JP2012532107A5 - - Google Patents
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- JP2012532107A5 JP2012532107A5 JP2012517823A JP2012517823A JP2012532107A5 JP 2012532107 A5 JP2012532107 A5 JP 2012532107A5 JP 2012517823 A JP2012517823 A JP 2012517823A JP 2012517823 A JP2012517823 A JP 2012517823A JP 2012532107 A5 JP2012532107 A5 JP 2012532107A5
- Authority
- JP
- Japan
- Prior art keywords
- pain
- composition
- disease
- enantiomer
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 14
- 208000002193 Pain Diseases 0.000 claims 13
- 241000124008 Mammalia Species 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 239000000651 prodrug Substances 0.000 claims 7
- 229940002612 prodrug Drugs 0.000 claims 7
- 239000012453 solvate Substances 0.000 claims 7
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 3
- 206010010904 Convulsion Diseases 0.000 claims 3
- 102000016913 Voltage-Gated Sodium Channels Human genes 0.000 claims 3
- 108010053752 Voltage-Gated Sodium Channels Proteins 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 208000003251 Pruritus Diseases 0.000 claims 2
- 230000004907 flux Effects 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 150000002500 ions Chemical class 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 230000001568 sexual effect Effects 0.000 claims 2
- YNHVBNGRNNVEMD-UHFFFAOYSA-N 2-(bromomethyl)-5-(trifluoromethyl)furan Chemical compound FC(F)(F)C1=CC=C(CBr)O1 YNHVBNGRNNVEMD-UHFFFAOYSA-N 0.000 claims 1
- 206010000599 Acromegaly Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- 206010058019 Cancer Pain Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010015150 Erythema Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 101000620451 Homo sapiens Leucine-rich glioma-inactivated protein 1 Proteins 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 206010020844 Hyperthermia malignant Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000007914 Labor Pain Diseases 0.000 claims 1
- 208000035945 Labour pain Diseases 0.000 claims 1
- 102100022275 Leucine-rich glioma-inactivated protein 1 Human genes 0.000 claims 1
- 208000026709 Liddle syndrome Diseases 0.000 claims 1
- 208000018717 Malignant hyperthermia of anesthesia Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 206010028372 Muscular weakness Diseases 0.000 claims 1
- 206010061533 Myotonia Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000000693 Neurogenic Urinary Bladder Diseases 0.000 claims 1
- 206010029279 Neurogenic bladder Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 208000012075 Paroxysmal dystonia Diseases 0.000 claims 1
- 208000010886 Peripheral nerve injury Diseases 0.000 claims 1
- 208000004983 Phantom Limb Diseases 0.000 claims 1
- 206010056238 Phantom pain Diseases 0.000 claims 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 206010037113 Pseudoaldosteronism Diseases 0.000 claims 1
- 208000005793 Restless legs syndrome Diseases 0.000 claims 1
- 206010039020 Rhabdomyolysis Diseases 0.000 claims 1
- 206010040744 Sinus headache Diseases 0.000 claims 1
- 108010052164 Sodium Channels Proteins 0.000 claims 1
- 102000018674 Sodium Channels Human genes 0.000 claims 1
- 208000027520 Somatoform disease Diseases 0.000 claims 1
- 206010049447 Tachyarrhythmia Diseases 0.000 claims 1
- 208000001871 Tachycardia Diseases 0.000 claims 1
- 206010057040 Temperature intolerance Diseases 0.000 claims 1
- 206010043269 Tension headache Diseases 0.000 claims 1
- 208000008548 Tension-Type Headache Diseases 0.000 claims 1
- 206010043994 Tonic convulsion Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 208000010118 dystonia Diseases 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 208000028329 epileptic seizure Diseases 0.000 claims 1
- 230000001667 episodic effect Effects 0.000 claims 1
- 231100000321 erythema Toxicity 0.000 claims 1
- 230000008543 heat sensitivity Effects 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 201000007004 malignant hyperthermia Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000036473 myasthenia Effects 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 208000027753 pain disease Diseases 0.000 claims 1
- 230000001314 paroxysmal effect Effects 0.000 claims 1
- 208000019865 paroxysmal extreme pain disease Diseases 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 230000002085 persistent effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 208000004371 toothache Diseases 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 230000000472 traumatic effect Effects 0.000 claims 1
- 206010044652 trigeminal neuralgia Diseases 0.000 claims 1
- 208000003663 ventricular fibrillation Diseases 0.000 claims 1
- 208000009935 visceral pain Diseases 0.000 claims 1
- NEBUOXBYNAHKFV-NRFANRHFSA-N O=C1N(Cc2ccc(C(F)(F)F)[o]2)c2ccccc2[C@@]11c(cc2OCOc2c2)c2OC1 Chemical compound O=C1N(Cc2ccc(C(F)(F)F)[o]2)c2ccccc2[C@@]11c(cc2OCOc2c2)c2OC1 NEBUOXBYNAHKFV-NRFANRHFSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22142409P | 2009-06-29 | 2009-06-29 | |
| US61/221,424 | 2009-06-29 | ||
| PCT/US2010/040187 WO2011002708A1 (en) | 2009-06-29 | 2010-06-28 | Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014235262A Division JP2015038153A (ja) | 2009-06-29 | 2014-11-20 | スピロ−オキシインドール化合物のエナンチオマーおよび治療剤としてのその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012532107A JP2012532107A (ja) | 2012-12-13 |
| JP2012532107A5 true JP2012532107A5 (https=) | 2013-08-01 |
Family
ID=42416878
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012517823A Withdrawn JP2012532107A (ja) | 2009-06-29 | 2010-06-28 | スピロ−オキシインドール化合物のエナンチオマーおよび治療剤としてのその使用 |
| JP2014235262A Withdrawn JP2015038153A (ja) | 2009-06-29 | 2014-11-20 | スピロ−オキシインドール化合物のエナンチオマーおよび治療剤としてのその使用 |
| JP2016198877A Withdrawn JP2017002085A (ja) | 2009-06-29 | 2016-10-07 | スピロ−オキシインドール化合物のエナンチオマーおよび治療剤としてのその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014235262A Withdrawn JP2015038153A (ja) | 2009-06-29 | 2014-11-20 | スピロ−オキシインドール化合物のエナンチオマーおよび治療剤としてのその使用 |
| JP2016198877A Withdrawn JP2017002085A (ja) | 2009-06-29 | 2016-10-07 | スピロ−オキシインドール化合物のエナンチオマーおよび治療剤としてのその使用 |
Country Status (34)
| Country | Link |
|---|---|
| US (4) | US8450358B2 (https=) |
| EP (3) | EP2448943B1 (https=) |
| JP (3) | JP2012532107A (https=) |
| KR (1) | KR101751378B1 (https=) |
| CN (2) | CN104650106A (https=) |
| AR (1) | AR077252A1 (https=) |
| AU (1) | AU2010266549B2 (https=) |
| BR (1) | BRPI1012129A2 (https=) |
| CA (1) | CA2764878C (https=) |
| CL (1) | CL2011003335A1 (https=) |
| CO (1) | CO6470866A2 (https=) |
| CY (1) | CY1117776T1 (https=) |
| DK (1) | DK2448943T3 (https=) |
| EC (1) | ECSP11011512A (https=) |
| ES (2) | ES2600160T3 (https=) |
| HR (2) | HRP20160732T1 (https=) |
| HU (1) | HUE029658T2 (https=) |
| IL (3) | IL217285A (https=) |
| MA (1) | MA33552B1 (https=) |
| MX (2) | MX2012000028A (https=) |
| MY (1) | MY159099A (https=) |
| NZ (1) | NZ596903A (https=) |
| PE (2) | PE20160216A1 (https=) |
| PH (2) | PH12011502619A1 (https=) |
| PL (2) | PL2789617T3 (https=) |
| PT (1) | PT2448943T (https=) |
| RU (1) | RU2535667C2 (https=) |
| SG (1) | SG176307A1 (https=) |
| SI (1) | SI2448943T1 (https=) |
| SM (1) | SMT201600203B (https=) |
| TN (1) | TN2011000664A1 (https=) |
| TW (1) | TWI465452B (https=) |
| WO (1) | WO2011002708A1 (https=) |
| ZA (1) | ZA201108960B (https=) |
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| US9278088B2 (en) | 2002-02-19 | 2016-03-08 | Xenon Pharmaceuticals Inc. | Methods for identifying analgesic agents |
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| AR056968A1 (es) | 2005-04-11 | 2007-11-07 | Xenon Pharmaceuticals Inc | Compuestos espiro-oxindol y composiciones farmacéuticas |
| WO2008060789A2 (en) | 2006-10-12 | 2008-05-22 | Xenon Pharmaceuticals Inc. | Use of spiro-oxindole compounds as therapeutic agents |
| US20110294842A9 (en) * | 2006-10-12 | 2011-12-01 | Xenon Pharmaceuticals Inc. | Spiro (furo [3, 2-c] pyridine-3-3' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain |
| CA2741024A1 (en) * | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| JO3032B1 (ar) * | 2008-10-17 | 2016-09-05 | Xenon Pharmaceuticals Inc | مركبات سبيرو – اوكسندول وإستعمالاتها كعوامل علاجية. |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| KR101763656B1 (ko) | 2009-06-29 | 2017-08-01 | 인사이트 홀딩스 코포레이션 | Ｐｉ3ｋ 저해물질로서의 피리미디논 |
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| KR20120099429A (ko) | 2009-10-14 | 2012-09-10 | 제논 파마슈티칼스 인크. | 스피로-옥스인돌 화합물의 합성 방법 |
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| KR20120099429A (ko) | 2009-10-14 | 2012-09-10 | 제논 파마슈티칼스 인크. | 스피로-옥스인돌 화합물의 합성 방법 |
| WO2011106729A2 (en) | 2010-02-26 | 2011-09-01 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents |
| HK1205114A1 (en) | 2012-04-12 | 2015-12-11 | Xenon Pharmaceuticals Inc. | Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents |
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2010
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2012
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