IL217285A - (s)-enantiomer of a spiro-oxindole compound and its uses in the manufacture of a medicament for decreasing ion flux through voltage-gated sodium channel - Google Patents

(s)-enantiomer of a spiro-oxindole compound and its uses in the manufacture of a medicament for decreasing ion flux through voltage-gated sodium channel

Info

Publication number
IL217285A
IL217285A IL217285A IL21728511A IL217285A IL 217285 A IL217285 A IL 217285A IL 217285 A IL217285 A IL 217285A IL 21728511 A IL21728511 A IL 21728511A IL 217285 A IL217285 A IL 217285A
Authority
IL
Israel
Prior art keywords
enantiomer
spiro
medicament
manufacture
voltage
Prior art date
Application number
IL217285A
Other languages
Hebrew (he)
Other versions
IL217285A0 (en
Inventor
Chafeev Mikhail
Fu Jianmin
Cadieux Jean-Jacques
Original Assignee
Xenon Pharmaceuticals Inc
Chafeev Mikhail
Fu Jianmin
Cadieux Jean-Jacques
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42416878&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL217285(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Xenon Pharmaceuticals Inc, Chafeev Mikhail, Fu Jianmin, Cadieux Jean-Jacques filed Critical Xenon Pharmaceuticals Inc
Publication of IL217285A0 publication Critical patent/IL217285A0/en
Publication of IL217285A publication Critical patent/IL217285A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
IL217285A 2009-06-29 2011-12-29 (s)-enantiomer of a spiro-oxindole compound and its uses in the manufacture of a medicament for decreasing ion flux through voltage-gated sodium channel IL217285A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22142409P 2009-06-29 2009-06-29
PCT/US2010/040187 WO2011002708A1 (en) 2009-06-29 2010-06-28 Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents

Publications (2)

Publication Number Publication Date
IL217285A0 IL217285A0 (en) 2012-02-29
IL217285A true IL217285A (en) 2016-09-29

Family

ID=42416878

Family Applications (3)

Application Number Title Priority Date Filing Date
IL217285A IL217285A (en) 2009-06-29 2011-12-29 (s)-enantiomer of a spiro-oxindole compound and its uses in the manufacture of a medicament for decreasing ion flux through voltage-gated sodium channel
IL241985A IL241985A (en) 2009-06-29 2015-10-08 Process of preparing (s)- enantiomer of a spiro-oxindole compound
IL250314A IL250314A0 (en) 2009-06-29 2017-01-26 Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL241985A IL241985A (en) 2009-06-29 2015-10-08 Process of preparing (s)- enantiomer of a spiro-oxindole compound
IL250314A IL250314A0 (en) 2009-06-29 2017-01-26 Enantiomers of spiro-oxindole compounds and their uses as therapeutic agents

Country Status (35)

Country Link
US (4) US8450358B2 (en)
EP (3) EP2448943B1 (en)
JP (3) JP2012532107A (en)
KR (1) KR101751378B1 (en)
CN (2) CN104650106A (en)
AR (1) AR077252A1 (en)
AU (1) AU2010266549B2 (en)
BR (1) BRPI1012129A2 (en)
CA (1) CA2764878C (en)
CL (1) CL2011003335A1 (en)
CO (1) CO6470866A2 (en)
CY (1) CY1117776T1 (en)
DK (1) DK2448943T3 (en)
EC (1) ECSP11011512A (en)
ES (2) ES2578779T3 (en)
HK (2) HK1168854A1 (en)
HR (2) HRP20110946A2 (en)
HU (1) HUE029658T2 (en)
IL (3) IL217285A (en)
MA (1) MA33552B1 (en)
MX (2) MX2012000028A (en)
MY (1) MY159099A (en)
NZ (1) NZ596903A (en)
PE (2) PE20120413A1 (en)
PH (1) PH12015502323A1 (en)
PL (2) PL2448943T3 (en)
PT (1) PT2448943T (en)
RU (1) RU2535667C2 (en)
SG (1) SG176307A1 (en)
SI (1) SI2448943T1 (en)
SM (1) SMT201600203B (en)
TN (1) TN2011000664A1 (en)
TW (1) TWI465452B (en)
WO (1) WO2011002708A1 (en)
ZA (1) ZA201108960B (en)

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US20130072537A1 (en) 2013-03-21
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US20150025121A1 (en) 2015-01-22
AU2010266549B2 (en) 2015-06-25
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