DK2674494T3 - Single-stranded RNA molecule with a nitrogen-containing alicyclic skeleton - Google Patents

Single-stranded RNA molecule with a nitrogen-containing alicyclic skeleton Download PDF

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Publication number
DK2674494T3
DK2674494T3 DK13184178.5T DK13184178T DK2674494T3 DK 2674494 T3 DK2674494 T3 DK 2674494T3 DK 13184178 T DK13184178 T DK 13184178T DK 2674494 T3 DK2674494 T3 DK 2674494T3
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region
rna
molecule
formula
expression
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DK13184178.5T
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Tadaaki Ohgi
Hirotake Hayashi
Hisao Shirohzu
Tomohiro Hamasaki
Akihiro Itoh
Hiroshi Suzuki
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Bonac Corp
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/351Conjugate
    • C12N2310/3519Fusion with another nucleic acid
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/50Physical structure
    • C12N2310/53Physical structure partially self-complementary or closed
    • C12N2310/531Stem-loop; Hairpin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/50Methods for regulating/modulating their activity
    • C12N2320/51Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2330/00Production
    • C12N2330/30Production chemically synthesised

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK13184178.5T 2010-08-03 2011-07-28 Single-stranded RNA molecule with a nitrogen-containing alicyclic skeleton DK2674494T3 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2010174915 2010-08-03
JP2010230806 2010-10-13
JP2010269823 2010-12-02
JP2011152381 2011-07-08
EP11748250.5A EP2436767B1 (en) 2010-08-03 2011-07-28 Single-stranded RNA molecule having nitrogen-containing alicyclic skeleton

Publications (1)

Publication Number Publication Date
DK2674494T3 true DK2674494T3 (en) 2015-02-23

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DK13184178.5T DK2674494T3 (en) 2010-08-03 2011-07-28 Single-stranded RNA molecule with a nitrogen-containing alicyclic skeleton

Country Status (9)

Country Link
EP (4) EP2628801B1 (https=)
JP (3) JP4965745B2 (https=)
KR (3) KR101894701B1 (https=)
CN (3) CN103052711B (https=)
DK (1) DK2674494T3 (https=)
ES (4) ES2527660T3 (https=)
PT (1) PT2674494E (https=)
TW (2) TWI515294B (https=)
WO (1) WO2012017919A1 (https=)

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Publication number Publication date
WO2012017919A1 (ja) 2012-02-09
ES2443346T3 (es) 2014-02-19
TWI572716B (zh) 2017-03-01
KR101894702B1 (ko) 2018-09-04
EP2639307A8 (en) 2014-04-30
KR20180040728A (ko) 2018-04-20
CN103052711B (zh) 2016-08-03
TWI515294B (zh) 2016-01-01
KR20130095738A (ko) 2013-08-28
KR20180040727A (ko) 2018-04-20
ES2528285T3 (es) 2015-02-06
ES2533129T3 (es) 2015-04-07
JP4965745B2 (ja) 2012-07-04
KR101849801B1 (ko) 2018-04-17
EP2436767B1 (en) 2013-11-20
EP2628801B1 (en) 2015-01-07
TW201219570A (en) 2012-05-16
JP2013138681A (ja) 2013-07-18
EP2674494A1 (en) 2013-12-18
CN104004018A (zh) 2014-08-27
PT2674494E (pt) 2015-02-27
JP5261677B2 (ja) 2013-08-14
CN104004018B (zh) 2017-01-04
EP2639307B1 (en) 2015-03-04
CN103052711A (zh) 2013-04-17
EP2639307A2 (en) 2013-09-18
CN104059911B (zh) 2017-01-04
JPWO2012017919A1 (ja) 2013-10-03
EP2639307A3 (en) 2014-02-05
ES2527660T3 (es) 2015-01-28
TW201615835A (zh) 2016-05-01
CN104059911A (zh) 2014-09-24
KR101894701B1 (ko) 2018-09-04
JP2013034470A (ja) 2013-02-21
JP5555346B2 (ja) 2014-07-23
EP2436767A1 (en) 2012-04-04
EP2674494B1 (en) 2014-12-17
EP2436767A4 (en) 2012-05-09
HK1189910A1 (en) 2014-06-20
EP2628801A1 (en) 2013-08-21
HK1200460A1 (en) 2015-08-07

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