MX2020009541A - Virus vaccinia oncolitico que expresa bloqueo de punto de control inmunologico para inmunoterapia de cancer. - Google Patents

Virus vaccinia oncolitico que expresa bloqueo de punto de control inmunologico para inmunoterapia de cancer.

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Publication number
MX2020009541A
MX2020009541A MX2020009541A MX2020009541A MX2020009541A MX 2020009541 A MX2020009541 A MX 2020009541A MX 2020009541 A MX2020009541 A MX 2020009541A MX 2020009541 A MX2020009541 A MX 2020009541A MX 2020009541 A MX2020009541 A MX 2020009541A
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Mexico
Prior art keywords
sup
e3lî
engineered
immune checkpoint
ctla
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MX2020009541A
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English (en)
Inventor
Jedd Wolchok
Wei Yan
Taha Merghoub
Liang Deng
Stewart Shuman
Weiyi Wang
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Memorial Sloan Kettering Cancer Center
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Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of MX2020009541A publication Critical patent/MX2020009541A/es

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/0011—Cancer antigens
    • A61K39/001136—Cytokines
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/507—Comprising a combination of two or more separate antibodies
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    • A61K2039/525—Virus
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
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    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24161—Methods of inactivation or attenuation
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    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24171—Demonstrated in vivo effect

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Abstract

En la presente solicitud se describen métodos y composiciones relacionados al tratamiento, prevención, y/o mejoría del cáncer en un individuo que lo necesite. En aspectos particulares, la presente tecnología se refiere al uso de Poxvirus, incluyendo una cepa de virus vaccinia (VACV) atenuado, diseñado que comprende una interrupción del dominio de unión a ADN N-terminal del gen E3L (E3L?83N) con una deleción de timidina quinasa (E3L?83N-TK-) diseñada para que exprese un anticuerpo que elige como blanco específicamente al antígeno de linfocito T citotóxico 4 (E3L?83N-TK--anti-CTLA-4), solo o en combinación con agentes bloqueadores de punto de control inmunológico o agentes inmunoestimuladores, como una composición oncolítica e inmunoterapéutica. En algunos aspectos, la presente tecnología se refiere a un virus E3L?83N-TK--anti-CTLA-4 diseñado adicionalmente para que exprese el ligando de tirosina quinasa 3 tipo Fms de humano (hFlt3L) (E3L?83N-TK--hFlt3Lanti-CTLA-4). En algunas modalidades, los virus diseñados se administran a un individuo, solos o en combinación con agentes bloqueadores de punto de control inmunológico o agentes inmunoestimuladores, como una composición oncolítica e inmunoterapéutica.
MX2020009541A 2018-03-13 2019-03-12 Virus vaccinia oncolitico que expresa bloqueo de punto de control inmunologico para inmunoterapia de cancer. MX2020009541A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862642565P 2018-03-13 2018-03-13
PCT/US2019/021853 WO2019178101A1 (en) 2018-03-13 2019-03-12 Oncolytic vaccinia virus expressing immune checkpoint blockade for cancer immunotherapy

Publications (1)

Publication Number Publication Date
MX2020009541A true MX2020009541A (es) 2021-01-08

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MX2020009541A MX2020009541A (es) 2018-03-13 2019-03-12 Virus vaccinia oncolitico que expresa bloqueo de punto de control inmunologico para inmunoterapia de cancer.

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US (1) US20210023151A1 (es)
EP (1) EP3765047A4 (es)
JP (1) JP7438122B2 (es)
KR (1) KR20200131863A (es)
CN (1) CN112088009A (es)
AU (1) AU2019234642A1 (es)
CA (1) CA3093696A1 (es)
MX (1) MX2020009541A (es)
SG (1) SG11202008589TA (es)
WO (1) WO2019178101A1 (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2954841A1 (en) * 2014-07-16 2016-01-21 Transgene Sa Oncolytic virus for expression of immune checkpoint modulators
EA201992755A1 (ru) 2017-05-19 2020-04-22 Уси Байолоджикс (Шанхай) Ко. Лтд. Новые моноклональные антитела к белку 4, ассоциированному с цитотоксическими т-лимфоцитами, (ctla-4)
BR112023002123A2 (pt) 2020-08-07 2023-03-07 Genentech Inc Proteína de fusão fc, ácidos nucleicos isolados, método de produção da proteína de fusão fc, formulação farmacêutica, métodos para expandir o número de células dendríticas (dcs) em um indivíduo e para tratar um câncer, proteína fc sem efetora e anticorpo
TW202321458A (zh) * 2021-09-22 2023-06-01 瑞典商生物創新國際公司 新穎抗體組合及其用途
CN114533862B (zh) * 2022-01-06 2024-04-26 南昌大学 一种鱼用dna疫苗及其制备方法与应用

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SG11201509595PA (en) * 2013-05-28 2015-12-30 Dcb Usa Llc Antibody locker for the inactivation of protein drug
CA2954841A1 (en) * 2014-07-16 2016-01-21 Transgene Sa Oncolytic virus for expression of immune checkpoint modulators
CN115300622A (zh) * 2015-02-25 2022-11-08 纪念斯隆-凯特琳癌症中心 使用灭活的修饰的痘苗病毒安卡拉作为实体肿瘤的单一免疫疗法或与免疫检查点阻断剂组合
JP7025339B2 (ja) * 2016-02-25 2022-02-24 メモリアル スローン ケタリング キャンサー センター 癌免疫療法のための、チミジンキナーゼの欠失を伴い、ヒトｆｌｔ３ｌまたはｇｍ－ｃｓｆの発現を伴うかまたは伴わない、複製可能な弱毒化ワクシニアウイルス
SG11201807022XA (en) * 2016-02-25 2018-09-27 Memorial Sloan Kettering Cancer Center Recombinant mva or mvadele3l expressing human flt3l and use thereof as immuno-therapeutic agents against solid tumors
GB201612520D0 (en) * 2016-07-19 2016-08-31 F-Star Beta Ltd Binding molecules

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Publication number Publication date
CN112088009A (zh) 2020-12-15
CA3093696A1 (en) 2019-09-19
EP3765047A1 (en) 2021-01-20
SG11202008589TA (en) 2020-10-29
WO2019178101A1 (en) 2019-09-19
EP3765047A4 (en) 2022-01-12
JP7438122B2 (ja) 2024-02-26
JP2021517814A (ja) 2021-07-29
KR20200131863A (ko) 2020-11-24
AU2019234642A1 (en) 2020-09-24
US20210023151A1 (en) 2021-01-28

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