JP2010533872A5 - - Google Patents
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- JP2010533872A5 JP2010533872A5 JP2010517171A JP2010517171A JP2010533872A5 JP 2010533872 A5 JP2010533872 A5 JP 2010533872A5 JP 2010517171 A JP2010517171 A JP 2010517171A JP 2010517171 A JP2010517171 A JP 2010517171A JP 2010533872 A5 JP2010533872 A5 JP 2010533872A5
- Authority
- JP
- Japan
- Prior art keywords
- aptamer
- target molecule
- tag
- minutes
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108091023037 Aptamer Proteins 0.000 claims 36
- 238000000034 method Methods 0.000 claims 33
- 239000007787 solid Substances 0.000 claims 17
- 239000000523 sample Substances 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 10
- 239000011324 bead Substances 0.000 claims 9
- 239000003153 chemical reaction reagent Substances 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 238000012360 testing method Methods 0.000 claims 4
- 210000001519 tissue Anatomy 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 3
- 239000000975 dye Substances 0.000 claims 3
- 150000004676 glycans Chemical class 0.000 claims 3
- 229920001282 polysaccharide Polymers 0.000 claims 3
- 239000005017 polysaccharide Substances 0.000 claims 3
- 238000000638 solvent extraction Methods 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 108090001008 Avidin Proteins 0.000 claims 2
- 108091093037 Peptide nucleic acid Proteins 0.000 claims 2
- 239000004793 Polystyrene Substances 0.000 claims 2
- 238000001190 Q-PCR Methods 0.000 claims 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 2
- 108010090804 Streptavidin Proteins 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 238000007385 chemical modification Methods 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 239000007850 fluorescent dye Substances 0.000 claims 2
- 239000011521 glass Substances 0.000 claims 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 108010087904 neutravidin Proteins 0.000 claims 2
- 229920001542 oligosaccharide Polymers 0.000 claims 2
- 150000002482 oligosaccharides Chemical class 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 229920002223 polystyrene Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 229910052710 silicon Inorganic materials 0.000 claims 2
- 239000010703 silicon Substances 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical group OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 claims 1
- 208000035657 Abasia Diseases 0.000 claims 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- 229920000936 Agarose Polymers 0.000 claims 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- 102000006306 Antigen Receptors Human genes 0.000 claims 1
- 108010083359 Antigen Receptors Proteins 0.000 claims 1
- JBRZTFJDHDCESZ-UHFFFAOYSA-N AsGa Chemical compound [As]#[Ga] JBRZTFJDHDCESZ-UHFFFAOYSA-N 0.000 claims 1
- 241000972773 Aulopiformes Species 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 229910001218 Gallium arsenide Inorganic materials 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- 239000004677 Nylon Substances 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims 1
- 210000004381 amniotic fluid Anatomy 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 229960000633 dextran sulfate Drugs 0.000 claims 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000007613 environmental effect Effects 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 229910052732 germanium Inorganic materials 0.000 claims 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims 1
- 230000000762 glandular Effects 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229940094991 herring sperm dna Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000009830 intercalation Methods 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 150000002739 metals Chemical class 0.000 claims 1
- 239000011325 microbead Substances 0.000 claims 1
- 230000003278 mimic effect Effects 0.000 claims 1
- 210000002445 nipple Anatomy 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 230000035764 nutrition Effects 0.000 claims 1
- 229920001778 nylon Polymers 0.000 claims 1
- 230000005298 paramagnetic effect Effects 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 150000004713 phosphodiesters Chemical class 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229920000447 polyanionic polymer Polymers 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 239000002096 quantum dot Substances 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 235000019515 salmon Nutrition 0.000 claims 1
- 210000000582 semen Anatomy 0.000 claims 1
- 229910052709 silver Inorganic materials 0.000 claims 1
- 239000004332 silver Substances 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 210000001179 synovial fluid Anatomy 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95028107P | 2007-07-17 | 2007-07-17 | |
| US95029307P | 2007-07-17 | 2007-07-17 | |
| US95028307P | 2007-07-17 | 2007-07-17 | |
| US60/950,293 | 2007-07-17 | ||
| US60/950,281 | 2007-07-17 | ||
| US60/950,283 | 2007-07-17 | ||
| US3142008P | 2008-02-26 | 2008-02-26 | |
| US61/031,420 | 2008-02-26 | ||
| US5159408P | 2008-05-08 | 2008-05-08 | |
| US61/051,594 | 2008-05-08 | ||
| PCT/US2008/070386 WO2009012420A1 (en) | 2007-07-17 | 2008-07-17 | Multiplexed analyses of test samples |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013220095A Division JP5956404B2 (ja) | 2007-07-17 | 2013-10-23 | 試験試料の多重化分析 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010533872A JP2010533872A (ja) | 2010-10-28 |
| JP2010533872A5 true JP2010533872A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2011-07-28 |
| JP5404620B2 JP5404620B2 (ja) | 2014-02-05 |
Family
ID=40260081
Family Applications (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517171A Active JP5404620B2 (ja) | 2007-07-17 | 2008-07-17 | 試験試料の多重化分析 |
| JP2010517170A Active JP5684568B2 (ja) | 2007-07-17 | 2008-07-17 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2013220095A Active JP5956404B2 (ja) | 2007-07-17 | 2013-10-23 | 試験試料の多重化分析 |
| JP2014203867A Active JP5938080B2 (ja) | 2007-07-17 | 2014-10-02 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2016028563A Active JP6491610B2 (ja) | 2007-07-17 | 2016-02-18 | 試験試料の多重化分析 |
| JP2016095782A Active JP6407195B2 (ja) | 2007-07-17 | 2016-05-12 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2018165689A Pending JP2019004901A (ja) | 2007-07-17 | 2018-09-05 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2018206262A Pending JP2019039929A (ja) | 2007-07-17 | 2018-11-01 | 試験試料の多重化分析 |
| JP2020009000A Withdrawn JP2020078311A (ja) | 2007-07-17 | 2020-01-23 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2021081339A Active JP7303244B2 (ja) | 2007-07-17 | 2021-05-13 | 改善されたオフ速度（ｏｆｆ－ｒａｔｅ）を持つアプタマーを生成するための方法 |
Family Applications After (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517170A Active JP5684568B2 (ja) | 2007-07-17 | 2008-07-17 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2013220095A Active JP5956404B2 (ja) | 2007-07-17 | 2013-10-23 | 試験試料の多重化分析 |
| JP2014203867A Active JP5938080B2 (ja) | 2007-07-17 | 2014-10-02 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2016028563A Active JP6491610B2 (ja) | 2007-07-17 | 2016-02-18 | 試験試料の多重化分析 |
| JP2016095782A Active JP6407195B2 (ja) | 2007-07-17 | 2016-05-12 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2018165689A Pending JP2019004901A (ja) | 2007-07-17 | 2018-09-05 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2018206262A Pending JP2019039929A (ja) | 2007-07-17 | 2018-11-01 | 試験試料の多重化分析 |
| JP2020009000A Withdrawn JP2020078311A (ja) | 2007-07-17 | 2020-01-23 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2021081339A Active JP7303244B2 (ja) | 2007-07-17 | 2021-05-13 | 改善されたオフ速度（ｏｆｆ－ｒａｔｅ）を持つアプタマーを生成するための方法 |
Country Status (17)
Families Citing this family (135)
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| EP2172566B2 (en) * | 2007-07-17 | 2022-05-18 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US8404830B2 (en) * | 2007-07-17 | 2013-03-26 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US8314052B2 (en) * | 2009-03-23 | 2012-11-20 | Base Pair Biotechnologies, Inc. | Methods for simultaneous generation of functional ligands |
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| US9464319B2 (en) | 2009-03-24 | 2016-10-11 | California Institute Of Technology | Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes |
| CN104722342B (zh) | 2009-03-24 | 2017-01-11 | 芝加哥大学 | 滑动式芯片装置和方法 |
| US8569252B2 (en) * | 2009-04-15 | 2013-10-29 | Postech Academy-Industry Foundation | Nucleolin specific aptamer and use thereof |
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| CN102912020B (zh) * | 2012-10-20 | 2014-02-19 | 江南大学 | 一种测定赭曲霉毒素a的适配体传感器的构建方法 |
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