|
PE20090717A1
(es)
|
2007-05-18 |
2009-07-18 |
Smithkline Beecham Corp |
Derivados de quinolina como inhibidores de la pi3 quinasa
|
|
ES2401557T3
(es)
|
2007-08-02 |
2013-04-22 |
Amgen, Inc |
Moduladores de Pl3 cinasas y métodos de uso
|
|
JP2011500823A
(ja)
*
|
2007-10-22 |
2011-01-06 |
グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー |
Ｐｉ３キナーゼ阻害物質としてのピリドスルホンアミド誘導体
|
|
US7820665B2
(en)
|
2007-12-19 |
2010-10-26 |
Amgen Inc. |
Imidazopyridazine inhibitors of PI3 kinase for cancer treatment
|
|
WO2009155121A2
(en)
|
2008-05-30 |
2009-12-23 |
Amgen Inc. |
Inhibitors of pi3 kinase
|
|
JPWO2009157196A1
(ja)
*
|
2008-06-25 |
2011-12-08 |
武田薬品工業株式会社 |
アミド化合物
|
|
US8735424B2
(en)
|
2008-09-02 |
2014-05-27 |
Novartis Ag |
Bicyclic kinase inhibitors
|
|
EP2370424A1
(en)
|
2008-11-10 |
2011-10-05 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
WO2010059549A1
(en)
*
|
2008-11-18 |
2010-05-27 |
Glaxosmithkline Llc |
Prolyl hydroxylase inhibitors
|
|
EP2376485B1
(en)
|
2008-12-19 |
2017-12-06 |
Vertex Pharmaceuticals Incorporated |
Pyrazine derivatives useful as inhibitors of atr kinase
|
|
RU2505539C2
(ru)
*
|
2008-12-23 |
2014-01-27 |
Эбботт Лэборетриз |
Антивирусные соединения
|
|
US8541424B2
(en)
|
2008-12-23 |
2013-09-24 |
Abbott Laboratories |
Anti-viral compounds
|
|
WO2010083436A1
(en)
|
2009-01-15 |
2010-07-22 |
Rutgers, The State University Of New Jersey |
Benzo [c] phenanthridines as antimicrobial agents
|
|
HUE027964T2
(en)
|
2009-04-02 |
2016-11-28 |
Fund Centro Nac De Investig Oncologicas Carlos Iii |
Imidazo [2,1-b] [1,3,4] thiadiazole derivatives
|
|
JP5734956B2
(ja)
|
2009-04-15 |
2015-06-17 |
アッヴィ・インコーポレイテッド |
抗ウィルス化合物
|
|
WO2010127307A1
(en)
|
2009-04-30 |
2010-11-04 |
Rutgers, The State University Of New Jersey |
Antimicrobial agents
|
|
WO2010130796A1
(en)
|
2009-05-15 |
2010-11-18 |
Novartis Ag |
Aryl pyridine as aldosterone synthase inhibitors
|
|
WO2010135568A1
(en)
|
2009-05-22 |
2010-11-25 |
Exelixis, Inc. |
Benzoxazepines as inhibitors of mtor and their use to treat cancer
|
|
CA2765819A1
(en)
*
|
2009-06-25 |
2010-12-29 |
Amgen Inc. |
Heterocyclic compounds and their uses as inhibitors of pi3 k activity
|
|
UA111579C2
(uk)
|
2009-08-17 |
2016-05-25 |
Інтеллікіне Ллк |
ГЕТЕРОЦИКЛІЧНІ ПОХІДНІ 2-АМІНОБЕНЗО[d]ОКСАЗОЛУ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЇХ ОСНОВІ ТА ЇХ ЗАСТОСУВАННЯ ДЛЯ ЛІКУВАННЯ ЗАХВОРЮВАННЯ, ПОВ'АНОГО З РІ3-КІНАЗОЮ
|
|
WO2011021678A1
(ja)
*
|
2009-08-21 |
2011-02-24 |
武田薬品工業株式会社 |
縮合複素環化合物
|
|
PT3575288T
(pt)
|
2009-09-03 |
2021-12-09 |
Bristol Myers Squibb Co |
Quinazolinas como inibidores dos canais iónicos de potássio
|
|
SG179085A1
(en)
*
|
2009-09-09 |
2012-04-27 |
Avila Therapeutics Inc |
Pi3 kinase inhibitors and uses thereof
|
|
AU2010295690B2
(en)
|
2009-09-16 |
2016-07-28 |
Celgene Avilomics Research, Inc. |
Protein kinase conjugates and inhibitors
|
|
EA201270475A1
(ru)
|
2009-09-28 |
2012-11-30 |
ГЛЭКСОСМИТКЛАЙН ЭлЭлСи |
Комбинация
|
|
JP2013507442A
(ja)
*
|
2009-10-12 |
2013-03-04 |
グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー |
組合せ
|
|
WO2011051958A1
(en)
|
2009-10-30 |
2011-05-05 |
E.I. Du Pont De Nemours And Company |
Fungicidal pyrazolones
|
|
KR20130067487A
(ko)
|
2009-12-30 |
2013-06-25 |
아빌라 테라퓨틱스, 인크. |
단백질의 리간드-지정 공유 변형
|
|
US8962631B2
(en)
|
2010-05-12 |
2015-02-24 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
EP2569284B1
(en)
|
2010-05-12 |
2015-07-08 |
Vertex Pharmaceuticals Incorporated |
2-aminopyridine derivatives useful as inhibitors of atr kinase
|
|
WO2011143399A1
(en)
|
2010-05-12 |
2011-11-17 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
JP2013526540A
(ja)
|
2010-05-12 |
2013-06-24 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Ａｔｒキナーゼ阻害剤として有用な化合物
|
|
EP2569286B1
(en)
|
2010-05-12 |
2014-08-20 |
Vertex Pharmaceuticals Inc. |
Compounds useful as inhibitors of atr kinase
|
|
KR20130066633A
(ko)
|
2010-05-12 |
2013-06-20 |
버텍스 파마슈티칼스 인코포레이티드 |
Ａｔｒ 키나제의 억제제로서 유용한 화합물
|
|
WO2011156626A1
(en)
|
2010-06-09 |
2011-12-15 |
Rutgers, The State University Of New Jersey |
Antimicrobial agents
|
|
WO2011163527A1
(en)
|
2010-06-23 |
2011-12-29 |
Vertex Pharmaceuticals Incorporated |
Pyrrolo- pyrazine derivatives useful as inhibitors of atr kinase
|
|
US9102617B2
(en)
|
2010-06-25 |
2015-08-11 |
Rutgers, The State University Of New Jersey |
Antimicrobial agents
|
|
SG10201505951VA
(en)
*
|
2010-07-30 |
2015-08-28 |
Oncotherapy Science Inc |
Quinoline derivatives and melk inhibitors containing the same
|
|
JP2013536192A
(ja)
*
|
2010-08-09 |
2013-09-19 |
グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー |
組み合わせ
|
|
EP2640366A2
(en)
|
2010-11-15 |
2013-09-25 |
Exelixis, Inc. |
Benzoxazepines as inhibitors of pi3k/mtor and methods of their use and manufacture
|
|
EP2640367A2
(en)
|
2010-11-15 |
2013-09-25 |
Exelixis, Inc. |
Benzoxazepines as inhibitors of pi3k/mtor and methods of their use and manufacture
|
|
JP2013545756A
(ja)
*
|
2010-11-16 |
2013-12-26 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー２、リミテッド |
投与および治療方法
|
|
CA2818544A1
(en)
*
|
2010-11-19 |
2012-05-24 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Method of treatment with braf inhibitor
|
|
WO2012071509A2
(en)
|
2010-11-24 |
2012-05-31 |
Exelixis, Inc. |
Benzoxazepines as inhibitors of p13k/mtor and methods of their use and manufacture
|
|
EP2678016B1
(en)
*
|
2011-02-23 |
2016-08-10 |
Intellikine, LLC |
Heterocyclic compounds and uses thereof
|
|
SG192769A1
(en)
|
2011-03-04 |
2013-09-30 |
Glaxosmithkline Ip No 2 Ltd |
Amino-quinolines as kinase inhibitors
|
|
US9051305B2
(en)
|
2011-03-08 |
2015-06-09 |
Eutropics Pharmaceuticals, Inc. |
Compositions and methods useful for treating diseases
|
|
CN102718745A
(zh)
*
|
2011-03-30 |
2012-10-10 |
中国科学院上海药物研究所 |
新型胺基吡啶类化合物、其制备方法、包含此类化合物的药物组合物及其用途
|
|
WO2012138938A1
(en)
|
2011-04-05 |
2012-10-11 |
Vertex Pharmaceuticals Incorporated |
Aminopyrazine compounds useful as inhibitors of tra kinase
|
|
EA201391606A1
(ru)
*
|
2011-04-29 |
2016-01-29 |
Экселиксис, Инк. |
Способ лечения лимфомы посредством пиридопиримидиноновых ингибиторов pi3k/mtor
|
|
US9309250B2
(en)
|
2011-06-22 |
2016-04-12 |
Vertex Pharmaceuticals Incorporated |
Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors
|
|
US9096602B2
(en)
|
2011-06-22 |
2015-08-04 |
Vertex Pharmaceuticals Incorporated |
Substituted pyrrolo[2,3-B]pyrazines as ATR kinase inhibitors
|
|
US8822469B2
(en)
|
2011-06-22 |
2014-09-02 |
Vertex Pharmaceuticals Incorporated |
Pyrrolo[2,3-B]pyrazines useful as inhibitors of ATR kinase
|
|
TWI547494B
(zh)
|
2011-08-18 |
2016-09-01 |
葛蘭素史克智慧財產發展有限公司 |
作為激酶抑制劑之胺基喹唑啉類
|
|
US8853217B2
(en)
|
2011-09-30 |
2014-10-07 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
IN2014KN00943A
(enExample)
|
2011-09-30 |
2015-08-21 |
Vertex Pharma |
|
|
CN103987709B
(zh)
|
2011-09-30 |
2016-09-28 |
沃泰克斯药物股份有限公司 |
用于制备可用作atr激酶抑制剂的化合物的方法
|
|
EP2751088B1
(en)
|
2011-09-30 |
2016-04-13 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
BR112014007690B1
(pt)
|
2011-09-30 |
2022-10-04 |
Vertex Pharmaceuticals Incorporated |
Usos de inibidores de atr no tratamento de câncer pancreático e câncer de pulmão de células não pequenas
|
|
BR112014010644A2
(pt)
|
2011-11-04 |
2017-04-25 |
Hoffmann La Roche |
novos derivados de aril-quinolina
|
|
WO2013071094A1
(en)
|
2011-11-09 |
2013-05-16 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
WO2013071090A1
(en)
|
2011-11-09 |
2013-05-16 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
US8841449B2
(en)
|
2011-11-09 |
2014-09-23 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
US8846917B2
(en)
|
2011-11-09 |
2014-09-30 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
WO2013071093A1
(en)
|
2011-11-09 |
2013-05-16 |
Vertex Pharmaceuticals Incorporated |
Pyrazine compounds useful as inhibitors of atr kinase
|
|
PL2790705T3
(pl)
|
2011-12-15 |
2018-06-29 |
Novartis Ag |
Zastosowanie inhibitorów czynności lub funkcji PI3K
|
|
WO2013106756A2
(en)
|
2012-01-13 |
2013-07-18 |
Rutgers, The State University Of New Jersey |
Antimicrobial agents
|
|
CA2861496A1
(en)
*
|
2012-02-06 |
2013-08-15 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Pi3k inhibitors for treating cough
|
|
CN104093408A
(zh)
*
|
2012-02-06 |
2014-10-08 |
葛兰素史克知识产权第二有限公司 |
用于治疗纤维化疾病的pi3k抑制剂
|
|
EP2828245A1
(en)
|
2012-03-21 |
2015-01-28 |
Rutgers, The State University of New Jersey |
Antimicrobial agents
|
|
EP3311816A1
(en)
|
2012-04-05 |
2018-04-25 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase for the treatment of cancer
|
|
US20150133450A1
(en)
|
2012-06-20 |
2015-05-14 |
Eutropics Pharmaceuticals, Inc. |
Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives
|
|
TWI592417B
(zh)
|
2012-09-13 |
2017-07-21 |
葛蘭素史克智慧財產發展有限公司 |
胺基喹唑啉激酶抑制劑之前藥
|
|
AR092530A1
(es)
|
2012-09-13 |
2015-04-22 |
Glaxosmithkline Llc |
Compuesto de amino-quinolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento
|
|
CN103497177B
(zh)
*
|
2012-09-29 |
2017-03-22 |
天津滨江药物研发有限公司 |
作为c‑Met抑制剂的氨基芳香杂环类化合物及其制备方法
|
|
US8999632B2
(en)
|
2012-10-04 |
2015-04-07 |
Vertex Pharmaceuticals Incorporated |
Method for measuring ATR inhibition mediated increases in DNA damage
|
|
EP2909202A1
(en)
|
2012-10-16 |
2015-08-26 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
CN103788071A
(zh)
*
|
2012-11-01 |
2014-05-14 |
中国人民解放军第二军医大学 |
N-(5-(喹啉-6-基)吡啶-3-基)苯磺酰胺衍生物、制备方法及治疗用途
|
|
US20160038503A1
(en)
|
2012-11-21 |
2016-02-11 |
David Richard |
Methods and compositions useful for treating diseases involving bcl-2 family proteins with isoquinoline and quinoline derivatives
|
|
PL3808749T3
(pl)
|
2012-12-07 |
2023-07-10 |
Vertex Pharmaceuticals Incorporated |
Pirazolo[1,5-a]pirymidyny użyteczne jako inhibitory kinazy atr do leczenia chorób nowotworowych
|
|
JP6301374B2
(ja)
|
2013-02-21 |
2018-03-28 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ |
キナーゼ阻害剤としてのキナゾリン類
|
|
JP2016512815A
(ja)
|
2013-03-15 |
2016-05-09 |
バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ |
Ａｔｒキナーゼの阻害剤として有用な縮合ピラゾロピリミジン誘導体
|
|
CN104098542A
(zh)
*
|
2013-04-11 |
2014-10-15 |
苏州朗信医药科技有限公司 |
一种6-溴代-4-(4-吡嗪基)喹啉的制备方法
|
|
WO2015017788A1
(en)
|
2013-08-01 |
2015-02-05 |
Eutropics Pharmaceuticals, Inc. |
Method for predicting cancer sensitivity
|
|
CN104418858B
(zh)
|
2013-08-30 |
2018-12-11 |
浙江医药股份有限公司新昌制药厂 |
2,6-二含氮取代的嘌呤衍生物及其制备方法和其药物组合物与应用
|
|
US9657007B2
(en)
|
2013-09-22 |
2017-05-23 |
Calitor Sciences, Llc |
Substituted aminopyrimidine compounds and methods of use
|
|
CN104557955B
(zh)
*
|
2013-10-23 |
2017-05-03 |
上海汇伦生命科技有限公司 |
作为PI3K/mTOR抑制剂的三环类化合物，其制备方法和用途
|
|
WO2015066305A1
(en)
|
2013-10-30 |
2015-05-07 |
Eutropics Pharmaceuticals, Inc. |
Methods for determining chemosensitivity and chemotoxicity
|
|
US9458150B2
(en)
|
2013-11-08 |
2016-10-04 |
Rutgers, The State University Of New Jersey |
Antimicrobial agents
|
|
AU2014354711B2
(en)
*
|
2013-11-27 |
2018-10-25 |
Signalchem Lifesciences Corporation |
Aminopyridine derivatives as TAM family kinase inhibitors
|
|
PL3077397T3
(pl)
|
2013-12-06 |
2020-04-30 |
Vertex Pharmaceuticals Inc. |
Związek 2-amino-6-fluoro-n-[5-fluoro-pirydyn-3-ylo]pyrazolo [1,5-a]pirymidino-3-karboksamidu przydatny jako inhibitor kinazy atr, jego wytwarzanie, różne postacie stałe i ich radioznakowane pochodne
|
|
ES2921874T3
(es)
|
2014-02-28 |
2022-09-01 |
Nimbus Lakshmi Inc |
Inhibidores de TYK2 y usos de los mismos
|
|
CN104922116B
(zh)
*
|
2014-03-23 |
2020-08-11 |
上海诗丹德生物技术有限公司 |
甲基丙烯酰基苯并咪唑酮衍生物的用途
|
|
NO2714752T3
(enExample)
*
|
2014-05-08 |
2018-04-21 |
|
|
|
SG10201902206QA
(en)
|
2014-06-05 |
2019-04-29 |
Vertex Pharma |
Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof
|
|
EP3159342B1
(en)
|
2014-06-17 |
2020-08-05 |
Cisen Pharmaceutical Co., Ltd. |
Pyridino[1,2-a]pyrimidone analogue used as mtor/pi3k inhibitor
|
|
PT3157566T
(pt)
|
2014-06-17 |
2019-07-11 |
Vertex Pharma |
Método para tratamento de cancro utilizando uma combinação de inibidores chk1 e atr
|
|
EP4578865A3
(en)
|
2014-08-12 |
2025-07-30 |
Monash University |
Lymph directing prodrugs
|
|
CN105330699B
(zh)
*
|
2014-08-13 |
2018-12-04 |
山东汇睿迪生物技术有限公司 |
一种含磷吡啶并[2,3-d]嘧啶-7-酮类化合物或其药学上可接受的盐、药物组合物及其应用
|
|
DK3180315T3
(da)
|
2014-08-15 |
2020-04-06 |
Janssen Pharmaceuticals Inc |
Pyrazoler
|
|
ES2791186T3
(es)
|
2014-08-15 |
2020-11-03 |
Janssen Pharmaceuticals Inc |
Triazoles como inhibidores de receptores NR2B
|
|
CA3220466A1
(en)
|
2014-10-29 |
2016-05-06 |
Bicyclerd Limited |
Bicyclic peptide ligands specific for mt1-mmp
|
|
ES2930585T3
(es)
|
2015-02-27 |
2022-12-19 |
Nimbus Lakshmi Inc |
Inhibidores de TYK2 y usos de los mismos
|
|
FR3033499A1
(fr)
|
2015-03-11 |
2016-09-16 |
Centre Leon-Berard |
Composition pour le traitement des tumeurs neuroendocrines pancreatiques
|
|
CN104961725B
(zh)
*
|
2015-06-18 |
2017-04-19 |
浙江大学 |
4‑α,β不饱和酰胺基喹啉类化合物及制备和应用
|
|
WO2017004134A1
(en)
|
2015-06-29 |
2017-01-05 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
|
PL3319963T3
(pl)
|
2015-07-09 |
2020-06-01 |
Janssen Pharmaceutica Nv |
Podstawione 4-azaindole i ich zastosowanie jako modulatorów receptora GluN2B
|
|
WO2017019828A1
(en)
*
|
2015-07-30 |
2017-02-02 |
Bristol-Myers Squibb Company |
Aryl substituted bicyclic heteroaryl compounds
|
|
WO2017027768A1
(en)
*
|
2015-08-13 |
2017-02-16 |
The Broad Institute, Inc. |
Compositions and methods for treating tuberculosis
|
|
US10023571B2
(en)
|
2015-09-02 |
2018-07-17 |
Nimbus Lakshimi, Inc. |
TYK2 inhibitors and uses thereof
|
|
CN108137482B
(zh)
|
2015-09-08 |
2024-03-15 |
莫纳什大学 |
定向淋巴的前药
|
|
WO2017044720A1
(en)
|
2015-09-11 |
2017-03-16 |
Navitor Pharmaceuticals, Inc. |
Rapamycin analogs and uses thereof
|
|
GB201516504D0
(en)
|
2015-09-17 |
2015-11-04 |
Astrazeneca Ab |
Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
|
|
RU2768621C1
(ru)
|
2015-09-30 |
2022-03-24 |
Вертекс Фармасьютикалз Инкорпорейтед |
Способ лечения рака с использованием комбинации повреждающих днк средств и ингибиторов atr
|
|
SI3364958T1
(sl)
|
2015-10-23 |
2023-05-31 |
Navitor Pharmaceuticals, Inc. |
Modulatorji interakcije sestrina in gator2 ter njihova uporaba
|
|
WO2017106352A1
(en)
|
2015-12-14 |
2017-06-22 |
Raze Therapeutics, Inc. |
Caffeine inhibitors of mthfd2 and uses thereof
|
|
TWI713655B
(zh)
*
|
2015-12-16 |
2020-12-21 |
大陸商上海嘉坦醫藥科技有限公司 |
吡啶並[1,2-a]嘧啶酮類似物的晶型及其製備方法和中間體
|
|
US10071988B2
(en)
|
2016-02-10 |
2018-09-11 |
Janssen Pharmaceutica Nv |
Substituted 1,2,3-triazoles as NR2B-selective NMDA modulators
|
|
CA3015768A1
(en)
|
2016-02-25 |
2017-08-31 |
Taxis Pharmaceuticals, Inc. |
Synthetic processes and intermediates
|
|
EP4234552A3
(en)
|
2016-03-09 |
2023-10-18 |
Raze Therapeutics, Inc. |
3-phosphoglycerate dehydrogenase inhibitors and uses thereof
|
|
PL3426243T3
(pl)
|
2016-03-09 |
2021-10-04 |
Raze Therapeutics, Inc. |
Inhibitory dehydrogenazy 3-fosfoglicerynianowej i ich zastosowania
|
|
WO2017177230A1
(en)
|
2016-04-08 |
2017-10-12 |
X4 Pharmaceuticals, Inc. |
Methods for treating cancer
|
|
CN109640988A
(zh)
|
2016-06-21 |
2019-04-16 |
X4 制药有限公司 |
Cxcr4抑制剂及其用途
|
|
CA3027500A1
(en)
|
2016-06-21 |
2017-12-28 |
X4 Pharmaceuticals, Inc. |
Cxcr4 inhibitors and uses thereof
|
|
EP3808748A1
(en)
|
2016-06-21 |
2021-04-21 |
X4 Pharmaceuticals, Inc. |
Substituted piperidines as cxcr4-inhibitors
|
|
US10154992B2
(en)
*
|
2016-07-12 |
2018-12-18 |
The Regents Of The University Of California |
Compounds and methods for treating HIV infection
|
|
ES2925211T3
(es)
*
|
2016-08-16 |
2022-10-14 |
Merck Patent Gmbh |
2-oxo-imidazopiridinas como inhibidores de BTK reversibles y usos de las mismas
|
|
TW201819376A
(zh)
|
2016-10-06 |
2018-06-01 |
比利時商健生藥品公司 |
經取代之１Ｈ－咪唑並［４，５－ｂ］吡啶－２（３Ｈ）－酮及其作為ＧＬＵＮ２Ｂ受體調節劑之用途
|
|
TWI825663B
(zh)
|
2016-10-14 |
2023-12-11 |
美商林伯士拉克許米公司 |
Tyk2抑制劑及其用途
|
|
EP3528816A4
(en)
|
2016-10-21 |
2020-04-08 |
Nimbus Lakshmi, Inc. |
TYK2 INHIBITORS AND USES THEREOF
|
|
WO2018089499A1
(en)
|
2016-11-08 |
2018-05-17 |
Navitor Pharmaceuticals, Inc. |
PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF
|
|
CN106580986B
(zh)
*
|
2016-11-28 |
2017-09-15 |
王保亮 |
一种治疗少弱精子症的药物组合物
|
|
JP2019535839A
(ja)
|
2016-11-29 |
2019-12-12 |
ピュアテック ヘルス エルエルシー |
治療剤の送達のためのエクソソーム
|
|
WO2018106636A1
(en)
|
2016-12-05 |
2018-06-14 |
Raze Therapeutics, Inc. |
Shmt inhibitors and uses thereof
|
|
US20180153922A1
(en)
|
2016-12-06 |
2018-06-07 |
New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery |
Inhibition of expansion and function of pathogenic age-associated b cells and use for the prevention and treatment of autoimmune disease
|
|
US11730819B2
(en)
|
2016-12-23 |
2023-08-22 |
Bicycletx Limited |
Peptide derivatives having novel linkage structures
|
|
CA3048546A1
(en)
*
|
2016-12-26 |
2018-07-05 |
Institute Of Materia Medica, Chinese Academy Of Medical Sciences |
Quinazoline compound and preparation method, application, and pharmaceutical compostion thereof
|
|
EP3565638B8
(en)
|
2017-01-06 |
2024-04-10 |
BicycleRD Limited |
Bicycle conjugate for treating cancer
|
|
US10336752B2
(en)
|
2017-03-08 |
2019-07-02 |
Nimbus Lakshmi, Inc. |
TYK2 inhibitors, uses, and methods for production thereof
|
|
EP3375778A1
(en)
|
2017-03-14 |
2018-09-19 |
Artax Biopharma Inc. |
Aryl-piperidine derivatives
|
|
EP3375784A1
(en)
|
2017-03-14 |
2018-09-19 |
Artax Biopharma Inc. |
Aza-dihydro-acridone derivatives
|
|
EP3600298A4
(en)
|
2017-03-30 |
2020-11-11 |
Taxis Pharmaceuticals, Inc. |
SYNTHESIS AND SYNTHESIS INTERMEDIARIES
|
|
WO2018191146A1
(en)
|
2017-04-10 |
2018-10-18 |
Navitor Pharmaceuticals, Inc. |
Heteroaryl rheb inhibitors and uses thereof
|
|
WO2018200625A1
(en)
|
2017-04-26 |
2018-11-01 |
Navitor Pharmaceuticals, Inc. |
Modulators of sestrin-gator2 interaction and uses thereof
|
|
EP3615550A1
(en)
|
2017-04-27 |
2020-03-04 |
BicycleTx Limited |
Bicyclic peptide ligands and uses thereof
|
|
CN110914265B
(zh)
*
|
2017-05-15 |
2022-12-23 |
密歇根大学董事会 |
作为lsd-1抑制剂的吡咯并[2,3-c]吡啶和相关类似物
|
|
EP3645549A1
(en)
|
2017-06-26 |
2020-05-06 |
BicycleRD Limited |
Bicyclic peptide ligands with detectable moieties and uses thereof
|
|
MY205416A
(en)
|
2017-07-28 |
2024-10-21 |
Takeda Pharmaceuticals Co |
Tyk2 inhibitors and uses thereof
|
|
US11261214B2
(en)
|
2017-08-04 |
2022-03-01 |
Bicycletx Limited |
Bicyclic peptide ligand specific for CD137
|
|
US20200291096A1
(en)
|
2017-08-14 |
2020-09-17 |
Bicyclerd Limited |
Bicyclic peptide ligand sting conjugates and uses thereof
|
|
EP3668550A1
(en)
|
2017-08-14 |
2020-06-24 |
Bicyclerd Limited |
Bicyclic peptide ligand prr-a conjugates and uses thereof
|
|
EP4306524A3
(en)
|
2017-08-29 |
2024-09-11 |
PureTech LYT, Inc. |
Lymphatic system-directing lipid prodrugs
|
|
US11883497B2
(en)
|
2017-08-29 |
2024-01-30 |
Puretech Lyt, Inc. |
Lymphatic system-directing lipid prodrugs
|
|
EP3684365A4
(en)
|
2017-09-22 |
2021-09-08 |
Kymera Therapeutics, Inc. |
PROTEIN DEGRADATION AGENTS AND USES OF SUCH
|
|
EP3684366A4
(en)
|
2017-09-22 |
2021-09-08 |
Kymera Therapeutics, Inc. |
CRBN LIGANDS AND USES OF THE LATEST
|
|
CN107793404A
(zh)
*
|
2017-11-07 |
2018-03-13 |
全椒先奇医药科技有限公司 |
一种治疗缺血性脑损伤药物组合物及其应用
|
|
GB201721265D0
(en)
|
2017-12-19 |
2018-01-31 |
Bicyclerd Ltd |
Bicyclic peptide ligands specific for EphA2
|
|
US11304954B2
(en)
|
2017-12-19 |
2022-04-19 |
Puretech Lyt, Inc. |
Lipid prodrugs of mycophenolic acid and uses thereof
|
|
US11608345B1
(en)
|
2017-12-19 |
2023-03-21 |
Puretech Lyt, Inc. |
Lipid prodrugs of rapamycin and its analogs and uses thereof
|
|
EP3727362A4
(en)
|
2017-12-19 |
2021-10-06 |
PureTech LYT, Inc. |
MYCOPHENOLIC ACID LIPID MEDICINAL PRODUCTS AND THEIR USES
|
|
TWI825046B
(zh)
|
2017-12-19 |
2023-12-11 |
英商拜西可泰克斯有限公司 |
Epha2特用之雙環胜肽配位基
|
|
IL315310A
(en)
|
2017-12-26 |
2024-10-01 |
Kymera Therapeutics Inc |
Irak degraders and uses thereof
|
|
EP3737675A4
(en)
|
2018-01-12 |
2022-01-05 |
Kymera Therapeutics, Inc. |
Crbn ligands and uses thereof
|
|
EP3737666A4
(en)
|
2018-01-12 |
2022-01-05 |
Kymera Therapeutics, Inc. |
PROTEIN DEGRADATION AGENTS AND ASSOCIATED USES
|
|
US10793563B2
(en)
|
2018-01-29 |
2020-10-06 |
Merck Patent Gmbh |
GCN2 inhibitors and uses thereof
|
|
KR20200116481A
(ko)
|
2018-01-29 |
2020-10-12 |
메르크 파텐트 게엠베하 |
Gcn2 억제제 및 이의 용도
|
|
MX2020008791A
(es)
|
2018-02-23 |
2021-01-08 |
Bicycletx Ltd |
Ligandos de peptidos biciclicos multimericos.
|
|
CN117304157A
(zh)
|
2018-02-27 |
2023-12-29 |
阿塔克斯生物制药有限公司 |
作为tcr-nck相互作用的抑制剂的色烯衍生物
|
|
IL277071B2
(en)
*
|
2018-03-08 |
2024-07-01 |
Incyte Corp |
AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS
|
|
JP7346441B2
(ja)
|
2018-04-04 |
2023-09-19 |
ヤンセン ファーマシューティカ エヌ．ベー． |
置換ピリジン及びピリミジン並びにｇｌｕｎ２ｂ受容体調節物質としてのそれらの使用
|
|
ES2969982T3
(es)
|
2018-04-24 |
2024-05-23 |
Vertex Pharma |
Compuestos de pteridinona y usos de los mismos
|
|
IL301501B2
(en)
|
2018-04-24 |
2024-10-01 |
Vertex Pharma |
Antiproliferation compounds and uses thereof
|
|
EP3807248A4
(en)
*
|
2018-05-29 |
2021-10-27 |
Council of Scientific and Industrial Research |
BICYCLIC TOPOISOMERASE I INHIBITOR COMPOUNDS, THEIR PREPARATION AND USE
|
|
EP3575305A1
(fr)
*
|
2018-05-31 |
2019-12-04 |
Biocidal Alternative Solutions |
Procédé de fabrication de composés comprenant un groupe fonctionnel oxazolopyridinones
|
|
JP7768505B2
(ja)
|
2018-06-01 |
2025-11-12 |
コーネル・ユニバーシティー |
Ｐｉ３ｋに関連する疾患または障害に対する併用療法
|
|
EA202092692A1
(ru)
|
2018-06-15 |
2021-04-21 |
Навитор Фармасьютикалз, Инк. |
Аналоги рапамицина и их применения
|
|
GB201810316D0
(en)
|
2018-06-22 |
2018-08-08 |
Bicyclerd Ltd |
Peptide ligands for binding to EphA2
|
|
IL279489B2
(en)
|
2018-06-22 |
2025-10-01 |
Bicycletx Ltd |
Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate
|
|
KR102595520B1
(ko)
|
2018-07-05 |
2023-10-30 |
엘지디스플레이 주식회사 |
헤테로아릴기를 가진 벤즈아졸 유도체 및 이를 포함하는 유기전계발광소자
|
|
EP3817822A4
(en)
|
2018-07-06 |
2022-07-27 |
Kymera Therapeutics, Inc. |
PROTEIN DEGRADANTS AND USES THEREOF
|
|
WO2020010177A1
(en)
|
2018-07-06 |
2020-01-09 |
Kymera Therapeutics, Inc. |
Tricyclic crbn ligands and uses thereof
|
|
US10548889B1
(en)
|
2018-08-31 |
2020-02-04 |
X4 Pharmaceuticals, Inc. |
Compositions of CXCR4 inhibitors and methods of preparation and use
|
|
EP3846793B1
(en)
|
2018-09-07 |
2024-01-24 |
PIC Therapeutics, Inc. |
Eif4e inhibitors and uses thereof
|
|
CN113271940A
(zh)
|
2018-10-15 |
2021-08-17 |
林伯士拉克许米公司 |
Tyk2抑制剂和其用途
|
|
WO2020084305A1
(en)
|
2018-10-23 |
2020-04-30 |
Bicycletx Limited |
Bicyclic peptide ligands and uses thereof
|
|
EP3870158A4
(en)
|
2018-10-24 |
2022-08-10 |
Navitor Pharmaceuticals, Inc. |
Polymorphic compounds and uses thereof
|
|
SG11202105424PA
(en)
|
2018-11-30 |
2021-06-29 |
Kymera Therapeutics Inc |
Irak degraders and uses thereof
|
|
CN113271938A
(zh)
|
2018-11-30 |
2021-08-17 |
林伯士拉克许米公司 |
Tyk2抑制剂和其用途
|
|
GB201820288D0
(en)
|
2018-12-13 |
2019-01-30 |
Bicycle Tx Ltd |
Bicycle peptide ligaands specific for MT1-MMP
|
|
GB201820325D0
(en)
|
2018-12-13 |
2019-01-30 |
Bicyclerd Ltd |
Bicyclic peptide ligands specific for psma
|
|
EP3670659A1
(en)
|
2018-12-20 |
2020-06-24 |
Abivax |
Biomarkers, and uses in treatment of viral infections, inflammations, or cancer
|
|
WO2020154474A1
(en)
|
2019-01-23 |
2020-07-30 |
Nimbus Lakshmi, Inc. |
Tyk2 inhibitors and uses thereof
|
|
WO2020165600A1
(en)
|
2019-02-14 |
2020-08-20 |
Bicycletx Limited |
Bicyclic peptide ligand sting conjugates and uses thereof
|
|
US20220184222A1
(en)
|
2019-04-02 |
2022-06-16 |
Bicycletx Limited |
Bicycle toxin conjugates and uses thereof
|
|
SG11202110829YA
(en)
|
2019-04-05 |
2021-10-28 |
Kymera Therapeutics Inc |
Stat degraders and uses thereof
|
|
EP3976027B1
(en)
*
|
2019-05-30 |
2025-11-05 |
Merck Sharp & Dohme LLC |
Quinoline derivatives as factor xi activation inhibitors
|
|
TW202108559A
(zh)
|
2019-05-31 |
2021-03-01 |
美商醫肯納腫瘤學公司 |
Tead抑制劑及其用途
|
|
CA3143276A1
(en)
|
2019-06-14 |
2020-12-17 |
Janssen Pharmaceutica Nv |
Substituted heteroaromatic pyrazolo-pyridines and their use as glun2b receptor modulators
|
|
CN114007691A
(zh)
|
2019-06-14 |
2022-02-01 |
詹森药业有限公司 |
吡啶氨基甲酸酯及其作为GluN2B受体调节剂的用途
|
|
US11459336B2
(en)
|
2019-06-14 |
2022-10-04 |
Janssen Pharmaceutica Nv |
Pyrazine carbamates and their use as GluN2B receptor modulators
|
|
CN113993868A
(zh)
|
2019-06-14 |
2022-01-28 |
詹森药业有限公司 |
取代的吡唑并吡啶酰胺以及它们作为glun2b受体调节剂的用途
|
|
CA3143105A1
(en)
|
2019-06-14 |
2020-12-17 |
Janssen Pharmaceutica Nv |
Substituted pyrazolo-pyrazines and their use as glun2b receptor modulators
|
|
JP7667097B2
(ja)
|
2019-06-14 |
2025-04-22 |
ヤンセン ファーマシューティカ エヌ．ベー． |
置換ピラゾロ－ピリジンアミド及びｇｌｕｎ２ｂ受容体調節因子としてのその使用
|
|
EP3983073A1
(en)
|
2019-06-14 |
2022-04-20 |
Janssen Pharmaceutica NV |
Substituted pyrazolo[4,3-b]pyridines and their use as glun2b receptor modulators
|
|
TWI860386B
(zh)
|
2019-07-30 |
2024-11-01 |
英商拜西可泰克斯有限公司 |
異質雙環肽複合物
|
|
AU2020345962A1
(en)
|
2019-09-11 |
2022-03-31 |
Vincere Biosciences, Inc. |
USP30 inhibitors and uses thereof
|
|
EP4027995A4
(en)
|
2019-09-13 |
2023-08-23 |
Nimbus Saturn, Inc. |
HPK1 ANTAGONISTS AND THEIR APPLICATIONS
|
|
TWI870497B
(zh)
|
2019-11-01 |
2025-01-21 |
美商奈維特製藥公司 |
使用mtorc1調節劑的治療方法
|
|
AU2020397938A1
(en)
|
2019-12-05 |
2022-06-23 |
Janssen Pharmaceutica Nv |
Rapamycin analogs and uses thereof
|
|
MX2022007576A
(es)
|
2019-12-17 |
2022-09-23 |
Kymera Therapeutics Inc |
Degradadores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos.
|
|
EP4076524A4
(en)
|
2019-12-17 |
2023-11-29 |
Kymera Therapeutics, Inc. |
IRAQ DEGRADERS AND USES THEREOF
|
|
IL294150A
(en)
|
2019-12-23 |
2022-08-01 |
Kymera Therapeutics Inc |
Smarca joints and their uses
|
|
JP2023514147A
(ja)
|
2020-02-05 |
2023-04-05 |
ピュアテック・エル・ワイ・ティ・インコーポレイテッド |
神経ステロイドの脂質プロドラッグ
|
|
AU2021230289A1
(en)
|
2020-03-03 |
2022-09-29 |
PIC Therapeutics, Inc. |
eIF4E inhibitors and uses thereof
|
|
MX2022011602A
(es)
|
2020-03-19 |
2023-01-04 |
Kymera Therapeutics Inc |
Degradadores de la proteína de homólogo de ratón de minuto 2 (mdm2) y usos de los mismos.
|
|
CN115484944A
(zh)
|
2020-03-31 |
2022-12-16 |
坎莫森特里克斯公司 |
使用ccr9抑制剂和抗il-23阻断抗体治疗炎症性肠病的组合物和方法
|
|
TW202210483A
(zh)
|
2020-06-03 |
2022-03-16 |
美商凱麥拉醫療公司 |
Irak降解劑之結晶型
|
|
EP4161521A4
(en)
|
2020-06-03 |
2024-07-10 |
Kymera Therapeutics, Inc. |
DEUTERED IRAQ DEGRADERS AND USES THEREOF
|
|
EP4196792A1
(en)
|
2020-08-17 |
2023-06-21 |
BicycleTX Limited |
Bicycle conjugates specific for nectin-4 and uses thereof
|
|
EP4232425A4
(en)
|
2020-10-23 |
2024-07-24 |
Nimbus Clotho, Inc. |
Ctps1 inhibitors and uses thereof
|
|
CA3200814A1
(en)
|
2020-12-02 |
2022-06-09 |
Alfredo C. Castro |
Tead inhibitors and uses thereof
|
|
WO2022120353A1
(en)
|
2020-12-02 |
2022-06-09 |
Ikena Oncology, Inc. |
Tead inhibitors and uses thereof
|
|
AU2021413371A1
(en)
|
2020-12-30 |
2023-07-13 |
Kymera Therapeutics, Inc. |
Irak degraders and uses thereof
|
|
AU2022215844A1
(en)
|
2021-02-02 |
2023-09-14 |
Liminal Biosciences Limited |
Gpr84 antagonists and uses thereof
|
|
CN117098757A
(zh)
|
2021-02-02 |
2023-11-21 |
里米诺生物科学有限公司 |
Gpr84拮抗剂和其用途
|
|
CN117120090A
(zh)
|
2021-02-12 |
2023-11-24 |
林伯士萨顿公司 |
Hpk1拮抗剂和其用途
|
|
AU2022220869A1
(en)
|
2021-02-15 |
2023-08-24 |
Kymera Therapeutics, Inc. |
Irak4 degraders and uses thereof
|
|
AU2022220043A1
(en)
|
2021-02-15 |
2023-08-31 |
Kymera Therapeutics, Inc. |
Irak4 degraders and uses thereof
|
|
US20240156805A1
(en)
|
2021-02-16 |
2024-05-16 |
Ribotech Co., Ltd. |
Compound for inhibiting nonsense-mediated mrna decay
|
|
US11926625B2
(en)
|
2021-03-05 |
2024-03-12 |
Nimbus Saturn, Inc. |
HPK1 antagonists and uses thereof
|
|
WO2022194248A1
(zh)
*
|
2021-03-18 |
2022-09-22 |
苏州国匡医药科技有限公司 |
Ctla-4小分子降解剂及其应用
|
|
EP4313989A4
(en)
|
2021-03-29 |
2025-03-05 |
Nimbus Saturn, Inc. |
HPK1 ANTAGONISTS AND USES THEREOF
|
|
EP4319756A4
(en)
|
2021-04-09 |
2025-02-26 |
Nimbus Clio, Inc. |
CBL-B MODULATORS AND USES THEREOF
|
|
JP2024514879A
(ja)
|
2021-04-16 |
2024-04-03 |
イケナ オンコロジー， インコーポレイテッド |
Ｍｅｋ阻害剤及びその使用
|
|
US12097261B2
(en)
|
2021-05-07 |
2024-09-24 |
Kymera Therapeutics, Inc. |
CDK2 degraders and uses thereof
|
|
CN115353512B
(zh)
*
|
2021-07-30 |
2025-07-08 |
上海翊石医药科技有限公司 |
一种杂环脲类化合物及其制备方法和用途
|
|
CN113416181B
(zh)
*
|
2021-08-02 |
2022-05-03 |
四川大学 |
喹唑啉类衍生物及其用途
|
|
JP2024532276A
(ja)
|
2021-08-25 |
2024-09-05 |
ピク セラピューティクス， インコーポレイテッド |
ｅＩＦ４Ｅ阻害剤及びその使用
|
|
CA3229560A1
(en)
|
2021-08-25 |
2023-03-02 |
Christopher L. Vandeusen |
Eif4e inhibitors and uses thereof
|
|
WO2023046182A1
(zh)
*
|
2021-09-27 |
2023-03-30 |
广州嘉越医药科技有限公司 |
一种吡啶并[1,2-a]嘧啶酮类化合物的应用
|
|
CN118302168A
(zh)
|
2021-10-29 |
2024-07-05 |
凯麦拉医疗公司 |
Irak4降解剂和其制备
|
|
WO2023114984A1
(en)
|
2021-12-17 |
2023-06-22 |
Ikena Oncology, Inc. |
Tead inhibitors and uses thereof
|
|
EP4472967A2
(en)
|
2022-01-31 |
2024-12-11 |
Kymera Therapeutics, Inc. |
Irak degraders and uses thereof
|
|
WO2023173057A1
(en)
|
2022-03-10 |
2023-09-14 |
Ikena Oncology, Inc. |
Mek inhibitors and uses thereof
|
|
WO2023173053A1
(en)
|
2022-03-10 |
2023-09-14 |
Ikena Oncology, Inc. |
Mek inhibitors and uses thereof
|
|
WO2023211889A1
(en)
|
2022-04-25 |
2023-11-02 |
Ikena Oncology, Inc. |
Polymorphic compounds and uses thereof
|
|
WO2023230205A1
(en)
|
2022-05-25 |
2023-11-30 |
Ikena Oncology, Inc. |
Mek inhibitors and uses thereof
|
|
WO2024012534A1
(zh)
*
|
2022-07-13 |
2024-01-18 |
武汉人福创新药物研发中心有限公司 |
杂环并苯环类化合物及其制备方法和用途
|
|
KR20250057800A
(ko)
|
2022-08-02 |
2025-04-29 |
리미널 바이오사이언시스 리미티드 |
헤테로아릴 카복스아마이드 및 관련 gpr84 길항제 및 이의 용도
|
|
WO2024028364A1
(en)
|
2022-08-02 |
2024-02-08 |
Liminal Biosciences Limited |
Aryl-triazolyl and related gpr84 antagonists and uses thereof
|
|
IL318576A
(en)
|
2022-08-02 |
2025-03-01 |
Liminal Biosciences Ltd |
Pyridoxine-substituted GPR84 antagonists and their uses
|
|
EP4605089A1
(en)
*
|
2022-10-20 |
2025-08-27 |
Mekanistic Therapeutics LLC |
Compounds useful in modulating egfr and pi3k
|
|
US20240208961A1
(en)
|
2022-11-22 |
2024-06-27 |
PIC Therapeutics, Inc. |
Eif4e inhibitors and uses thereof
|
|
CN116239594B
(zh)
*
|
2023-03-05 |
2023-09-22 |
贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) |
6-(咪唑并[1,2-a]吡啶-6-基)喹唑啉衍生物及用途
|
|
WO2024264017A2
(en)
|
2023-06-23 |
2024-12-26 |
Kymera Therapeutics, Inc. |
Irak degraders and uses thereof
|
|
WO2025045915A1
(en)
*
|
2023-08-29 |
2025-03-06 |
Institut National de la Santé et de la Recherche Médicale |
Methods for inducing muscle hypertrophy
|
|
TW202529769A
(zh)
|
2023-09-21 |
2025-08-01 |
日商武田藥品工業股份有限公司 |
Ｔｙｋ２抑制劑及其用途
|
|
CN118126038B
(zh)
*
|
2024-05-08 |
2024-07-12 |
烟台大学 |
吡唑并吡啶类衍生物及其制备方法和应用
|