JP2013138681A5 - - Google Patents
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- JP2013138681A5 JP2013138681A5 JP2013048777A JP2013048777A JP2013138681A5 JP 2013138681 A5 JP2013138681 A5 JP 2013138681A5 JP 2013048777 A JP2013048777 A JP 2013048777A JP 2013048777 A JP2013048777 A JP 2013048777A JP 2013138681 A5 JP2013138681 A5 JP 2013138681A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid molecule
- stranded rna
- region
- rna nucleic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000014509 gene expression Effects 0.000 claims description 32
- 239000000203 mixture Substances 0.000 claims description 3
- 125000003729 nucleotide group Chemical group 0.000 claims description 3
- 238000000034 method Methods 0.000 claims 11
- 230000001629 suppression Effects 0.000 claims 11
- 229910052799 carbon Inorganic materials 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 125000004429 atom Chemical group 0.000 claims 6
- 125000005647 linker group Chemical group 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 239000004721 Polyphenylene oxide Substances 0.000 claims 4
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 230000009368 gene silencing by RNA Effects 0.000 claims 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims 4
- 229920000570 polyether Polymers 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000001301 oxygen Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
- 101150112014 Gapdh gene Proteins 0.000 description 8
- 0 CC(C)C(C)(CCC(C)C(C)O**)CCN1C(COC)CCC1 Chemical compound CC(C)C(C)(CCC(C)C(C)O**)CCN1C(COC)CCC1 0.000 description 7
- 238000010586 diagram Methods 0.000 description 5
- NAGJZTKCGNOGPW-UHFFFAOYSA-K dioxido-sulfanylidene-sulfido-$l^{5}-phosphane Chemical compound [O-]P([O-])([S-])=S NAGJZTKCGNOGPW-UHFFFAOYSA-K 0.000 description 4
- 238000001962 electrophoresis Methods 0.000 description 4
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 3
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000008139 complexing agent Substances 0.000 description 2
- 239000001177 diphosphate Substances 0.000 description 2
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 2
- 235000011180 diphosphates Nutrition 0.000 description 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 2
- 239000001226 triphosphate Substances 0.000 description 2
- 235000011178 triphosphate Nutrition 0.000 description 2
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 1
- 102100023387 Endoribonuclease Dicer Human genes 0.000 description 1
- 101000907904 Homo sapiens Endoribonuclease Dicer Proteins 0.000 description 1
- 102100026720 Interferon beta Human genes 0.000 description 1
- 108090000467 Interferon-beta Proteins 0.000 description 1
- 101150077556 LMNA gene Proteins 0.000 description 1
- 101100127662 Mus musculus Lama1 gene Proteins 0.000 description 1
- 101710163270 Nuclease Proteins 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- 108010083644 Ribonucleases Proteins 0.000 description 1
- 102000006382 Ribonucleases Human genes 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical compound OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 description 1
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229960005305 adenosine Drugs 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229940029575 guanosine Drugs 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 150000004712 monophosphates Chemical class 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- -1 sulfur-substituted monophosphate Chemical class 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013048777A JP5555346B2 (ja) | 2010-08-03 | 2013-03-12 | 含窒素脂環式骨格を有する一本鎖核酸分子 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010174915 | 2010-08-03 | ||
| JP2010174915 | 2010-08-03 | ||
| JP2010230806 | 2010-10-13 | ||
| JP2010230806 | 2010-10-13 | ||
| JP2010269823 | 2010-12-02 | ||
| JP2010269823 | 2010-12-02 | ||
| JP2011152381 | 2011-07-08 | ||
| JP2011152381 | 2011-07-08 | ||
| JP2013048777A JP5555346B2 (ja) | 2010-08-03 | 2013-03-12 | 含窒素脂環式骨格を有する一本鎖核酸分子 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012026878A Division JP5261677B2 (ja) | 2010-08-03 | 2012-02-10 | 含窒素脂環式骨格を有する一本鎖核酸分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013138681A JP2013138681A (ja) | 2013-07-18 |
| JP2013138681A5 true JP2013138681A5 (https=) | 2013-08-29 |
| JP5555346B2 JP5555346B2 (ja) | 2014-07-23 |
Family
ID=45559420
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537085A Expired - Fee Related JP4965745B2 (ja) | 2010-08-03 | 2011-07-28 | 含窒素脂環式骨格を有する一本鎖核酸分子 |
| JP2012026878A Expired - Fee Related JP5261677B2 (ja) | 2010-08-03 | 2012-02-10 | 含窒素脂環式骨格を有する一本鎖核酸分子 |
| JP2013048777A Expired - Fee Related JP5555346B2 (ja) | 2010-08-03 | 2013-03-12 | 含窒素脂環式骨格を有する一本鎖核酸分子 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537085A Expired - Fee Related JP4965745B2 (ja) | 2010-08-03 | 2011-07-28 | 含窒素脂環式骨格を有する一本鎖核酸分子 |
| JP2012026878A Expired - Fee Related JP5261677B2 (ja) | 2010-08-03 | 2012-02-10 | 含窒素脂環式骨格を有する一本鎖核酸分子 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8691782B2 (https=) |
| EP (4) | EP2639307B1 (https=) |
| JP (3) | JP4965745B2 (https=) |
| KR (3) | KR101894702B1 (https=) |
| CN (3) | CN104004018B (https=) |
| DK (1) | DK2674494T3 (https=) |
| ES (4) | ES2527660T3 (https=) |
| PT (1) | PT2674494E (https=) |
| TW (2) | TWI515294B (https=) |
| WO (1) | WO2012017919A1 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2639307B1 (en) | 2010-08-03 | 2015-03-04 | Bonac Corporation | Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton |
| WO2013077446A1 (ja) * | 2011-11-26 | 2013-05-30 | 株式会社ボナック | 遺伝子発現制御のための一本鎖核酸分子 |
| EP2824184B1 (en) * | 2012-03-04 | 2017-09-27 | Bonac Corporation | micro-RNA INHIBITOR |
| WO2013133393A1 (ja) * | 2012-03-07 | 2013-09-12 | 学校法人東京医科大学 | Ｖｅｇｆ遺伝子の発現抑制用一本鎖核酸分子 |
| CA2868716A1 (en) * | 2012-03-29 | 2013-10-03 | Kyushu University National University Corporation | Nucleic acid molecule capable of inhibiting expression of periostin gene, method for inhibiting expression of periostin gene, and use of said nucleic acid molecule |
| WO2013180038A1 (ja) | 2012-05-26 | 2013-12-05 | 株式会社ボナック | デリバリー機能を有する遺伝子発現制御用の一本鎖核酸分子 |
| US20160304866A1 (en) * | 2013-09-27 | 2016-10-20 | Aqua Therapeutics Co., Ltd. | Drug for Disease Caused by Expression of Periostin Except Eye Disease, and Use Thereof |
| WO2015093495A1 (ja) * | 2013-12-16 | 2015-06-25 | 株式会社ボナック | ＴＧＦ－β１遺伝子発現制御のための一本鎖核酸分子 |
| WO2015099122A1 (ja) | 2013-12-26 | 2015-07-02 | 学校法人東京医科大学 | 遺伝子発現制御のための人工ミミックｍｉＲＮＡおよびその用途 |
| JP6492014B2 (ja) * | 2013-12-27 | 2019-03-27 | 株式会社ボナック | 遺伝子発現制御のための人工マッチ型ｍｉＲＮＡおよびその用途 |
| CN106068324B (zh) * | 2013-12-27 | 2020-12-29 | 株式会社博纳克 | 控制基因表达的人工匹配型miRNA及其用途 |
| EP3235906B1 (en) * | 2014-12-15 | 2021-06-23 | Bonac Corporation | Single-stranded nucleic acid molecule for inhibiting tgf- beta 1 expression |
| KR20170098914A (ko) * | 2014-12-27 | 2017-08-30 | 가부시키가이샤 보낙 | 유전자 발현 제어를 위한 천연형 miRNA 및 그의 용도 |
| BR112017014090A2 (pt) * | 2014-12-29 | 2018-03-06 | Bonac Corporation | composição, e, métodos para produção de uma composição e estabilização de uma molécula de ácido nucleico. |
| WO2016158809A1 (ja) | 2015-03-27 | 2016-10-06 | 株式会社ボナック | デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子 |
| US20180099004A1 (en) * | 2015-04-17 | 2018-04-12 | The University Of Tokyo | Therapeutic agent for eye disease |
| SG11201803410RA (en) | 2015-10-30 | 2018-05-30 | Bonac Corp | COMPOSITION STABLY CONTAINING SINGLE-STRANDED NUCLEIC ACID MOLECULE THAT SUPPRESSES EXPRESSION OF TGF-ß1 GENE |
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| WO2017131124A1 (ja) | 2016-01-26 | 2017-08-03 | 日産化学工業株式会社 | 一本鎖オリゴヌクレオチド |
| CN109072224B (zh) * | 2016-01-30 | 2022-07-15 | 株式会社博纳克 | 人工单导rna及其用途 |
| EP3450439B8 (en) * | 2016-04-26 | 2021-06-30 | Sumitomo Chemical Company, Limited | Method for producing monomer for single-stranded nucleic acid molecule |
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| JPWO2018182008A1 (ja) | 2017-03-31 | 2020-02-06 | 株式会社ボナック | 遺伝子発現制御機能を有する環状型核酸分子 |
| JPWO2018199338A1 (ja) * | 2017-04-27 | 2020-03-12 | 国立大学法人広島大学 | Ｂ型肝炎治療用核酸分子 |
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| BR112020018902A2 (pt) | 2018-03-20 | 2021-01-26 | Tokyo Institute Of Technology | oligonucleotídeo antissenso com toxicidade reduzida |
| JP6817493B2 (ja) * | 2018-03-30 | 2021-01-20 | 住友化学株式会社 | 一本鎖ｒｎａの製造方法 |
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| KR102670605B1 (ko) * | 2018-04-24 | 2024-05-29 | 스미또모 가가꾸 가부시끼가이샤 | 아미다이트 화합물 및 그 화합물을 사용한 폴리뉴클레오티드의 제조 방법 |
| KR20210069628A (ko) | 2018-10-02 | 2021-06-11 | 도레이 카부시키가이샤 | 헤어핀형 단일쇄 rna 분자의 제조 방법 |
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| JP7368455B2 (ja) | 2019-03-29 | 2023-10-24 | 住友化学株式会社 | 無機多孔質担体、及びこれを用いた核酸の製造方法 |
| JP7640461B2 (ja) | 2019-10-11 | 2025-03-05 | 住友化学株式会社 | 核酸オリゴマーの製造方法 |
| EP4098655A4 (en) | 2020-01-29 | 2024-02-28 | Sumitomo Chemical Company, Limited | METHOD FOR PRODUCING NUCLEIC ACID OLIGOMERS |
| JP7667788B2 (ja) | 2020-01-29 | 2025-04-23 | 住友化学株式会社 | 核酸オリゴマーの製造方法 |
| EP4130018A4 (en) * | 2020-03-27 | 2024-04-17 | Sumitomo Chemical Company, Limited | METHOD FOR PRODUCING A NUCLEIC ACID OLIGOMER |
| WO2021230293A1 (ja) | 2020-05-13 | 2021-11-18 | 住友化学株式会社 | 無機多孔質基材、無機多孔質担体、および核酸の製造方法 |
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