JP2012526838A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012526838A5 JP2012526838A5 JP2012510987A JP2012510987A JP2012526838A5 JP 2012526838 A5 JP2012526838 A5 JP 2012526838A5 JP 2012510987 A JP2012510987 A JP 2012510987A JP 2012510987 A JP2012510987 A JP 2012510987A JP 2012526838 A5 JP2012526838 A5 JP 2012526838A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- item
- aryl
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 178
- 150000003839 salts Chemical class 0.000 claims description 21
- 229940002612 prodrug Drugs 0.000 claims description 19
- 239000000651 prodrug Substances 0.000 claims description 19
- 208000005176 Hepatitis C Diseases 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 6
- 230000000069 prophylactic effect Effects 0.000 claims description 3
- 230000001225 therapeutic effect Effects 0.000 claims description 3
- 229940123066 Polymerase inhibitor Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 4
- 101800001554 RNA-directed RNA polymerase Proteins 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 description 613
- 125000000623 heterocyclic group Chemical group 0.000 description 362
- 125000003118 aryl group Chemical group 0.000 description 285
- 125000003710 aryl alkyl group Chemical group 0.000 description 215
- 125000000753 cycloalkyl group Chemical group 0.000 description 200
- 125000001188 haloalkyl group Chemical group 0.000 description 200
- 125000005843 halogen group Chemical group 0.000 description 170
- 125000003545 alkoxy group Chemical group 0.000 description 168
- 125000003342 alkenyl group Chemical group 0.000 description 129
- 125000004438 haloalkoxy group Chemical group 0.000 description 126
- 125000000304 alkynyl group Chemical group 0.000 description 105
- 229910052739 hydrogen Inorganic materials 0.000 description 105
- 239000001257 hydrogen Substances 0.000 description 105
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 105
- 125000004183 alkoxy alkyl group Chemical group 0.000 description 104
- 125000004093 cyano group Chemical group *C#N 0.000 description 99
- 125000004043 oxo group Chemical group O=* 0.000 description 99
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 97
- -1 carboxy, formyl Chemical group 0.000 description 86
- 125000004415 heterocyclylalkyl group Chemical group 0.000 description 86
- 125000004966 cyanoalkyl group Chemical group 0.000 description 76
- 125000004122 cyclic group Chemical group 0.000 description 71
- 125000001072 heteroaryl group Chemical group 0.000 description 67
- 229920006395 saturated elastomer Polymers 0.000 description 62
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 60
- 125000004448 alkyl carbonyl group Chemical group 0.000 description 57
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 54
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 52
- 229910052717 sulfur Inorganic materials 0.000 description 49
- 229910052799 carbon Inorganic materials 0.000 description 48
- 125000004994 halo alkoxy alkyl group Chemical group 0.000 description 46
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 46
- 125000005844 heterocyclyloxy group Chemical group 0.000 description 45
- 125000005099 aryl alkyl carbonyl group Chemical group 0.000 description 44
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 description 44
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 description 43
- 125000005129 aryl carbonyl group Chemical group 0.000 description 43
- 125000004963 sulfonylalkyl group Chemical group 0.000 description 43
- 125000003302 alkenyloxy group Chemical group 0.000 description 42
- 125000000278 alkyl amino alkyl group Chemical group 0.000 description 42
- 125000004103 aminoalkyl group Chemical group 0.000 description 42
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 description 42
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 description 42
- 125000000392 cycloalkenyl group Chemical group 0.000 description 40
- 125000001424 substituent group Chemical group 0.000 description 38
- 125000004429 atom Chemical group 0.000 description 37
- 125000005842 heteroatom Chemical group 0.000 description 36
- 125000000033 alkoxyamino group Chemical group 0.000 description 35
- 125000004391 aryl sulfonyl group Chemical group 0.000 description 35
- 150000001721 carbon Chemical group 0.000 description 31
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 31
- 125000004390 alkyl sulfonyl group Chemical group 0.000 description 28
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 description 28
- 229910052760 oxygen Inorganic materials 0.000 description 27
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 23
- LKDRXBCSQODPBY-AMVSKUEXSA-N L-(-)-Sorbose Chemical compound OCC1(O)OC[C@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-AMVSKUEXSA-N 0.000 description 22
- 125000005083 alkoxyalkoxy group Chemical group 0.000 description 22
- 125000005180 haloalkoxyalkyloxy group Chemical group 0.000 description 20
- 125000005324 aryloxy alkyloxy group Chemical group 0.000 description 19
- 125000000000 cycloalkoxy group Chemical group 0.000 description 19
- 125000002102 aryl alkyloxo group Chemical group 0.000 description 18
- 125000005159 cyanoalkoxy group Chemical group 0.000 description 18
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 18
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 13
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 description 12
- 125000002619 bicyclic group Chemical group 0.000 description 12
- 125000005339 cyanocycloalkoxy group Chemical group 0.000 description 10
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 8
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 description 8
- 125000004686 alkyl sulfanyl alkyl group Chemical group 0.000 description 8
- 125000005018 aryl alkenyl group Chemical group 0.000 description 8
- 125000002837 carbocyclic group Chemical group 0.000 description 8
- 125000004181 carboxyalkyl group Chemical group 0.000 description 8
- 229910052757 nitrogen Inorganic materials 0.000 description 8
- 125000006163 5-membered heteroaryl group Chemical group 0.000 description 6
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 description 6
- 125000004702 alkoxy alkyl carbonyl group Chemical group 0.000 description 6
- 125000004688 alkyl sulfonyl alkyl group Chemical group 0.000 description 6
- 125000005282 allenyl group Chemical group 0.000 description 6
- 125000005144 cycloalkylsulfonyl group Chemical group 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 6
- 125000004993 haloalkoxycarbonyl group Chemical group 0.000 description 6
- 125000005347 halocycloalkyl group Chemical group 0.000 description 6
- 125000005182 hydroxyalkylcarbonyl group Chemical group 0.000 description 6
- 125000004433 nitrogen atom Chemical group N* 0.000 description 6
- 102000014150 Interferons Human genes 0.000 description 5
- 108010050904 Interferons Proteins 0.000 description 5
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 description 5
- 125000004858 cycloalkoxyalkyl group Chemical group 0.000 description 5
- 229940079322 interferon Drugs 0.000 description 5
- 125000000165 tricyclic carbocycle group Chemical group 0.000 description 5
- 125000004008 6 membered carbocyclic group Chemical group 0.000 description 4
- 125000005330 8 membered heterocyclic group Chemical group 0.000 description 4
- 125000005160 aryl oxy alkyl group Chemical group 0.000 description 4
- 239000003610 charcoal Substances 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 125000002950 monocyclic group Chemical group 0.000 description 4
- 125000000169 tricyclic heterocycle group Chemical group 0.000 description 4
- 125000004414 alkyl thio group Chemical group 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 125000002883 imidazolyl group Chemical group 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000002777 nucleoside Substances 0.000 description 3
- 125000006661 (C4-C6) heterocyclic group Chemical group 0.000 description 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 description 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 description 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical class N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 description 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical group O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 description 2
- 125000005093 alkyl carbonyl alkyl group Chemical group 0.000 description 2
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 description 2
- 125000005127 aryl alkoxy alkyl group Chemical group 0.000 description 2
- 125000005163 aryl sulfanyl group Chemical group 0.000 description 2
- 125000004104 aryloxy group Chemical group 0.000 description 2
- 125000002618 bicyclic heterocycle group Chemical group 0.000 description 2
- 150000001602 bicycloalkyls Chemical group 0.000 description 2
- 125000004965 chloroalkyl group Chemical group 0.000 description 2
- 125000004439 haloalkylsulfanyl group Chemical group 0.000 description 2
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 description 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 description 2
- 125000005326 heteroaryloxy alkyl group Chemical group 0.000 description 2
- 125000005553 heteroaryloxy group Chemical group 0.000 description 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 description 2
- 125000004449 heterocyclylalkenyl group Chemical group 0.000 description 2
- 125000005113 hydroxyalkoxy group Chemical group 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000013160 medical therapy Methods 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 2
- 150000003833 nucleoside derivatives Chemical class 0.000 description 2
- 125000003003 spiro group Chemical group 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- IWUCXVSUMQZMFG-RGDLXGNYSA-N 1-[(2s,3s,4r,5s)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide Chemical compound N1=C(C(=O)N)N=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 IWUCXVSUMQZMFG-RGDLXGNYSA-N 0.000 description 1
- TZYVRXZQAWPIAB-FCLHUMLKSA-N 5-amino-3-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4h-[1,3]thiazolo[4,5-d]pyrimidine-2,7-dione Chemical compound O=C1SC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O TZYVRXZQAWPIAB-FCLHUMLKSA-N 0.000 description 1
- 101001023866 Arabidopsis thaliana Mannosyl-oligosaccharide glucosidase GCS1 Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- FWKQNCXZGNBPFD-UHFFFAOYSA-N Guaiazulene Chemical compound CC(C)C1=CC=C(C)C2=CC=C(C)C2=C1 FWKQNCXZGNBPFD-UHFFFAOYSA-N 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 101800001838 Serine protease/helicase NS3 Proteins 0.000 description 1
- 125000005356 cycloalkylalkenyl group Chemical group 0.000 description 1
- 125000005357 cycloalkylalkynyl group Chemical group 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 125000005343 heterocyclic alkyl group Chemical group 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229950003954 isatoribine Drugs 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000006626 methoxycarbonylamino group Chemical group 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical group C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- 229940127073 nucleoside analogue Drugs 0.000 description 1
- 229960000329 ribavirin Drugs 0.000 description 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- NHKZSTHOYNWEEZ-AFCXAGJDSA-N taribavirin Chemical compound N1=C(C(=N)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NHKZSTHOYNWEEZ-AFCXAGJDSA-N 0.000 description 1
- 229950006081 taribavirin Drugs 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17797209P | 2009-05-13 | 2009-05-13 | |
| US61/177,972 | 2009-05-13 | ||
| US22474509P | 2009-07-10 | 2009-07-10 | |
| US61/224,745 | 2009-07-10 | ||
| US23876009P | 2009-09-01 | 2009-09-01 | |
| US61/238,760 | 2009-09-01 | ||
| PCT/US2010/034600 WO2010132601A1 (en) | 2009-05-13 | 2010-05-12 | Antiviral compounds |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014107359A Division JP5744283B2 (ja) | 2009-05-13 | 2014-05-23 | 抗ウイルス化合物 |
| JP2014124325A Division JP5745727B2 (ja) | 2009-05-13 | 2014-06-17 | 抗ウイルス化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012526838A JP2012526838A (ja) | 2012-11-01 |
| JP2012526838A5 true JP2012526838A5 (enExample) | 2014-07-10 |
| JP5582662B2 JP5582662B2 (ja) | 2014-09-03 |
Family
ID=42645241
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510987A Active JP5582662B2 (ja) | 2009-05-13 | 2010-05-12 | 抗ウイルス化合物 |
| JP2014107359A Active JP5744283B2 (ja) | 2009-05-13 | 2014-05-23 | 抗ウイルス化合物 |
| JP2014124325A Active JP5745727B2 (ja) | 2009-05-13 | 2014-06-17 | 抗ウイルス化合物 |
| JP2015091474A Withdrawn JP2015157842A (ja) | 2009-05-13 | 2015-04-28 | 抗ウイルス化合物 |
| JP2017095523A Withdrawn JP2017145254A (ja) | 2009-05-13 | 2017-05-12 | 抗ウイルス化合物 |
| JP2018240826A Withdrawn JP2019104732A (ja) | 2009-05-13 | 2018-12-25 | 抗ウイルス化合物 |
| JP2020159623A Pending JP2021001214A (ja) | 2009-05-13 | 2020-09-24 | 抗ウイルス化合物 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014107359A Active JP5744283B2 (ja) | 2009-05-13 | 2014-05-23 | 抗ウイルス化合物 |
| JP2014124325A Active JP5745727B2 (ja) | 2009-05-13 | 2014-06-17 | 抗ウイルス化合物 |
| JP2015091474A Withdrawn JP2015157842A (ja) | 2009-05-13 | 2015-04-28 | 抗ウイルス化合物 |
| JP2017095523A Withdrawn JP2017145254A (ja) | 2009-05-13 | 2017-05-12 | 抗ウイルス化合物 |
| JP2018240826A Withdrawn JP2019104732A (ja) | 2009-05-13 | 2018-12-25 | 抗ウイルス化合物 |
| JP2020159623A Pending JP2021001214A (ja) | 2009-05-13 | 2020-09-24 | 抗ウイルス化合物 |
Country Status (40)
Families Citing this family (209)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100503628C (zh) | 2003-05-30 | 2009-06-24 | 法莫赛特股份有限公司 | 修饰的氟化核苷类似物 |
| AR067413A1 (es) * | 2007-07-05 | 2009-10-07 | Genentech Inc | Compuestos heterociclicos que contienen ciclopenta[d]pirimidina inhibidores de proteinquinasas akt, composiciones farmaceuticas que los contienen, metodo de preparacion y uso de las mismas para el tratamiento de enfermedades hiperproliferativas, tales como cancer |
| KR101784830B1 (ko) * | 2008-12-03 | 2017-10-16 | 프레시디오 파마슈티칼스, 인코포레이티드 | Ｈｃｖ ｎｓ5ａ의 억제제 |
| BRPI0922364A2 (pt) | 2008-12-03 | 2017-08-29 | Presidio Pharmaceuticals Inc | Composto, composição farmacêutica e uso de um composto |
| CN102264737A (zh) | 2008-12-23 | 2011-11-30 | 雅培制药有限公司 | 抗病毒化合物 |
| MX2011006333A (es) | 2008-12-23 | 2011-06-27 | Abbott Lab | Compuestos antivirales. |
| US8314135B2 (en) | 2009-02-09 | 2012-11-20 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole antivirals |
| US8188132B2 (en) | 2009-02-17 | 2012-05-29 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| TWI438200B (zh) * | 2009-02-17 | 2014-05-21 | 必治妥美雅史谷比公司 | Ｃ型肝炎病毒抑制劑 |
| US8637561B2 (en) * | 2009-02-17 | 2014-01-28 | Enanta Pharmaceuticals, Inc. | Linked diimidazole derivatives |
| US8394968B2 (en) | 2009-02-17 | 2013-03-12 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8242156B2 (en) | 2009-02-17 | 2012-08-14 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| EP2398474A4 (en) * | 2009-02-23 | 2012-12-05 | Presidio Pharmaceuticals Inc | HCV NS5A SHEMMER |
| US8673954B2 (en) | 2009-02-27 | 2014-03-18 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US9765087B2 (en) | 2009-02-27 | 2017-09-19 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| US8101643B2 (en) * | 2009-02-27 | 2012-01-24 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
| CA2756255A1 (en) | 2009-03-27 | 2010-09-30 | Presidio Pharmaceuticals, Inc. | Substituted bicyclic hcv inhibitors |
| US8796466B2 (en) | 2009-03-30 | 2014-08-05 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| TW201038559A (en) * | 2009-04-09 | 2010-11-01 | Bristol Myers Squibb Co | Hepatitis C virus inhibitors |
| US8143414B2 (en) | 2009-04-13 | 2012-03-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| RU2541571C2 (ru) | 2009-04-15 | 2015-02-20 | Эббви Инк. | Противовирусные соединения |
| US8436036B2 (en) * | 2009-04-24 | 2013-05-07 | Janssen R&D Ireland | Diaryl ethers |
| AU2010249080A1 (en) * | 2009-05-12 | 2012-01-12 | Merck Sharp & Dohme Corp. | Fused tricyclic aryl compounds useful for the treatment of viral diseases |
| KR20180028070A (ko) | 2009-05-13 | 2018-03-15 | 길리애드 파마셋 엘엘씨 | 항바이러스 화합물 |
| US8138215B2 (en) * | 2009-05-29 | 2012-03-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CA2763140A1 (en) * | 2009-05-29 | 2010-12-02 | Schering Corporation | Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c |
| WO2010138790A1 (en) * | 2009-05-29 | 2010-12-02 | Schering Corporation | Antiviral compounds composed of three aligned aryl moieties to treat diseases such as hepatitis c |
| US8211928B2 (en) | 2009-05-29 | 2012-07-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
| US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
| UA118080C2 (uk) * | 2009-06-11 | 2018-11-26 | Еббві Айрленд Анлімітед Компані | Противірусні сполуки |
| US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
| US8609648B2 (en) | 2009-07-02 | 2013-12-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| JP2012533569A (ja) | 2009-07-16 | 2012-12-27 | ヴァーテックス ファーマシューティカルズ、 インコーポレイテッド | フラビウイルス感染症を治療又は予防するためのベンゾイミダゾール類似体 |
| AU2010280712B2 (en) * | 2009-08-07 | 2015-10-22 | Janssen Sciences Ireland Uc | Bis-benzimidazole derivatives as hepatitis C virus inhibitors |
| AU2010280711A1 (en) * | 2009-08-07 | 2012-02-09 | Janssen Sciences Ireland Uc | Phenyl ethynyl derivatives as hepatitis C virus inhibitors |
| EP2473056A4 (en) | 2009-09-04 | 2013-02-13 | Glaxosmithkline Llc | CHEMICAL COMPOUNDS |
| US8927709B2 (en) * | 2009-09-11 | 2015-01-06 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| WO2011031904A1 (en) * | 2009-09-11 | 2011-03-17 | Enanta Pharmaceuticals, Inc | Hepatitis c virus inhibitors |
| US8815928B2 (en) | 2009-09-11 | 2014-08-26 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8759332B2 (en) * | 2009-09-11 | 2014-06-24 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8703938B2 (en) * | 2009-09-11 | 2014-04-22 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8822700B2 (en) | 2009-09-11 | 2014-09-02 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| EP2475254A4 (en) * | 2009-09-11 | 2013-05-22 | Enanta Pharm Inc | HEPATITIS C-VIRUS HEMMER |
| UA108211C2 (uk) | 2009-11-04 | 2015-04-10 | Янссен Рід Айрленд | Бензімідазолімідазольні похідні |
| US20110274648A1 (en) * | 2009-11-11 | 2011-11-10 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US20110269956A1 (en) | 2009-11-11 | 2011-11-03 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US20110281910A1 (en) * | 2009-11-12 | 2011-11-17 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| AU2010325980B2 (en) * | 2009-12-04 | 2016-04-07 | National Health Research Institutes | Proline derivatives |
| US8653070B2 (en) * | 2009-12-14 | 2014-02-18 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8377980B2 (en) | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CN104530079B (zh) * | 2009-12-18 | 2017-10-20 | 北京凯因科技股份有限公司 | C型肝炎病毒复制的新型抑制剂 |
| AR079528A1 (es) * | 2009-12-18 | 2012-02-01 | Idenix Pharmaceuticals Inc | Inhibidores de arileno o heteroarileno 5,5-fusionado del virus de la hepatitis c |
| JP2013515746A (ja) * | 2009-12-24 | 2013-05-09 | ヴァーテックス ファーマシューティカルズ、 インコーポレイテッド | フラビウイルス感染症の治療又は予防のための類似体 |
| US8362020B2 (en) | 2009-12-30 | 2013-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8933110B2 (en) | 2010-01-25 | 2015-01-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| EA201201031A1 (ru) | 2010-01-25 | 2013-02-28 | Энанта Фармасьютиклз, Инк. | Ингибиторы вируса гепатита с |
| JP2013518062A (ja) * | 2010-01-28 | 2013-05-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃ型肝炎阻害化合物 |
| US8178531B2 (en) * | 2010-02-23 | 2012-05-15 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
| US8623814B2 (en) * | 2010-02-23 | 2014-01-07 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
| KR20120124495A (ko) * | 2010-03-04 | 2012-11-13 | 이난타 파마슈티칼스, 인코포레이티드 | Ｈｃｖ 복제의 억제제로서의 조합 제약 작용제 |
| EP2550268A1 (en) * | 2010-03-24 | 2013-01-30 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
| CN102869657A (zh) * | 2010-03-24 | 2013-01-09 | 沃泰克斯药物股份有限公司 | 用于治疗或预防黄病毒感染的类似物 |
| EP2555622A4 (en) | 2010-04-09 | 2013-09-18 | Enanta Pharm Inc | HEPATITIS C-VIRUS HEMMER |
| US9125904B1 (en) | 2010-05-11 | 2015-09-08 | Achillion Pharmaceuticals, Inc. | Biphenyl imidazoles and related compounds useful for treating HCV infections |
| CA2800530A1 (en) * | 2010-05-28 | 2011-12-01 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
| US8778938B2 (en) | 2010-06-04 | 2014-07-15 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| TW201201801A (en) * | 2010-06-09 | 2012-01-16 | Presidio Pharmaceuticals Inc | Inhibitors of HCV NS5A protein |
| NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
| US20120195857A1 (en) * | 2010-08-12 | 2012-08-02 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| EP2603080A4 (en) | 2010-08-12 | 2014-01-22 | Enanta Pharm Inc | HEPATITIS C-VIRUS HEMMER |
| WO2012020036A1 (en) * | 2010-08-13 | 2012-02-16 | F. Hoffmann-La Roche Ag | Hepatitis c virus inhibitors |
| US8859595B2 (en) | 2010-08-26 | 2014-10-14 | Rfs Pharma, Llc | Potent and selective inhibitors of hepatitis C virus |
| WO2012050918A2 (en) | 2010-09-29 | 2012-04-19 | Presidio Pharmaceutical, Inc. | Tricyclic fused ring inhibitors of hepatitis c |
| AU2011328980B2 (en) | 2010-11-17 | 2015-07-30 | Gilead Sciences, Inc. | Antiviral compounds |
| RU2452735C1 (ru) * | 2010-11-30 | 2012-06-10 | Александр Васильевич Иващенко | Замещенные азолы, противовирусный активный компонент, фармацевтическая композиция, способ получения и применения |
| US20150232455A1 (en) * | 2010-12-15 | 2015-08-20 | Allan C. Krueger | Anti-viral compounds |
| EP2651925A4 (en) * | 2010-12-15 | 2014-06-18 | Abbvie Inc | ANTI-VIRAL COMPOUNDS |
| US20140364616A1 (en) * | 2010-12-15 | 2014-12-11 | Abbvie Inc. | Anti-viral compounds |
| WO2012087596A1 (en) * | 2010-12-20 | 2012-06-28 | Gilead Sciences, Inc. | Combinations for treating hcv |
| WO2012087976A2 (en) * | 2010-12-21 | 2012-06-28 | Intermune, Inc. | Novel inhibitors of hepatitis c virus replication |
| US8552047B2 (en) | 2011-02-07 | 2013-10-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| JP2012188400A (ja) * | 2011-03-11 | 2012-10-04 | Tosoh Corp | ジチエノベンゾジチオフェンの製造方法 |
| WO2012122716A1 (en) | 2011-03-17 | 2012-09-20 | Merck Sharp & Dohme Corp. | Tetracyclic xanthene derivatives and methods of use thereof for treatment of viral diseases |
| US8835456B1 (en) | 2011-03-18 | 2014-09-16 | Achillion Pharmaceuticals, Inc. | NS5A inhibitors useful for treating HCV |
| US20120252721A1 (en) * | 2011-03-31 | 2012-10-04 | Idenix Pharmaceuticals, Inc. | Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor |
| US9546160B2 (en) * | 2011-05-12 | 2017-01-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| JP5669984B2 (ja) | 2011-05-18 | 2015-02-18 | エナンタ ファーマシューティカルズ インコーポレイテッド | ５−アザスピロ［２．４］ヘプタン−６−カルボン酸およびその誘導体の製造方法 |
| CA2837481A1 (en) | 2011-05-27 | 2012-12-06 | Achillion Pharmaceuticals, Inc. | Substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes useful for treating hcv infections |
| CA2841095A1 (en) | 2011-07-09 | 2013-01-17 | Sunshine Lake Pharma Co., Ltd. | Spiro compounds as hepatitis c virus inhibitors |
| WO2013021344A1 (en) | 2011-08-08 | 2013-02-14 | Lupin Limited | Imidazole derivatives as antiviral agents |
| WO2013025975A1 (en) * | 2011-08-17 | 2013-02-21 | Glaxosmithkline Llc | Combination treatments for hepatitis c |
| MX2014002171A (es) * | 2011-08-24 | 2014-04-25 | Glaxosmithkline Llc | Tratamientos de combinacion para hepatitis c. |
| WO2013030750A1 (en) | 2011-09-01 | 2013-03-07 | Lupin Limited | Antiviral compounds |
| AU2012308295B2 (en) | 2011-09-16 | 2017-10-26 | Gilead Sciences, Inc. | Methods for treating HCV |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| EP2583680A3 (en) * | 2011-10-21 | 2013-06-12 | Abbvie Inc. | Mono (PSI-7977) or combination treatment of DAAs for use in treating HCV |
| SE1450130A1 (sv) | 2011-10-21 | 2014-05-07 | Abbvie Inc | Förfaranden för att behandla hcv innefattande minst två direktverkande antivirala agenser, ribavirin men inte interferon |
| KR20140091036A (ko) | 2011-11-03 | 2014-07-18 | 세라밴스 인코포레이티드 | 단편 [2-[4-(바이페닐-4-일)-1h-이미다조-2-일]피롤리딘-1-카르보닐메틸]아민을 포함하는 간상 c형 간염 바이러스 억제제 |
| DK2907816T3 (en) * | 2011-11-16 | 2018-09-24 | Gilead Pharmasset Llc | CONDENSED IMIDAZOLYLIMIDAZOLES AS ANTIVIRAL COMPOUNDS |
| CA2858659A1 (en) | 2011-12-28 | 2013-07-04 | Janssen R&D Ireland | Hetero-bicyclic derivatives as hcv inhibitors |
| EP2797586A1 (en) * | 2011-12-29 | 2014-11-05 | AbbVie Inc. | Solid compositions comprising an hcv inhibitor |
| US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
| US9326973B2 (en) * | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| NZ628515A (en) | 2012-02-10 | 2016-06-24 | Lupin Ltd | Antiviral compounds with a dibenzooxaheterocycle moiety |
| AU2013221571A1 (en) | 2012-02-14 | 2014-08-28 | University Of Georgia Research Foundation, Inc. | Spiro [2.4] heptanes for treatment of Flaviviridae infections |
| ITMI20120424A1 (it) | 2012-03-19 | 2013-09-20 | Rottapharm Spa | Composti chimici |
| SI2850075T1 (sl) | 2012-04-25 | 2017-06-30 | Theravance Biopharma R&D Ip, Llc | Piperazin-piperidinske spojine kot inhibitorji virusa hepatitisa C |
| JP6069492B2 (ja) | 2012-04-25 | 2017-02-01 | セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー | Ｃ型肝炎ウイルス阻害剤 |
| US20130309196A1 (en) | 2012-05-16 | 2013-11-21 | Gilead Sciences, Inc. | Antiviral compounds |
| US9079887B2 (en) * | 2012-05-16 | 2015-07-14 | Gilead Sciences, Inc. | Antiviral compounds |
| US8969588B2 (en) * | 2012-06-05 | 2015-03-03 | Gilead Pharmasset Llc | Solid forms of an antiviral compound |
| US9056860B2 (en) * | 2012-06-05 | 2015-06-16 | Gilead Pharmasset Llc | Synthesis of antiviral compound |
| TWI610916B (zh) | 2012-08-03 | 2018-01-11 | 廣東東陽光藥業有限公司 | 作爲丙型肝炎抑制劑的橋環化合物及其在藥物中的應用 |
| TW201412709A (zh) * | 2012-09-28 | 2014-04-01 | Sunshine Lake Pharma Co Ltd | 作為丙型肝炎抑制劑的螺環化合物及其在藥物中的應用 |
| WO2014082380A1 (en) * | 2012-11-29 | 2014-06-05 | Sunshine Lake Pharma Co., Ltd. | Fused ring compounds as hepatitis c virus inhibitors, pharmaceutical compositions and uses thereof |
| CN103848819B (zh) * | 2012-11-29 | 2017-04-12 | 广东东阳光药业有限公司 | 作为丙型肝炎抑制剂的螺环化合物、药物组合物及它们在药物中的应用 |
| WO2014082379A1 (en) * | 2012-11-29 | 2014-06-05 | Sunshine Lake Pharma Co.,Ltd. | Spiro ring compound as hepatitis c virus (hcv) inhibitor and uses thereof field of the invention |
| CN103880823B (zh) * | 2012-12-21 | 2017-12-05 | 广东东阳光药业有限公司 | 作为丙型肝炎抑制剂的螺环化合物及其在药物中的应用 |
| MY172166A (en) | 2013-01-31 | 2019-11-15 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
| RU2507201C1 (ru) * | 2013-02-07 | 2014-02-20 | Александр Васильевич Иващенко | Алкил [(s)-1-((s)-2-{5-[4-(4-{2-[(s)-1-((s)-2-метоксикарбониламино-3-метил-бутирил)-пирролидин-2-ил]-3н-имидазол-4-ил}-бута-1,3-диинил)-фенил]-1н-имидазол-2-ил}-пирролидин-1-карбонил)-2-метил-пропил]-карбамат нафталин-1,5-дисульфонат, фармацевтическая композиция, лекарственное средство, способ лечения вирусных заболеваний |
| RU2518369C1 (ru) * | 2013-02-07 | 2014-06-10 | Общество с ограниченной ответственностью "Интеллектуальный Диалог" | Алкил [2-(2-{5-[4-(4-{2-[1-(2-метоксикарбониламино-ацетил)-пирролидин-2-ил]-3н-имидазол-4-ил}-фенил)-бута-1,3-диинил]-1н-имидазол-2-ил}-пирролидин-1-ил)-2-оксо-этил]-карбамат, фармацевтическая композиция, лекарственное средство, способ лечения вирусных заболеваний |
| TW201439060A (zh) * | 2013-02-27 | 2014-10-16 | Sunshine Lake Pharma Co Ltd | 作爲丙型肝炎抑制劑的橋環化合物及其藥物組合物和用途 |
| US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
| WO2014197400A1 (en) | 2013-06-04 | 2014-12-11 | Gilead Pharmasset Llc | Preventing and treating recurrence of hcv infection after liver transplant |
| CN105837561B (zh) * | 2013-06-06 | 2019-06-28 | 上海爱博医药科技有限公司 | 抑制丙肝病毒的化合物、药物组合物及其应用 |
| US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
| WO2015009744A1 (en) | 2013-07-17 | 2015-01-22 | Bristol-Myers Squibb Company | Combinations comprising biphenyl derivatives for use in the treatment of hcv |
| EP3650014B1 (en) | 2013-08-27 | 2021-10-06 | Gilead Pharmasset LLC | Combination formulation of two antiviral compounds |
| CN104418785A (zh) * | 2013-09-05 | 2015-03-18 | 浙江九洲药业股份有限公司 | 一种药物中间体的制备方法 |
| WO2015042375A1 (en) | 2013-09-20 | 2015-03-26 | Idenix Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
| CN104610272B (zh) * | 2013-11-05 | 2017-03-29 | 上海唐润医药科技有限公司 | 环状黄酮或异黄酮类化合物及其用途 |
| KR101561964B1 (ko) | 2013-11-15 | 2015-10-20 | 한국과학기술연구원 | 옥사졸리디논 화합물 및 이를 포함하는 c형 간염 예방 또는 치료용 약학 조성물 |
| WO2015084741A2 (en) | 2013-12-02 | 2015-06-11 | Gilead Pharmasset Llc | Methods of treating hepatitis c virus infection in subjects with cirrhosis |
| WO2015096674A1 (zh) * | 2013-12-23 | 2015-07-02 | 南京圣和药业股份有限公司 | 丙型肝炎病毒抑制剂及其应用 |
| TW201609785A (zh) | 2013-12-23 | 2016-03-16 | 吉李德製藥公司 | 固體型之抗病毒化合物 |
| CA2935089C (en) * | 2013-12-31 | 2018-11-27 | Nanjing Sanhome Pharmaceutical Co., Ltd. | 9,9,10,10-tetrafluoro-9,10-dihydrophenanthrene hepatitis c virus inhibitor and application thereof |
| WO2015103490A1 (en) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Solid antiviral dosage forms |
| WO2015110048A1 (en) * | 2014-01-23 | 2015-07-30 | Sunshine Lake Pharma Co., Ltd. | Bridged ring compounds as hepatitis c virus inhibitors, pharmaceutical compositions and uses thereof |
| CN104860935A (zh) * | 2014-02-21 | 2015-08-26 | 常州寅盛药业有限公司 | 作为丙肝病毒抑制剂的噻吩或其变体衍生物及其制药用途 |
| CN104860931A (zh) * | 2014-02-21 | 2015-08-26 | 常州寅盛药业有限公司 | 丙肝病毒抑制剂及其制药用途 |
| WO2015184644A1 (zh) * | 2014-06-06 | 2015-12-10 | 爱博新药研发(上海)有限公司 | 抑制丙肝病毒的化合物、药物组合物及其应用 |
| CN104140417B (zh) * | 2014-06-11 | 2016-04-06 | 苏州景泓生物技术有限公司 | 合成gs5885用的中间体的先期化合物的合成方法 |
| TWI721947B (zh) | 2014-06-11 | 2021-03-21 | 美商基利法瑪席特有限責任公司 | 抗病毒化合物的固態形式 |
| CN105524049B (zh) * | 2014-09-28 | 2018-11-06 | 正大天晴药业集团股份有限公司 | 氘代的丙型肝炎病毒ns5a蛋白抑制剂 |
| CN104513147B (zh) * | 2014-11-20 | 2016-05-11 | 上海众强药业有限公司 | 芴乙酮衍生物的制备方法 |
| TWI675029B (zh) * | 2014-12-16 | 2019-10-21 | 大陸商廣東東陽光藥業有限公司 | 作為丙型肝炎抑制劑的橋環化合物及其製備方法 |
| WO2016103232A1 (en) * | 2014-12-24 | 2016-06-30 | Granules India Limited | An improved process for the preparation of hcv inhibitor |
| CN104530016A (zh) * | 2014-12-25 | 2015-04-22 | 上海泓博智源医药技术有限公司 | 一种雷迪帕韦的制备方法及其中间体 |
| SG10202105371YA (en) | 2014-12-26 | 2021-07-29 | Univ Emory | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| JP2018505201A (ja) | 2015-02-13 | 2018-02-22 | サンド・アクチエンゲゼルシヤフト | レジパスビルおよびソホスブビルを含む医薬組成物 |
| CN105985355B (zh) * | 2015-03-01 | 2020-05-05 | 南京圣和药业股份有限公司 | 稠合三环类肝炎病毒抑制剂及其应用 |
| PL3097102T3 (pl) | 2015-03-04 | 2018-04-30 | Gilead Sciences Inc | Związki 4,6-diamino-pirydo[3,2-d]pirymidyny modulujące działanie receptora toll-podobnego |
| WO2016145269A1 (en) | 2015-03-12 | 2016-09-15 | Teva Pharmaceuticals International Gmbh | Solid state forms ledipasvir and processes for preparation of ledipasvir |
| CN104829599B (zh) * | 2015-03-17 | 2017-06-09 | 上海众强药业有限公司 | 雷迪帕韦及其衍生物的制备方法及用于制备雷迪帕韦的中间体化合物 |
| US20160375017A1 (en) | 2015-06-26 | 2016-12-29 | Abbvie Inc. | Solid Pharmaceutical Compositions for Treating HCV |
| CN105017228A (zh) * | 2015-07-03 | 2015-11-04 | 上海众强药业有限公司 | 一种雷迪帕韦中间体单硫酸盐、其晶型及其制备方法 |
| CA3132620C (en) | 2015-07-24 | 2024-03-05 | Lumos Pharma, Inc. | Salts and prodrugs of 1-methyl-d-tryptophan |
| US10617675B2 (en) | 2015-08-06 | 2020-04-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| KR101919194B1 (ko) * | 2015-09-15 | 2018-11-15 | 주식회사 엘지화학 | 헤테로고리 화합물 및 이를 포함하는 유기 발광 소자 |
| CN105294713A (zh) * | 2015-10-09 | 2016-02-03 | 重庆康施恩化工有限公司 | Velpatasvir中间体及其制备方法 |
| WO2017072596A1 (en) * | 2015-10-26 | 2017-05-04 | Optimus Drugs (P) Ltd | An improved process for the preparation of ledipasvir |
| WO2017072714A1 (en) | 2015-10-30 | 2017-05-04 | Lupin Limited | Stable ledipasvir premix and process of preparation thereof |
| WO2017076201A1 (zh) * | 2015-11-06 | 2017-05-11 | 江苏豪森药业集团有限公司 | Hcv抑制剂、其制备方法与应用 |
| CN106117187B (zh) * | 2016-01-12 | 2019-01-01 | 深圳市塔吉瑞生物医药有限公司 | 一种丙型肝炎病毒抑制剂、药物组合物及其应用 |
| US20190062332A1 (en) * | 2016-02-01 | 2019-02-28 | Lupin Limited | Process for the preparation of ledipasvir and intermediates thereof |
| WO2017145028A1 (en) * | 2016-02-26 | 2017-08-31 | Glenmark Pharmaceuticals Limited | Process for preparation of ledipasvir |
| WO2017184670A2 (en) | 2016-04-22 | 2017-10-26 | Gilead Sciences, Inc. | Methods for treating zika virus infections |
| EA201892448A1 (ru) | 2016-04-28 | 2019-06-28 | Эмори Юниверсити | Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения |
| WO2017197051A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Amine-linked c3-glutarimide degronimers for target protein degradation |
| CN109562113A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的螺环降解决定子体 |
| ES2989988T3 (es) | 2016-05-10 | 2024-11-28 | C4 Therapeutics Inc | Degronímeros heterorocíclicos para la degradación de proteínas diana |
| WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
| WO2017195147A1 (en) * | 2016-05-12 | 2017-11-16 | Lupin Limited | Process for the preparation of ledipasvir and intermediates thereof |
| ES2969239T3 (es) | 2016-05-27 | 2024-05-17 | Gilead Sciences Inc | Combinación de ledipasvir y sofosbuvir para su uso en el tratamiento de infecciones por el virus de la hepatitis B en humanos |
| JOP20170127A1 (ar) | 2016-06-02 | 2017-12-02 | Gilead Pharmasset Llc | صيغة مشتركة مكونة من ثلاث مركبات مضادة للفيروسات |
| CN107663196A (zh) * | 2016-07-27 | 2018-02-06 | 广东东阳光药业有限公司 | 制备化合物的方法 |
| WO2018035410A1 (en) * | 2016-08-19 | 2018-02-22 | Temple University-Of The Commonwealth System Of Higher Education | Compositions and methods of treatment using expanded-size dna analogs |
| ES2826748T3 (es) | 2016-09-02 | 2021-05-19 | Gilead Sciences Inc | Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll |
| KR102268448B1 (ko) | 2016-09-02 | 2021-06-22 | 길리애드 사이언시즈, 인코포레이티드 | 톨 유사 수용체 조정제 화합물 |
| JP2018095561A (ja) * | 2016-12-08 | 2018-06-21 | 金剛化学株式会社 | ジフェニルアゼチジン誘導体の製造方法 |
| CN106632275B (zh) * | 2016-12-20 | 2018-03-06 | 上海同昌生物医药科技有限公司 | 一种雷迪帕韦的制备方法及制备雷迪帕韦的中间体 |
| RU2650610C1 (ru) | 2017-02-28 | 2018-04-16 | Васильевич Иващенко Александр | Противовирусная композиция и способ ее применения |
| US10392370B2 (en) | 2017-03-13 | 2019-08-27 | Optimus Drugs Pvt Ltd | Process for the preparation of Daclatasvir dihydrochloride and its intermediates |
| JOP20180040A1 (ar) | 2017-04-20 | 2019-01-30 | Gilead Sciences Inc | مثبطات pd-1/pd-l1 |
| US11472806B2 (en) | 2017-05-12 | 2022-10-18 | Domain Therapeutics | Substituted heterocyclic compounds as allosteric modulators of group II metabotropic glutamate receptors |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| FI3706762T3 (fi) | 2017-12-07 | 2024-12-13 | Univ Emory | N4-hydroksisytidiini ja johdannaisia sekä niihin liittyviä virusten vastaisia käyttötapoja |
| WO2019160882A1 (en) | 2018-02-13 | 2019-08-22 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| WO2019204609A1 (en) | 2018-04-19 | 2019-10-24 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| SG11202011261PA (en) | 2018-05-15 | 2020-12-30 | University Of Louisville Research Foundation Inc | Urolithin a and derivatives thereof for use in therapy |
| BR112020026746A2 (pt) | 2018-07-13 | 2021-03-30 | Gilead Sciences, Inc. | Composto, composição farmacêutica, métodos para inibir pd-1, pd-l1 e/ou a interação de pd-1/pd-l1 e para tratar câncer, e, kit para tratar ou prevenir câncer ou uma doença ou condição. |
| CN112955435B (zh) | 2018-10-24 | 2024-09-06 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
| WO2020219808A1 (en) * | 2019-04-25 | 2020-10-29 | Beta Pharma, Inc. | Dicarbamate inhibitors of ns5a for treatment of hepatitis c virus infections and related diseases |
| CA3140708A1 (en) | 2019-06-18 | 2020-12-24 | Helen Horton | Combination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives |
| IL295955A (en) * | 2020-02-28 | 2022-10-01 | Remix Therapeutics Inc | Compounds and methods for modulating splicing |
| US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
| EP4079748A1 (en) | 2021-04-23 | 2022-10-26 | Insusense ApS | Modulators of sortilin activity |
| EP4089102A1 (en) | 2021-05-14 | 2022-11-16 | Insusense ApS | Modulators of sortilin activity |
| US12037340B2 (en) | 2021-05-21 | 2024-07-16 | Gilead Sciences, Inc. | Pentacyclic derivatives as Zika virus inhibitors |
| CN117321059A (zh) * | 2021-05-21 | 2023-12-29 | 吉利德科学公司 | 用于治疗寨卡病毒感染的四环化合物 |
| KR20240035513A (ko) | 2021-07-09 | 2024-03-15 | 알리고스 테라퓨틱스 인코포레이티드 | 항바이러스 화합물 |
| US12065428B2 (en) | 2021-09-17 | 2024-08-20 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| WO2023154528A1 (en) * | 2022-02-11 | 2023-08-17 | Wave Life Sciences Ltd. | Stereoselective technologies for chiral compounds |
| CN117567414B (zh) * | 2023-10-13 | 2026-01-23 | 濮阳惠成电子材料股份有限公司 | 一种光电材料中间体1-溴二苯并呋喃的合成方法 |
| CN117224539A (zh) * | 2023-10-20 | 2023-12-15 | 南京正济医药研究有限公司 | 苯并咪唑类化合物在制备预防或治疗hpv感染的药物中的应用 |
Family Cites Families (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816570A (en) | 1982-11-30 | 1989-03-28 | The Board Of Regents Of The University Of Texas System | Biologically reversible phosphate and phosphonate protective groups |
| US4968788A (en) | 1986-04-04 | 1990-11-06 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective gruops |
| EP0533833B1 (en) | 1990-06-13 | 1995-12-20 | GLAZIER, Arnold | Phosphorous produgs |
| DE69129650T2 (de) | 1990-09-14 | 1999-03-25 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic, Prag/Praha | Wirkstoffvorläufer von Phosphonaten |
| US5543523A (en) | 1994-11-15 | 1996-08-06 | Regents Of The University Of Minnesota | Method and intermediates for the synthesis of korupensamines |
| PT1778702E (pt) | 2004-07-16 | 2011-10-18 | Gilead Sciences Inc | Compostos antivirais |
| US7323447B2 (en) * | 2005-02-08 | 2008-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8143288B2 (en) | 2005-06-06 | 2012-03-27 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| US7659270B2 (en) | 2006-08-11 | 2010-02-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8329159B2 (en) * | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8303944B2 (en) * | 2006-08-11 | 2012-11-06 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7759495B2 (en) | 2006-08-11 | 2010-07-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| US7741347B2 (en) | 2007-05-17 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP2168959A1 (en) * | 2007-06-19 | 2010-03-31 | Kyorin Pharmaceutical Co., Ltd. | Pyridazinone derivative and pde inhibitor containing the same as active ingredient |
| US8629171B2 (en) * | 2007-08-08 | 2014-01-14 | Bristol-Myers Squibb Company | Crystalline form of methyl ((1S)-1-((25)-2-(5-(4'-(2-((25)-1((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt |
| US7728027B2 (en) | 2007-08-08 | 2010-06-01 | Bristol-Myers Squibb Company | Process for synthesizing compounds useful for treating hepatitis C |
| PT2250163E (pt) | 2008-02-12 | 2012-06-01 | Bristol Myers Squibb Co | Inibidores do vírus da hepatite c |
| BRPI0822323A2 (pt) | 2008-02-13 | 2015-06-16 | Bristol Myers Squibb Co | Imidazolil bifenil imidazóis como inibidores do vírus da hepatite c |
| US8147818B2 (en) | 2008-02-13 | 2012-04-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7704992B2 (en) * | 2008-02-13 | 2010-04-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| GB2457659A (en) | 2008-02-19 | 2009-08-26 | Malcolm Mulheron | Foldable meal tray |
| WO2010004843A1 (ja) | 2008-07-08 | 2010-01-14 | Ntn株式会社 | 減速装置 |
| KR20110036609A (ko) | 2008-07-10 | 2011-04-07 | 프로시디온 리미티드 | 피페리디닐 ｇｐｃｒ 작용제 |
| US7906655B2 (en) * | 2008-08-07 | 2011-03-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8383094B2 (en) * | 2008-10-01 | 2013-02-26 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8729077B2 (en) | 2008-11-28 | 2014-05-20 | Glaxosmithkline Llc | Anti-viral compounds, compositions, and methods of use |
| KR101784830B1 (ko) * | 2008-12-03 | 2017-10-16 | 프레시디오 파마슈티칼스, 인코포레이티드 | Ｈｃｖ ｎｓ5ａ의 억제제 |
| BRPI0922364A2 (pt) * | 2008-12-03 | 2017-08-29 | Presidio Pharmaceuticals Inc | Composto, composição farmacêutica e uso de um composto |
| WO2010091413A1 (en) | 2009-02-09 | 2010-08-12 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
| TWI438200B (zh) | 2009-02-17 | 2014-05-21 | 必治妥美雅史谷比公司 | Ｃ型肝炎病毒抑制劑 |
| WO2010096462A1 (en) | 2009-02-17 | 2010-08-26 | Enanta Pharmaceuticals, Inc | Linked diimidazole derivatives |
| UY32462A (es) | 2009-02-23 | 2010-09-30 | Arrow Therapeutics Ltd | Derivados de bifenilo novedosos para el tratamiento de infección por virus de hepatitis c 644 |
| EP2398474A4 (en) | 2009-02-23 | 2012-12-05 | Presidio Pharmaceuticals Inc | HCV NS5A SHEMMER |
| CN102427731B (zh) | 2009-02-27 | 2015-05-13 | 英安塔制药有限公司 | 丙型肝炎病毒抑制剂 |
| MX2011009728A (es) | 2009-03-20 | 2011-10-14 | Alios Biopharma Inc | Analogos nucleotido y nucleosido sustituidos. |
| PE20120773A1 (es) | 2009-03-27 | 2012-07-19 | Presidio Pharmaceuticals Inc | Anillos triciclicos fusionados sustituidos como inhibidores del virus de hepatitis c |
| CA2756255A1 (en) | 2009-03-27 | 2010-09-30 | Presidio Pharmaceuticals, Inc. | Substituted bicyclic hcv inhibitors |
| NZ595410A (en) | 2009-03-27 | 2013-12-20 | Merck Sharp & Dohme | Inhibitors of hepatitis c virus replication |
| US8796466B2 (en) | 2009-03-30 | 2014-08-05 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| TWI476190B (zh) * | 2009-03-30 | 2015-03-11 | 必治妥美雅史谷比公司 | Ｃ型肝炎病毒抑制劑 |
| TW201038559A (en) | 2009-04-09 | 2010-11-01 | Bristol Myers Squibb Co | Hepatitis C virus inhibitors |
| US8143414B2 (en) | 2009-04-13 | 2012-03-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| RU2541571C2 (ru) | 2009-04-15 | 2015-02-20 | Эббви Инк. | Противовирусные соединения |
| US8436036B2 (en) | 2009-04-24 | 2013-05-07 | Janssen R&D Ireland | Diaryl ethers |
| AU2010249080A1 (en) | 2009-05-12 | 2012-01-12 | Merck Sharp & Dohme Corp. | Fused tricyclic aryl compounds useful for the treatment of viral diseases |
| KR20180028070A (ko) * | 2009-05-13 | 2018-03-15 | 길리애드 파마셋 엘엘씨 | 항바이러스 화합물 |
| US8138215B2 (en) | 2009-05-29 | 2012-03-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CA2763140A1 (en) | 2009-05-29 | 2010-12-02 | Schering Corporation | Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c |
| US8211928B2 (en) | 2009-05-29 | 2012-07-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2010138790A1 (en) | 2009-05-29 | 2010-12-02 | Schering Corporation | Antiviral compounds composed of three aligned aryl moieties to treat diseases such as hepatitis c |
| UA118080C2 (uk) * | 2009-06-11 | 2018-11-26 | Еббві Айрленд Анлімітед Компані | Противірусні сполуки |
| WO2010148006A1 (en) | 2009-06-16 | 2010-12-23 | Enanta Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
| US8221737B2 (en) * | 2009-06-16 | 2012-07-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| WO2011004276A1 (en) | 2009-07-06 | 2011-01-13 | Pfizer Limited | Hepatitis c virus inhibitors |
| JP2012533569A (ja) | 2009-07-16 | 2012-12-27 | ヴァーテックス ファーマシューティカルズ、 インコーポレイテッド | フラビウイルス感染症を治療又は予防するためのベンゾイミダゾール類似体 |
| AU2010280711A1 (en) | 2009-08-07 | 2012-02-09 | Janssen Sciences Ireland Uc | Phenyl ethynyl derivatives as hepatitis C virus inhibitors |
| AU2010280712B2 (en) | 2009-08-07 | 2015-10-22 | Janssen Sciences Ireland Uc | Bis-benzimidazole derivatives as hepatitis C virus inhibitors |
| FR2949465B1 (fr) | 2009-09-01 | 2011-08-12 | Pf Medicament | Derives chromones, leur procede de preparation et leurs applications therapeutiques |
| WO2011026920A1 (en) | 2009-09-03 | 2011-03-10 | Tibotec Pharmaceuticals | Bis-benzimidazole derivatives |
| EP2473056A4 (en) | 2009-09-04 | 2013-02-13 | Glaxosmithkline Llc | CHEMICAL COMPOUNDS |
| EP2475254A4 (en) | 2009-09-11 | 2013-05-22 | Enanta Pharm Inc | HEPATITIS C-VIRUS HEMMER |
| WO2011031904A1 (en) | 2009-09-11 | 2011-03-17 | Enanta Pharmaceuticals, Inc | Hepatitis c virus inhibitors |
| US8415374B2 (en) | 2009-10-12 | 2013-04-09 | Bristol-Myers Squibb Company | Combinations of hepatitis C virus inhibitors |
| WO2011050146A1 (en) | 2009-10-23 | 2011-04-28 | Glaxosmithkline Llc | Chemical compounds |
| UA108211C2 (uk) | 2009-11-04 | 2015-04-10 | Янссен Рід Айрленд | Бензімідазолімідазольні похідні |
| US20110274648A1 (en) | 2009-11-11 | 2011-11-10 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US20110269956A1 (en) | 2009-11-11 | 2011-11-03 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US20110281910A1 (en) | 2009-11-12 | 2011-11-17 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| EP2503881B1 (en) | 2009-11-25 | 2015-05-13 | Merck Sharp & Dohme Corp. | Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases |
| US20110137633A1 (en) * | 2009-12-03 | 2011-06-09 | Abbott Laboratories | Anti-viral compounds and methods of identifying the same |
| US8653070B2 (en) * | 2009-12-14 | 2014-02-18 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
| US8377980B2 (en) | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CN104530079B (zh) | 2009-12-18 | 2017-10-20 | 北京凯因科技股份有限公司 | C型肝炎病毒复制的新型抑制剂 |
| AR079528A1 (es) * | 2009-12-18 | 2012-02-01 | Idenix Pharmaceuticals Inc | Inhibidores de arileno o heteroarileno 5,5-fusionado del virus de la hepatitis c |
| WO2011087740A1 (en) | 2009-12-22 | 2011-07-21 | Schering Corporation | Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases |
| JP2013515746A (ja) | 2009-12-24 | 2013-05-09 | ヴァーテックス ファーマシューティカルズ、 インコーポレイテッド | フラビウイルス感染症の治療又は予防のための類似体 |
| US8362020B2 (en) | 2009-12-30 | 2013-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2011091446A1 (en) | 2010-01-22 | 2011-07-28 | Glaxosmithkline Llc | Chemical compounds |
| AU2011224698A1 (en) | 2010-03-09 | 2012-11-01 | Merck Sharp & Dohme Corp. | Fused Tricyclic Silyl Compounds and methods of use thereof for the treatment of viral diseases |
| US20110312996A1 (en) | 2010-05-17 | 2011-12-22 | Intermune, Inc. | Novel inhibitors of hepatitis c virus replication |
| EP2571882A1 (en) * | 2010-05-21 | 2013-03-27 | Gilead Sciences, Inc. | Heterocyclic flaviviridae virus inhibitors |
| US20110306541A1 (en) * | 2010-06-10 | 2011-12-15 | Gilead Sciences, Inc. | Methods for treating hcv |
| US8859595B2 (en) | 2010-08-26 | 2014-10-14 | Rfs Pharma, Llc | Potent and selective inhibitors of hepatitis C virus |
| WO2012041014A1 (en) | 2010-09-29 | 2012-04-05 | Merck Sharp & Dohme Corp. | Tetracyclic indole derivatives for treating hepatitis c virus infection |
| WO2012048421A1 (en) | 2010-10-14 | 2012-04-19 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibitor compounds |
| AU2011328980B2 (en) | 2010-11-17 | 2015-07-30 | Gilead Sciences, Inc. | Antiviral compounds |
| WO2012087596A1 (en) * | 2010-12-20 | 2012-06-28 | Gilead Sciences, Inc. | Combinations for treating hcv |
| WO2012087976A2 (en) | 2010-12-21 | 2012-06-28 | Intermune, Inc. | Novel inhibitors of hepatitis c virus replication |
| AU2012308295B2 (en) * | 2011-09-16 | 2017-10-26 | Gilead Sciences, Inc. | Methods for treating HCV |
| DK2907816T3 (en) | 2011-11-16 | 2018-09-24 | Gilead Pharmasset Llc | CONDENSED IMIDAZOLYLIMIDAZOLES AS ANTIVIRAL COMPOUNDS |
| US8969588B2 (en) * | 2012-06-05 | 2015-03-03 | Gilead Pharmasset Llc | Solid forms of an antiviral compound |
| US8841340B2 (en) * | 2012-08-17 | 2014-09-23 | Gilead Sciences, Inc. | Solid forms of an antiviral compound |
-
2010
- 2010-05-12 KR KR1020187006008A patent/KR20180028070A/ko not_active Ceased
- 2010-05-12 MX MX2014005933A patent/MX360800B/es unknown
- 2010-05-12 KR KR1020207001908A patent/KR20200011049A/ko not_active Ceased
- 2010-05-12 MX MX2014006862A patent/MX363732B/es unknown
- 2010-05-12 HU HUE10720970A patent/HUE025983T2/en unknown
- 2010-05-12 ES ES14175539.7T patent/ES2596247T3/es active Active
- 2010-05-12 MX MX2014005805A patent/MX360803B/es unknown
- 2010-05-12 RS RS20171281A patent/RS56654B8/sr unknown
- 2010-05-12 EP EP10720970.2A patent/EP2430014B1/en active Active
- 2010-05-12 LT LTEP14175539.7T patent/LT2873665T/lt unknown
- 2010-05-12 SG SG10201402280QA patent/SG10201402280QA/en unknown
- 2010-05-12 SI SI201031950T patent/SI3309157T1/sl unknown
- 2010-05-12 RS RS20150758A patent/RS54386B8/sr unknown
- 2010-05-12 BR BR122014012810A patent/BR122014012810B1/pt active IP Right Grant
- 2010-05-12 PT PT151806353T patent/PT3002281T/pt unknown
- 2010-05-12 JP JP2012510987A patent/JP5582662B2/ja active Active
- 2010-05-12 HR HRP20151000TT patent/HRP20151000T8/hr unknown
- 2010-05-12 KR KR1020167017466A patent/KR101727876B1/ko active Active
- 2010-05-12 UY UY0001032629A patent/UY32629A/es not_active Application Discontinuation
- 2010-05-12 EP EP17190692.8A patent/EP3309157B1/en active Active
- 2010-05-12 TW TW109105841A patent/TW202042807A/zh unknown
- 2010-05-12 CN CN201410226959.7A patent/CN104211689B/zh active Active
- 2010-05-12 TW TW104133224A patent/TW201617073A/zh unknown
- 2010-05-12 HU HUE14175539A patent/HUE030465T2/hu unknown
- 2010-05-12 NZ NZ61920510A patent/NZ619205A/en unknown
- 2010-05-12 TW TW103134405A patent/TW201503888A/zh unknown
- 2010-05-12 PT PT107209702T patent/PT2430014E/pt unknown
- 2010-05-12 CN CN201410227599.2A patent/CN104016971B/zh active Active
- 2010-05-12 AP AP2016008993A patent/AP2016008993A0/xx unknown
- 2010-05-12 PL PL17190692T patent/PL3309157T3/pl unknown
- 2010-05-12 EP EP14175539.7A patent/EP2873665B1/en active Active
- 2010-05-12 PE PE2014001982A patent/PE20150202A1/es active IP Right Grant
- 2010-05-12 PL PL14175539T patent/PL2873665T3/pl unknown
- 2010-05-12 LT LTEP15180635.3T patent/LT3002281T/lt unknown
- 2010-05-12 BR BRPI1010795A patent/BRPI1010795B1/pt active IP Right Grant
- 2010-05-12 ME MEP-2017-262A patent/ME02916B/me unknown
- 2010-05-12 DK DK14175539.7T patent/DK2873665T3/en active
- 2010-05-12 RS RS20160824A patent/RS55249B8/sr unknown
- 2010-05-12 MX MX2011012058A patent/MX2011012058A/es active IP Right Grant
- 2010-05-12 NO NO15180635A patent/NO3002281T3/no unknown
- 2010-05-12 KR KR1020147016501A patent/KR20140122705A/ko not_active Ceased
- 2010-05-12 EA EA201490853A patent/EA201490853A1/ru unknown
- 2010-05-12 EP EP20140175570 patent/EP2857394A1/en not_active Withdrawn
- 2010-05-12 AR ARP100101639A patent/AR076765A1/es not_active Application Discontinuation
- 2010-05-12 PL PL15180635T patent/PL3002281T3/pl unknown
- 2010-05-12 CN CN201811070551.XA patent/CN109020961A/zh active Pending
- 2010-05-12 EP EP19193481.9A patent/EP3626716A1/en not_active Withdrawn
- 2010-05-12 ES ES15180635.3T patent/ES2646131T3/es active Active
- 2010-05-12 SI SI201031024T patent/SI2430014T1/sl unknown
- 2010-05-12 KR KR1020117029699A patent/KR101546119B1/ko active Active
- 2010-05-12 BR BR122014013631A patent/BR122014013631B8/pt active IP Right Grant
- 2010-05-12 EA EA201190259A patent/EA021974B1/ru active Protection Beyond IP Right Term
- 2010-05-12 UA UAA201413049A patent/UA121454C2/uk unknown
- 2010-05-12 PL PL10720970T patent/PL2430014T3/pl unknown
- 2010-05-12 NZ NZ706236A patent/NZ706236A/en unknown
- 2010-05-12 CN CN201410226164.6A patent/CN103977406B/zh active Active
- 2010-05-12 PT PT171906928T patent/PT3309157T/pt unknown
- 2010-05-12 NZ NZ596444A patent/NZ596444A/en unknown
- 2010-05-12 TW TW105117036A patent/TWI629981B/zh active
- 2010-05-12 SG SG2011083151A patent/SG176015A1/en unknown
- 2010-05-12 ES ES10720970.2T patent/ES2548156T3/es active Active
- 2010-05-12 KR KR1020147016504A patent/KR101503752B1/ko active Active
- 2010-05-12 EA EA201790515A patent/EA037281B1/ru unknown
- 2010-05-12 ES ES17190692T patent/ES2758726T3/es active Active
- 2010-05-12 SI SI201031290T patent/SI2873665T1/sl unknown
- 2010-05-12 SM SM20170570T patent/SMT201700570T1/it unknown
- 2010-05-12 PT PT141755397T patent/PT2873665T/pt unknown
- 2010-05-12 AP AP2011005987A patent/AP3622A/xx active
- 2010-05-12 TW TW099115093A patent/TWI465444B/zh active
- 2010-05-12 CN CN201410226767.6A patent/CN104230900B/zh active Active
- 2010-05-12 PE PE2011001965A patent/PE20120509A1/es active IP Right Grant
- 2010-05-12 CN CN201410227574.2A patent/CN104211713B/zh active Active
- 2010-05-12 DK DK15180635.3T patent/DK3002281T3/en active
- 2010-05-12 TW TW107113373A patent/TWI689305B/zh active
- 2010-05-12 HU HUE15180635A patent/HUE036906T2/hu unknown
- 2010-05-12 EA EA201490854A patent/EA026536B1/ru unknown
- 2010-05-12 KR KR1020177009423A patent/KR20170041924A/ko not_active Ceased
- 2010-05-12 CA CA2761258A patent/CA2761258C/en active Active
- 2010-05-12 SI SI201031554T patent/SI3002281T1/sl unknown
- 2010-05-12 EP EP15180635.3A patent/EP3002281B1/en active Active
- 2010-05-12 CN CN201080029503.1A patent/CN102596936B/zh active Active
- 2010-05-12 EA EA201590073A patent/EA027493B1/ru unknown
- 2010-05-12 KR KR1020197007083A patent/KR20190029771A/ko not_active Ceased
- 2010-05-12 ME MEP-2015-196A patent/ME02321B/me unknown
- 2010-05-12 AU AU2010249043A patent/AU2010249043B2/en active Active
- 2010-05-12 CN CN201611104976.9A patent/CN106588890B/zh active Active
- 2010-05-12 TW TW103134406A patent/TWI547495B/zh active
- 2010-05-12 US US12/779,023 patent/US8088368B2/en active Active
- 2010-05-12 DK DK10720970.2T patent/DK2430014T3/en active
- 2010-05-12 ME MEP-2016-215A patent/ME02536B/me unknown
- 2010-05-12 CA CA2886322A patent/CA2886322A1/en not_active Abandoned
- 2010-05-12 MX MX2019003738A patent/MX376550B/es active IP Right Grant
- 2010-05-12 WO PCT/US2010/034600 patent/WO2010132601A1/en not_active Ceased
-
2011
- 2011-11-08 US US13/291,977 patent/US8273341B2/en active Active
- 2011-11-10 IL IL216254A patent/IL216254A/en active IP Right Grant
- 2011-11-11 MX MX2020011251A patent/MX2020011251A/es unknown
- 2011-11-11 CL CL2011002825A patent/CL2011002825A1/es unknown
- 2011-11-17 ZA ZA2011/08436A patent/ZA201108436B/en unknown
- 2011-11-30 CO CO11164618A patent/CO6470842A2/es active IP Right Grant
- 2011-12-12 EC EC2011011517A patent/ECSP11011517A/es unknown
-
2012
- 2012-06-07 US US13/491,446 patent/US8669234B2/en active Active
- 2012-07-19 US US13/553,517 patent/US8575118B2/en active Active
-
2013
- 2013-07-31 US US13/956,195 patent/US8822430B2/en active Active
- 2013-10-03 US US14/045,717 patent/US8841278B2/en active Active
-
2014
- 2014-05-16 US US14/280,478 patent/US9511056B2/en active Active
- 2014-05-23 JP JP2014107359A patent/JP5744283B2/ja active Active
- 2014-06-10 IL IL233044A patent/IL233044A/en active IP Right Grant
- 2014-06-10 IL IL233042A patent/IL233042A0/en unknown
- 2014-06-17 JP JP2014124325A patent/JP5745727B2/ja active Active
- 2014-07-17 IL IL233678A patent/IL233678B/en active IP Right Grant
- 2014-07-17 IL IL233679A patent/IL233679B/en active IP Right Grant
-
2015
- 2015-04-28 JP JP2015091474A patent/JP2015157842A/ja not_active Withdrawn
- 2015-11-17 CY CY20151101032T patent/CY1116942T1/el unknown
- 2015-11-19 SM SM201500284T patent/SMT201500284B/it unknown
-
2016
- 2016-01-07 HU HUS1600001C patent/HUS1600001I1/hu unknown
- 2016-01-11 LT LTPA2016002C patent/LTC2430014I2/lt unknown
- 2016-01-22 CY CY2016001C patent/CY2016001I1/el unknown
- 2016-02-05 FR FR16C0005C patent/FR16C0005I2/fr active Active
- 2016-02-17 NO NO2016004C patent/NO2016004I2/no not_active IP Right Cessation
- 2016-02-18 NL NL300796C patent/NL300796I2/nl unknown
- 2016-09-28 US US15/279,303 patent/US9981955B2/en active Active
- 2016-09-29 HR HRP20161242TT patent/HRP20161242T8/hr unknown
- 2016-10-04 CY CY20161100986T patent/CY1118048T1/el unknown
- 2016-10-05 SM SM201600351T patent/SMT201600351B/it unknown
-
2017
- 2017-05-12 JP JP2017095523A patent/JP2017145254A/ja not_active Withdrawn
- 2017-11-14 HR HRP20171759TT patent/HRP20171759T8/hr unknown
- 2017-12-06 CY CY20171101286T patent/CY1119684T1/el unknown
-
2018
- 2018-10-05 HK HK18112717.7A patent/HK1253517B/en unknown
- 2018-12-25 JP JP2018240826A patent/JP2019104732A/ja not_active Withdrawn
-
2020
- 2020-09-24 JP JP2020159623A patent/JP2021001214A/ja active Pending
- 2020-12-18 NO NO2020046C patent/NO2020046I1/no unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012526838A5 (enExample) | ||
| JP2013542996A5 (enExample) | ||
| AU2023263567B2 (en) | Protein tyrosine phosphatase inhibitors and methods of use thereof | |
| JP5612612B2 (ja) | Ｃ型肝炎ウイルス阻害剤 | |
| KR20240052096A (ko) | Ras 저해용 조성물 및 방법 | |
| IL324019A (en) | Protein tyrosine phosphatase inhibitor compounds and uses thereof | |
| EP2811997B1 (en) | Substituted prolines/piperidines as orexin receptor antagonists | |
| JP5596861B2 (ja) | Ｃ型肝炎ウイルス阻害剤 | |
| TW202019900A (zh) | Ptpn11抑制劑 | |
| JP5977819B2 (ja) | Ｃ型肝炎ウイルス阻害剤 | |
| JP2019535759A5 (enExample) | ||
| JP2010527373A5 (enExample) | ||
| RU2006134020A (ru) | Конденсированные производные пиразола | |
| EP3560926B1 (en) | 6-amino-7,9-dihydro-8h-purin-8-one compounds as brk inhibitors | |
| KR20110134497A (ko) | Ｃ형 간염 바이러스 억제제 | |
| JP2013533317A5 (enExample) | ||
| JP7751582B2 (ja) | タンパク質チロシンホスファターゼ阻害剤及びそれらの使用方法 | |
| JP2007509917A (ja) | グルコキナーゼ調節剤としてのピリジンカルボン酸誘導体 | |
| KR20120133366A (ko) | Ｃ형 간염 바이러스 억제제 | |
| CA2916194A1 (en) | Heteroaryl substituted pyrazoles | |
| KR960704884A (ko) | 항종양제 또는 항바이러스제로서의 디스타마이신 A 동족체 (Distamycin A analogues as antitumour or antiviral agents) | |
| RU2007120454A (ru) | Производные хинуклидина и их применение в качестве антагонистов мускариновых рецепторов м3 | |
| CA2728098A1 (en) | Pyrazole-containing tricyclic compounds as_antagonits of an ep1 receptor | |
| KR20180015262A (ko) | 피라졸 유도체, 또는 그 약리학적으로 허용되는 염 | |
| AU2018356430A1 (en) | Aromatic sulfonamide derivatives for the treatment of Ischemic Stroke |