BR112018016948A2 - mva recombinante ou mva¿e3l que expressa flt3l humano e uso do mesmo como agente imunoterapêutico contra tumores sólidos - Google Patents

mva recombinante ou mva¿e3l que expressa flt3l humano e uso do mesmo como agente imunoterapêutico contra tumores sólidos

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Publication number
BR112018016948A2
BR112018016948A2 BR112018016948A BR112018016948A BR112018016948A2 BR 112018016948 A2 BR112018016948 A2 BR 112018016948A2 BR 112018016948 A BR112018016948 A BR 112018016948A BR 112018016948 A BR112018016948 A BR 112018016948A BR 112018016948 A2 BR112018016948 A2 BR 112018016948A2
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Prior art keywords
mva
recombinant
solid tumors
expressing human
immunotherapeutic agent
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BR112018016948A
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English (en)
Inventor
Wolchok Jedd
Deng Liang
Yang Ning
Dai Peihong
Shuman Stewart
Merghoub Taha
Wang Weiyi
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Memorial Sloan Kettering Cancer Center
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Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of BR112018016948A2 publication Critical patent/BR112018016948A2/pt

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Abstract

a presente divulgação refere-se de forma geral aos campos de oncologia, virologia e imunoterapia. refere-se a poxvírus, especificamente ao vírus vaccinia ankara modificado (mva) altamente atenuado e a um vírus vaccinia ankara modificado recombinante com deleção do fator de virulência e3 de vaccinia (mva¿e3l), cada um adicionalmente modificado para expressar o ligante de tirosina quinase 3 similar a fms (flt3l) ou gm-csf humano. a divulgação refere-se ao uso dos vírus recombinantes anteriores como agentes imunoterapêutico para câncer. os poxvírus recombinantes anteriores também podem ser utilizados em combinação com terapia de bloqueio de pontos de verificação imunológicos.
BR112018016948A 2016-02-25 2017-02-25 mva recombinante ou mva¿e3l que expressa flt3l humano e uso do mesmo como agente imunoterapêutico contra tumores sólidos BR112018016948A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662300066P 2016-02-25 2016-02-25
US201662418786P 2016-11-07 2016-11-07
US201662418788P 2016-11-08 2016-11-08
PCT/US2017/019549 WO2017147554A2 (en) 2016-02-25 2017-02-25 Recombinant mva or mvadele3l expressing human flt3l and use thereof as immuno-therapeutic agents against solid tumors

Publications (1)

Publication Number Publication Date
BR112018016948A2 true BR112018016948A2 (pt) 2019-01-08

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BR112018016948A BR112018016948A2 (pt) 2016-02-25 2017-02-25 mva recombinante ou mva¿e3l que expressa flt3l humano e uso do mesmo como agente imunoterapêutico contra tumores sólidos

Country Status (12)

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US (3) US10736962B2 (pt)
EP (1) EP3419662A4 (pt)
JP (2) JP7034080B2 (pt)
KR (1) KR20180130500A (pt)
CN (1) CN109152827B (pt)
AU (2) AU2017222687B2 (pt)
BR (1) BR112018016948A2 (pt)
CA (1) CA3015818A1 (pt)
IL (2) IL261321B2 (pt)
MX (2) MX2018010231A (pt)
SG (1) SG11201807022XA (pt)
WO (1) WO2017147554A2 (pt)

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