MX2021003013A - Poxvirus recombinantes para inmunoterapia contra cáncer. - Google Patents

Poxvirus recombinantes para inmunoterapia contra cáncer.

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Publication number
MX2021003013A
MX2021003013A MX2021003013A MX2021003013A MX2021003013A MX 2021003013 A MX2021003013 A MX 2021003013A MX 2021003013 A MX2021003013 A MX 2021003013A MX 2021003013 A MX2021003013 A MX 2021003013A MX 2021003013 A MX2021003013 A MX 2021003013A
Authority
MX
Mexico
Prior art keywords
mva
ox40l
vacv
deletion
engineered
Prior art date
Application number
MX2021003013A
Other languages
English (en)
Inventor
Yi Wang
Jedd Wolchok
Taha Merghoub
Liang Deng
Stewart Shuman
Weiyi Wang
Peihong Dai
Ning Yang
Gregory Mazo
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of MX2021003013A publication Critical patent/MX2021003013A/es

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Abstract

En la presente descripción se describen métodos y composiciones relacionadas con el tratamiento, prevención, y/o mejora del cáncer en un individuo que lo necesite. En aspectos particulares, la presente tecnología se refiere al uso de poxvirus genéticamente diseñados o recombinantes, incluyendo un virus vaccinia Ankara modificado (MVA) que comprende una deleción de E3L (MVA?E3L) diseñado para expresar OX40L (MVA?E3L-OX40L), un virus MVA que comprende una deleción de C7L (MVA?C7L) diseñado para expresar OX40L (MVA?C7L-OX40L), un MVA?C7L diseñado para expresar OX40L y ligando de tirosina quinasa 3 de tipo Fms de humano (hFlt3L) (MVA?C7L-hFlt3L-OX40L), un MVA que comprende una deleción de E5R (MVA?E5R), un virus vaccinia que comprende una deleción de C7L (VACV?C7L) diseñado para expresar OX40L (VACV?C7L-OX40L), un VACV?C7L diseñado para expresar tanto a OX40L como a hFlt3L (VACV?C7L-hFlt3L-OX40L), un VACV que comprende una deleción de E5R (VACV?E5R), un virus myxoma (MYXV) que comprende una deleción de M31R (MYXV?M31R), o combinaciones de los mismos, solo o en combinación con otros agentes, como una composición oncolítica e inmunoterapéutica.
MX2021003013A 2018-09-15 2019-09-16 Poxvirus recombinantes para inmunoterapia contra cáncer. MX2021003013A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862731876P 2018-09-15 2018-09-15
US201862767485P 2018-11-14 2018-11-14
US201962828975P 2019-04-03 2019-04-03
PCT/US2019/051343 WO2020056424A1 (en) 2018-09-15 2019-09-16 Recombinant poxviruses for cancer immunotherapy

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