CA2784212C - Biphotonic photosensitizers, nanoparticles containing the same and their use as drugs - Google Patents

Biphotonic photosensitizers, nanoparticles containing the same and their use as drugs Download PDF

Info

Publication number
CA2784212C
CA2784212C CA2784212A CA2784212A CA2784212C CA 2784212 C CA2784212 C CA 2784212C CA 2784212 A CA2784212 A CA 2784212A CA 2784212 A CA2784212 A CA 2784212A CA 2784212 C CA2784212 C CA 2784212C
Authority
CA
Canada
Prior art keywords
group
ranging
carbon atoms
nanoparticle
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2784212A
Other languages
English (en)
French (fr)
Other versions
CA2784212A1 (en
Inventor
David Brevet
Laurence Raehm
Mireille Blanchard-Desce
Olivier Mongin
Magali Gary-Bobo-Sable-Teychene
Marcel Garcia
Alain Morere
Jean-Olivier Durand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite de Rennes 1
Institut National de la Sante et de la Recherche Medicale INSERM
Universite de Montpellier
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite de Rennes 1
Institut National de la Sante et de la Recherche Medicale INSERM
Universite de Montpellier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Universite de Rennes 1, Institut National de la Sante et de la Recherche Medicale INSERM, Universite de Montpellier filed Critical Centre National de la Recherche Scientifique CNRS
Publication of CA2784212A1 publication Critical patent/CA2784212A1/en
Application granted granted Critical
Publication of CA2784212C publication Critical patent/CA2784212C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0801—General processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2784212A 2009-12-15 2010-12-07 Biphotonic photosensitizers, nanoparticles containing the same and their use as drugs Active CA2784212C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09306238 2009-12-15
EP09306238.8 2009-12-15
PCT/EP2010/069035 WO2011073054A1 (en) 2009-12-15 2010-12-07 Biphotonic photosensitizers, nanoparticles containing the same and their use as drugs

Publications (2)

Publication Number Publication Date
CA2784212A1 CA2784212A1 (en) 2011-06-23
CA2784212C true CA2784212C (en) 2018-01-16

Family

ID=42021128

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2784212A Active CA2784212C (en) 2009-12-15 2010-12-07 Biphotonic photosensitizers, nanoparticles containing the same and their use as drugs

Country Status (5)

Country Link
US (1) US8709747B2 (https=)
EP (1) EP2513083B1 (https=)
JP (1) JP5926685B2 (https=)
CA (1) CA2784212C (https=)
WO (1) WO2011073054A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2988721B1 (fr) 2012-03-27 2014-04-04 Centre Nat Rech Scient Nanoparticules de silicium poreux fonctionnalisees et leurs utilisations en therapie photodynamique
FR3044676B1 (fr) * 2015-12-04 2017-11-24 Univ Rennes Dendrimeres photosensibilisateurs biphotoniques, procede de fabrication et utilisations
CN111818944A (zh) * 2017-12-08 2020-10-23 南洋理工大学 具有光动力活性的有机二氧化硅纳米粒子及其医学用途
CN114504551B (zh) * 2020-11-16 2024-01-02 北京厚燊维康科技有限责任公司 可用于光动力治疗或诊断的制剂
CN117327098B (zh) * 2023-09-28 2025-11-11 江汉大学 一种以用于i型光动力治疗为主的aie型光敏剂的制备方法与应用
WO2025207959A1 (en) 2024-03-27 2025-10-02 Biogen Ma Inc. Anti-transferrin receptor antibodies and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITFI940095A1 (it) * 1994-05-23 1995-11-23 Molteni & C Coniugati fotodinamici aventi proprieta' biocide
CN100408026C (zh) * 2003-01-24 2008-08-06 纽约州立大学研究基金会 用于包裹光动力学疗法治疗剂的陶瓷纳米微粒及其使用方法
WO2008030624A2 (en) * 2006-09-08 2008-03-13 The Research Foundation Of State University Of New York Nanoparticles for two-photon activated photodynamic therapy and imaging

Also Published As

Publication number Publication date
CA2784212A1 (en) 2011-06-23
WO2011073054A1 (en) 2011-06-23
EP2513083B1 (en) 2016-04-06
EP2513083A1 (en) 2012-10-24
US8709747B2 (en) 2014-04-29
JP2013513632A (ja) 2013-04-22
US20130065849A1 (en) 2013-03-14
JP5926685B2 (ja) 2016-05-25

Similar Documents

Publication Publication Date Title
Han et al. Super-efficient in vivo two-photon photodynamic therapy with a gold nanocluster as a type I photosensitizer
CA2784212C (en) Biphotonic photosensitizers, nanoparticles containing the same and their use as drugs
Bayda et al. Carbon dots for cancer nanomedicine: a bright future
Xu et al. Hypoxia-activated NIR photosensitizer anchoring in the mitochondria for photodynamic therapy
Zhang et al. Noncovalent ruthenium (II) complexes–single-walled carbon nanotube composites for bimodal photothermal and photodynamic therapy with near-infrared irradiation
Ding et al. Zinc (II) metalated porphyrins as photothermogenic photosensitizers for cancer photodynamic/photothermal synergistic therapy
Wang et al. Hexagonal boron nitride nanomaterials for biomedical applications
Santos et al. Enhanced photodynamic therapy effects of graphene quantum dots conjugated with aminoporphyrins
Mahajan et al. A potential mediator for photodynamic therapy based on silver nanoparticles functionalized with porphyrin
Zhang et al. Near infrared light triggered reactive oxygen species responsive nanoparticles for chemo-photodynamic combined therapy
Hlapisi et al. Encapsulation of gold nanorods with porphyrins for the potential treatment of cancer and bacterial diseases: A critical review
Perumal et al. Biotin-decorated NIR-absorbing nanosheets for targeted photodynamic cancer therapy
Vuilleumier et al. Photocontrolled release of the anticancer drug chlorambucil with caged harmonic nanoparticles
Nalepa et al. A [60] fullerene nanoconjugate with gemcitabine: synthesis, biophysical properties and biological evaluation for treating pancreatic cancer
CN103183697A (zh) 基于二联杂环并吡咯基团的近红外氟硼二吡咯化合物及其制法和用途
Chen et al. A mitochondria-localized iridium (III)–chlorin E6 conjugate for synergistic sonodynamic and two-photon photodynamic therapy against melanoma
Zhang et al. Multifunctional tetracene/pentacene host/guest nanorods for enhanced upconversion photodynamic tumor therapy
Chen et al. Quantum Dot‐mediated Photoproduction of Reactive Oxygen Species for Cancer Cell Annihilation
Li et al. Folate chitosan conjugated doxorubicin and pyropheophorbide acid nanoparticles (FCDP–NPs) for enhance photodynamic therapy
Öztürk Gündüz et al. NI-Bodipy-GO nanocomposites for targeted PDT
Kim et al. Triphenylphosphonium-functionalized dimeric BODIPY-based nanoparticles for mitochondria-targeting photodynamic therapy
Nisa et al. Applications of supramolecular assemblies in drug delivery and photodynamic therapy
Hou et al. GSH-activatable camptothecin prodrug-loaded gold nanostars coated with hyaluronic acid for targeted breast cancer therapy via multiple radiosensitization strategies
WO2010029232A1 (fr) Derives de metalloporphyrines, nanoparticules les comprenant et leur utilisation pour le traitement par therapie photodynamique
Gao et al. Cancer cell membrane-camouflaged and H 2 O 2-activatable nanocomposites for synergistic chemotherapy and two-photon photodynamic therapy against melanoma

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20151118

H11 Ip right ceased following rejected request for revival

Free format text: ST27 STATUS EVENT CODE: T-6-6-H10-H11-H101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TIME LIMIT FOR REVERSAL EXPIRED

Effective date: 20240719