|
PE20090717A1
(es)
*
|
2007-05-18 |
2009-07-18 |
Smithkline Beecham Corp |
Derivados de quinolina como inhibidores de la pi3 quinasa
|
|
ES2401557T3
(es)
|
2007-08-02 |
2013-04-22 |
Amgen, Inc |
Moduladores de Pl3 cinasas y métodos de uso
|
|
EP2211615A4
(en)
*
|
2007-10-22 |
2010-10-13 |
Glaxosmithkline Llc |
PYRIDOSULFONAMIDE DERIVATIVES AS PI3 KINASE INHIBITORS
|
|
CL2008003798A1
(es)
|
2007-12-19 |
2009-10-09 |
Amgen Inc |
Compuestos derivados de heterobiciclos aromaticos sustituidos, inhibidores de pi3 quinasa; composicion farmaceutica; utiles en el tratamiento de cancer, melanomas, glioblastomas, entre otras enfermedades.
|
|
EP2307400B1
(en)
|
2008-05-30 |
2014-04-23 |
Amgen, Inc |
Inhibitors of pi3 kinase
|
|
WO2009157196A1
(ja)
*
|
2008-06-25 |
2009-12-30 |
武田薬品工業株式会社 |
アミド化合物
|
|
BRPI0918496A2
(pt)
|
2008-09-02 |
2019-09-24 |
Novartis Ag |
composto inibidor bicíclico de quinase, uso do mesmo, composição farmacêutica e método para inibir a atividade da quinase pim em uma célula
|
|
MX2011004953A
(es)
|
2008-11-10 |
2011-12-14 |
Vertex Pharma |
Compuestos utiles como inhibidores de cinasa atr.
|
|
WO2010059549A1
(en)
*
|
2008-11-18 |
2010-05-27 |
Glaxosmithkline Llc |
Prolyl hydroxylase inhibitors
|
|
ES2921576T3
(es)
|
2008-12-19 |
2022-08-29 |
Vertex Pharma |
Compuestos útiles como inhibidores de la quinasa ATR
|
|
MX2011006333A
(es)
*
|
2008-12-23 |
2011-06-27 |
Abbott Lab |
Compuestos antivirales.
|
|
CN102264737A
(zh)
|
2008-12-23 |
2011-11-30 |
雅培制药有限公司 |
抗病毒化合物
|
|
US8741917B2
(en)
|
2009-01-15 |
2014-06-03 |
Rutgers, The State University Of New Jersey |
Benzo [C] phenanthridines as antimicrobial agents
|
|
SI2414369T1
(sl)
|
2009-04-02 |
2015-12-31 |
Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii |
Derivati imidazo(2,1-b)(1,3,4)tiadiazola
|
|
RU2541571C2
(ru)
|
2009-04-15 |
2015-02-20 |
Эббви Инк. |
Противовирусные соединения
|
|
WO2010127307A1
(en)
|
2009-04-30 |
2010-11-04 |
Rutgers, The State University Of New Jersey |
Antimicrobial agents
|
|
JP5659224B2
(ja)
|
2009-05-15 |
2015-01-28 |
ノバルティス アーゲー |
アルドステロンシンターゼ阻害剤としてのアリールピリジン
|
|
WO2010135568A1
(en)
|
2009-05-22 |
2010-11-25 |
Exelixis, Inc. |
Benzoxazepines as inhibitors of mtor and their use to treat cancer
|
|
JP2012531436A
(ja)
*
|
2009-06-25 |
2012-12-10 |
アムジエン・インコーポレーテツド |
複素環式化合物およびそれらのpi3k活性阻害剤としての使用
|
|
GEP201706639B
(en)
|
2009-08-17 |
2017-03-27 |
Intellikine Llc |
Heterocyclic compounds and uses thereof
|
|
WO2011021678A1
(ja)
*
|
2009-08-21 |
2011-02-24 |
武田薬品工業株式会社 |
縮合複素環化合物
|
|
EP3575288B1
(en)
*
|
2009-09-03 |
2021-10-27 |
Bristol-Myers Squibb Company |
Quinazolines as potassium ion channel inhibitors
|
|
WO2011031896A2
(en)
*
|
2009-09-09 |
2011-03-17 |
Avila Therapeutics, Inc. |
Pi3 kinase inhibitors and uses thereof
|
|
IN2012DN02534A
(enExample)
|
2009-09-16 |
2015-08-28 |
Avila Therapeutics Inc |
|
|
BR112012006968A2
(pt)
|
2009-09-28 |
2019-09-24 |
Glaxosmithkline Llc |
combinação
|
|
WO2011046894A1
(en)
*
|
2009-10-12 |
2011-04-21 |
Glaxosmithkline Llc |
Combination
|
|
WO2011051958A1
(en)
|
2009-10-30 |
2011-05-05 |
E.I. Du Pont De Nemours And Company |
Fungicidal pyrazolones
|
|
US20110269244A1
(en)
|
2009-12-30 |
2011-11-03 |
Petter Russell C |
Ligand-directed covalent modification of protein
|
|
WO2011143419A1
(en)
|
2010-05-12 |
2011-11-17 |
Vertex Pharmaceuticals Incorporated |
Pyrazines useful as inhibitors of atr kinase
|
|
NZ603478A
(en)
|
2010-05-12 |
2014-09-26 |
Vertex Pharma |
2 -aminopyridine derivatives useful as inhibitors of atr kinase
|
|
EP2569286B1
(en)
|
2010-05-12 |
2014-08-20 |
Vertex Pharmaceuticals Inc. |
Compounds useful as inhibitors of atr kinase
|
|
EP2569313A1
(en)
|
2010-05-12 |
2013-03-20 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
US9334244B2
(en)
|
2010-05-12 |
2016-05-10 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
US8969356B2
(en)
|
2010-05-12 |
2015-03-03 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
US8933096B2
(en)
|
2010-06-09 |
2015-01-13 |
Rugers, The State University of New Jersey |
Antimicrobial agents
|
|
EP2585468A1
(en)
|
2010-06-23 |
2013-05-01 |
Vertex Pharmaceuticals Incorporated |
Pyrrolo- pyrazine derivatives useful as inhibitors of atr kinase
|
|
CA2803890A1
(en)
*
|
2010-06-25 |
2011-12-29 |
Rutgers, The State University Of New Jersey |
Antimicrobial agents
|
|
SG187633A1
(en)
*
|
2010-07-30 |
2013-03-28 |
Oncotherapy Science Inc |
Quinoline derivatives and melk inhibitors containing the same
|
|
EP2603078A4
(en)
*
|
2010-08-09 |
2014-01-01 |
Glaxosmithkline Llc |
COMBINATION
|
|
US20140066431A1
(en)
|
2010-11-15 |
2014-03-06 |
Exelixis, Inc. |
Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture
|
|
US20140080810A1
(en)
|
2010-11-15 |
2014-03-20 |
Exelixis, Inc. |
Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture
|
|
WO2012068231A1
(en)
*
|
2010-11-16 |
2012-05-24 |
Glaxosmithkline Llc |
Method of administration and treatment
|
|
US20130231347A1
(en)
*
|
2010-11-19 |
2013-09-05 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Method of treatment with braf inhibitor
|
|
US20140378436A9
(en)
|
2010-11-24 |
2014-12-25 |
Exelixis, Inc. |
Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their use and Manufacture
|
|
JP5808826B2
(ja)
*
|
2011-02-23 |
2015-11-10 |
インテリカイン, エルエルシー |
複素環化合物およびその使用
|
|
KR101940340B1
(ko)
|
2011-03-04 |
2019-01-18 |
글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 |
키나제 억제제로서의 아미노-퀴놀린
|
|
WO2012122370A2
(en)
*
|
2011-03-08 |
2012-09-13 |
Eutropics Pharmaceuticals, Inc. |
Compositions and methods useful for treating diseases
|
|
CN102718745A
(zh)
*
|
2011-03-30 |
2012-10-10 |
中国科学院上海药物研究所 |
新型胺基吡啶类化合物、其制备方法、包含此类化合物的药物组合物及其用途
|
|
AU2012240030A1
(en)
|
2011-04-05 |
2013-10-24 |
Vertex Pharmaceuticals Incorporated |
Aminopyrazine compounds useful as inhibitors of TRA kinase
|
|
EP2701690A1
(en)
*
|
2011-04-29 |
2014-03-05 |
Exelixis, Inc. |
Method of treating lymphoma using pyridopyrimidinone inhibitors of pi3k/mtor
|
|
US9309250B2
(en)
|
2011-06-22 |
2016-04-12 |
Vertex Pharmaceuticals Incorporated |
Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors
|
|
EP2723747A1
(en)
|
2011-06-22 |
2014-04-30 |
Vertex Pharmaceuticals Inc. |
Compounds useful as inhibitors of atr kinase
|
|
WO2012178123A1
(en)
|
2011-06-22 |
2012-12-27 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
TWI547494B
(zh)
|
2011-08-18 |
2016-09-01 |
葛蘭素史克智慧財產發展有限公司 |
作為激酶抑制劑之胺基喹唑啉類
|
|
EP3878851A1
(en)
|
2011-09-30 |
2021-09-15 |
Vertex Pharmaceuticals Incorporated |
Process for making compounds useful as inhibitors of atr kinase
|
|
CA2850564A1
(en)
|
2011-09-30 |
2013-04-04 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
RU2018108589A
(ru)
|
2011-09-30 |
2019-02-25 |
Вертекс Фармасьютикалз Инкорпорейтед |
Лечение рака поджелудочной железы и немелкоклеточного рака легкого ингибиторами atr
|
|
US8765751B2
(en)
|
2011-09-30 |
2014-07-01 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
WO2013049720A1
(en)
|
2011-09-30 |
2013-04-04 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
BR112014010644A2
(pt)
|
2011-11-04 |
2017-04-25 |
Hoffmann La Roche |
novos derivados de aril-quinolina
|
|
EP2776420A1
(en)
|
2011-11-09 |
2014-09-17 |
Vertex Pharmaceuticals Incorporated |
Pyrazine compounds useful as inhibitors of atr kinase
|
|
WO2013071090A1
(en)
|
2011-11-09 |
2013-05-16 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
US8846917B2
(en)
|
2011-11-09 |
2014-09-30 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
JP2015502925A
(ja)
|
2011-11-09 |
2015-01-29 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
Atrキナーゼの阻害剤として有用なピラジン化合物
|
|
EP2776429A1
(en)
|
2011-11-09 |
2014-09-17 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
CA2857302C
(en)
|
2011-12-15 |
2020-08-25 |
Novartis Ag |
Use of inhibitors of the activity or function of pi3k
|
|
US9822108B2
(en)
|
2012-01-13 |
2017-11-21 |
Rutgers, The State University Of New Jersey |
Antimicrobial agents
|
|
WO2013117503A2
(en)
|
2012-02-06 |
2013-08-15 |
Glaxosmithkline Intellectual Property (No. 2) Limited |
Novel use
|
|
US20150031702A1
(en)
|
2012-02-06 |
2015-01-29 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Pi3k inhibitors for treating cough
|
|
CA2868002C
(en)
|
2012-03-21 |
2021-07-13 |
Rutgers, The State University Of New Jersey |
Antimicrobial agents
|
|
PT2833973T
(pt)
|
2012-04-05 |
2017-12-21 |
Vertex Pharma |
Compostos úteis como inibidores da cinase atr e terapias de combinação dos mesmos
|
|
IN2014DN11205A
(enExample)
|
2012-06-20 |
2015-10-02 |
Eutropics Pharmaceuticals Inc |
|
|
AR092530A1
(es)
|
2012-09-13 |
2015-04-22 |
Glaxosmithkline Llc |
Compuesto de amino-quinolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento
|
|
AR092529A1
(es)
|
2012-09-13 |
2015-04-22 |
Glaxosmithkline Llc |
Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento
|
|
CN103497177B
(zh)
*
|
2012-09-29 |
2017-03-22 |
天津滨江药物研发有限公司 |
作为c‑Met抑制剂的氨基芳香杂环类化合物及其制备方法
|
|
WO2014055756A1
(en)
|
2012-10-04 |
2014-04-10 |
Vertex Pharmaceuticals Incorporated |
Method for measuring atr inhibition mediated increases in dna damage
|
|
EP2909202A1
(en)
|
2012-10-16 |
2015-08-26 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
CN103788071A
(zh)
*
|
2012-11-01 |
2014-05-14 |
中国人民解放军第二军医大学 |
N-(5-(喹啉-6-基)吡啶-3-基)苯磺酰胺衍生物、制备方法及治疗用途
|
|
US20160038503A1
(en)
|
2012-11-21 |
2016-02-11 |
David Richard |
Methods and compositions useful for treating diseases involving bcl-2 family proteins with isoquinoline and quinoline derivatives
|
|
WO2014089379A1
(en)
|
2012-12-07 |
2014-06-12 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
BR112015019624A2
(pt)
|
2013-02-21 |
2017-07-18 |
Glaxosmithkline Ip Dev Ltd |
quinazolinas como inibidores de quinase
|
|
US9663519B2
(en)
|
2013-03-15 |
2017-05-30 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
CN104098542A
(zh)
*
|
2013-04-11 |
2014-10-15 |
苏州朗信医药科技有限公司 |
一种6-溴代-4-(4-吡嗪基)喹啉的制备方法
|
|
WO2015017788A1
(en)
|
2013-08-01 |
2015-02-05 |
Eutropics Pharmaceuticals, Inc. |
Method for predicting cancer sensitivity
|
|
CN104418858B
(zh)
|
2013-08-30 |
2018-12-11 |
浙江医药股份有限公司新昌制药厂 |
2,6-二含氮取代的嘌呤衍生物及其制备方法和其药物组合物与应用
|
|
KR20160060100A
(ko)
|
2013-09-22 |
2016-05-27 |
칼리토르 사이언시즈, 엘엘씨 |
치환된 아미노피리미딘 화합물 및 이용 방법
|
|
CN104557955B
(zh)
*
|
2013-10-23 |
2017-05-03 |
上海汇伦生命科技有限公司 |
作为PI3K/mTOR抑制剂的三环类化合物,其制备方法和用途
|
|
AU2014342269B2
(en)
|
2013-10-30 |
2020-02-27 |
Eutropics Pharmaceuticals, Inc. |
Methods for determining chemosensitivity and chemotoxicity
|
|
US9458150B2
(en)
|
2013-11-08 |
2016-10-04 |
Rutgers, The State University Of New Jersey |
Antimicrobial agents
|
|
KR102398473B1
(ko)
*
|
2013-11-27 |
2022-05-16 |
시그널켐 라이프사이언시즈 코포레이션 |
Tam 패밀리 키나제 억제제로서의 아미노피리딘 유도체
|
|
WO2015085132A1
(en)
|
2013-12-06 |
2015-06-11 |
Vertex Pharmaceuticals Incorporated |
2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof
|
|
EP4019518A1
(en)
|
2014-02-28 |
2022-06-29 |
Nimbus Lakshmi, Inc. |
Tyk2 inhibitors and uses thereof
|
|
CN104922116B
(zh)
*
|
2014-03-23 |
2020-08-11 |
上海诗丹德生物技术有限公司 |
甲基丙烯酰基苯并咪唑酮衍生物的用途
|
|
NO2714752T3
(enExample)
*
|
2014-05-08 |
2018-04-21 |
|
|
|
HRP20200186T1
(hr)
|
2014-06-05 |
2020-05-29 |
Vertex Pharmaceuticals Inc. |
Radioaktivno obilježeni derivati 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-karboksamid spojeva koji se koriste kao inhibitori atr kinaze, priprava navedenih spojeva i njihovi različiti čvrsti oblici
|
|
JP6386177B2
(ja)
|
2014-06-17 |
2018-09-05 |
ツーセン ファーマシューティカル カンパニー リミテッド |
mTOR/PI3K阻害剤としてのピリド[1,2−a]ピリミジノン類似体
|
|
JP6936007B2
(ja)
|
2014-06-17 |
2021-09-15 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
Chk1阻害剤とatr阻害剤との組み合わせを使用してがんを処置する方法
|
|
EP4578865A3
(en)
|
2014-08-12 |
2025-07-30 |
Monash University |
Lymph directing prodrugs
|
|
CN105330699B
(zh)
*
|
2014-08-13 |
2018-12-04 |
山东汇睿迪生物技术有限公司 |
一种含磷吡啶并[2,3-d]嘧啶-7-酮类化合物或其药学上可接受的盐、药物组合物及其应用
|
|
PT3180329T
(pt)
|
2014-08-15 |
2020-06-08 |
Janssen Pharmaceuticals Inc |
Triazóis como inibidores do recetor nr2b
|
|
HUE049278T2
(hu)
|
2014-08-15 |
2020-09-28 |
Janssen Pharmaceuticals Inc |
Pirazolok
|
|
RS61853B1
(sr)
|
2014-10-29 |
2021-06-30 |
Bicyclerd Ltd |
Biciklični peptidni ligandi specifični za mt1-mmp
|
|
TWI788655B
(zh)
|
2015-02-27 |
2023-01-01 |
美商林伯士拉克許米公司 |
酪胺酸蛋白質激酶2(tyk2)抑制劑及其用途
|
|
FR3033499A1
(fr)
|
2015-03-11 |
2016-09-16 |
Centre Leon-Berard |
Composition pour le traitement des tumeurs neuroendocrines pancreatiques
|
|
CN104961725B
(zh)
*
|
2015-06-18 |
2017-04-19 |
浙江大学 |
4‑α,β不饱和酰胺基喹啉类化合物及制备和应用
|
|
WO2017004134A1
(en)
|
2015-06-29 |
2017-01-05 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
|
LT3319963T
(lt)
|
2015-07-09 |
2020-03-25 |
Janssen Pharmaceutica Nv |
Pakeistieji 4-azaindolai ir jų, kaip glun2b receptoriaus moduliatorių, panaudojimas
|
|
WO2017019828A1
(en)
*
|
2015-07-30 |
2017-02-02 |
Bristol-Myers Squibb Company |
Aryl substituted bicyclic heteroaryl compounds
|
|
US10329257B2
(en)
*
|
2015-08-13 |
2019-06-25 |
The Broad Institute, Inc. |
Compositions and methods for treating tuberculosis
|
|
JP6802263B2
(ja)
|
2015-09-02 |
2020-12-16 |
ニンバス ラクシュミ, インコーポレイテッド |
Tyk2阻害剤およびその使用
|
|
JP7118888B2
(ja)
|
2015-09-08 |
2022-08-16 |
モナッシュ ユニバーシティ |
リンパ指向性プロドラッグ
|
|
WO2017044720A1
(en)
|
2015-09-11 |
2017-03-16 |
Navitor Pharmaceuticals, Inc. |
Rapamycin analogs and uses thereof
|
|
GB201516504D0
(en)
|
2015-09-17 |
2015-11-04 |
Astrazeneca Ab |
Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
|
|
EP3355926B1
(en)
|
2015-09-30 |
2025-12-24 |
Vertex Pharmaceuticals Inc. |
Combination of dna damaging agents and atr inhibitors for use in a method for treating cancer using
|
|
SI3364958T1
(sl)
|
2015-10-23 |
2023-05-31 |
Navitor Pharmaceuticals, Inc. |
Modulatorji interakcije sestrina in gator2 ter njihova uporaba
|
|
EP3389664A4
(en)
|
2015-12-14 |
2020-01-08 |
Raze Therapeutics Inc. |
MTHFD2 CAFFEIN INHIBITORS AND USES THEREOF
|
|
WO2017101829A1
(zh)
*
|
2015-12-16 |
2017-06-22 |
辰欣药业股份有限公司 |
吡啶并[1,2-a]嘧啶酮类似物的晶型及其制备方法和中间体
|
|
CA3014314A1
(en)
|
2016-02-10 |
2017-08-17 |
Janssen Pharmaceutica Nv |
Substituted 1,2,3-triazoles as nr2b-selective nmda modulators
|
|
US10513528B2
(en)
|
2016-02-25 |
2019-12-24 |
Taxis Pharmaceuticals, Inc. |
Synthetic processes and intermediates
|
|
PL3884939T3
(pl)
|
2016-03-09 |
2024-02-26 |
Raze Therapeutics, Inc. |
Inhibitory dehydrogenazy 3-fosfoglicerynianowej i ich zastosowania
|
|
EP4234552A3
(en)
|
2016-03-09 |
2023-10-18 |
Raze Therapeutics, Inc. |
3-phosphoglycerate dehydrogenase inhibitors and uses thereof
|
|
US11337969B2
(en)
|
2016-04-08 |
2022-05-24 |
X4 Pharmaceuticals, Inc. |
Methods for treating cancer
|
|
JP7054529B2
(ja)
|
2016-06-21 |
2022-04-14 |
エックス4 ファーマシューティカルズ, インコーポレイテッド |
Cxcr4阻害剤およびその使用
|
|
US11332470B2
(en)
|
2016-06-21 |
2022-05-17 |
X4 Pharmaceuticals, Inc. |
CXCR4 inhibitors and uses thereof
|
|
US10988465B2
(en)
|
2016-06-21 |
2021-04-27 |
X4 Pharmaceuticals, Inc. |
CXCR4 inhibitors and uses thereof
|
|
US10154992B2
(en)
*
|
2016-07-12 |
2018-12-18 |
The Regents Of The University Of California |
Compounds and methods for treating HIV infection
|
|
AU2017312970B2
(en)
*
|
2016-08-16 |
2021-08-12 |
Merck Patent Gmbh |
2-oxo-imidazopyridines as reversible BTK inhibitors and uses thereof
|
|
TW201819376A
(zh)
|
2016-10-06 |
2018-06-01 |
比利時商健生藥品公司 |
經取代之1H-咪唑並[4,5-b]吡啶-2(3H)-酮及其作為GLUN2B受體調節劑之用途
|
|
CN115448916A
(zh)
|
2016-10-14 |
2022-12-09 |
林伯士拉克许米公司 |
Tyk2抑制剂及其用途
|
|
AU2017345736B2
(en)
|
2016-10-21 |
2022-04-07 |
Takeda Pharmaceutical Company Limited |
TYK2 inhibitors and uses thereof
|
|
WO2018089499A1
(en)
|
2016-11-08 |
2018-05-17 |
Navitor Pharmaceuticals, Inc. |
PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF
|
|
CN106580986B
(zh)
*
|
2016-11-28 |
2017-09-15 |
王保亮 |
一种治疗少弱精子症的药物组合物
|
|
WO2018102397A1
(en)
|
2016-11-29 |
2018-06-07 |
PureTech Health LLC |
Exosomes for delivery of therapeutic agents
|
|
US11091451B2
(en)
|
2016-12-05 |
2021-08-17 |
Raze Therapeutics, Inc. |
SHMT inhibitors and uses thereof
|
|
US20180153922A1
(en)
|
2016-12-06 |
2018-06-07 |
New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery |
Inhibition of expansion and function of pathogenic age-associated b cells and use for the prevention and treatment of autoimmune disease
|
|
US11730819B2
(en)
|
2016-12-23 |
2023-08-22 |
Bicycletx Limited |
Peptide derivatives having novel linkage structures
|
|
EP4169918B8
(en)
|
2016-12-26 |
2025-09-24 |
Institute of Materia Medica, Chinese Academy of Medical Sciences |
Quinazoline derivatives as inhibitors of pi3k for the treatment of cancer
|
|
WO2018127699A1
(en)
|
2017-01-06 |
2018-07-12 |
Bicyclerd Limited |
Compounds for treating cancer
|
|
US11447503B2
(en)
|
2019-06-14 |
2022-09-20 |
Janssen Pharmaceutica Nv |
Pyridine carbamates and their use as GLUN2B receptor modulators
|
|
CA3055209A1
(en)
|
2017-03-08 |
2018-09-13 |
Nimbus Lakshmi, Inc. |
Tyk2 inhibitors, uses, and methods for production thereof
|
|
EP3375778A1
(en)
|
2017-03-14 |
2018-09-19 |
Artax Biopharma Inc. |
Aryl-piperidine derivatives
|
|
EP3375784A1
(en)
|
2017-03-14 |
2018-09-19 |
Artax Biopharma Inc. |
Aza-dihydro-acridone derivatives
|
|
US10774093B2
(en)
|
2017-03-30 |
2020-09-15 |
Taxis Pharmaceuticals, Inc. |
Synthetic processes and synthetic intermediates
|
|
WO2018191146A1
(en)
|
2017-04-10 |
2018-10-18 |
Navitor Pharmaceuticals, Inc. |
Heteroaryl rheb inhibitors and uses thereof
|
|
ES3040534T3
(en)
|
2017-04-26 |
2025-11-03 |
Navitor Pharm Inc |
Modulator of sestrin-gator2 interaction for use in the treatment of treatment-resistant depression
|
|
EP3615550A1
(en)
|
2017-04-27 |
2020-03-04 |
BicycleTx Limited |
Bicyclic peptide ligands and uses thereof
|
|
US11168082B2
(en)
*
|
2017-05-15 |
2021-11-09 |
The Regents Of The University Of Michigan |
Pyrrolo[2,3-C]pyridines and related analogs as LSD-1 inhibitors
|
|
EP3645549A1
(en)
|
2017-06-26 |
2020-05-06 |
BicycleRD Limited |
Bicyclic peptide ligands with detectable moieties and uses thereof
|
|
JP7216705B2
(ja)
|
2017-07-28 |
2023-02-02 |
ニンバス ラクシュミ, インコーポレイテッド |
Tyk2阻害剤およびその使用方法
|
|
JP7670481B2
(ja)
|
2017-08-04 |
2025-04-30 |
バイスクルテクス・リミテッド |
Cd137に対して特異的な二環式ペプチドリガンド
|
|
US20200283482A1
(en)
|
2017-08-14 |
2020-09-10 |
Bicyclerd Limited |
Bicyclic peptide ligand prr-a conjugates and uses thereof
|
|
US20200291096A1
(en)
|
2017-08-14 |
2020-09-17 |
Bicyclerd Limited |
Bicyclic peptide ligand sting conjugates and uses thereof
|
|
US11883497B2
(en)
|
2017-08-29 |
2024-01-30 |
Puretech Lyt, Inc. |
Lymphatic system-directing lipid prodrugs
|
|
EP3675838A4
(en)
|
2017-08-29 |
2021-04-21 |
PureTech LYT, Inc. |
LIPID PRODRUGS DIRECTED TO THE LYMPHATIC SYSTEM
|
|
US11358948B2
(en)
|
2017-09-22 |
2022-06-14 |
Kymera Therapeutics, Inc. |
CRBN ligands and uses thereof
|
|
WO2019060742A1
(en)
|
2017-09-22 |
2019-03-28 |
Kymera Therapeutics, Inc |
AGENTS FOR DEGRADING PROTEINS AND USES THEREOF
|
|
CN107793404A
(zh)
*
|
2017-11-07 |
2018-03-13 |
全椒先奇医药科技有限公司 |
一种治疗缺血性脑损伤药物组合物及其应用
|
|
US11304954B2
(en)
|
2017-12-19 |
2022-04-19 |
Puretech Lyt, Inc. |
Lipid prodrugs of mycophenolic acid and uses thereof
|
|
US11608345B1
(en)
|
2017-12-19 |
2023-03-21 |
Puretech Lyt, Inc. |
Lipid prodrugs of rapamycin and its analogs and uses thereof
|
|
TWI825046B
(zh)
|
2017-12-19 |
2023-12-11 |
英商拜西可泰克斯有限公司 |
Epha2特用之雙環胜肽配位基
|
|
WO2019126378A1
(en)
|
2017-12-19 |
2019-06-27 |
Ariya Therapeutics, Inc. |
Lipid prodrugs of mycophenolic acid and uses thereof
|
|
GB201721265D0
(en)
|
2017-12-19 |
2018-01-31 |
Bicyclerd Ltd |
Bicyclic peptide ligands specific for EphA2
|
|
IL315310A
(en)
|
2017-12-26 |
2024-10-01 |
Kymera Therapeutics Inc |
Irak degraders and uses thereof
|
|
WO2019140387A1
(en)
|
2018-01-12 |
2019-07-18 |
Kymera Therapeutics, Inc. |
Crbn ligands and uses thereof
|
|
US11485743B2
(en)
|
2018-01-12 |
2022-11-01 |
Kymera Therapeutics, Inc. |
Protein degraders and uses thereof
|
|
JP7229257B2
(ja)
|
2018-01-29 |
2023-02-28 |
メルク パテント ゲーエムベーハー |
Gcn2阻害剤およびその使用
|
|
KR20200115620A
(ko)
|
2018-01-29 |
2020-10-07 |
메르크 파텐트 게엠베하 |
Gcn2 억제제 및 이의 용도
|
|
KR20200128518A
(ko)
|
2018-02-23 |
2020-11-13 |
바이사이클티엑스 리미티드 |
다량체성 비사이클릭 펩타이드 리간드
|
|
US10696663B2
(en)
|
2018-02-27 |
2020-06-30 |
Artax Biopharma Inc. |
Chromene derivatives as inhibitors of TCR-NCK interaction
|
|
TWI903299B
(zh)
|
2018-03-08 |
2025-11-01 |
美商英塞特公司 |
作為PI3K-γ抑制劑之胺基吡嗪二醇化合物
|
|
WO2019193516A2
(en)
|
2018-04-04 |
2019-10-10 |
Janssen Pharmaceutica Nv |
Substituted pyridine and pyrimidines and their use as glun2b receptor modulators
|
|
EP4043460B1
(en)
|
2018-04-24 |
2024-06-05 |
Merck Patent GmbH |
Antiproliferation compounds and uses thereof
|
|
ES2969982T3
(es)
|
2018-04-24 |
2024-05-23 |
Vertex Pharma |
Compuestos de pteridinona y usos de los mismos
|
|
US12172991B2
(en)
*
|
2018-05-29 |
2024-12-24 |
Council Of Scientific & Industrial Research |
Bicycle topoisomerase i inhibiting compounds, process for preparation and use thereof
|
|
EP3575305A1
(fr)
*
|
2018-05-31 |
2019-12-04 |
Biocidal Alternative Solutions |
Procédé de fabrication de composés comprenant un groupe fonctionnel oxazolopyridinones
|
|
US12324807B2
(en)
|
2018-06-01 |
2025-06-10 |
Cornell University |
Combination therapy for PI3K-associated disease or disorder
|
|
BR112020025283A2
(pt)
|
2018-06-15 |
2021-03-09 |
Navitor Pharmaceuticals, Inc. |
Análogos de rapamicina e usos dos mesmos
|
|
GB201810316D0
(en)
|
2018-06-22 |
2018-08-08 |
Bicyclerd Ltd |
Peptide ligands for binding to EphA2
|
|
US11180531B2
(en)
|
2018-06-22 |
2021-11-23 |
Bicycletx Limited |
Bicyclic peptide ligands specific for Nectin-4
|
|
KR102595520B1
(ko)
|
2018-07-05 |
2023-10-30 |
엘지디스플레이 주식회사 |
헤테로아릴기를 가진 벤즈아졸 유도체 및 이를 포함하는 유기전계발광소자
|
|
WO2020010227A1
(en)
|
2018-07-06 |
2020-01-09 |
Kymera Therapeutics, Inc. |
Protein degraders and uses thereof
|
|
WO2020010177A1
(en)
|
2018-07-06 |
2020-01-09 |
Kymera Therapeutics, Inc. |
Tricyclic crbn ligands and uses thereof
|
|
US10548889B1
(en)
|
2018-08-31 |
2020-02-04 |
X4 Pharmaceuticals, Inc. |
Compositions of CXCR4 inhibitors and methods of preparation and use
|
|
US12030875B2
(en)
|
2018-09-07 |
2024-07-09 |
PIC Therapeutics, Inc. |
EIF4E inhibitors and uses thereof
|
|
US11414431B2
(en)
|
2018-10-15 |
2022-08-16 |
Nimbus Lakshmi, Inc. |
Substituted pyrazolo[1,5-a]pyrimidines as TYK2 inhibitors
|
|
CN112955459A
(zh)
|
2018-10-23 |
2021-06-11 |
拜斯科技术开发有限公司 |
双环肽配体和其用途
|
|
CA3117336A1
(en)
|
2018-10-24 |
2020-04-30 |
Navitor Pharmaceuticals, Inc. |
Polymorphs of (s)-2-amino-5,5-difluoro-4,4-dimethylpentanoic acid for use in modulating mtorc1
|
|
CA3120866A1
(en)
|
2018-11-30 |
2020-06-04 |
Nimbus Lakshmi, Inc. |
Tyk2 inhibitors and uses thereof
|
|
CA3119773A1
(en)
|
2018-11-30 |
2020-06-04 |
Kymera Therapeutics, Inc. |
Irak degraders and uses thereof
|
|
GB201820288D0
(en)
|
2018-12-13 |
2019-01-30 |
Bicycle Tx Ltd |
Bicycle peptide ligaands specific for MT1-MMP
|
|
GB201820295D0
(en)
|
2018-12-13 |
2019-01-30 |
Bicyclerd Ltd |
Bicyclic peptide ligands specific for MT1-MMP
|
|
GB201820325D0
(en)
|
2018-12-13 |
2019-01-30 |
Bicyclerd Ltd |
Bicyclic peptide ligands specific for psma
|
|
EP3670659A1
(en)
|
2018-12-20 |
2020-06-24 |
Abivax |
Biomarkers, and uses in treatment of viral infections, inflammations, or cancer
|
|
CN113474045A
(zh)
|
2018-12-21 |
2021-10-01 |
拜斯科技术开发有限公司 |
Pd-l1特异性的双环肽配体
|
|
WO2020128527A1
(en)
|
2018-12-21 |
2020-06-25 |
Bicyclerd Limited |
Bicyclic peptide ligands specific for pd-l1
|
|
US11174264B2
(en)
|
2019-01-23 |
2021-11-16 |
Nimbus Lakshmi, Inc. |
TYK2 inhibitors and uses thereof
|
|
WO2020165600A1
(en)
|
2019-02-14 |
2020-08-20 |
Bicycletx Limited |
Bicyclic peptide ligand sting conjugates and uses thereof
|
|
AU2020253990A1
(en)
|
2019-04-02 |
2021-10-28 |
Bicycletx Limited |
Bicycle toxin conjugates and uses thereof
|
|
JP2022527114A
(ja)
|
2019-04-05 |
2022-05-30 |
カイメラ セラピューティクス, インコーポレイテッド |
分解剤およびそれらの使用
|
|
US12304899B2
(en)
|
2019-05-30 |
2025-05-20 |
Merck Sharp & Dohme Llc |
Factor XI activation inhibitors
|
|
TW202108559A
(zh)
|
2019-05-31 |
2021-03-01 |
美商醫肯納腫瘤學公司 |
Tead抑制劑及其用途
|
|
US12521438B2
(en)
|
2019-06-10 |
2026-01-13 |
Kymera Therapeutics, Inc. |
SMARCA degraders and uses thereof
|
|
CN113993583A
(zh)
|
2019-06-14 |
2022-01-28 |
詹森药业有限公司 |
取代的吡唑并[4,3-b]吡啶及其作为GLUN2B受体调节剂的用途
|
|
EP3983075A1
(en)
|
2019-06-14 |
2022-04-20 |
Janssen Pharmaceutica NV |
Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulators
|
|
PH12021552839A1
(en)
|
2019-06-14 |
2022-10-03 |
Janssen Pharmaceutica Nv |
Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulators
|
|
US11459336B2
(en)
|
2019-06-14 |
2022-10-04 |
Janssen Pharmaceutica Nv |
Pyrazine carbamates and their use as GluN2B receptor modulators
|
|
BR112021025141A2
(pt)
|
2019-06-14 |
2022-01-25 |
Janssen Pharmaceutica Nv |
Pirazolo-piridinas heteroaromáticas substituídas e seu uso como moduladores do receptor glun2b
|
|
KR20220024403A
(ko)
|
2019-06-14 |
2022-03-03 |
얀센 파마슈티카 엔.브이. |
치환된 피라졸로-피라진 및 이들의 glun2b 수용체 조절제로서의 용도
|
|
MX2021015995A
(es)
|
2019-06-28 |
2022-03-11 |
Kymera Therapeutics Inc |
Degradadores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos.
|
|
US12558427B2
(en)
|
2019-07-17 |
2026-02-24 |
Kymera Therapeutics, Inc. |
IRAK degraders and uses thereof
|
|
TWI862640B
(zh)
|
2019-07-30 |
2024-11-21 |
英商拜西可泰克斯有限公司 |
異質雙環肽複合物
|
|
JP2022548594A
(ja)
|
2019-09-11 |
2022-11-21 |
ビンシア・バイオサイエンシーズ・インコーポレイテッド |
Usp30阻害剤及びその使用
|
|
CN119874700A
(zh)
|
2019-09-13 |
2025-04-25 |
林伯士萨顿公司 |
Hpk1拮抗剂和其用途
|
|
IL292612A
(en)
|
2019-11-01 |
2022-07-01 |
Navitor Pharm Inc |
Treatment methods using mtorc1 modulator
|
|
AU2020397938A1
(en)
|
2019-12-05 |
2022-06-23 |
Janssen Pharmaceutica Nv |
Rapamycin analogs and uses thereof
|
|
US12551564B2
(en)
|
2019-12-10 |
2026-02-17 |
Kymera Therapeutics, Inc. |
IRAK degraders and uses thereof
|
|
CN115052627A
(zh)
|
2019-12-17 |
2022-09-13 |
凯麦拉医疗公司 |
Irak降解剂和其用途
|
|
US11591332B2
(en)
|
2019-12-17 |
2023-02-28 |
Kymera Therapeutics, Inc. |
IRAK degraders and uses thereof
|
|
US12569485B2
(en)
|
2019-12-23 |
2026-03-10 |
Kymera Therapeutics, Inc. |
SMARCA inhibitors and uses thereof
|
|
BR112022012410A2
(pt)
|
2019-12-23 |
2022-08-30 |
Kymera Therapeutics Inc |
Degradadores smarca e usos dos mesmos
|
|
CA3166908A1
(en)
|
2020-02-05 |
2021-08-12 |
Daniel Kenneth BONNER |
Lipid prodrugs of neurosteroids
|
|
AU2021230289A1
(en)
|
2020-03-03 |
2022-09-29 |
PIC Therapeutics, Inc. |
eIF4E inhibitors and uses thereof
|
|
MX2022011602A
(es)
|
2020-03-19 |
2023-01-04 |
Kymera Therapeutics Inc |
Degradadores de la proteína de homólogo de ratón de minuto 2 (mdm2) y usos de los mismos.
|
|
TWI904146B
(zh)
|
2020-03-31 |
2025-11-11 |
美商卡默森屈有限公司 |
使用ccr9抑制劑及抗il-23阻斷抗體治療發炎性腸道疾病的組成物及方法
|
|
EP4161521A4
(en)
|
2020-06-03 |
2024-07-10 |
Kymera Therapeutics, Inc. |
DEUTERED IRAQ DEGRADERS AND USES THEREOF
|
|
TW202210483A
(zh)
|
2020-06-03 |
2022-03-16 |
美商凱麥拉醫療公司 |
Irak降解劑之結晶型
|
|
KR20230074119A
(ko)
|
2020-08-03 |
2023-05-26 |
바이사이클티엑스 리미티드 |
펩타이드 기반 링커
|
|
EP4196792A1
(en)
|
2020-08-17 |
2023-06-21 |
BicycleTX Limited |
Bicycle conjugates specific for nectin-4 and uses thereof
|
|
EP4232425A4
(en)
|
2020-10-23 |
2024-07-24 |
Nimbus Clotho, Inc. |
Ctps1 inhibitors and uses thereof
|
|
WO2022120353A1
(en)
|
2020-12-02 |
2022-06-09 |
Ikena Oncology, Inc. |
Tead inhibitors and uses thereof
|
|
CN117015531A
(zh)
|
2020-12-02 |
2023-11-07 |
医肯纳肿瘤学公司 |
Tead抑制剂及其用途
|
|
CA3202360A1
(en)
|
2020-12-30 |
2022-07-07 |
Nello Mainolfi |
Irak degraders and uses thereof
|
|
CN117098757A
(zh)
|
2021-02-02 |
2023-11-21 |
里米诺生物科学有限公司 |
Gpr84拮抗剂和其用途
|
|
MX2023009059A
(es)
|
2021-02-02 |
2023-09-15 |
Liminal Biosciences Ltd |
Antagonistas de gpr84 y usos de estos.
|
|
US12252488B2
(en)
|
2021-02-12 |
2025-03-18 |
Nimbus Saturn, Inc. |
HPK1 antagonists and uses thereof
|
|
CA3207049A1
(en)
|
2021-02-15 |
2022-08-18 |
Jared Gollob |
Irak4 degraders and uses thereof
|
|
US11773103B2
(en)
|
2021-02-15 |
2023-10-03 |
Kymera Therapeutics, Inc. |
IRAK4 degraders and uses thereof
|
|
WO2022177267A1
(ko)
|
2021-02-16 |
2022-08-25 |
라이보텍(주) |
넌센스-매개 mrna 분해를 억제하기 위한 화합물
|
|
US11926625B2
(en)
|
2021-03-05 |
2024-03-12 |
Nimbus Saturn, Inc. |
HPK1 antagonists and uses thereof
|
|
JP7710756B2
(ja)
*
|
2021-03-18 |
2025-07-22 |
蘇州国匡医葯科技有限公司 |
Ctla-4低分子分解剤及びその使用
|
|
JP2024513011A
(ja)
|
2021-03-29 |
2024-03-21 |
ニンバス サターン, インコーポレイテッド |
Hpk1アンタゴニスト及びその使用
|
|
US12325697B2
(en)
|
2021-04-09 |
2025-06-10 |
Nimbus Clio, Inc. |
CBL-B modulators and uses thereof
|
|
KR20230172548A
(ko)
|
2021-04-16 |
2023-12-22 |
이케나 온콜로지, 인코포레이티드 |
Mek 억제제 및 이의 용도
|
|
KR20240020735A
(ko)
|
2021-05-07 |
2024-02-15 |
카이메라 쎄라퓨틱스 인코포레이티드 |
Cdk2 분해제 및 그 용도
|
|
CN115353512B
(zh)
*
|
2021-07-30 |
2025-07-08 |
上海翊石医药科技有限公司 |
一种杂环脲类化合物及其制备方法和用途
|
|
CN113416181B
(zh)
*
|
2021-08-02 |
2022-05-03 |
四川大学 |
喹唑啉类衍生物及其用途
|
|
JP2024534127A
(ja)
|
2021-08-25 |
2024-09-18 |
ピク セラピューティクス, インコーポレイテッド |
eIF4E阻害剤及びその使用
|
|
CN118019739A
(zh)
|
2021-08-25 |
2024-05-10 |
皮克医疗公司 |
Eif4e抑制剂及其用途
|
|
WO2023046182A1
(zh)
*
|
2021-09-27 |
2023-03-30 |
广州嘉越医药科技有限公司 |
一种吡啶并[1,2-a]嘧啶酮类化合物的应用
|
|
CA3236265A1
(en)
|
2021-10-29 |
2023-05-04 |
William Leong |
Irak4 degraders and synthesis thereof
|
|
WO2023114984A1
(en)
|
2021-12-17 |
2023-06-22 |
Ikena Oncology, Inc. |
Tead inhibitors and uses thereof
|
|
US12091411B2
(en)
|
2022-01-31 |
2024-09-17 |
Kymera Therapeutics, Inc. |
IRAK degraders and uses thereof
|
|
WO2023173053A1
(en)
|
2022-03-10 |
2023-09-14 |
Ikena Oncology, Inc. |
Mek inhibitors and uses thereof
|
|
WO2023173057A1
(en)
|
2022-03-10 |
2023-09-14 |
Ikena Oncology, Inc. |
Mek inhibitors and uses thereof
|
|
WO2023211889A1
(en)
|
2022-04-25 |
2023-11-02 |
Ikena Oncology, Inc. |
Polymorphic compounds and uses thereof
|
|
TW202404581A
(zh)
|
2022-05-25 |
2024-02-01 |
美商醫肯納腫瘤學公司 |
Mek抑制劑及其用途
|
|
CN117402146A
(zh)
*
|
2022-07-13 |
2024-01-16 |
武汉人福创新药物研发中心有限公司 |
杂环并苯环类化合物及其制备方法和用途
|
|
KR20250056924A
(ko)
|
2022-08-02 |
2025-04-28 |
리미널 바이오사이언시스 리미티드 |
치환된 피리돈 gpr84 길항제 및 이의 용도
|
|
EP4565568A1
(en)
|
2022-08-02 |
2025-06-11 |
Liminal Biosciences Limited |
Heteroaryl carboxamide and related gpr84 antagonists and uses thereof
|
|
CN119894873A
(zh)
|
2022-08-02 |
2025-04-25 |
里米诺生物科学有限公司 |
芳基三唑基和相关gpr84拮抗剂及其用途
|
|
AU2023365344A1
(en)
*
|
2022-10-20 |
2025-05-08 |
Mekanistic Therapeutics Llc |
Compounds useful in modulating egfr and pi3k
|
|
WO2024112894A1
(en)
|
2022-11-22 |
2024-05-30 |
PIC Therapeutics, Inc. |
Eif4e inhibitors and uses thereof
|
|
CN116239594B
(zh)
*
|
2023-03-05 |
2023-09-22 |
贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) |
6-(咪唑并[1,2-a]吡啶-6-基)喹唑啉衍生物及用途
|
|
CN120379669A
(zh)
|
2023-06-23 |
2025-07-25 |
凯麦拉医疗公司 |
Irak降解剂及其用途
|
|
WO2025045915A1
(en)
*
|
2023-08-29 |
2025-03-06 |
Institut National de la Santé et de la Recherche Médicale |
Methods for inducing muscle hypertrophy
|
|
WO2025062372A1
(en)
|
2023-09-21 |
2025-03-27 |
Takeda Pharmaceutical Company Limited |
Tyk2 inhibitors for use in the treatment of inflammatory bowel disease
|
|
CN118126038B
(zh)
*
|
2024-05-08 |
2024-07-12 |
烟台大学 |
吡唑并吡啶类衍生物及其制备方法和应用
|