JP2013513632A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013513632A5 JP2013513632A5 JP2012543599A JP2012543599A JP2013513632A5 JP 2013513632 A5 JP2013513632 A5 JP 2013513632A5 JP 2012543599 A JP2012543599 A JP 2012543599A JP 2012543599 A JP2012543599 A JP 2012543599A JP 2013513632 A5 JP2013513632 A5 JP 2013513632A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- linear
- alkyl chain
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 38
- 125000004432 carbon atom Chemical group C* 0.000 claims 26
- 239000002105 nanoparticle Substances 0.000 claims 22
- 125000000217 alkyl group Chemical group 0.000 claims 20
- 239000000377 silicon dioxide Substances 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 11
- 239000002202 Polyethylene glycol Substances 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000003827 glycol group Chemical group 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 229920001223 polyethylene glycol Polymers 0.000 claims 6
- GKWLILHTTGWKLQ-UHFFFAOYSA-N 2,3-dihydrothieno[3,4-b][1,4]dioxine Chemical group O1CCOC2=CSC=C21 GKWLILHTTGWKLQ-UHFFFAOYSA-N 0.000 claims 4
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- GNVMUORYQLCPJZ-UHFFFAOYSA-M Thiocarbamate Chemical compound NC([S-])=O GNVMUORYQLCPJZ-UHFFFAOYSA-M 0.000 claims 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 4
- 150000001408 amides Chemical class 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 239000004202 carbamide Substances 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 4
- 125000005647 linker group Chemical group 0.000 claims 4
- 230000008685 targeting Effects 0.000 claims 4
- 150000001450 anions Chemical class 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000003504 photosensitizing agent Substances 0.000 claims 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 2
- 238000002059 diagnostic imaging Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000010791 quenching Methods 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 230000009897 systematic effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09306238 | 2009-12-15 | ||
| EP09306238.8 | 2009-12-15 | ||
| PCT/EP2010/069035 WO2011073054A1 (en) | 2009-12-15 | 2010-12-07 | Biphotonic photosensitizers, nanoparticles containing the same and their use as drugs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013513632A JP2013513632A (ja) | 2013-04-22 |
| JP2013513632A5 true JP2013513632A5 (https=) | 2014-01-30 |
| JP5926685B2 JP5926685B2 (ja) | 2016-05-25 |
Family
ID=42021128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543599A Expired - Fee Related JP5926685B2 (ja) | 2009-12-15 | 2010-12-07 | 二光子光増感剤、それらを含むナノ粒子および薬物としてのそれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8709747B2 (https=) |
| EP (1) | EP2513083B1 (https=) |
| JP (1) | JP5926685B2 (https=) |
| CA (1) | CA2784212C (https=) |
| WO (1) | WO2011073054A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2988721B1 (fr) | 2012-03-27 | 2014-04-04 | Centre Nat Rech Scient | Nanoparticules de silicium poreux fonctionnalisees et leurs utilisations en therapie photodynamique |
| FR3044676B1 (fr) * | 2015-12-04 | 2017-11-24 | Univ Rennes | Dendrimeres photosensibilisateurs biphotoniques, procede de fabrication et utilisations |
| CN111818944A (zh) * | 2017-12-08 | 2020-10-23 | 南洋理工大学 | 具有光动力活性的有机二氧化硅纳米粒子及其医学用途 |
| CN114504551B (zh) * | 2020-11-16 | 2024-01-02 | 北京厚燊维康科技有限责任公司 | 可用于光动力治疗或诊断的制剂 |
| CN117327098B (zh) * | 2023-09-28 | 2025-11-11 | 江汉大学 | 一种以用于i型光动力治疗为主的aie型光敏剂的制备方法与应用 |
| WO2025207959A1 (en) | 2024-03-27 | 2025-10-02 | Biogen Ma Inc. | Anti-transferrin receptor antibodies and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITFI940095A1 (it) * | 1994-05-23 | 1995-11-23 | Molteni & C | Coniugati fotodinamici aventi proprieta' biocide |
| CN100408026C (zh) * | 2003-01-24 | 2008-08-06 | 纽约州立大学研究基金会 | 用于包裹光动力学疗法治疗剂的陶瓷纳米微粒及其使用方法 |
| WO2008030624A2 (en) * | 2006-09-08 | 2008-03-13 | The Research Foundation Of State University Of New York | Nanoparticles for two-photon activated photodynamic therapy and imaging |
-
2010
- 2010-12-07 JP JP2012543599A patent/JP5926685B2/ja not_active Expired - Fee Related
- 2010-12-07 EP EP10790539.0A patent/EP2513083B1/en not_active Not-in-force
- 2010-12-07 US US13/516,010 patent/US8709747B2/en active Active
- 2010-12-07 WO PCT/EP2010/069035 patent/WO2011073054A1/en not_active Ceased
- 2010-12-07 CA CA2784212A patent/CA2784212C/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Ning et al. | Type-I AIE photosensitizer loaded biomimetic system boosting cuproptosis to inhibit breast cancer metastasis and rechallenge | |
| Chaudhari et al. | Cutting-edge approaches for targeted drug delivery in breast cancer: beyond conventional therapies | |
| Wang et al. | Metal–organic framework derived multicomponent nanoagent as a reactive oxygen species amplifier for enhanced photodynamic therapy | |
| Jin et al. | Albumin-assisted synthesis of ultrasmall FeS2 nanodots for imaging-guided photothermal enhanced photodynamic therapy | |
| JP2013513632A5 (https=) | ||
| JP6049712B2 (ja) | 抗癌治療及び画像化並びに骨障害治療のための金属ビスホスホネートナノ粒子 | |
| Della Rocca et al. | Polysilsesquioxane nanoparticles for triggered release of cisplatin and effective cancer chemoradiotherapy | |
| EP3065713B1 (en) | Nanoscale carriers for the delivery or co-delivery of chemotherapeutics, nucleic acids and photosensitizers | |
| Wang et al. | Hybrid mesoporous–microporous nanocarriers for overcoming multidrug resistance by sequential drug delivery | |
| Sun et al. | Taxanes prodrug-based nanomedicines for cancer therapy | |
| Xin et al. | Fluorinated organic polymers for cancer drug delivery | |
| Zeng et al. | PEGylated nanoscale metal–organic frameworks for targeted cancer imaging and drug delivery | |
| JP2023526501A (ja) | 金属有機構造体が癌免疫療法の為の低分子及びバイオ高分子を送達する | |
| CN108619511A (zh) | 一种基于阿糖胞苷小分子前药的金属有机框架载药系统的制备方法和应用 | |
| CN102429870A (zh) | 一种喜树碱类药物的新型肿瘤靶向树状聚合物纳米载体 | |
| JP2013510181A5 (https=) | ||
| KR20130066521A (ko) | 유전자 나노 복합체 및 이를 이용한 유전자의 세포 내재화 방법 | |
| Larsson et al. | Local co-administration of gene-silencing RNA and drugs in cancer therapy: State-of-the art and therapeutic potential | |
| CN103936883B (zh) | 含巯基壳聚糖衍生物及复合物纳米粒子及制备方法 | |
| Chu et al. | Recent advances in functionalized upconversion nanoparticles for light-activated tumor therapy | |
| Choi et al. | Enabling nanohybrid drug discovery through the soft chemistry telescope | |
| Jin et al. | Detoxification and functionalization of gold nanorods with organic polymers and their applications in cancer photothermal therapy | |
| CN1678353A (zh) | 新抗癌化合物 | |
| Duan et al. | Proton sponge nanocomposites for synergistic tumor elimination via autophagy inhibition-promoted cell apoptosis and macrophage repolarization-enhanced immune response | |
| JP5926685B2 (ja) | 二光子光増感剤、それらを含むナノ粒子および薬物としてのそれらの使用 |