MX2022014644A - Mva recombinante o mvadele3l que expresa el flt3l humano y uso de los mismos como agentes inmunoterapeuticos contra tumores solidos. - Google Patents

Mva recombinante o mvadele3l que expresa el flt3l humano y uso de los mismos como agentes inmunoterapeuticos contra tumores solidos.

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Publication number
MX2022014644A
MX2022014644A MX2022014644A MX2022014644A MX2022014644A MX 2022014644 A MX2022014644 A MX 2022014644A MX 2022014644 A MX2022014644 A MX 2022014644A MX 2022014644 A MX2022014644 A MX 2022014644A MX 2022014644 A MX2022014644 A MX 2022014644A
Authority
MX
Mexico
Prior art keywords
mva
mvadele3l
immuno
therapeutic agents
solid tumors
Prior art date
Application number
MX2022014644A
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English (en)
Inventor
Jedd Wolchok
Taha Merghoub
Liang Deng
Stewart Shuman
Weiyi Wang
Peihong Dai
Ning Yang
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of MX2022014644A publication Critical patent/MX2022014644A/es

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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
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    • C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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  • Health & Medical Sciences (AREA)
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Abstract

La presente invención en general se relaciona con los campos de la oncología, la virología y la inmunoterapia. Más particularmente, se relaciona con el uso de un virus de la vaccinia Ankara modificada (MVA) recombinante que comprende una MVA que alberga un ligando de la tirosina quinasa 3 similar a Fms humano (hFlt3L) (MVA-hFtl3L). El virus de la vaccinia Ankara (MVA) anterior se puede suministrar a las células tumorales de un sujeto afectado con un tumor sólido maligno, para tratar el tumor. En un aspecto relacionado, la presente descripción se relaciona con un virus de la vaccinia Ankara modificada recombinante con la deleción del factor E3 de virulencia de la vaccinia (MV At.E3L) modificado para expresar el ligando de la tirosina quinasa 3 similar a Fms humano (hFlt3L) aislado, adecuado para utilizarse como un agente inmunoterapéutico contra un tumor sólido maligno.
MX2022014644A 2016-02-25 2018-08-23 Mva recombinante o mvadele3l que expresa el flt3l humano y uso de los mismos como agentes inmunoterapeuticos contra tumores solidos. MX2022014644A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662300066P 2016-02-25 2016-02-25
US201662418786P 2016-11-07 2016-11-07
US201662418788P 2016-11-08 2016-11-08

Publications (1)

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MX2022014644A true MX2022014644A (es) 2022-12-15

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ID=59685692

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MX2018010231A MX2018010231A (es) 2016-02-25 2017-02-25 Mva recombinante o mvadele3l que expresa el flt3l humano y uso de los mismos como agentes inmunoterapéuticos contra tumores sólidos.
MX2022014644A MX2022014644A (es) 2016-02-25 2018-08-23 Mva recombinante o mvadele3l que expresa el flt3l humano y uso de los mismos como agentes inmunoterapeuticos contra tumores solidos.

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MX2018010231A MX2018010231A (es) 2016-02-25 2017-02-25 Mva recombinante o mvadele3l que expresa el flt3l humano y uso de los mismos como agentes inmunoterapéuticos contra tumores sólidos.

Country Status (12)

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US (3) US10736962B2 (es)
EP (1) EP3419662A4 (es)
JP (2) JP7034080B2 (es)
KR (1) KR20180130500A (es)
CN (1) CN109152827B (es)
AU (2) AU2017222687B2 (es)
BR (1) BR112018016948A2 (es)
CA (1) CA3015818A1 (es)
IL (2) IL261321B2 (es)
MX (2) MX2018010231A (es)
SG (1) SG11201807022XA (es)
WO (1) WO2017147554A2 (es)

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