JP2021502346A5 - - Google Patents
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- Publication number
- JP2021502346A5 JP2021502346A5 JP2020524544A JP2020524544A JP2021502346A5 JP 2021502346 A5 JP2021502346 A5 JP 2021502346A5 JP 2020524544 A JP2020524544 A JP 2020524544A JP 2020524544 A JP2020524544 A JP 2020524544A JP 2021502346 A5 JP2021502346 A5 JP 2021502346A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- bound
- substituted
- branched
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 54
- 150000001875 compounds Chemical class 0.000 claims 36
- 125000003342 alkenyl group Chemical group 0.000 claims 32
- 230000004927 fusion Effects 0.000 claims 29
- 125000003545 alkoxy group Chemical group 0.000 claims 18
- 239000000203 mixture Substances 0.000 claims 11
- 125000000304 alkynyl group Chemical group 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 9
- 239000013543 active substance Substances 0.000 claims 8
- 125000003636 chemical group Chemical group 0.000 claims 5
- 150000002632 lipids Chemical class 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 150000001345 alkine derivatives Chemical class 0.000 claims 4
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 125000005647 linker group Chemical group 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 3
- 125000005549 heteroarylene group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000000732 arylene group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 239000002502 liposome Substances 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 239000002105 nanoparticle Substances 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims 1
- VKDFNHQDYUZPIN-UHFFFAOYSA-N 1-ethoxy-2-(1-ethoxy-1-methoxy-2-methylpropan-2-yl)oxy-1-methoxy-2-methylpropane Chemical compound COC(C(C)(C)OC(C(OC)OCC)(C)C)OCC VKDFNHQDYUZPIN-UHFFFAOYSA-N 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 108700011259 MicroRNAs Proteins 0.000 claims 1
- 108091030071 RNAI Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 150000005215 alkyl ethers Chemical class 0.000 claims 1
- 150000008378 aryl ethers Chemical class 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 230000009368 gene silencing by RNA Effects 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 0 CN1CC(*)C1 Chemical compound CN1CC(*)C1 0.000 description 13
- IDLMUDWGSOKKEP-INIZCTEOSA-N CC[C@@H](CCCCCC(C)(C)CC(CC)(CC)N=O)NC Chemical compound CC[C@@H](CCCCCC(C)(C)CC(CC)(CC)N=O)NC IDLMUDWGSOKKEP-INIZCTEOSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762582252P | 2017-11-06 | 2017-11-06 | |
| US62/582,252 | 2017-11-06 | ||
| PCT/US2018/059504 WO2019090359A1 (en) | 2017-11-06 | 2018-11-06 | Fusogenic compounds for delivery of biologically active molecules |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021502346A JP2021502346A (ja) | 2021-01-28 |
| JP2021502346A5 true JP2021502346A5 (https=) | 2021-12-16 |
| JP7423518B2 JP7423518B2 (ja) | 2024-01-29 |
Family
ID=66326532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020524544A Active JP7423518B2 (ja) | 2017-11-06 | 2018-11-06 | 生物学的活性分子を送達するための融合性化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11413243B2 (https=) |
| EP (1) | EP3706729A4 (https=) |
| JP (1) | JP7423518B2 (https=) |
| KR (1) | KR102751412B1 (https=) |
| CN (2) | CN117105811B (https=) |
| AU (2) | AU2018359904B2 (https=) |
| BR (1) | BR112020008451A2 (https=) |
| CA (1) | CA3081758A1 (https=) |
| WO (1) | WO2019090359A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117105811B (zh) * | 2017-11-06 | 2025-12-12 | 日东电工株式会社 | 用于递送生物活性分子的膜融合化合物 |
| JP2023526284A (ja) * | 2020-05-15 | 2023-06-21 | トランスレイト バイオ， インコーポレイテッド | ｍＲＮＡ送達のための脂質ナノ粒子製剤 |
| CN112891560B (zh) * | 2021-02-07 | 2023-05-16 | 深圳深信生物科技有限公司 | 一种mRNA递送载体及其制备方法和用途 |
| WO2022241723A1 (zh) * | 2021-05-20 | 2022-11-24 | 北京理工大学 | 化合物、脂质体及其用途 |
| CN114805113B (zh) * | 2022-01-22 | 2023-09-15 | 苏州天澜生物材料科技有限公司 | 一种安全高效的可降解脂质纳米颗粒及其制备方法和应用 |
| WO2024012272A1 (zh) * | 2022-07-11 | 2024-01-18 | 传信生物医药(苏州)有限公司 | 脂质化合物及其应用 |
| KR102921785B1 (ko) * | 2022-12-19 | 2026-02-03 | 주식회사 녹십자 | 핵산 전달용 사이클로알칸계 지질 화합물 및 이를 포함하는 지질 나노입자 |
| WO2025127402A1 (ko) * | 2023-12-14 | 2025-06-19 | 한국생명공학연구원 | mRNA/LNP 백신의 면역원성 향상용 지질 |
| WO2026015831A1 (en) * | 2024-07-12 | 2026-01-15 | Nitto Denko Corporation | Cationic lipids, lipid nanoparticles comprising the same and methods of delivering nucleic acids |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69534300T2 (de) * | 1994-08-18 | 2006-05-18 | Ariad Gene Therapeutics, Inc., Cambridge | Neues multimerisierendes reagenz |
| CA2395636A1 (en) * | 1999-12-30 | 2001-07-12 | Novartis Ag | Novel colloid synthetic vectors for gene therapy |
| US7129208B2 (en) * | 2002-01-14 | 2006-10-31 | Washington University | Synthetic ion channels |
| EP1664316B1 (en) | 2003-09-15 | 2012-08-29 | Protiva Biotherapeutics Inc. | Polyethyleneglycol-modified lipid compounds and uses thereof |
| EP2069500B1 (en) * | 2006-10-04 | 2014-09-24 | Centre National De La Recherche Scientifique (Cnrs) | Compositions comprising a sirna and lipidic 4,5-disubstituted 2-deoxystreptamine ring aminoglycoside derivatives and uses thereof |
| TW201021852A (en) | 2008-11-17 | 2010-06-16 | Enzon Pharmaceuticals Inc | Releasable fusogenic lipids for nucleic acids delivery systems |
| CA3009891C (en) | 2009-12-23 | 2020-09-15 | Novartis Ag | Lipids, lipid compositions, and methods of using them |
| RU2615143C2 (ru) | 2010-03-24 | 2017-04-04 | Адвирна | Самодоставляющие PHKi соединения уменьшенного размера |
| US20160015656A2 (en) * | 2010-08-05 | 2016-01-21 | Nitto Denko Corporation | Composition for regenerating normal tissue from fibrotic tissue |
| US9011903B2 (en) | 2011-06-08 | 2015-04-21 | Nitto Denko Corporation | Cationic lipids for therapeutic agent delivery formulations |
| EP2718261B1 (en) * | 2011-06-08 | 2016-02-24 | Nitto Denko Corporation | Compounds for targeting drug delivery and enhancing sirna activity |
| PE20181541A1 (es) | 2011-10-27 | 2018-09-26 | Massachusetts Inst Technology | Derivados de aminoacidos funcionalizados en la terminal n capaces de formar microesferas encapsuladoras de farmaco |
| US9579338B2 (en) | 2011-11-04 | 2017-02-28 | Nitto Denko Corporation | Method of producing lipid nanoparticles for drug delivery |
| HRP20181855T1 (hr) | 2012-06-08 | 2018-12-28 | Nitto Denko Corporation | Lipidi za formulacije namijenjene unosu terapijskog sredstva |
| CN104837996A (zh) | 2012-11-15 | 2015-08-12 | 罗氏创新中心哥本哈根有限公司 | 抗apob反义缀合物化合物 |
| US10264976B2 (en) * | 2014-12-26 | 2019-04-23 | The University Of Akron | Biocompatible flavonoid compounds for organelle and cell imaging |
| CN117105811B (zh) * | 2017-11-06 | 2025-12-12 | 日东电工株式会社 | 用于递送生物活性分子的膜融合化合物 |
| WO2024012272A1 (zh) | 2022-07-11 | 2024-01-18 | 传信生物医药(苏州)有限公司 | 脂质化合物及其应用 |
-
2018
- 2018-11-06 CN CN202311077520.8A patent/CN117105811B/zh active Active
- 2018-11-06 JP JP2020524544A patent/JP7423518B2/ja active Active
- 2018-11-06 AU AU2018359904A patent/AU2018359904B2/en active Active
- 2018-11-06 KR KR1020207015977A patent/KR102751412B1/ko active Active
- 2018-11-06 US US16/182,571 patent/US11413243B2/en active Active
- 2018-11-06 CN CN201880071515.7A patent/CN111386105B/zh active Active
- 2018-11-06 WO PCT/US2018/059504 patent/WO2019090359A1/en not_active Ceased
- 2018-11-06 EP EP18872775.4A patent/EP3706729A4/en active Pending
- 2018-11-06 BR BR112020008451-4A patent/BR112020008451A2/pt unknown
- 2018-11-06 CA CA3081758A patent/CA3081758A1/en active Pending
-
2022
- 2022-04-05 US US17/658,078 patent/US12440445B2/en active Active
-
2023
- 2023-05-04 AU AU2023202793A patent/AU2023202793B2/en active Active
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