)

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JP2018516915A (ja) * 2015-05-28 2018-06-28 カイト ファーマ インコーポレイテッドＫｉｔｅ Ｐｈａｒｍａ， Ｉｎｃ Ｔ細胞療法のために患者をコンディショニングする方法
JP2018531618A (ja) * 2015-10-30 2018-11-01 チルドレンズ ナショナル メディカル センターＣｈｉｌｄｒｅｎ’Ｓ Ｎａｔｉｏｎａｌ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ ナイーブｔ細胞集団からのｈｐｖ抗原特異的ｔ細胞の生成
JP2018534327A (ja) * 2015-11-19 2018-11-22 ノバルティス アーゲー レンチウイルス調製物の安定化のための緩衝液
JP2020532954A (ja) * 2017-08-09 2020-11-19 ジュノー セラピューティクス インコーポレイテッド 遺伝子操作された細胞の組成物および関連組成物を産生するための方法
JP2021507716A (ja) * 2017-12-22 2021-02-25 キャンサー・リサーチ・テクノロジー・リミテッド 融合タンパク質
JP2021531825A (ja) * 2018-07-09 2021-11-25 マルチチュード インコーポレーテッドMultitude Inc. 葉酸受容体アルファに特異的な抗体
JP2022504826A (ja) * 2018-10-10 2022-01-13 ザイムワークス，インコーポレイテッド ４－１ｂｂ及び腫瘍関連抗原に結合する抗体構築物ならびにその使用
JP2022553200A (ja) * 2019-10-16 2022-12-22 ウモジャ バイオファーマ， インコーポレイテッド ユニバーサル受容体療法のためのレトロウイルスベクター
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KR20140004174A (ko) * 2011-01-18 2014-01-10 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 암 치료를 위한 조성물 및 방법
BR112014029417B1 (pt) 2012-05-25 2023-03-07 Cellectis Método ex vivo para a preparação de células t para imunoterapia
WO2014055442A2 (en) * 2012-10-01 2014-04-10 The Trustees Of The University Of Pennsylvania Compositions and methods for targeting stromal cells for the treatment of cancer
WO2014055657A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
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KR102375998B1 (ko) * 2014-02-14 2022-03-21 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 키메라 항원 수용체 및 제조방법
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HUE049514T2 (hu) 2014-04-25 2020-09-28 Bluebird Bio Inc Javított eljárások adoptív sejtterápiák kialakítására
PL3134432T3 (pl) 2014-04-25 2020-10-19 Bluebird Bio, Inc. Promotor mnd chimeryczne receptory antygenowe
CN113604491A (zh) * 2014-05-02 2021-11-05 宾夕法尼亚大学董事会 嵌合自身抗体受体t细胞的组合物和方法
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BR112017001183A2 (pt) 2014-07-21 2017-11-28 Novartis Ag tratamento de câncer usando receptor de antígeno quimérico anti-bcma humanizado
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TWI719942B (zh) 2014-07-21 2021-03-01 瑞士商諾華公司 使用ｃｄ３３嵌合抗原受體治療癌症
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ES2878449T3 (es) 2014-07-24 2021-11-18 2Seventy Bio Inc Receptores antigénicos quiméricos de BCMA
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