JP2011079828A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011079828A5 JP2011079828A5 JP2010227222A JP2010227222A JP2011079828A5 JP 2011079828 A5 JP2011079828 A5 JP 2011079828A5 JP 2010227222 A JP2010227222 A JP 2010227222A JP 2010227222 A JP2010227222 A JP 2010227222A JP 2011079828 A5 JP2011079828 A5 JP 2011079828A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- cycloalkyl
- heterocyclyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 35
- 125000003118 aryl group Chemical group 0.000 claims 35
- 125000001072 heteroaryl group Chemical group 0.000 claims 26
- 125000000623 heterocyclic group Chemical group 0.000 claims 26
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 24
- 229910052760 oxygen Inorganic materials 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000005843 halogen group Chemical group 0.000 claims 18
- 125000005842 heteroatom Chemical group 0.000 claims 18
- 229910052717 sulfur Inorganic materials 0.000 claims 18
- 229910052757 nitrogen Inorganic materials 0.000 claims 15
- 229910052799 carbon Inorganic materials 0.000 claims 14
- 125000001424 substituent group Chemical group 0.000 claims 14
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 12
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 11
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 8
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 8
- 125000001624 naphthyl group Chemical group 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 239000003443 antiviral agent Substances 0.000 claims 6
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 6
- 229920006395 saturated elastomer Polymers 0.000 claims 6
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- -1 N (R 7 ) 2 Chemical group 0.000 claims 4
- 125000004122 cyclic group Chemical group 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229940122604 HCV protease inhibitor Drugs 0.000 claims 2
- 229940124772 HCV-NS5B polymerase inhibitor Drugs 0.000 claims 2
- 101800001838 Serine protease/helicase NS3 Proteins 0.000 claims 2
- 125000004419 alkynylene group Chemical group 0.000 claims 2
- 229960005475 antiinfective agent Drugs 0.000 claims 2
- 239000004599 antimicrobial Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000002955 immunomodulating agent Substances 0.000 claims 2
- 229940121354 immunomodulator Drugs 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- 0 CC(C)[C@@](C(N(C[C@@](C1)OC(N(Cc2ccc3)Cc2c3C=CCCCN2*)=O)[C@@]1C(N[C@](C1)([C@]1C=C)C(NS(C1CC1)(=O)=O)=O)=O)=O)NC2=* Chemical compound CC(C)[C@@](C(N(C[C@@](C1)OC(N(Cc2ccc3)Cc2c3C=CCCCN2*)=O)[C@@]1C(N[C@](C1)([C@]1C=C)C(NS(C1CC1)(=O)=O)=O)=O)=O)NC2=* 0.000 description 12
- ULELCQYQCBHXFY-UHFFFAOYSA-N CNCCC1CC1 Chemical compound CNCCC1CC1 ULELCQYQCBHXFY-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70076405P | 2005-07-20 | 2005-07-20 | |
| US60/700,764 | 2005-07-20 | ||
| US72456605P | 2005-10-07 | 2005-10-07 | |
| US60/724,566 | 2005-10-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008522888A Division JP4621282B2 (ja) | 2005-07-20 | 2006-07-14 | Ｈｃｖｎｓ３プロテアーゼ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011079828A JP2011079828A (ja) | 2011-04-21 |
| JP2011079828A5 true JP2011079828A5 (cg-RX-API-DMAC10.html) | 2011-08-11 |
| JP5345117B2 JP5345117B2 (ja) | 2013-11-20 |
Family
ID=37467463
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008522888A Active JP4621282B2 (ja) | 2005-07-20 | 2006-07-14 | Ｈｃｖｎｓ３プロテアーゼ阻害剤 |
| JP2010227222A Active JP5345117B2 (ja) | 2005-07-20 | 2010-10-07 | Ｈｃｖｎｓ３プロテアーゼ阻害剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008522888A Active JP4621282B2 (ja) | 2005-07-20 | 2006-07-14 | Ｈｃｖｎｓ３プロテアーゼ阻害剤 |
Country Status (37)
Families Citing this family (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003007697A (ja) * | 2001-06-21 | 2003-01-10 | Hitachi Kokusai Electric Inc | 半導体装置の製造方法、基板処理方法および基板処理装置 |
| MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| JP4705164B2 (ja) * | 2005-05-02 | 2011-06-22 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｈｃｖｎｓ３プロテアーゼ阻害剤 |
| CN102643175B (zh) * | 2005-07-04 | 2014-12-10 | 赞南科技(上海)有限公司 | 钌络合物配体、钌络合物、固载钌络合物催化剂及其制备方法和用途 |
| TWI387603B (zh) * | 2005-07-20 | 2013-03-01 | Merck Sharp & Dohme | Ｈｃｖ ｎｓ３蛋白酶抑制劑 |
| KR101294467B1 (ko) * | 2005-07-25 | 2013-09-09 | 인터뮨, 인크. | Ｃ형 간염 바이러스 복제의 신규 거대고리형 억제제 |
| JP4705984B2 (ja) * | 2005-08-01 | 2011-06-22 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｈｃｖｎｓ３プロテアーゼ阻害剤としての大環状ペプチド |
| DE602006019323D1 (de) * | 2005-10-11 | 2011-02-10 | Intermune Inc | Verbindungen und verfahren zur inhibierung der replikation des hepatitis-c-virus |
| US7741281B2 (en) | 2005-11-03 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| GB0609492D0 (en) * | 2006-05-15 | 2006-06-21 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| GB0612423D0 (en) * | 2006-06-23 | 2006-08-02 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| RU2008152171A (ru) * | 2006-07-05 | 2010-08-10 | Интермьюн, Инк. (Us) | Новые ингибиторы вирусной репликации гепатита с |
| US7935670B2 (en) | 2006-07-11 | 2011-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP2076278B1 (en) * | 2006-10-24 | 2015-05-06 | Merck Sharp & Dohme Corp. | Macrocyclic HCV NS3 protease inhibitors |
| EP2079479B1 (en) * | 2006-10-24 | 2014-11-26 | Merck Sharp & Dohme Corp. | Hcv ns3 protease inhibitors |
| CA2667266C (en) * | 2006-10-24 | 2015-11-24 | Merck & Co., Inc. | Hcv ns3 protease inhibitors |
| KR101615500B1 (ko) * | 2006-10-27 | 2016-04-27 | 머크 샤프 앤드 돔 코포레이션 | Ｈｃｖ ｎｓ3 프로테아제 억제제 |
| WO2008057208A2 (en) * | 2006-10-27 | 2008-05-15 | Merck & Co., Inc. | Hcv ns3 protease inhibitors |
| US8343477B2 (en) | 2006-11-01 | 2013-01-01 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
| US7772180B2 (en) | 2006-11-09 | 2010-08-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8003604B2 (en) | 2006-11-16 | 2011-08-23 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7763584B2 (en) | 2006-11-16 | 2010-07-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7888464B2 (en) | 2006-11-16 | 2011-02-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| GB0625349D0 (en) * | 2006-12-20 | 2007-01-31 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| WO2008075103A1 (en) * | 2006-12-20 | 2008-06-26 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Antiviral indoles |
| GB0625345D0 (en) * | 2006-12-20 | 2007-01-31 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| EP2118301A4 (en) | 2007-03-09 | 2011-04-20 | Merck Sharp & Dohme | IN VIVO HCV RESISTANCE TO ANTI-VIRAL HEMMER |
| CA2684086C (en) * | 2007-04-24 | 2014-05-27 | F. Hoffmann-La Roche Ag | Process for hcv protease inhibitor intermediate |
| CL2008001274A1 (es) * | 2007-05-03 | 2008-11-03 | Intermune Inc Y Array Biopharma Inc | Compuestos macrolidos derivados de 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropan[e]pirrolo[1,2-a][1,4]diazaciclopentadecinilo, inhibidores de la actividad de la proteasa ns3-ns4; su procedimiento de preparacion; composicion farmaceutica; compuestos intermediarios y procedimiento de preparacion; y uso en el tratamiento de..... |
| US7932277B2 (en) | 2007-05-10 | 2011-04-26 | Intermune, Inc. | Peptide inhibitors of hepatitis C virus replication |
| EP2178886A1 (en) * | 2007-07-17 | 2010-04-28 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Macrocyclic indole derivatives for the treatment of hepatitis c infections |
| US8927569B2 (en) * | 2007-07-19 | 2015-01-06 | Merck Sharp & Dohme Corp. | Macrocyclic compounds as antiviral agents |
| US8383583B2 (en) * | 2007-10-26 | 2013-02-26 | Enanta Pharmaceuticals, Inc. | Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors |
| CL2008003384A1 (es) | 2007-11-14 | 2009-12-11 | Enanta Pharm Inc | Compuestos derivados de quinoxalina macrocíclica, inhibidores de serina proteasa; composicion farmaceutica que los comprende; y su uso en el tratamiento de la hepatitis c. |
| JP2011503201A (ja) | 2007-11-14 | 2011-01-27 | エナンタ ファーマシューティカルズ インコーポレイテッド | 大環状テトラゾリルｃ型肝炎セリンプロテアーゼ阻害剤 |
| MX2010006518A (es) | 2007-12-14 | 2010-08-10 | Enanta Pharm Inc | Inhibidores de serina proteasa de hepatitis c de oximil macrociclica. |
| US8273709B2 (en) | 2007-12-14 | 2012-09-25 | Enanta Pharmaceuticals, Inc. | Triazole-containing macrocyclic HCV serine protease inhibitors |
| US8476257B2 (en) | 2007-12-19 | 2013-07-02 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US8283309B2 (en) | 2007-12-20 | 2012-10-09 | Enanta Pharmaceuticals, Inc. | Bridged carbocyclic oxime hepatitis C virus serine protease inhibitors |
| US8293705B2 (en) | 2007-12-21 | 2012-10-23 | Avila Therapeutics, Inc. | HCV protease inhibitors and uses thereof |
| US8309685B2 (en) * | 2007-12-21 | 2012-11-13 | Celgene Avilomics Research, Inc. | HCV protease inhibitors and uses thereof |
| US8202996B2 (en) | 2007-12-21 | 2012-06-19 | Bristol-Myers Squibb Company | Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide |
| AU2008340257B2 (en) * | 2007-12-21 | 2015-06-11 | Celgene Avilomics Research, Inc. | HCV protease inhibitors and uses thereof |
| EP2237666A4 (en) * | 2007-12-21 | 2012-05-16 | Avila Therapeutics Inc | HCV PROTEASE INHIBITORS AND USES THEREOF |
| AU2015224437B2 (en) * | 2007-12-21 | 2017-05-25 | Celgene Avilomics Research, Inc. | HCV protease inhibitors and uses thereof |
| WO2009099596A2 (en) * | 2008-02-04 | 2009-08-13 | Idenix Pharamaceuticals, Inc. | Macrocyclic serine protease inhibitors |
| US8591878B2 (en) | 2008-02-25 | 2013-11-26 | Merck Sharp & Dohme Corp. | Therapeutic compounds |
| WO2009117594A1 (en) * | 2008-03-20 | 2009-09-24 | Enanta Pharmaceuticals, Inc. | Fluorinated macrocyclic compounds as hepatitis c virus inhibitors |
| EP2282762A2 (en) * | 2008-04-15 | 2011-02-16 | Intermune, Inc. | Novel macrocyclic inhibitors of hepatitis c virus replication |
| US8163921B2 (en) | 2008-04-16 | 2012-04-24 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2009134624A1 (en) * | 2008-04-28 | 2009-11-05 | Merck & Co., Inc. | Hcv ns3 protease inhibitors |
| US7964560B2 (en) | 2008-05-29 | 2011-06-21 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP2300491B1 (en) | 2008-05-29 | 2016-01-06 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| UA100436C2 (en) * | 2008-07-22 | 2012-12-25 | Mepk Шарп Энд Доме Корп. | Macrocyclic quinoxaline compounds as hcv ns3 protease inhibitors |
| US8188137B2 (en) | 2008-08-15 | 2012-05-29 | Avila Therapeutics, Inc. | HCV protease inhibitors and uses thereof |
| US8207341B2 (en) | 2008-09-04 | 2012-06-26 | Bristol-Myers Squibb Company | Process or synthesizing substituted isoquinolines |
| US8563505B2 (en) | 2008-09-29 | 2013-10-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8044087B2 (en) | 2008-09-29 | 2011-10-25 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8283310B2 (en) | 2008-12-15 | 2012-10-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| AU2009335904A1 (en) * | 2008-12-19 | 2011-08-04 | Gilead Sciences, Inc. | HCV NS3 protease inhibitors |
| CN102271699A (zh) | 2009-01-07 | 2011-12-07 | 西尼克斯公司 | 用于治疗hcv和hiv感染的环孢菌素衍生物 |
| WO2010082050A1 (en) | 2009-01-16 | 2010-07-22 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Macrocyclic and 7-aminoalkyl-substituted benzoxazocines for treatment of hepatitis c infections |
| AR075584A1 (es) * | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
| TW201040181A (en) | 2009-04-08 | 2010-11-16 | Idenix Pharmaceuticals Inc | Macrocyclic serine protease inhibitors |
| CA2761650C (en) * | 2009-05-13 | 2015-05-26 | Enanta Pharmaceuticals, Inc. | Macrocyclic compounds as hepatitis c virus inhibitors |
| EP2432318A4 (en) * | 2009-05-22 | 2012-11-21 | Sequoia Pharmaceuticals Inc | NS3 PROTEASE INHIBITORS OF BIPACROCYCLIC HEPATITIS C VIRUS |
| WO2011014487A1 (en) | 2009-07-30 | 2011-02-03 | Merck Sharp & Dohme Corp. | Hepatitis c virus ns3 protease inhibitors |
| CA2769652A1 (en) | 2009-08-05 | 2011-02-10 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv |
| JP5789260B2 (ja) * | 2009-08-27 | 2015-10-07 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｃ型肝炎ウイルスのプロテアーゼ阻害薬の調製方法 |
| JP2013505952A (ja) * | 2009-09-28 | 2013-02-21 | インターミューン・インコーポレーテッド | Ｃ型肝炎ウイルス複製の新しい大環状阻害剤 |
| TW201119667A (en) | 2009-10-19 | 2011-06-16 | Enanta Pharm Inc | Bismacrocyclic compounds as hepatitis C virus inhibitors |
| BR112012018897A2 (pt) | 2010-01-27 | 2017-10-03 | Ab Pharma Ltd | Compostos poli-heterocíclicos altamente potentes como inibidores de hcv |
| CN103096891A (zh) | 2010-06-24 | 2013-05-08 | 判米德有限公司 | 利用羟氯喹或羟氯喹和抗病毒剂的组合治疗丙型肝炎病毒相关疾病 |
| NZ608720A (en) | 2010-09-21 | 2015-03-27 | Enanta Pharm Inc | Macrocyclic proline derived hcv serine protease inhibitors |
| US8729014B2 (en) | 2010-11-01 | 2014-05-20 | Rfs Pharma, Llc | Specific HCV NS3 protease inhibitors |
| EP2651884A2 (en) * | 2010-12-14 | 2013-10-23 | Merck Sharp & Dohme Corp. | Process and intermediates for preparing macrolactams |
| TW201309690A (zh) | 2011-02-10 | 2013-03-01 | Idenix Pharmaceuticals Inc | 巨環絲胺酸蛋白酶抑制劑，其醫藥組合物及其於治療ｈｃｖ感染之用途 |
| US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8691757B2 (en) | 2011-06-15 | 2014-04-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2012171332A1 (zh) * | 2011-06-16 | 2012-12-20 | 爱博新药研发(上海)有限公司 | 抑制丙型肝炎病毒的大环状杂环化合物及其制备和应用 |
| WO2012176149A1 (en) | 2011-06-23 | 2012-12-27 | Panmed Ltd. | Treatment of hepatitis c virus |
| US9238604B2 (en) | 2011-08-19 | 2016-01-19 | Merck Sharp & Dohme Corp. | Process and intermediates for preparing macrolactams |
| AU2013201532B2 (en) | 2011-10-21 | 2014-10-02 | Abbvie Ireland Unlimited Company | Methods for treating HCV |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| EA201490837A1 (ru) | 2011-10-21 | 2014-11-28 | Эббви Инк. | Способы лечения hcv, включающие по меньшей мере два противовирусных агента прямого действия, рибавирин, но не интерферон |
| AU2012332832A1 (en) * | 2011-10-31 | 2014-04-17 | Msd Italia S.R.L. | Compositions useful for the treatment of viral diseases |
| MX355102B (es) * | 2012-01-11 | 2018-04-05 | Abbvie Ireland Unlimited Co | Procesos para hacer los inhibidores de la proteasa del hcv. |
| WO2013106689A1 (en) | 2012-01-12 | 2013-07-18 | Ref Pharma, Llc. | Hcv ns3 protease inhibitors |
| CN102617705B (zh) | 2012-02-16 | 2014-12-31 | 上海纬诺医药科技有限公司 | 抑制丙肝病毒复制的大环类化合物 |
| UA119315C2 (uk) | 2012-07-03 | 2019-06-10 | Гіліад Фармассет Елелсі | Інгібітори вірусу гепатиту с |
| TW201408669A (zh) | 2012-08-08 | 2014-03-01 | Merck Sharp & Dohme | Ｈｃｖ ｎｓ３蛋白酶抑制劑 |
| SI2909205T1 (sl) | 2012-10-19 | 2017-02-28 | Bristol-Myers Squibb Company | 9-metil substituiran heksadekahidrociklopropa(e)pirolo(1,2-A)(1,4)diazaciklopentadecinil karbamat derivati kot nestrukturalni 3 (NS3) proteazni inhibitorji za zdravljenje hepatitis C virusnih infekcij |
| US9643999B2 (en) | 2012-11-02 | 2017-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2014070964A1 (en) | 2012-11-02 | 2014-05-08 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| EP2914598B1 (en) | 2012-11-02 | 2017-10-18 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| US9409943B2 (en) | 2012-11-05 | 2016-08-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| WO2014121418A1 (en) | 2013-02-07 | 2014-08-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c |
| WO2014121417A1 (en) | 2013-02-07 | 2014-08-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c |
| JP6342922B2 (ja) | 2013-03-07 | 2018-06-13 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｃ型肝炎ウイルス阻害剤 |
| US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
| US9708354B2 (en) | 2013-03-15 | 2017-07-18 | Cerenis Therapeutics Holding Sa | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
| BR112015021768A2 (pt) | 2013-03-15 | 2016-02-02 | Gilead Sciences Inc | inibidores do vírus da hepatite c |
| EP3363805B1 (en) | 2013-03-15 | 2020-12-16 | Cerenis Therapeutics Holding SA | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
| CN105636923A (zh) | 2013-10-18 | 2016-06-01 | 默沙东公司 | 用于制备大环内酯酰胺的方法和中间体 |
| EA201892448A1 (ru) | 2016-04-28 | 2019-06-28 | Эмори Юниверсити | Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения |
| ES2990061T3 (es) | 2016-05-10 | 2024-11-28 | C4 Therapeutics Inc | Degronímeros espirocíclicos para la degradación de proteínas diana |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| CN109562107A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的杂环降解决定子体 |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| WO2021209563A1 (en) | 2020-04-16 | 2021-10-21 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
| US12083099B2 (en) | 2020-10-28 | 2024-09-10 | Accencio LLC | Methods of treating symptoms of coronavirus infection with viral protease inhibitors |
Family Cites Families (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3480613A (en) * | 1967-07-03 | 1969-11-25 | Merck & Co Inc | 2-c or 3-c-alkylribofuranosyl - 1-substituted compounds and the nucleosides thereof |
| FR2722210B1 (fr) * | 1994-07-08 | 1996-08-14 | Rhone Poulenc Rorer Sa | Nouvelles streptogramines et procede de preparation de streptogramines par mutasynthese |
| US6128582A (en) | 1996-04-30 | 2000-10-03 | Vertex Pharmaceuticals Incorporated | Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them |
| GB9623908D0 (en) | 1996-11-18 | 1997-01-08 | Hoffmann La Roche | Amino acid derivatives |
| GB9707659D0 (en) | 1997-04-16 | 1997-06-04 | Peptide Therapeutics Ltd | Hepatitis C NS3 Protease inhibitors |
| EP1003775B1 (en) | 1997-08-11 | 2005-03-16 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis c inhibitor peptides |
| JP4452401B2 (ja) | 1997-08-11 | 2010-04-21 | ベーリンガー インゲルハイム （カナダ） リミテッド | Ｃ型肝炎ウイルス阻害ペプチドアナログ |
| IT1299134B1 (it) | 1998-02-02 | 2000-02-29 | Angeletti P Ist Richerche Bio | Procedimento per la produzione di peptidi con proprieta' inibitrici della proteasi ns3 del virus hcv, peptidi cosi' ottenibili e peptidi |
| MXPA00008348A (es) | 1998-02-25 | 2005-07-15 | Univ Emory | 2-fluronucleosidos. |
| GB9806815D0 (en) | 1998-03-30 | 1998-05-27 | Hoffmann La Roche | Amino acid derivatives |
| DK1066247T3 (da) | 1998-03-31 | 2007-04-02 | Vertex Pharma | Inhibitorer af serinproteaser, især hepatitis C virus NS3 protease |
| GB9812523D0 (en) | 1998-06-10 | 1998-08-05 | Angeletti P Ist Richerche Bio | Peptide inhibitors of hepatitis c virus ns3 protease |
| US6323180B1 (en) * | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| US6602982B1 (en) | 1998-08-10 | 2003-08-05 | Hokkaido Electric Power Company, Incorporated | Process for the preparation of regular glycopeptides |
| JP2002528499A (ja) | 1998-10-29 | 2002-09-03 | ブリストル−マイヤーズ スクイブ カンパニー | Ｉｍｐｄｈ酵素のインヒビターであるアミノ核誘導化合物 |
| UA74546C2 (en) | 1999-04-06 | 2006-01-16 | Boehringer Ingelheim Ca Ltd | Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition |
| US6608027B1 (en) * | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
| EP1196414B1 (en) | 1999-06-25 | 2003-09-03 | Vertex Pharmaceuticals Incorporated | Prodrugs of carbamate inhibitors of impdh |
| WO2001047883A1 (fr) | 1999-12-27 | 2001-07-05 | Japan Tobacco Inc. | Composes a cycles accoles et leur utilisation comme medicaments |
| US6495677B1 (en) | 2000-02-15 | 2002-12-17 | Kanda S. Ramasamy | Nucleoside compounds |
| US6455508B1 (en) | 2000-02-15 | 2002-09-24 | Kanda S. Ramasamy | Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides |
| CA2400274A1 (en) * | 2000-02-18 | 2001-08-23 | Shire Biochem Inc. | Method for the treatment or prevention of flavivirus infections using nucleoside analogues |
| CA2405521C (en) | 2000-04-05 | 2010-06-29 | Schering Corporation | Macrocyclic ns3-serine protease inhibitors of hepatitis c virus comprising n-cyclic p2 moieties |
| AU2001253206A1 (en) | 2000-04-05 | 2001-10-23 | Tularik, Inc. | Ns5b hcv polymerase inhibitors |
| EP1284741B1 (en) | 2000-04-13 | 2008-11-19 | Pharmasset, Inc. | 3'-or 2'-hydroxymethyl substituted nucleoside derivatives for treatment of viral infections |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| NZ547204A (en) | 2000-05-26 | 2008-01-31 | Idenix Cayman Ltd | Methods and compositions for treating flaviviruses and pestiviruses |
| US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| GB0017676D0 (en) | 2000-07-19 | 2000-09-06 | Angeletti P Ist Richerche Bio | Inhibitors of viral polymerase |
| JP3943015B2 (ja) * | 2000-08-10 | 2007-07-11 | トラスティーズ オブ ボストン カレッジ | リサイクル可能メタセシス触媒 |
| US6955174B2 (en) * | 2000-08-18 | 2005-10-18 | Uryovascular Systems, Inc. | Cryotherapy method for detecting and treating vulnerable plaque |
| US20030008841A1 (en) | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
| WO2002020497A1 (en) | 2000-09-01 | 2002-03-14 | Shionogi & Co., Ltd. | Compounds having anti-hepatitis c virus effect |
| KR100905221B1 (ko) | 2000-10-18 | 2009-07-01 | 파마셋 인코포레이티드 | 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한변형된 뉴클레오시드 |
| HUP0303436A2 (hu) | 2000-12-12 | 2004-01-28 | Schering Corp. | Diaril-peptidek mint a hepatitis C vírus NS3-szerin proteáz inhibitorai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
| WO2002048116A2 (en) | 2000-12-13 | 2002-06-20 | Bristol-Myers Squibb Pharma Company | Inhibitors of hepatitis c virus ns3 protease |
| EP1366055A2 (en) | 2000-12-15 | 2003-12-03 | Pharmasset Limited | Antiviral agents for treatment of flaviviridae infections |
| EP1346724A4 (en) | 2000-12-26 | 2004-11-17 | Mitsubishi Pharma Corp | AGENT FOR TREATING HEPATITIS C |
| SI1355916T1 (sl) * | 2001-01-22 | 2007-04-30 | Merck & Co Inc | Nukleozidni derivati kot inhibitorji RNA-odvisne RNA virusne polimeraze |
| GB0114286D0 (en) * | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
| CN100542612C (zh) | 2001-08-14 | 2009-09-23 | 特拉维夫大学未来技术研发有限公司 | 类脂化糖胺聚糖颗粒及其在诊断和治疗用药物和基因传递中的应用 |
| US7138376B2 (en) * | 2001-09-28 | 2006-11-21 | Idenix Pharmaceuticals, Inc. | Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides |
| US20040006002A1 (en) | 2001-09-28 | 2004-01-08 | Jean-Pierre Sommadossi | Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside |
| US6867185B2 (en) | 2001-12-20 | 2005-03-15 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
| JP2005515254A (ja) | 2002-01-17 | 2005-05-26 | スミスクライン ビーチャム コーポレーション | カテプシンｋ阻害剤として有用なシクロアルキルケトアミド誘導体 |
| GB0201179D0 (en) | 2002-01-18 | 2002-03-06 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| CA2369711A1 (en) * | 2002-01-30 | 2003-07-30 | Boehringer Ingelheim (Canada) Ltd. | Macrocyclic peptides active against the hepatitis c virus |
| US6828301B2 (en) | 2002-02-07 | 2004-12-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for hepatitis C viral protease inhibitors |
| JP2005527499A (ja) | 2002-02-13 | 2005-09-15 | メルク エンド カムパニー インコーポレーテッド | ヌクレオシド化合物を用いてオルトポックスウイルスの複製を阻害する方法 |
| CN1653077A (zh) | 2002-05-06 | 2005-08-10 | 健亚生物科技公司 | 治疗c型肝炎病毒感染的核苷衍生物 |
| MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| AU2003269890A1 (en) | 2002-06-21 | 2004-01-06 | Isis Pharmaceuticals, Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| AU2003269892A1 (en) | 2002-06-27 | 2004-01-19 | Isis Pharmaceuticals, Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| AU2003248748A1 (en) | 2002-06-28 | 2004-01-19 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| AU2003263412A1 (en) | 2002-06-28 | 2004-01-19 | Centre National De La Recherche Scientifique (Cnrs) | 1'-, 2'- and 3'- modified nucleoside derivatives for treating flaviviridae infections |
| MY140819A (en) | 2002-06-28 | 2010-01-29 | Idenix Caymans Ltd | Modified 2' and 3'-nucleoside prodrugs for treating flaviviridae |
| CA2490666A1 (en) | 2002-07-16 | 2004-01-22 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| KR20050037559A (ko) | 2002-07-25 | 2005-04-22 | 마이크로로직스 바이오테크, 인코포레이티드 | 항바이러스성 ７-데아자 ｄ-뉴클레오시드 및 그의 용도 |
| JP2006507235A (ja) | 2002-08-01 | 2006-03-02 | フアーマセツト・インコーポレイテツド | フラビウイルス科ウイルス感染治療のためのビシクロ［４．２．１］ノナン系を有する化合物 |
| US20050075279A1 (en) | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
| CN1771050A (zh) * | 2003-02-07 | 2006-05-10 | 益安药业 | 丙型肝炎丝氨酸蛋白酶的大环抑制剂 |
| US20040254159A1 (en) * | 2003-02-27 | 2004-12-16 | Hasvold Lisa A. | Heterocyclic kinase inhibitors |
| WO2004101605A1 (en) * | 2003-03-05 | 2004-11-25 | Boehringer Ingelheim International Gmbh | Hepatitis c inhibiting compounds |
| KR20050108420A (ko) | 2003-04-02 | 2005-11-16 | 베링거 인겔하임 인터내셔날 게엠베하 | Ｃ형 간염 바이러스 프로테아제 억제제를 위한 약제학적조성물 |
| ATE422895T1 (de) * | 2003-04-16 | 2009-03-15 | Bristol Myers Squibb Co | Makrocyclische isochinolinpeptidinhibitoren des hepatitis-c-virus |
| US7176208B2 (en) * | 2003-04-18 | 2007-02-13 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
| AR044129A1 (es) | 2003-05-06 | 2005-08-24 | Altana Pharma Ag | Compuestos intermedios de imidazopiridina. proceso de preparacion. |
| EA009295B1 (ru) * | 2003-05-21 | 2007-12-28 | Бёрингер Ингельхайм Интернациональ Гмбх | Соединения в качестве ингибиторов вируса гепатита с |
| US6955184B2 (en) | 2003-05-29 | 2005-10-18 | Honeywell International, Inc. | Pneumatic generator system for simulating operating conditions of an aircraft |
| JP2006527719A (ja) * | 2003-06-19 | 2006-12-07 | エフ．ホフマン−ラ ロシュ アーゲー | ４’−アジドヌクレオシド誘導体の調製方法 |
| US7125845B2 (en) | 2003-07-03 | 2006-10-24 | Enanta Pharmaceuticals, Inc. | Aza-peptide macrocyclic hepatitis C serine protease inhibitors |
| BRPI0509467A (pt) | 2004-03-30 | 2007-09-11 | Intermune Inc | compostos macrocìclicos como inibidores de replicação viral |
| TWI387603B (zh) * | 2005-07-20 | 2013-03-01 | Merck Sharp & Dohme | Ｈｃｖ ｎｓ３蛋白酶抑制劑 |
| GB0519797D0 (en) | 2005-09-29 | 2005-11-09 | Istituto Di Ricerche D Biolog | Therapeutic agents |
| GB0609492D0 (en) | 2006-05-15 | 2006-06-21 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| WO2008019303A2 (en) | 2006-08-04 | 2008-02-14 | Enanta Pharmaceuticals, Inc. | Pyridazinonyl macrocyclic hepatitis c serine protease inhibitors |
| WO2008057208A2 (en) | 2006-10-27 | 2008-05-15 | Merck & Co., Inc. | Hcv ns3 protease inhibitors |
| JP2011503201A (ja) | 2007-11-14 | 2011-01-27 | エナンタ ファーマシューティカルズ インコーポレイテッド | 大環状テトラゾリルｃ型肝炎セリンプロテアーゼ阻害剤 |
| CL2008003384A1 (es) | 2007-11-14 | 2009-12-11 | Enanta Pharm Inc | Compuestos derivados de quinoxalina macrocíclica, inhibidores de serina proteasa; composicion farmaceutica que los comprende; y su uso en el tratamiento de la hepatitis c. |
-
2006
- 2006-07-12 TW TW095125510A patent/TWI387603B/zh not_active IP Right Cessation
- 2006-07-12 US US11/484,925 patent/US7470664B2/en active Active
- 2006-07-12 AR ARP060102995A patent/AR057456A1/es active IP Right Grant
- 2006-07-14 PT PT06787475T patent/PT1924593E/pt unknown
- 2006-07-14 DK DK06787475.0T patent/DK1924593T3/da active
- 2006-07-14 GE GEAP200610513A patent/GEP20115248B/en unknown
- 2006-07-14 NZ NZ565223A patent/NZ565223A/en not_active IP Right Cessation
- 2006-07-14 EP EP06787698.7A patent/EP1910404B9/en not_active Not-in-force
- 2006-07-14 CA CA2615022A patent/CA2615022C/en not_active Expired - Fee Related
- 2006-07-14 MX MX2008000866A patent/MX2008000866A/es active IP Right Grant
- 2006-07-14 EP EP06787475A patent/EP1924593B9/en active Active
- 2006-07-14 HR HR20090627T patent/HRP20090627T1/hr unknown
- 2006-07-14 BR BRPI0613633-8A patent/BRPI0613633A2/pt not_active IP Right Cessation
- 2006-07-14 DE DE602006009280T patent/DE602006009280D1/de active Active
- 2006-07-14 ES ES06787698.7T patent/ES2446015T3/es active Active
- 2006-07-14 WO PCT/US2006/027573 patent/WO2007015787A1/en not_active Ceased
- 2006-07-14 AT AT06787475T patent/ATE443075T1/de active
- 2006-07-14 AU AU2006276189A patent/AU2006276189B9/en not_active Ceased
- 2006-07-14 WO PCT/US2006/027831 patent/WO2007015855A1/en not_active Ceased
- 2006-07-14 KR KR1020087001532A patent/KR101296095B1/ko not_active Expired - Fee Related
- 2006-07-14 ES ES06787475T patent/ES2332821T3/es active Active
- 2006-07-14 RS RSP-2009/0548A patent/RS51101B/sr unknown
- 2006-07-14 EA EA200800371A patent/EA013331B1/ru not_active IP Right Cessation
- 2006-07-14 SG SG201005254-6A patent/SG164376A1/en unknown
- 2006-07-14 SI SI200630496T patent/SI1924593T1/sl unknown
- 2006-07-14 JP JP2008522888A patent/JP4621282B2/ja active Active
- 2006-07-14 PL PL06787475T patent/PL1924593T3/pl unknown
- 2006-07-17 GT GT200600317A patent/GT200600317A/es unknown
- 2006-07-17 JO JO2006229A patent/JO2593B1/en active
- 2006-07-18 PE PE2006000864A patent/PE20070364A1/es not_active Application Discontinuation
- 2006-07-19 DO DO2006000171A patent/DOP2006000171A/es unknown
- 2006-07-19 MY MYPI20063431A patent/MY142240A/en unknown
-
2007
- 2007-12-20 CR CR9621A patent/CR9621A/es unknown
-
2008
- 2008-01-06 IL IL188618A patent/IL188618A0/en unknown
- 2008-01-14 EC EC2008008107A patent/ECSP088107A/es unknown
- 2008-01-21 HN HN2008000087A patent/HN2008000087A/es unknown
- 2008-01-21 TN TNP2008000033A patent/TNSN08033A1/en unknown
- 2008-02-18 MA MA30655A patent/MA30198B1/fr unknown
- 2008-02-19 NO NO20080879A patent/NO20080879L/no not_active Application Discontinuation
- 2008-12-01 US US12/325,965 patent/US8216999B2/en active Active
-
2009
- 2009-04-27 DO DO2009000094A patent/DOP2009000094A/es unknown
- 2009-12-14 CY CY20091101328T patent/CY1109671T1/el unknown
-
2010
- 2010-10-07 JP JP2010227222A patent/JP5345117B2/ja active Active