JP2008535916A5 - - Google Patents
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- Publication number
- JP2008535916A5 JP2008535916A5 JP2008506574A JP2008506574A JP2008535916A5 JP 2008535916 A5 JP2008535916 A5 JP 2008535916A5 JP 2008506574 A JP2008506574 A JP 2008506574A JP 2008506574 A JP2008506574 A JP 2008506574A JP 2008535916 A5 JP2008535916 A5 JP 2008535916A5
- Authority
- JP
- Japan
- Prior art keywords
- heteroaryl
- aryl
- heterocyclyl
- aralkyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000001072 heteroaryl group Chemical group 0.000 claims 182
- 125000003118 aryl group Chemical group 0.000 claims 179
- 125000000623 heterocyclic group Chemical group 0.000 claims 164
- 125000003710 aryl alkyl group Chemical group 0.000 claims 162
- 125000000217 alkyl group Chemical group 0.000 claims 154
- 125000000753 cycloalkyl group Chemical group 0.000 claims 128
- 229910052739 hydrogen Inorganic materials 0.000 claims 114
- 239000001257 hydrogen Substances 0.000 claims 114
- 125000001188 haloalkyl group Chemical group 0.000 claims 101
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 89
- 150000002431 hydrogen Chemical class 0.000 claims 88
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 87
- 125000004093 cyano group Chemical group *C#N 0.000 claims 85
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 76
- 125000005843 halogen group Chemical group 0.000 claims 59
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 55
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 55
- 125000003342 alkenyl group Chemical group 0.000 claims 39
- 125000000304 alkynyl group Chemical group 0.000 claims 39
- 125000001424 substituent group Chemical group 0.000 claims 37
- 229910052757 nitrogen Inorganic materials 0.000 claims 33
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 26
- 125000004450 alkenylene group Chemical group 0.000 claims 22
- 125000002947 alkylene group Chemical group 0.000 claims 22
- 125000004419 alkynylene group Chemical group 0.000 claims 22
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 22
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 20
- 125000003545 alkoxy group Chemical group 0.000 claims 19
- 125000000262 haloalkenyl group Chemical group 0.000 claims 19
- 125000004438 haloalkoxy group Chemical group 0.000 claims 19
- -1 aralkenyl Chemical group 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 16
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 15
- 208000002193 Pain Diseases 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 11
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 239000000651 prodrug Substances 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- 125000004076 pyridyl group Chemical group 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000002904 solvent Substances 0.000 claims 5
- 125000001544 thienyl group Chemical group 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 3
- 102000016913 Voltage-Gated Sodium Channels Human genes 0.000 claims 2
- 108010053752 Voltage-Gated Sodium Channels Proteins 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 206010003119 arrhythmia Diseases 0.000 claims 2
- 230000006793 arrhythmia Effects 0.000 claims 2
- 230000004941 influx Effects 0.000 claims 2
- 150000002500 ions Chemical class 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- FJQFHTVTRAQBQI-UHFFFAOYSA-N 1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-pyrrolo[2,3-b]pyridine]-2'-one Chemical compound C12=CC=CN=C2N(CCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 FJQFHTVTRAQBQI-UHFFFAOYSA-N 0.000 claims 1
- LTQRQUSEENKDEL-UHFFFAOYSA-N 1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-pyrrolo[3,2-b]pyridine]-2'-one Chemical compound C12=NC=CC=C2N(CCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 LTQRQUSEENKDEL-UHFFFAOYSA-N 0.000 claims 1
- YKYKMOLNWHNSSJ-UHFFFAOYSA-N 1'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,3'-pyrrolo[3,2-c]pyridine]-2'-one Chemical compound C12=CN=CC=C2N(CCCCC)C(=O)C11C2=CC(OCO3)=C3C=C2OC1 YKYKMOLNWHNSSJ-UHFFFAOYSA-N 0.000 claims 1
- YAVXCTQVGCPGJE-UHFFFAOYSA-N 4'-pentylspiro[6h-furo[2,3-f][1,3]benzodioxole-7,6'-thieno[3,2-b]pyrrole]-5'-one Chemical compound C1OC2=CC=3OCOC=3C=C2C21C(=O)N(CCCCC)C1=C2SC=C1 YAVXCTQVGCPGJE-UHFFFAOYSA-N 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 206010058019 Cancer Pain Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 101000620451 Homo sapiens Leucine-rich glioma-inactivated protein 1 Proteins 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010020844 Hyperthermia malignant Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000007914 Labor Pain Diseases 0.000 claims 1
- 208000035945 Labour pain Diseases 0.000 claims 1
- 102100022275 Leucine-rich glioma-inactivated protein 1 Human genes 0.000 claims 1
- 208000026709 Liddle syndrome Diseases 0.000 claims 1
- 208000018717 Malignant hyperthermia of anesthesia Diseases 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 206010028372 Muscular weakness Diseases 0.000 claims 1
- 206010061533 Myotonia Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000000693 Neurogenic Urinary Bladder Diseases 0.000 claims 1
- 206010029279 Neurogenic bladder Diseases 0.000 claims 1
- 208000010886 Peripheral nerve injury Diseases 0.000 claims 1
- 208000004983 Phantom Limb Diseases 0.000 claims 1
- 206010056238 Phantom pain Diseases 0.000 claims 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- 206010037113 Pseudoaldosteronism Diseases 0.000 claims 1
- 208000005793 Restless legs syndrome Diseases 0.000 claims 1
- 206010039020 Rhabdomyolysis Diseases 0.000 claims 1
- 206010040744 Sinus headache Diseases 0.000 claims 1
- 108010052164 Sodium Channels Proteins 0.000 claims 1
- 102000018674 Sodium Channels Human genes 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010043269 Tension headache Diseases 0.000 claims 1
- 208000008548 Tension-Type Headache Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000005298 acute pain Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000028683 bipolar I disease Diseases 0.000 claims 1
- 208000025307 bipolar depression Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 230000035606 childbirth Effects 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000009610 hypersensitivity Effects 0.000 claims 1
- 208000003532 hypothyroidism Diseases 0.000 claims 1
- 230000002989 hypothyroidism Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 201000007004 malignant hyperthermia Diseases 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000036473 myasthenia Effects 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 230000004112 neuroprotection Effects 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000001314 paroxysmal effect Effects 0.000 claims 1
- 208000019865 paroxysmal extreme pain disease Diseases 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 230000002085 persistent effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 206010044652 trigeminal neuralgia Diseases 0.000 claims 1
- 208000003663 ventricular fibrillation Diseases 0.000 claims 1
- 208000009935 visceral pain Diseases 0.000 claims 1
- 0 *c1c(*)c(*=*)c(C(C**C2)(C(C(C3)C3CCC*(CC3)I)C3N3*)C3=O)c2c1* Chemical compound *c1c(*)c(*=*)c(C(C**C2)(C(C(C3)C3CCC*(CC3)I)C3N3*)C3=O)c2c1* 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67096205P | 2005-04-11 | 2005-04-11 | |
| PCT/US2006/013318 WO2006110654A1 (en) | 2005-04-11 | 2006-04-11 | Spiroheterocyclic compounds and their uses as therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008535916A JP2008535916A (ja) | 2008-09-04 |
| JP2008535916A5 true JP2008535916A5 (https=) | 2009-04-02 |
Family
ID=36694990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008506574A Pending JP2008535916A (ja) | 2005-04-11 | 2006-04-11 | スピロ複素環化合物および治療剤としてのその使用 |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US7799798B2 (https=) |
| EP (1) | EP1888592B1 (https=) |
| JP (1) | JP2008535916A (https=) |
| KR (1) | KR20080007250A (https=) |
| CN (2) | CN101166744A (https=) |
| AR (1) | AR053710A1 (https=) |
| AT (1) | ATE504587T1 (https=) |
| AU (1) | AU2006235329B2 (https=) |
| BR (1) | BRPI0608995A2 (https=) |
| CA (1) | CA2604010A1 (https=) |
| DE (1) | DE602006021169D1 (https=) |
| EC (1) | ECSP077848A (https=) |
| ES (1) | ES2362908T3 (https=) |
| HR (1) | HRP20070499A2 (https=) |
| IL (1) | IL186615A0 (https=) |
| MA (1) | MA29685B1 (https=) |
| MX (1) | MX2007012637A (https=) |
| MY (1) | MY145694A (https=) |
| NO (1) | NO20074620L (https=) |
| NZ (1) | NZ561204A (https=) |
| PL (1) | PL1888592T3 (https=) |
| RU (1) | RU2428424C2 (https=) |
| SG (1) | SG161264A1 (https=) |
| TN (1) | TNSN07384A1 (https=) |
| TW (1) | TW200720278A (https=) |
| WO (1) | WO2006110654A1 (https=) |
| ZA (1) | ZA200709004B (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR053710A1 (es) | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
| AR056968A1 (es) * | 2005-04-11 | 2007-11-07 | Xenon Pharmaceuticals Inc | Compuestos espiro-oxindol y composiciones farmacéuticas |
| AR053713A1 (es) * | 2005-04-20 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos heterociclicos y sus usos como agentes terapeuticos |
| AR063277A1 (es) * | 2006-10-12 | 2009-01-14 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y usos como agentes terapeuticos |
| US20110294842A9 (en) * | 2006-10-12 | 2011-12-01 | Xenon Pharmaceuticals Inc. | Spiro (furo [3, 2-c] pyridine-3-3' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain |
| WO2008060789A2 (en) * | 2006-10-12 | 2008-05-22 | Xenon Pharmaceuticals Inc. | Use of spiro-oxindole compounds as therapeutic agents |
| WO2008046087A2 (en) * | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Spiro compounds and their uses as therapeutic agents |
| WO2008046082A2 (en) * | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Use of heterocyclic compounds as therapeutic agents |
| AU2007307635A1 (en) * | 2006-10-12 | 2008-04-17 | Xenon Pharmaceuticals Inc. | Tricyclic spiro-oxindole derivatives and their uses as therapeutic agents |
| US20100010092A1 (en) * | 2006-12-19 | 2010-01-14 | Arless Ltd. | Use of modafinil to treat restless leg syndrome |
| US7795228B2 (en) | 2006-12-28 | 2010-09-14 | Theracos, Inc. | Spiroheterocyclic glycosides and methods of use |
| US8309544B2 (en) * | 2007-05-16 | 2012-11-13 | Merck Sharp & Dohme Corp. | Spiroindalones |
| CA2701203A1 (en) * | 2007-10-04 | 2009-04-09 | Merck Sharp & Dohme Corp. | N-substituted oxindoline derivatives as calcium channel blockers |
| US20100204247A1 (en) * | 2007-10-04 | 2010-08-12 | Duffy Joseph L | N-substituted oxindoline derivatives as calcium channel blockers |
| UA101004C2 (en) | 2007-12-13 | 2013-02-25 | Теракос, Инк. | Derivatives of benzylphenylcyclohexane and use thereof |
| CN102015711B (zh) | 2008-04-29 | 2013-05-01 | 诺瓦提斯公司 | 用于治疗寄生虫病的螺-吲哚衍生物 |
| CN103910702A (zh) | 2008-08-22 | 2014-07-09 | 泰拉科斯有限公司 | 制备sglt2抑制剂的方法 |
| JO3032B1 (ar) * | 2008-10-17 | 2016-09-05 | Xenon Pharmaceuticals Inc | مركبات سبيرو – اوكسندول وإستعمالاتها كعوامل علاجية. |
| CA2741024A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| WO2010053998A1 (en) * | 2008-11-05 | 2010-05-14 | Xenon Pharmaceuticals, Inc. | Spiro-condensed indole derivatives as sodium channel inhibitors |
| WO2010078307A1 (en) * | 2008-12-29 | 2010-07-08 | Xenon Pharmaceuticals Inc. | Spiro-oxindole-derivatives as sodium channel blockers |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| KR20120099429A (ko) | 2009-10-14 | 2012-09-10 | 제논 파마슈티칼스 인크. | 스피로-옥스인돌 화합물의 합성 방법 |
| US20110086899A1 (en) * | 2009-10-14 | 2011-04-14 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions for oral administration |
| WO2011106729A2 (en) | 2010-02-26 | 2011-09-01 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents |
| WO2011153712A1 (en) | 2010-06-12 | 2011-12-15 | Theracos, Inc. | Crystalline form of benzylbenzene sglt2 inhibitor |
| WO2013152476A1 (en) | 2012-04-10 | 2013-10-17 | Theracos, Inc. | Process for the preparation of benzylbenzene sglt2 inhibitors |
| HK1205114A1 (en) | 2012-04-12 | 2015-12-11 | Xenon Pharmaceuticals Inc. | Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents |
| CN105611920B (zh) | 2013-10-12 | 2021-07-16 | 泰拉科斯萨普有限责任公司 | 羟基-二苯甲烷衍生物的制备 |
| WO2016127068A1 (en) | 2015-02-05 | 2016-08-11 | Teva Pharmaceuticals International Gmbh | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
| US9840513B2 (en) * | 2015-07-16 | 2017-12-12 | Abbvie S.Á.R.L. | Substituted tricyclics and method of use |
| US10100060B2 (en) | 2016-06-16 | 2018-10-16 | Xenon Pharmaceuticals Inc. | Asymmetric synthesis of funapide |
| US20250368647A1 (en) * | 2022-06-09 | 2025-12-04 | Glaxosmithkline Intellectual Property Development Limited | Nitrogen containing condensed 2,3-dihydroquinazolinone compounds as nav1.8 inhibitors |
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- 2006-04-11 JP JP2008506574A patent/JP2008535916A/ja active Pending
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- 2006-04-11 RU RU2007141633/04A patent/RU2428424C2/ru not_active IP Right Cessation
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- 2006-04-11 KR KR1020077026138A patent/KR20080007250A/ko not_active Ceased
- 2006-04-11 CN CNA2006800118134A patent/CN101166744A/zh active Pending
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