JP2011004755A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011004755A5 JP2011004755A5 JP2010176511A JP2010176511A JP2011004755A5 JP 2011004755 A5 JP2011004755 A5 JP 2011004755A5 JP 2010176511 A JP2010176511 A JP 2010176511A JP 2010176511 A JP2010176511 A JP 2010176511A JP 2011004755 A5 JP2011004755 A5 JP 2011004755A5
- Authority
- JP
- Japan
- Prior art keywords
- mva virus
- recombinant mva
- sequence
- homologous
- virus according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241001183012 Modified Vaccinia Ankara virus Species 0.000 claims 36
- 108090000623 proteins and genes Proteins 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 9
- 238000000034 method Methods 0.000 claims 7
- 239000013598 vector Substances 0.000 claims 7
- 238000003780 insertion Methods 0.000 claims 5
- 230000037431 insertion Effects 0.000 claims 5
- 241001465754 Metazoa Species 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 241000710831 Flavivirus Species 0.000 claims 2
- 230000010354 integration Effects 0.000 claims 2
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 108020001019 DNA Primers Proteins 0.000 claims 1
- 239000003155 DNA primer Substances 0.000 claims 1
- 241000725619 Dengue virus Species 0.000 claims 1
- 108091029795 Intergenic region Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 206010046865 Vaccinia virus infection Diseases 0.000 claims 1
- 108020005202 Viral DNA Proteins 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000013615 primer Substances 0.000 claims 1
- 208000007089 vaccinia Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200200752 | 2002-05-16 | ||
| DKPA200200753 | 2002-05-16 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004506501A Division JP4693092B2 (ja) | 2002-05-16 | 2003-05-14 | ポックスウイルスゲノムに挿入された相同遺伝子を発現させる組換えポックスウイルス |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011004755A JP2011004755A (ja) | 2011-01-13 |
| JP2011004755A5 true JP2011004755A5 (OSRAM) | 2011-07-28 |
Family
ID=29551228
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004506500A Expired - Lifetime JP4895505B2 (ja) | 2002-05-16 | 2003-05-14 | 変異ワクシニアウイルスアンカラ（ｍｖａ）ゲノム中の挿入部位としての遺伝子間領域 |
| JP2004506501A Expired - Lifetime JP4693092B2 (ja) | 2002-05-16 | 2003-05-14 | ポックスウイルスゲノムに挿入された相同遺伝子を発現させる組換えポックスウイルス |
| JP2010176511A Pending JP2011004755A (ja) | 2002-05-16 | 2010-08-05 | ポックスウイルスゲノムに挿入された相同遺伝子を発現させる組換えポックスウイルス |
| JP2010176512A Expired - Lifetime JP5777199B2 (ja) | 2002-05-16 | 2010-08-05 | ポックスウイルスゲノムに挿入された相同遺伝子を発現させる組換えポックスウイルス |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004506500A Expired - Lifetime JP4895505B2 (ja) | 2002-05-16 | 2003-05-14 | 変異ワクシニアウイルスアンカラ（ｍｖａ）ゲノム中の挿入部位としての遺伝子間領域 |
| JP2004506501A Expired - Lifetime JP4693092B2 (ja) | 2002-05-16 | 2003-05-14 | ポックスウイルスゲノムに挿入された相同遺伝子を発現させる組換えポックスウイルス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010176512A Expired - Lifetime JP5777199B2 (ja) | 2002-05-16 | 2010-08-05 | ポックスウイルスゲノムに挿入された相同遺伝子を発現させる組換えポックスウイルス |
Country Status (22)
| Country | Link |
|---|---|
| US (14) | US7338662B2 (OSRAM) |
| EP (3) | EP1506301B1 (OSRAM) |
| JP (4) | JP4895505B2 (OSRAM) |
| KR (4) | KR101041691B1 (OSRAM) |
| CN (6) | CN102719408A (OSRAM) |
| AT (1) | ATE315660T1 (OSRAM) |
| AU (4) | AU2003236646B2 (OSRAM) |
| BR (2) | BR0310051A (OSRAM) |
| CA (3) | CA2481799C (OSRAM) |
| DE (1) | DE60303218T2 (OSRAM) |
| DK (2) | DK1506301T3 (OSRAM) |
| EA (3) | EA020230B1 (OSRAM) |
| ES (1) | ES2256776T3 (OSRAM) |
| IL (4) | IL164172A0 (OSRAM) |
| MX (2) | MXPA04011194A (OSRAM) |
| NO (3) | NO334273B1 (OSRAM) |
| NZ (2) | NZ536502A (OSRAM) |
| PL (2) | PL218318B1 (OSRAM) |
| PT (1) | PT1407033E (OSRAM) |
| SI (1) | SI1407033T1 (OSRAM) |
| UA (1) | UA82479C2 (OSRAM) |
| WO (2) | WO2003097845A1 (OSRAM) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4101327C1 (OSRAM) * | 1991-01-18 | 1991-10-24 | Mercedes-Benz Aktiengesellschaft, 7000 Stuttgart, De | |
| HU230198B1 (hu) * | 2000-11-23 | 2015-10-28 | Bavarian Nordic A/S | Módosított Vacciniavírus Ankara-variáns |
| WO2004022729A1 (en) * | 2002-09-05 | 2004-03-18 | Bavarian Nordic A/S | Method for the cultivation of primary cells and for the amplification of viruses under serum free conditions |
| EP2204180A3 (en) * | 2002-04-19 | 2010-12-22 | Bavarian Nordic A/S | Modified Vaccinia Virus Ankara for the vaccination of neonates |
| PL218318B1 (pl) | 2002-05-16 | 2014-11-28 | Bavarian Nordic As | Rekombinowany wirus krowianki Ankara (MVA), zawierająca go komórka, szczepionka lub kompozycja farmaceutyczna, sposób lub zestaw do jego otrzymywania, sekwencja DNA zawierająca genom tego wirusa oraz sposób wykrywania tego wirusa lub komórek nim zainfekowanych |
| US7501127B2 (en) | 2002-05-16 | 2009-03-10 | Bavarian Nordic A/S | Intergenic regions as novel sites for insertion of HIV DNA sequences in the genome of Modified Vaccinia virus Ankara |
| EP1601333B1 (en) * | 2003-02-20 | 2013-01-23 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services | Novel insertion sites in pox vectors |
| GB2402391A (en) * | 2003-06-04 | 2004-12-08 | Oxxon Pharmaccines Ltd | Fowlpox recombinant genome |
| WO2006052826A2 (en) * | 2004-11-05 | 2006-05-18 | The Government Of The United States Of America As Represented By The Secretary | Methods for preparing cells and viruses |
| HUE030037T2 (en) | 2005-02-23 | 2017-04-28 | Bavarian Nordic As | Use of modified anemic virus for rapid induction of immunity against gluten virus or other agents |
| WO2007136865A2 (en) * | 2006-05-19 | 2007-11-29 | Glycofi, Inc | Recombinant vectors |
| WO2008142479A2 (en) * | 2006-08-25 | 2008-11-27 | The Government Of The United States Of Amercia, As Represented By The Secretary, Department Of Health And Human Services | Intergenic sites between conserved genes in the genome of modified vaccinia ankara (mva) vaccinia virus |
| US20090098529A1 (en) * | 2006-10-16 | 2009-04-16 | Nanhai Chen | Methods for attenuating virus strains for diagnostic and therapeutic uses |
| EP2086526B1 (en) * | 2006-11-09 | 2014-07-23 | The United States Of America As Represented By The Secretary of the Navy | Induction of an immune response against Dengue virus using prime-boost approach |
| US8440202B2 (en) * | 2006-11-09 | 2013-05-14 | The United States Of America As Represented By The Secretary Of The Navy | Induction of an immune response against dengue virus using the prime-boost approach |
| CA2675355C (en) * | 2007-01-30 | 2015-04-28 | Transgene S.A. | Papillomavirus vaccine |
| US8268327B2 (en) | 2007-04-27 | 2012-09-18 | Bavarian Nordic A/S | Immediate protection against pathogens via MVA |
| CN101688223B (zh) * | 2007-05-15 | 2013-07-31 | 特兰斯吉恩股份有限公司 | 用于多基因表达的载体 |
| MX2009013030A (es) * | 2007-05-30 | 2010-03-25 | Wyeth Llc | Poxvirus de mapache que expresa genes de antigenos felinos. |
| TW200907058A (en) * | 2007-05-30 | 2009-02-16 | Wyeth Corp | Raccoon poxvirus expressing rabies glycoproteins |
| ES2608604T3 (es) | 2007-10-18 | 2017-04-12 | Bavarian Nordic A/S | Uso de MVA para tratar el cáncer de próstata |
| WO2009152969A1 (en) * | 2008-06-20 | 2009-12-23 | Bavarian Nordic A/S | Recombinant modified vaccinia virus measles vaccine |
| KR100894430B1 (ko) * | 2008-11-11 | 2009-04-22 | 시스템디엔디(주) | 초음파, 음향 및 온도변화를 이용한 밸브의 유체누설 측정장치 및 이를 이용한 유체누설 측정방법 |
| CA2742247C (en) * | 2008-11-21 | 2017-07-04 | Bavarian Nordic A/S | Vector comprising multiple homologous nucleotide sequences |
| US8580276B2 (en) | 2009-06-05 | 2013-11-12 | City Of Hope | Genetically stable recombinant modified vaccinia ankara (rMVA) vaccines and methods of preparation thereof |
| EA201270108A1 (ru) | 2009-10-08 | 2012-08-30 | Бавариан Нордик А/С | Формирование полиспецифического t-клеточного ответа против вич у человека |
| EP2488649B1 (en) | 2009-10-16 | 2019-04-03 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Recombinant modified vaccinia ankara (mva) vaccinia virus containing restructured insertion sites |
| WO2011087839A1 (en) | 2009-12-22 | 2011-07-21 | Baxter International Inc. | Vaccine to influenza a virus |
| WO2011120045A1 (en) * | 2010-03-26 | 2011-09-29 | Emergent Product Development Gaithersburg Inc. | Ectodomains of influenza matrix 2 protein, expression system, and uses thereof |
| CA2802430C (en) | 2010-07-20 | 2021-07-20 | Bavarian Nordic A/S | Method for harvesting poxvirus |
| WO2012040474A2 (en) * | 2010-09-23 | 2012-03-29 | Baxter International Inc. | Recombinant viral vectors and methods for inducing an immune response to yellow fever virus |
| WO2012048817A2 (en) | 2010-10-15 | 2012-04-19 | Bavarian Nordic A/S | Recombinant modified vaccinia virus ankara influenza vaccine |
| ES2733211T3 (es) | 2011-04-15 | 2019-11-28 | Genelux Corp | Cepas clonales de virus vaccinia atenuados y métodos de uso de las mismas |
| EP2788021B1 (en) | 2011-12-09 | 2017-01-18 | Bavarian Nordic A/S | Poxvirus vector for the expression of bacterial antigens linked to tetanus toxin fragment c |
| EP2620446A1 (en) | 2012-01-27 | 2013-07-31 | Laboratorios Del Dr. Esteve, S.A. | Immunogens for HIV vaccination |
| KR20150021088A (ko) | 2012-06-05 | 2015-02-27 | 디 오스트레일리언 내셔널 유니버시티 | 인터루킨-4 길항제를 이용한 백신접종 |
| SI2879702T1 (sl) | 2012-08-01 | 2020-02-28 | Bavarian Nordic A/S | Cepivo na osnovi rekombinantnega modificiranega virusa vakcinacije Ankara (MVA) proti respiratornemu sincitialnemu virusu (RSV) |
| WO2014043535A1 (en) | 2012-09-14 | 2014-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions for the treatment of cancer |
| US20140140959A1 (en) | 2012-10-05 | 2014-05-22 | Aladar A. Szalay | Energy Absorbing-Based Diagnostic and Therapeutic Methods Employing Nucleic Acid Molecules Encoding Chromophore-Producing Enzymes |
| EP2908851A1 (en) | 2012-10-19 | 2015-08-26 | Bavarian Nordic Inc. | Methods and compositions for the treatment of cancer |
| DE102013004595A1 (de) | 2013-03-15 | 2014-09-18 | Emergent Product Development Germany Gmbh | RSV-Impfstoffe |
| WO2014139587A1 (en) * | 2013-03-15 | 2014-09-18 | Okairòs Ag | Improved poxviral vaccines |
| MY193724A (en) * | 2013-03-15 | 2022-10-27 | Sementis Ltd | Immune modulation |
| US10238700B2 (en) | 2014-01-02 | 2019-03-26 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
| KR101645642B1 (ko) | 2014-10-16 | 2016-08-11 | 대한민국 | Kvac１０３ 유래의 재조합 백시니아 바이러스 |
| KR101623498B1 (ko) | 2014-10-16 | 2016-05-24 | 대한민국 | 약독화 백시니아 바이러스주 kvac１０３ |
| JP2018510143A (ja) | 2015-02-25 | 2018-04-12 | メモリアル スローン ケタリング キャンサー センター | 不活化非複製改変ワクシニアウイルスアンカラ（ｍｖａ）の固形腫瘍のための単独療法又は免疫チェックポイント遮断剤併用における使用 |
| CN107847534B (zh) | 2015-04-17 | 2022-10-04 | 纪念斯隆凯特琳癌症中心 | Mva或mvaδe3l作为抗实体瘤的免疫治疗剂的应用 |
| KR20160140075A (ko) * | 2015-05-29 | 2016-12-07 | 코오롱생명과학 주식회사 | 폭스바이러스 유래 프로모터 및 이를 포함하는 벡터 |
| WO2016202828A1 (en) * | 2015-06-15 | 2016-12-22 | Bavarian Nordic A/S | Recombinant modified vaccinia virus ankara (mva) foot and mouth disease virus (fmdv) vaccine |
| FR3042121A1 (fr) | 2015-10-08 | 2017-04-14 | Jean-Marc Limacher | Composition anti-tumorale |
| CN106591361A (zh) * | 2015-10-20 | 2017-04-26 | 钱文斌 | 一种重组痘溶瘤病毒及其构建方法和应用 |
| AU2017206102C1 (en) | 2016-01-08 | 2022-02-10 | Geovax Inc. | Compositions and methods for generating an immune response to a tumor associated antigen |
| PL3407910T3 (pl) | 2016-01-29 | 2022-08-16 | Bavarian Nordic A/S | Rekombinowana zmodyfikowana szczepionka przeciwko wirusowi krowianki ankara (mva) przeciwko wirusowi zapalenia mózgu koni |
| US20190030157A1 (en) * | 2016-02-03 | 2019-01-31 | Geovax Inc. | Compositions and Methods for Generating an Immune Response to a Flavivirus |
| BR112018016948A2 (pt) | 2016-02-25 | 2019-01-08 | Memorial Sloan Kettering Cancer Center | mva recombinante ou mva¿e3l que expressa flt3l humano e uso do mesmo como agente imunoterapêutico contra tumores sólidos |
| EP3419648A4 (en) | 2016-02-25 | 2019-09-11 | Memorial Sloan-Kettering Cancer Center | REPLICATING COMPETENTES WEAKENED VACCINIA VIRUSES WITH DELETION OF THYMIDINE KINASE WITH AND WITHOUT EXPRESSION OF HUMAN FLT3L OR GM-CSF FOR CANCER IMMUNOTHERAPY |
| CA3021341A1 (en) | 2016-05-02 | 2017-11-09 | Janssen Vaccine & Prevention B.V. | Therapeutic hpv vaccine combinations |
| AR110624A1 (es) * | 2016-08-19 | 2019-04-17 | Sementis Ltd | Vacunas virales |
| WO2018064516A1 (en) * | 2016-09-30 | 2018-04-05 | Monsanto Technology Llc | Method for selecting target sites for site-specific genome modification in plants |
| US11242509B2 (en) | 2017-05-12 | 2022-02-08 | Memorial Sloan Kettering Cancer Center | Vaccinia virus mutants useful for cancer immunotherapy |
| KR20200015759A (ko) * | 2017-06-15 | 2020-02-12 | 얀센 백신스 앤드 프리벤션 비.브이. | Hiv 항원을 인코딩하는 폭스바이러스 벡터, 및 그 사용 방법 |
| US11311612B2 (en) | 2017-09-19 | 2022-04-26 | Geovax, Inc. | Compositions and methods for generating an immune response to treat or prevent malaria |
| WO2019216929A1 (en) * | 2018-05-11 | 2019-11-14 | City Of Hope | Mva vectors for expressing multiple cytomegalovirus (cmv) antigens and use thereof |
| CN112512568A (zh) | 2018-05-11 | 2021-03-16 | 希望之城 | 遗传修饰的重组痘苗安卡拉(rmva)疫苗改善的稳定性及其制备方法 |
| US12252702B2 (en) | 2018-09-15 | 2025-03-18 | Memorial Sloan Kettering Cancer Center | Recombinant poxviruses for cancer immunotherapy |
| CN111979204B (zh) * | 2019-05-24 | 2023-10-13 | 杭州功楚生物科技有限公司 | 携带海绵凝集素基因的溶瘤痘苗病毒、构建方法及用途 |
| AU2020384323A1 (en) | 2019-11-14 | 2022-06-02 | Aelix Therapeutics, S.L. | Dosage regimens for vaccines |
| EP3842065A1 (en) * | 2019-12-23 | 2021-06-30 | Transgene | Process for designing a recombinant poxvirus for a therapeutic vaccine |
| TW202203966A (zh) * | 2020-03-31 | 2022-02-01 | 澳大利亞商賽門蒂斯公司 | 用於防範ｃｏｖｉｄ－１９之以減毒的痘病毒載體為底質之疫苗 |
| AU2022215566A1 (en) | 2021-02-02 | 2023-08-17 | Geovax, Inc. | Viral constructs for use in enhancing t-cell priming during vaccination |
| EP4551240A1 (en) | 2022-07-08 | 2025-05-14 | Viromissile, Inc. | Oncolytic vaccinia viruses and recombinant viruses and methods of use thereof |
| FR3160186A1 (fr) | 2024-03-13 | 2025-09-19 | Odimma Therapeutics | Vecteur non-viral pour transcription augmentee |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5338683A (en) * | 1981-12-24 | 1994-08-16 | Health Research Incorporated | Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins |
| JPH0795956B2 (ja) * | 1986-09-22 | 1995-10-18 | 京都大学長 | ポックスウイルス由来発現制御領域 |
| US5093258A (en) * | 1988-08-26 | 1992-03-03 | Therion Biologics Corporation | Recombinant fowlpox virus and recombination vector |
| US5225336A (en) * | 1989-03-08 | 1993-07-06 | Health Research Incorporated | Recombinant poxvirus host range selection system |
| US5651972A (en) | 1989-04-21 | 1997-07-29 | University Of Florida Research Foundation, Inc. | Use of recombinant swine poxvirus as a live vaccine vector |
| MY109299A (en) * | 1990-08-15 | 1996-12-31 | Virogenetics Corp | Recombinant pox virus encoding flaviviral structural proteins |
| US5514375A (en) | 1990-08-15 | 1996-05-07 | Virogenetics Corporation | Flavivirus recombinant poxvirus vaccine |
| US6893845B1 (en) * | 1990-09-28 | 2005-05-17 | Applied Molecular Evolution, Inc. | Surface expression libraries of heteromeric receptors |
| AU672359B2 (en) * | 1991-03-07 | 1996-10-03 | Virogenetics Corporation | Genetically engineered vaccine strain |
| BE1004877A3 (fr) * | 1991-05-27 | 1993-02-16 | Solvay | Virus de l'avipox recombinant, culture de cellules infectees par ce virus et vaccins pour la volaille derives de ce virus. |
| FR2679249B1 (fr) * | 1991-07-15 | 1993-11-26 | Centre Nal Recherc Scientifique | Souches de levure avec integration stable de genes heterologues. |
| JPH06509235A (ja) | 1991-07-26 | 1994-10-20 | ヴァイロジェネティクス コーポレイション | 伝染性ファブリキウス嚢病ウイルス組換えポックスウイルスワクチン |
| EP0561034B1 (en) * | 1991-08-26 | 1999-06-09 | IMMUNO Aktiengesellschaft | Direct molecular cloning of a modified chordopox virus genome |
| DK0538496T3 (da) * | 1991-08-26 | 2004-02-23 | Baxter Healthcare Sa | Rekombinant fjerkrækoppevirus med intakt FPV tk-gen |
| US5676950A (en) | 1994-10-28 | 1997-10-14 | University Of Florida | Enterically administered recombinant poxvirus vaccines |
| UA68327C2 (en) * | 1995-07-04 | 2004-08-16 | Gsf Forschungszentrum Fur Unwe | A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals |
| EP0753581A1 (en) * | 1995-07-10 | 1997-01-15 | Immuno Ag | Improved recombinant eukaryotic cytoplasmic viruses, method for their production and their use as vaccines |
| DE19629828A1 (de) * | 1996-07-24 | 1998-01-29 | Bayer Ag | Carbanilide |
| MY150893A (en) * | 1996-09-24 | 2014-03-14 | Bavarian Nordic As | Recombinant mva virus expressing dengue virus antigens, and the use thereof in vaccines |
| AUPP380598A0 (en) * | 1998-05-29 | 1998-06-25 | Commonwealth Scientific And Industrial Research Organisation | Genetically manipulated entomopoxvirus |
| US6252871B1 (en) | 1998-07-01 | 2001-06-26 | Powerwave Technologies, Inc. | Switchable combiner/splitter |
| US20040265324A1 (en) * | 1999-03-23 | 2004-12-30 | Cardosa Mary Jane | Recombinant MVA virus expressing dengue virus antigens, and the use thereof in vaccines |
| DK1180155T3 (da) * | 1999-05-28 | 2009-02-16 | Helmholtz Zentrum Muenchen | Vektor til integration af heterologe sekvenser i poxvirale genomer |
| EE05633B1 (et) * | 2000-03-14 | 2013-02-15 | Mayr Anton | Muundatud vaktsiiniaviirus Ankara (MVA), sellega nakatatud peremeesrakk ning seda sisaldav farmatseutiline kompositsioon, MVA valmistamine ja raviotstarbeline kasutamine |
| CA2341356C (en) * | 2000-04-14 | 2011-10-11 | Transgene S.A. | Poxvirus with targeted infection specificity |
| DE60130569D1 (de) * | 2000-08-29 | 2007-10-31 | Wyeth Corp | Verpackung von replikon-partikeln eines positiv-strängigen rna-virus |
| HU230198B1 (hu) * | 2000-11-23 | 2015-10-28 | Bavarian Nordic A/S | Módosított Vacciniavírus Ankara-variáns |
| PL218318B1 (pl) | 2002-05-16 | 2014-11-28 | Bavarian Nordic As | Rekombinowany wirus krowianki Ankara (MVA), zawierająca go komórka, szczepionka lub kompozycja farmaceutyczna, sposób lub zestaw do jego otrzymywania, sekwencja DNA zawierająca genom tego wirusa oraz sposób wykrywania tego wirusa lub komórek nim zainfekowanych |
| US7501127B2 (en) * | 2002-05-16 | 2009-03-10 | Bavarian Nordic A/S | Intergenic regions as novel sites for insertion of HIV DNA sequences in the genome of Modified Vaccinia virus Ankara |
| EA012723B1 (ru) * | 2002-11-25 | 2009-12-30 | Бавариан Нордик А/С | Рекомбинантный поксвирус, содержащий по меньшей мере два промотора ati вируса коровьей оспы, и его применение |
-
2003
- 2003-05-14 PL PL372088A patent/PL218318B1/pl unknown
- 2003-05-14 BR BR0310051A patent/BR0310051A/pt not_active IP Right Cessation
- 2003-05-14 CN CN2012101926963A patent/CN102719408A/zh active Pending
- 2003-05-14 IL IL16417203A patent/IL164172A0/xx unknown
- 2003-05-14 CN CNB038111225A patent/CN100494388C/zh not_active Expired - Lifetime
- 2003-05-14 CN CN200910208520A patent/CN101831411A/zh active Pending
- 2003-05-14 PL PL372093A patent/PL216760B1/pl unknown
- 2003-05-14 AT AT03752741T patent/ATE315660T1/de active
- 2003-05-14 MX MXPA04011194A patent/MXPA04011194A/es active IP Right Grant
- 2003-05-14 PT PT03752741T patent/PT1407033E/pt unknown
- 2003-05-14 DK DK03735384T patent/DK1506301T3/da active
- 2003-05-14 CN CN2012101928085A patent/CN102703393A/zh active Pending
- 2003-05-14 EP EP20030735384 patent/EP1506301B1/en not_active Expired - Lifetime
- 2003-05-14 US US10/510,189 patent/US7338662B2/en not_active Expired - Lifetime
- 2003-05-14 WO PCT/EP2003/005045 patent/WO2003097845A1/en not_active Ceased
- 2003-05-14 CA CA2481799A patent/CA2481799C/en not_active Expired - Lifetime
- 2003-05-14 SI SI200330215T patent/SI1407033T1/sl unknown
- 2003-05-14 DE DE2003603218 patent/DE60303218T2/de not_active Expired - Lifetime
- 2003-05-14 KR KR1020047018165A patent/KR101041691B1/ko not_active Expired - Lifetime
- 2003-05-14 KR KR1020117031095A patent/KR20120002627A/ko not_active Withdrawn
- 2003-05-14 AU AU2003236646A patent/AU2003236646B2/en not_active Expired
- 2003-05-14 JP JP2004506500A patent/JP4895505B2/ja not_active Expired - Lifetime
- 2003-05-14 BR BRPI0311178A patent/BRPI0311178B8/pt not_active IP Right Cessation
- 2003-05-14 US US10/514,761 patent/US7550147B2/en not_active Expired - Lifetime
- 2003-05-14 WO PCT/EP2003/005047 patent/WO2003097846A1/en not_active Ceased
- 2003-05-14 EA EA200900180A patent/EA020230B1/ru not_active IP Right Cessation
- 2003-05-14 MX MXPA04010713A patent/MXPA04010713A/es active IP Right Grant
- 2003-05-14 AU AU2003242540A patent/AU2003242540A1/en not_active Abandoned
- 2003-05-14 UA UA20041109409A patent/UA82479C2/uk unknown
- 2003-05-14 EP EP10008120.7A patent/EP2253709B1/en not_active Expired - Lifetime
- 2003-05-14 NZ NZ536502A patent/NZ536502A/en not_active IP Right Cessation
- 2003-05-14 CA CA 2812019 patent/CA2812019A1/en not_active Abandoned
- 2003-05-14 NZ NZ536501A patent/NZ536501A/en not_active IP Right Cessation
- 2003-05-14 EA EA200401506A patent/EA012160B1/ru not_active IP Right Cessation
- 2003-05-14 CN CN038111063A patent/CN1653183B/zh not_active Expired - Lifetime
- 2003-05-14 CA CA2481521A patent/CA2481521C/en not_active Expired - Lifetime
- 2003-05-14 JP JP2004506501A patent/JP4693092B2/ja not_active Expired - Lifetime
- 2003-05-14 CN CN2011100588236A patent/CN102199628A/zh active Pending
- 2003-05-14 EA EA200401507A patent/EA007811B1/ru not_active IP Right Cessation
- 2003-05-14 KR KR1020047018293A patent/KR101005630B1/ko not_active Expired - Lifetime
- 2003-05-14 IL IL16417703A patent/IL164177A0/xx active IP Right Grant
- 2003-05-14 ES ES03752741T patent/ES2256776T3/es not_active Expired - Lifetime
- 2003-05-14 EP EP20030752741 patent/EP1407033B1/en not_active Expired - Lifetime
- 2003-05-14 KR KR1020107021891A patent/KR101138067B1/ko not_active Expired - Lifetime
- 2003-05-14 DK DK03752741T patent/DK1407033T3/da active
-
2004
- 2004-11-12 NO NO20044940A patent/NO334273B1/no not_active IP Right Cessation
- 2004-12-16 NO NO20045480A patent/NO336489B1/no not_active IP Right Cessation
-
2007
- 2007-11-15 US US11/985,510 patent/US9109233B2/en active Active
-
2008
- 2008-07-28 IL IL193087A patent/IL193087A/en active IP Right Grant
- 2008-07-28 IL IL19308808A patent/IL193088A/en active IP Right Grant
- 2008-12-09 AU AU2008255213A patent/AU2008255213B2/en not_active Expired
- 2008-12-19 US US12/339,743 patent/US20100173388A1/en not_active Abandoned
-
2009
- 2009-02-03 AU AU2009200380A patent/AU2009200380C1/en not_active Expired
- 2009-05-19 US US12/468,127 patent/US8034354B2/en not_active Expired - Lifetime
- 2009-05-19 US US12/468,120 patent/US7964374B2/en not_active Expired - Lifetime
-
2010
- 2010-08-05 JP JP2010176511A patent/JP2011004755A/ja active Pending
- 2010-08-05 JP JP2010176512A patent/JP5777199B2/ja not_active Expired - Lifetime
- 2010-09-30 US US12/894,589 patent/US20110053260A1/en not_active Abandoned
- 2010-09-30 US US12/894,550 patent/US20110053259A1/en not_active Abandoned
-
2011
- 2011-04-15 US US13/087,715 patent/US8288125B2/en not_active Expired - Fee Related
- 2011-04-15 US US13/087,649 patent/US8309326B2/en not_active Expired - Fee Related
- 2011-09-15 US US13/233,329 patent/US8414900B2/en not_active Expired - Fee Related
- 2011-09-16 US US13/234,230 patent/US8435543B2/en not_active Expired - Fee Related
- 2011-09-29 NO NO20111324A patent/NO20111324A1/no not_active Application Discontinuation
-
2012
- 2012-02-13 US US13/371,580 patent/US20120178157A1/en not_active Abandoned
-
2013
- 2013-05-02 US US13/886,093 patent/US8741308B2/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011004755A5 (OSRAM) | ||
| JP2010259446A5 (OSRAM) | ||
| KR102135818B1 (ko) | 강력한 ｔ-세포 및 항체 반응을 위한 ｐｒ13.5 프로모터 | |
| CN104894075B (zh) | CRISPR/Cas9和Cre/lox系统编辑伪狂犬病毒基因组制备疫苗方法和应用 | |
| JP5777199B2 (ja) | ポックスウイルスゲノムに挿入された相同遺伝子を発現させる組換えポックスウイルス | |
| Lasaro et al. | New insights on adenovirus as vaccine vectors | |
| ES2685124T3 (es) | Sistema de expresión de poxvirus | |
| US20200368333A1 (en) | Cmv vectors comprising microrna recognition elements | |
| JP2013507935A5 (OSRAM) | ||
| RU2013152648A (ru) | Аденовирус обезьян и гибридные аденовирусные векторы | |
| WO2008142479A3 (en) | Intergenic sites between conserved genes in the genome of modified vaccinia ankara (mva) vaccinia virus | |
| Alharbi | Poxviral promoters for improving the immunogenicity of MVA delivered vaccines | |
| Liu et al. | Development of recombinant goatpox virus expressing Echinococcus granulosus EG95 vaccine antigen | |
| Zhang et al. | Potential threat of human pathogenic orthopoxviruses to public health and control strategies | |
| Marín-López et al. | Generation of recombinant modified vaccinia virus Ankara encoding VP2, NS1, and VP7 proteins of bluetongue virus | |
| CN105879060B (zh) | 以成纤维激活蛋白α为靶点的肿瘤DNA疫苗及病毒载体疫苗 | |
| CN103298936A (zh) | 具有新型流感病毒来源的血凝素蛋白基因的重组痘苗病毒 | |
| JP5584407B2 (ja) | Ｃ型肝炎ウイルス遺伝子を有する組換えワクシニアウイルス | |
| Alharbi et al. | Deletion of fifteen open reading frames from modified vaccinia virus Ankara fails to improve immunogenicity | |
| CN107206035B (zh) | 丙型肝炎的治疗和/或预防用药物组合物 | |
| JP5944210B2 (ja) | 新型インフルエンザウイルス由来ヘマグルチニンタンパク質遺伝子が組み込まれたｂ５ｒ遺伝子欠損組換えワクシニアウイルス | |
| JPWO2006013815A1 (ja) | ＨＣＶウイルスタンパク質をコードするＤＮＡを保有する組換えワクチニアウイルスＤＩｓ株、およびその利用 | |
| Orubu et al. | Expression and Cellular Immunogenicity of a Transgenic Antigen Driven by | |
| Spencer | Matthew G. Cottingham, Rikke F. Andersen, Alexandra J. Spencer, Saroj Saurya, Julie Furze, Adrian VS Hill and Sarah C. Gilbert | |
| Cottingham et al. | Recombination-Mediated Genetic Engineering of a Bacterial Artificial |