|
PE20090717A1
(es)
*
|
2007-05-18 |
2009-07-18 |
Smithkline Beecham Corp |
Derivados de quinolina como inhibidores de la pi3 quinasa
|
|
CA2694136C
(en)
|
2007-08-02 |
2013-09-17 |
Amgen Inc. |
Pi3 kinase modulators and methods of use
|
|
JP2011500823A
(ja)
*
|
2007-10-22 |
2011-01-06 |
グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー |
Pi3キナーゼ阻害物質としてのピリドスルホンアミド誘導体
|
|
WO2009085230A1
(en)
|
2007-12-19 |
2009-07-09 |
Amgen Inc. |
Inhibitors of pi3 kinase
|
|
EP2307400B1
(en)
|
2008-05-30 |
2014-04-23 |
Amgen, Inc |
Inhibitors of pi3 kinase
|
|
US20110130384A1
(en)
*
|
2008-06-25 |
2011-06-02 |
Takeda Pharmaceutical Company Limited |
Amide compound
|
|
CA2735779A1
(en)
|
2008-09-02 |
2010-03-11 |
Matthew Burger |
Bicyclic kinase inhibitors
|
|
CA2743134A1
(en)
|
2008-11-10 |
2010-05-14 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
WO2010059549A1
(en)
*
|
2008-11-18 |
2010-05-27 |
Glaxosmithkline Llc |
Prolyl hydroxylase inhibitors
|
|
PT3354650T
(pt)
|
2008-12-19 |
2022-06-20 |
Vertex Pharma |
Compostos úteis como inibidores da cinase atr
|
|
US8546405B2
(en)
|
2008-12-23 |
2013-10-01 |
Abbott Laboratories |
Anti-viral compounds
|
|
US8541424B2
(en)
|
2008-12-23 |
2013-09-24 |
Abbott Laboratories |
Anti-viral compounds
|
|
WO2010083436A1
(en)
|
2009-01-15 |
2010-07-22 |
Rutgers, The State University Of New Jersey |
Benzo [c] phenanthridines as antimicrobial agents
|
|
WO2010112874A1
(en)
|
2009-04-02 |
2010-10-07 |
Centro Nacional De Investigaciones Oncologicas (Cnio) |
Imidazo [2, 1-b] [ 1, 3, 4 ] thiadiazole derivatives
|
|
RU2541571C2
(ru)
|
2009-04-15 |
2015-02-20 |
Эббви Инк. |
Противовирусные соединения
|
|
CA2760526A1
(en)
|
2009-04-30 |
2010-11-04 |
Rutgers, The State University Of New Jersey |
Antimicrobial agents
|
|
BRPI1010600A2
(pt)
|
2009-05-15 |
2016-03-15 |
Novartis Ag |
aril piridina como inibidores de aldosterona sintase
|
|
WO2010135568A1
(en)
|
2009-05-22 |
2010-11-25 |
Exelixis, Inc. |
Benzoxazepines as inhibitors of mtor and their use to treat cancer
|
|
JP2012531436A
(ja)
*
|
2009-06-25 |
2012-12-10 |
アムジエン・インコーポレーテツド |
複素環式化合物およびそれらのpi3k活性阻害剤としての使用
|
|
ES2709108T3
(es)
|
2009-08-17 |
2019-04-15 |
Intellikine Llc |
Compuestos heterocíclicos y usos de los mismos
|
|
WO2011021678A1
(ja)
*
|
2009-08-21 |
2011-02-24 |
武田薬品工業株式会社 |
縮合複素環化合物
|
|
HRP20161669T1
(hr)
|
2009-09-03 |
2017-02-24 |
Bristol-Myers Squibb Company |
Kinolini kao inhbitori kalijevih ionskih kanala
|
|
MX339584B
(es)
*
|
2009-09-09 |
2016-06-01 |
Avila Therapeutics Inc |
Inhibidores de pi3 cinasa y usos de los mismos.
|
|
RU2012114902A
(ru)
|
2009-09-16 |
2013-10-27 |
Авила Терапьютикс, Инк. |
Конъюгаты и ингибиторы протеинкиназы
|
|
WO2011038380A2
(en)
*
|
2009-09-28 |
2011-03-31 |
Glaxosmithkline Llc |
Combination
|
|
CA2777561A1
(en)
*
|
2009-10-12 |
2011-04-21 |
Glaxosmithkline Llc |
Combination
|
|
WO2011051958A1
(en)
|
2009-10-30 |
2011-05-05 |
E.I. Du Pont De Nemours And Company |
Fungicidal pyrazolones
|
|
SG181965A1
(en)
|
2009-12-30 |
2012-08-30 |
Avila Therapeutics Inc |
Ligand-directed covalent modification of protein
|
|
EP2569286B1
(en)
|
2010-05-12 |
2014-08-20 |
Vertex Pharmaceuticals Inc. |
Compounds useful as inhibitors of atr kinase
|
|
US8962631B2
(en)
|
2010-05-12 |
2015-02-24 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
US9630956B2
(en)
|
2010-05-12 |
2017-04-25 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
CA2798760A1
(en)
|
2010-05-12 |
2011-11-17 |
Vertex Pharmaceuticals Incorporated |
2-aminopyridine derivatives useful as inhibitors of atr kinase
|
|
US8969356B2
(en)
|
2010-05-12 |
2015-03-03 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
EP2569287B1
(en)
|
2010-05-12 |
2014-07-09 |
Vertex Pharmaceuticals Inc. |
Compounds useful as inhibitors of atr kinase
|
|
CA2810162A1
(en)
|
2010-06-09 |
2011-12-15 |
Rutgers, The State University Of New Jersey |
Antimicrobial agents
|
|
CA2803802A1
(en)
|
2010-06-23 |
2011-12-29 |
Vertex Pharmaceuticals Incorporated |
Pyrrolo- pyrazine derivatives useful as inhibitors of atr kinase
|
|
CA2803890A1
(en)
*
|
2010-06-25 |
2011-12-29 |
Rutgers, The State University Of New Jersey |
Antimicrobial agents
|
|
CN103153063B
(zh)
*
|
2010-07-30 |
2016-02-17 |
肿瘤疗法科学股份有限公司 |
喹啉衍生物及含有其的melk抑制剂
|
|
WO2012021480A1
(en)
*
|
2010-08-09 |
2012-02-16 |
Glaxosmithkline Llc |
Combination
|
|
US20140066431A1
(en)
|
2010-11-15 |
2014-03-06 |
Exelixis, Inc. |
Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture
|
|
US20140080810A1
(en)
|
2010-11-15 |
2014-03-20 |
Exelixis, Inc. |
Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture
|
|
EP2640468A4
(en)
*
|
2010-11-16 |
2014-04-16 |
Glaxosmithkline Ip No 2 Ltd |
ADMINISTRATIVE AND TREATMENT PROCEDURES
|
|
EP2640387A4
(en)
*
|
2010-11-19 |
2014-08-20 |
Glaxosmithkline Ip No 2 Ltd |
METHOD OF TREATMENT USING BRAF INHIBITOR
|
|
EP2643316A2
(en)
|
2010-11-24 |
2013-10-02 |
Exelixis, Inc. |
Benzoxazepines as inhibitors of p13k/mtor and methods of their use and manufacture
|
|
EP2678016B1
(en)
|
2011-02-23 |
2016-08-10 |
Intellikine, LLC |
Heterocyclic compounds and uses thereof
|
|
CA2829131C
(en)
|
2011-03-04 |
2018-11-20 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Amino-quinolines as kinase inhibitors
|
|
US9051305B2
(en)
|
2011-03-08 |
2015-06-09 |
Eutropics Pharmaceuticals, Inc. |
Compositions and methods useful for treating diseases
|
|
CN102718745A
(zh)
*
|
2011-03-30 |
2012-10-10 |
中国科学院上海药物研究所 |
新型胺基吡啶类化合物、其制备方法、包含此类化合物的药物组合物及其用途
|
|
CA2832100A1
(en)
|
2011-04-05 |
2012-10-11 |
Vertex Pharmaceuticals Incorporated |
Aminopyrazine compounds useful as inhibitors of tra kinase
|
|
KR20140040726A
(ko)
*
|
2011-04-29 |
2014-04-03 |
엑셀리시스, 인코포레이티드 |
PI3K/mTOR의 피리도피리미디논 억제제를 사용하는 림프종을 치료하는 방법
|
|
EP2723746A1
(en)
|
2011-06-22 |
2014-04-30 |
Vertex Pharmaceuticals Inc. |
Compounds useful as inhibitors of atr kinase
|
|
JP2014522818A
(ja)
|
2011-06-22 |
2014-09-08 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Atrキナーゼ阻害剤として有用な化合物
|
|
WO2012178123A1
(en)
|
2011-06-22 |
2012-12-27 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
TWI547494B
(zh)
|
2011-08-18 |
2016-09-01 |
葛蘭素史克智慧財產發展有限公司 |
作為激酶抑制劑之胺基喹唑啉類
|
|
US8853217B2
(en)
|
2011-09-30 |
2014-10-07 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
KR20140084112A
(ko)
|
2011-09-30 |
2014-07-04 |
버텍스 파마슈티칼스 인코포레이티드 |
Atr 키나제의 억제제로서 유용한 화합물
|
|
HUE046429T2
(hu)
|
2011-09-30 |
2020-03-30 |
Vertex Pharma |
ATR kináz inhibítoraként használható vegyületek elõállítására szolgáló eljárás
|
|
WO2013049719A1
(en)
|
2011-09-30 |
2013-04-04 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
JP6162126B2
(ja)
|
2011-09-30 |
2017-08-23 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
Atr阻害剤による膵臓癌及び非小細胞肺癌の治療
|
|
EP2773619B1
(en)
|
2011-11-04 |
2016-11-16 |
F.Hoffmann-La Roche Ag |
New aryl-quinoline derivatives
|
|
US8846917B2
(en)
|
2011-11-09 |
2014-09-30 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
WO2013071093A1
(en)
|
2011-11-09 |
2013-05-16 |
Vertex Pharmaceuticals Incorporated |
Pyrazine compounds useful as inhibitors of atr kinase
|
|
WO2013071094A1
(en)
|
2011-11-09 |
2013-05-16 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
EP2776422A1
(en)
|
2011-11-09 |
2014-09-17 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
WO2013071085A1
(en)
|
2011-11-09 |
2013-05-16 |
Vertex Pharmaceuticals Incorporated |
Pyrazine compounds useful as inhibitors of atr kinase
|
|
ES2661510T3
(es)
|
2011-12-15 |
2018-04-02 |
Novartis Ag |
Uso de inhibidores de la actividad o función de PI3K
|
|
US9822108B2
(en)
|
2012-01-13 |
2017-11-21 |
Rutgers, The State University Of New Jersey |
Antimicrobial agents
|
|
CA2861521A1
(en)
|
2012-02-06 |
2013-08-15 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Novel use
|
|
BR112014018122A8
(pt)
|
2012-02-06 |
2017-07-11 |
Glaxosmithkline Ip No 2 Ltd |
Composto, uso de um composto, e, método para tratar tosse
|
|
CA2868002C
(en)
|
2012-03-21 |
2021-07-13 |
Rutgers, The State University Of New Jersey |
Antimicrobial agents
|
|
HK1205028A1
(en)
|
2012-04-05 |
2015-12-11 |
沃泰克斯药物股份有限公司 |
Compounds useful as inhibitors of atr kinase and combination therapies thereof
|
|
WO2013192423A2
(en)
|
2012-06-20 |
2013-12-27 |
Eutropics Pharmaceuticals, Inc. |
Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives
|
|
TWI592417B
(zh)
|
2012-09-13 |
2017-07-21 |
葛蘭素史克智慧財產發展有限公司 |
胺基喹唑啉激酶抑制劑之前藥
|
|
TW201425307A
(zh)
|
2012-09-13 |
2014-07-01 |
Glaxosmithkline Llc |
作為激酶抑制劑之胺基-喹啉類
|
|
CN103497177B
(zh)
*
|
2012-09-29 |
2017-03-22 |
天津滨江药物研发有限公司 |
作为c‑Met抑制剂的氨基芳香杂环类化合物及其制备方法
|
|
US8999632B2
(en)
|
2012-10-04 |
2015-04-07 |
Vertex Pharmaceuticals Incorporated |
Method for measuring ATR inhibition mediated increases in DNA damage
|
|
EP2909202A1
(en)
|
2012-10-16 |
2015-08-26 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
CN103788071A
(zh)
*
|
2012-11-01 |
2014-05-14 |
中国人民解放军第二军医大学 |
N-(5-(喹啉-6-基)吡啶-3-基)苯磺酰胺衍生物、制备方法及治疗用途
|
|
US20160038503A1
(en)
|
2012-11-21 |
2016-02-11 |
David Richard |
Methods and compositions useful for treating diseases involving bcl-2 family proteins with isoquinoline and quinoline derivatives
|
|
US9340546B2
(en)
|
2012-12-07 |
2016-05-17 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
WO2014128622A1
(en)
|
2013-02-21 |
2014-08-28 |
Glaxosmithkline Intellectual Property Development Limited |
Quinazolines as kinase inhibitors
|
|
US9663519B2
(en)
|
2013-03-15 |
2017-05-30 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
CN104098542A
(zh)
*
|
2013-04-11 |
2014-10-15 |
苏州朗信医药科技有限公司 |
一种6-溴代-4-(4-吡嗪基)喹啉的制备方法
|
|
US10732182B2
(en)
|
2013-08-01 |
2020-08-04 |
Eutropics Pharmaceuticals, Inc. |
Method for predicting cancer sensitivity
|
|
CN104418858B
(zh)
|
2013-08-30 |
2018-12-11 |
浙江医药股份有限公司新昌制药厂 |
2,6-二含氮取代的嘌呤衍生物及其制备方法和其药物组合物与应用
|
|
CA2918938C
(en)
|
2013-09-22 |
2021-05-18 |
Calitor Sciences, Llc |
Substituted aminopyrimidine compounds and methods of use
|
|
CN104557955B
(zh)
*
|
2013-10-23 |
2017-05-03 |
上海汇伦生命科技有限公司 |
作为PI3K/mTOR抑制剂的三环类化合物,其制备方法和用途
|
|
EP3063302B1
(en)
|
2013-10-30 |
2019-12-04 |
Eutropics Pharmaceuticals, Inc. |
Methods for determining chemosensitivity and chemotoxicity
|
|
US9458150B2
(en)
|
2013-11-08 |
2016-10-04 |
Rutgers, The State University Of New Jersey |
Antimicrobial agents
|
|
WO2015081257A2
(en)
*
|
2013-11-27 |
2015-06-04 |
Signalchem Lifesciences Corporation |
Aminopyridine derivatives as tam family kinase inhibitors
|
|
WO2015085132A1
(en)
|
2013-12-06 |
2015-06-11 |
Vertex Pharmaceuticals Incorporated |
2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof
|
|
EP4019518A1
(en)
|
2014-02-28 |
2022-06-29 |
Nimbus Lakshmi, Inc. |
Tyk2 inhibitors and uses thereof
|
|
CN104922116B
(zh)
*
|
2014-03-23 |
2020-08-11 |
上海诗丹德生物技术有限公司 |
甲基丙烯酰基苯并咪唑酮衍生物的用途
|
|
NO2714752T3
(enExample)
*
|
2014-05-08 |
2018-04-21 |
|
|
|
CN107074863B
(zh)
|
2014-06-05 |
2019-12-03 |
沃泰克斯药物股份有限公司 |
Atr激酶抑制剂的制备方法及其不同的固体形式
|
|
RU2658912C1
(ru)
|
2014-06-17 |
2018-06-26 |
Шанхай Цзя Тань Фарматек Ко. Лтд. |
АНАЛОГ ПИРИДИНО[1,2-А]ПИРИМИДОНА, ИСПОЛЬЗУЕМЫЙ В КАЧЕСТВЕ ИНГИБИТОРА mTOR/PI3K
|
|
CA2950780C
(en)
|
2014-06-17 |
2023-05-16 |
Vertex Pharmaceuticals Incorporated |
Method for treating cancer using a combination of chk1 and atr inhibitors
|
|
CN112430250A
(zh)
|
2014-08-12 |
2021-03-02 |
莫纳什大学 |
定向淋巴的前药
|
|
CN105330699B
(zh)
*
|
2014-08-13 |
2018-12-04 |
山东汇睿迪生物技术有限公司 |
一种含磷吡啶并[2,3-d]嘧啶-7-酮类化合物或其药学上可接受的盐、药物组合物及其应用
|
|
JP6605020B2
(ja)
|
2014-08-15 |
2019-11-13 |
ヤンセン ファーマシューティカルズ,インコーポレーテッド |
Nr2b受容体阻害剤としてのトリアゾール
|
|
WO2016025918A1
(en)
|
2014-08-15 |
2016-02-18 |
Janssen Pharmaceuticals, Inc. |
Pyrazoles
|
|
WO2016067035A1
(en)
|
2014-10-29 |
2016-05-06 |
Bicycle Therapeutics Limited |
Bicyclic peptide ligands specific for mt1-mmp
|
|
EP3262049B1
(en)
|
2015-02-27 |
2022-07-20 |
Nimbus Lakshmi, Inc. |
Tyk2 inhibitors and uses thereof
|
|
FR3033499A1
(fr)
|
2015-03-11 |
2016-09-16 |
Centre Leon-Berard |
Composition pour le traitement des tumeurs neuroendocrines pancreatiques
|
|
CN104961725B
(zh)
*
|
2015-06-18 |
2017-04-19 |
浙江大学 |
4‑α,β不饱和酰胺基喹啉类化合物及制备和应用
|
|
WO2017004134A1
(en)
|
2015-06-29 |
2017-01-05 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
|
BR112018000468A2
(pt)
*
|
2015-07-09 |
2018-09-18 |
Janssen Pharmaceutica Nv |
4-azaindóis substituídos e seu uso como moduladores do receptor de glun2b
|
|
US10517870B2
(en)
*
|
2015-07-30 |
2019-12-31 |
Bristol-Myers Squibb Company |
Aryl substituted bicycle heteroaryl compounds
|
|
WO2017027768A1
(en)
|
2015-08-13 |
2017-02-16 |
The Broad Institute, Inc. |
Compositions and methods for treating tuberculosis
|
|
TWI707852B
(zh)
|
2015-09-02 |
2020-10-21 |
美商林伯士拉克許米公司 |
Tyk2 抑制劑及其用途
|
|
WO2017041139A1
(en)
|
2015-09-08 |
2017-03-16 |
Monash University |
Lymph directing prodrugs
|
|
WO2017044720A1
(en)
|
2015-09-11 |
2017-03-16 |
Navitor Pharmaceuticals, Inc. |
Rapamycin analogs and uses thereof
|
|
GB201516504D0
(en)
|
2015-09-17 |
2015-11-04 |
Astrazeneca Ab |
Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
|
|
HK1258570A1
(zh)
|
2015-09-30 |
2019-11-15 |
Vertex Pharmaceuticals Inc. |
使用dna损伤剂及atr抑制剂的组合治疗癌症的方法
|
|
HRP20230331T1
(hr)
|
2015-10-23 |
2023-07-07 |
Navitor Pharmaceuticals, Inc. |
Modulatori interakcije sestrin-gator2 i njihova uporaba
|
|
WO2017106352A1
(en)
|
2015-12-14 |
2017-06-22 |
Raze Therapeutics, Inc. |
Caffeine inhibitors of mthfd2 and uses thereof
|
|
CN108368111B
(zh)
*
|
2015-12-16 |
2020-07-31 |
上海嘉坦医药科技有限公司 |
吡啶并[1,2-a]嘧啶酮类似物的晶型及其制备方法和中间体
|
|
JP6923543B2
(ja)
|
2016-02-10 |
2021-08-18 |
ヤンセン ファーマシューティカ エヌ.ベー. |
Nr2b選択的nmda調節因子としての置換1,2,3−トリアゾール
|
|
WO2017147316A1
(en)
|
2016-02-25 |
2017-08-31 |
Taxis Pharmaceuticals, Inc. |
Synthetic processes and intermediates
|
|
US11014882B2
(en)
*
|
2016-03-09 |
2021-05-25 |
Raze Therapeutics, Inc. |
3-phosphoglycerate dehydrogenase inhibitors and uses thereof
|
|
LT3426243T
(lt)
|
2016-03-09 |
2021-08-10 |
Raze Therapeutics, Inc. |
3-fosfogliceratdehidrogenazės inhibitoriai ir jų panaudojimas
|
|
CA3019394A1
(en)
|
2016-04-08 |
2017-10-12 |
X4 Pharmaceuticals, Inc. |
Methods for treating cancer
|
|
JP6994767B2
(ja)
|
2016-06-21 |
2022-01-14 |
エックス4 ファーマシューティカルズ, インコーポレイテッド |
Cxcr4阻害剤およびその使用
|
|
WO2017223229A1
(en)
|
2016-06-21 |
2017-12-28 |
X4 Pharmaceuticals, Inc. |
Cxcr4 inhibitors and uses thereof
|
|
EP3808748A1
(en)
|
2016-06-21 |
2021-04-21 |
X4 Pharmaceuticals, Inc. |
Substituted piperidines as cxcr4-inhibitors
|
|
US10154992B2
(en)
*
|
2016-07-12 |
2018-12-18 |
The Regents Of The University Of California |
Compounds and methods for treating HIV infection
|
|
WO2018035080A1
(en)
*
|
2016-08-16 |
2018-02-22 |
Merck Patent Gmbh |
2-oxo-imidazopyridines as reversible btk inhibitors and uses thereof
|
|
TW201819376A
(zh)
|
2016-10-06 |
2018-06-01 |
比利時商健生藥品公司 |
經取代之1H-咪唑並[4,5-b]吡啶-2(3H)-酮及其作為GLUN2B受體調節劑之用途
|
|
JP7082130B2
(ja)
|
2016-10-14 |
2022-06-07 |
ニンバス ラクシュミ, インコーポレイテッド |
Tyk2阻害剤およびその使用
|
|
AU2017345736B2
(en)
|
2016-10-21 |
2022-04-07 |
Takeda Pharmaceutical Company Limited |
TYK2 inhibitors and uses thereof
|
|
WO2018089499A1
(en)
|
2016-11-08 |
2018-05-17 |
Navitor Pharmaceuticals, Inc. |
PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF
|
|
CN106580986B
(zh)
*
|
2016-11-28 |
2017-09-15 |
王保亮 |
一种治疗少弱精子症的药物组合物
|
|
CA3043768A1
(en)
|
2016-11-29 |
2018-06-07 |
PureTech Health LLC |
Exosomes for delivery of therapeutic agents
|
|
WO2018106636A1
(en)
|
2016-12-05 |
2018-06-14 |
Raze Therapeutics, Inc. |
Shmt inhibitors and uses thereof
|
|
US20180153922A1
(en)
|
2016-12-06 |
2018-06-07 |
New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery |
Inhibition of expansion and function of pathogenic age-associated b cells and use for the prevention and treatment of autoimmune disease
|
|
CN110603261A
(zh)
|
2016-12-23 |
2019-12-20 |
拜斯科阿迪有限公司 |
具有新型键结构的肽衍生物
|
|
WO2018121550A1
(zh)
*
|
2016-12-26 |
2018-07-05 |
中国医学科学院药物研究所 |
喹唑啉类化合物及其制备方法、用途和药物组合物
|
|
ES2985986T3
(es)
|
2017-01-06 |
2024-11-08 |
Bicyclerd Ltd |
Conjugado biciclo para tratar el cáncer
|
|
EP4338802A3
(en)
|
2017-03-08 |
2024-09-04 |
Takeda Pharmaceutical Company Limited |
Tyk2 inhibitors, uses, and methods for production thereof
|
|
EP3375784A1
(en)
|
2017-03-14 |
2018-09-19 |
Artax Biopharma Inc. |
Aza-dihydro-acridone derivatives
|
|
EP3375778A1
(en)
|
2017-03-14 |
2018-09-19 |
Artax Biopharma Inc. |
Aryl-piperidine derivatives
|
|
WO2018183917A1
(en)
|
2017-03-30 |
2018-10-04 |
Taxis Pharmaceuticals, Inc. |
Synthetic processes and synthetic intermediates
|
|
WO2018191146A1
(en)
|
2017-04-10 |
2018-10-18 |
Navitor Pharmaceuticals, Inc. |
Heteroaryl rheb inhibitors and uses thereof
|
|
JP7179015B2
(ja)
|
2017-04-26 |
2022-11-28 |
ナビター ファーマシューティカルズ, インコーポレイテッド |
Sestrin-GATOR2相互座用のモジュレーターおよびその使用
|
|
EP3615550A1
(en)
|
2017-04-27 |
2020-03-04 |
BicycleTx Limited |
Bicyclic peptide ligands and uses thereof
|
|
US11168082B2
(en)
*
|
2017-05-15 |
2021-11-09 |
The Regents Of The University Of Michigan |
Pyrrolo[2,3-C]pyridines and related analogs as LSD-1 inhibitors
|
|
EP3645549A1
(en)
|
2017-06-26 |
2020-05-06 |
BicycleRD Limited |
Bicyclic peptide ligands with detectable moieties and uses thereof
|
|
CN111194317A
(zh)
|
2017-07-28 |
2020-05-22 |
林伯士拉克许米公司 |
Tyk2抑制剂与其用途
|
|
CN111183147B
(zh)
|
2017-08-04 |
2024-07-05 |
拜斯科技术开发有限公司 |
Cd137特异性的双环肽配体
|
|
EP3668550A1
(en)
|
2017-08-14 |
2020-06-24 |
Bicyclerd Limited |
Bicyclic peptide ligand prr-a conjugates and uses thereof
|
|
US20200291096A1
(en)
|
2017-08-14 |
2020-09-17 |
Bicyclerd Limited |
Bicyclic peptide ligand sting conjugates and uses thereof
|
|
WO2019046491A1
(en)
|
2017-08-29 |
2019-03-07 |
Ariya Therapeutics, Inc. |
LIPIDIC PRODRUGS DIRECTING TO THE LYMPHATIC SYSTEM
|
|
US11883497B2
(en)
|
2017-08-29 |
2024-01-30 |
Puretech Lyt, Inc. |
Lymphatic system-directing lipid prodrugs
|
|
EP4624467A2
(en)
|
2017-09-22 |
2025-10-01 |
Kymera Therapeutics, Inc. |
Protein degraders and uses thereof
|
|
US11358948B2
(en)
|
2017-09-22 |
2022-06-14 |
Kymera Therapeutics, Inc. |
CRBN ligands and uses thereof
|
|
CN107793404A
(zh)
*
|
2017-11-07 |
2018-03-13 |
全椒先奇医药科技有限公司 |
一种治疗缺血性脑损伤药物组合物及其应用
|
|
TWI825046B
(zh)
|
2017-12-19 |
2023-12-11 |
英商拜西可泰克斯有限公司 |
Epha2特用之雙環胜肽配位基
|
|
US11608345B1
(en)
|
2017-12-19 |
2023-03-21 |
Puretech Lyt, Inc. |
Lipid prodrugs of rapamycin and its analogs and uses thereof
|
|
EP3727362A4
(en)
|
2017-12-19 |
2021-10-06 |
PureTech LYT, Inc. |
MYCOPHENOLIC ACID LIPID PRODRUGS AND THEIR USES
|
|
US11304954B2
(en)
|
2017-12-19 |
2022-04-19 |
Puretech Lyt, Inc. |
Lipid prodrugs of mycophenolic acid and uses thereof
|
|
GB201721265D0
(en)
|
2017-12-19 |
2018-01-31 |
Bicyclerd Ltd |
Bicyclic peptide ligands specific for EphA2
|
|
IL315310A
(en)
|
2017-12-26 |
2024-10-01 |
Kymera Therapeutics Inc |
Irak degraders and uses thereof
|
|
EP3737675A4
(en)
|
2018-01-12 |
2022-01-05 |
Kymera Therapeutics, Inc. |
Crbn ligands and uses thereof
|
|
WO2019140380A1
(en)
|
2018-01-12 |
2019-07-18 |
Kymera Therapeutics, Inc. |
Protein degraders and uses thereof
|
|
TWI816742B
(zh)
|
2018-01-29 |
2023-10-01 |
美商維泰克斯製藥公司 |
Gcn2抑制劑及其用途
|
|
MX2020007797A
(es)
|
2018-01-29 |
2020-09-18 |
Merck Patent Gmbh |
Inhibidores de la cinasa 2 de control general no desrepresible (gcn2) y usos de los mismos.
|
|
EP3755725A1
(en)
|
2018-02-23 |
2020-12-30 |
BicycleTX Limited |
Multimeric bicyclic peptide ligands
|
|
CN112189009B
(zh)
|
2018-02-27 |
2023-09-29 |
阿塔克斯生物制药有限公司 |
作为tcr-nck相互作用的抑制剂的色烯衍生物
|
|
LT3762368T
(lt)
|
2018-03-08 |
2022-06-10 |
Incyte Corporation |
Aminopirazindiolio junginiai, kaip pi3k-γ inhibitoriai
|
|
US11008302B2
(en)
|
2018-04-04 |
2021-05-18 |
Janssen Pharmaceutica Nv |
Substituted pyridine and pyrimidines and their use as GluN2B receptor modulators
|
|
TWI884914B
(zh)
|
2018-04-24 |
2025-06-01 |
美商維泰克斯製藥公司 |
喋啶酮化合物及其用途
|
|
IL301501B2
(en)
|
2018-04-24 |
2024-10-01 |
Vertex Pharma |
Antiproliferation compounds and uses thereof
|
|
WO2019229765A1
(en)
*
|
2018-05-29 |
2019-12-05 |
Council Of Scientific & Industrial Research, India |
Bicycle topoisomerase i inhibiting compounds, process for preparation and use thereof
|
|
EP3575305A1
(fr)
*
|
2018-05-31 |
2019-12-04 |
Biocidal Alternative Solutions |
Procédé de fabrication de composés comprenant un groupe fonctionnel oxazolopyridinones
|
|
CN113194752A
(zh)
|
2018-06-01 |
2021-07-30 |
康奈尔大学 |
Pi3k相关疾病或病症的组合疗法
|
|
CN117843659A
(zh)
|
2018-06-15 |
2024-04-09 |
詹森药业有限公司 |
雷帕霉素类似物和其用途
|
|
GB201810316D0
(en)
|
2018-06-22 |
2018-08-08 |
Bicyclerd Ltd |
Peptide ligands for binding to EphA2
|
|
IL279489B2
(en)
|
2018-06-22 |
2025-10-01 |
Bicycletx Ltd |
Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate
|
|
KR102595520B1
(ko)
|
2018-07-05 |
2023-10-30 |
엘지디스플레이 주식회사 |
헤테로아릴기를 가진 벤즈아졸 유도체 및 이를 포함하는 유기전계발광소자
|
|
US12454520B2
(en)
|
2018-07-06 |
2025-10-28 |
Kymera Therapeutics, Inc. |
Protein degraders and uses thereof
|
|
WO2020010177A1
(en)
|
2018-07-06 |
2020-01-09 |
Kymera Therapeutics, Inc. |
Tricyclic crbn ligands and uses thereof
|
|
US10548889B1
(en)
|
2018-08-31 |
2020-02-04 |
X4 Pharmaceuticals, Inc. |
Compositions of CXCR4 inhibitors and methods of preparation and use
|
|
EP3846793B1
(en)
|
2018-09-07 |
2024-01-24 |
PIC Therapeutics, Inc. |
Eif4e inhibitors and uses thereof
|
|
CN113271940A
(zh)
|
2018-10-15 |
2021-08-17 |
林伯士拉克许米公司 |
Tyk2抑制剂和其用途
|
|
JP2022512779A
(ja)
|
2018-10-23 |
2022-02-07 |
バイスクルテクス・リミテッド |
二環式ペプチドリガンドおよびその使用
|
|
US11345654B2
(en)
|
2018-10-24 |
2022-05-31 |
Navitor Pharmaceuticals, Inc. |
Polymorphic compounds and uses thereof
|
|
KR102891608B1
(ko)
|
2018-11-30 |
2025-11-28 |
카이메라 쎄라퓨틱스 인코포레이티드 |
Irak 분해제 및 이의 용도
|
|
WO2020112937A1
(en)
|
2018-11-30 |
2020-06-04 |
Nimbus Lakshmi, Inc. |
Tyk2 inhibitors and uses thereof
|
|
GB201820288D0
(en)
|
2018-12-13 |
2019-01-30 |
Bicycle Tx Ltd |
Bicycle peptide ligaands specific for MT1-MMP
|
|
GB201820325D0
(en)
|
2018-12-13 |
2019-01-30 |
Bicyclerd Ltd |
Bicyclic peptide ligands specific for psma
|
|
GB201820295D0
(en)
|
2018-12-13 |
2019-01-30 |
Bicyclerd Ltd |
Bicyclic peptide ligands specific for MT1-MMP
|
|
EP3670659A1
(en)
|
2018-12-20 |
2020-06-24 |
Abivax |
Biomarkers, and uses in treatment of viral infections, inflammations, or cancer
|
|
EP3897849A1
(en)
|
2018-12-21 |
2021-10-27 |
BicycleTx Limited |
Bicyclic peptide ligands specific for pd-l1
|
|
WO2020154474A1
(en)
|
2019-01-23 |
2020-07-30 |
Nimbus Lakshmi, Inc. |
Tyk2 inhibitors and uses thereof
|
|
WO2020165600A1
(en)
|
2019-02-14 |
2020-08-20 |
Bicycletx Limited |
Bicyclic peptide ligand sting conjugates and uses thereof
|
|
EP3946462A1
(en)
|
2019-04-02 |
2022-02-09 |
BicycleTX Limited |
Bicycle toxin conjugates and uses thereof
|
|
KR20220006139A
(ko)
|
2019-04-05 |
2022-01-14 |
카이메라 쎄라퓨틱스 인코포레이티드 |
Stat 분해제 및 이의 용도
|
|
EP3976027B1
(en)
|
2019-05-30 |
2025-11-05 |
Merck Sharp & Dohme LLC |
Quinoline derivatives as factor xi activation inhibitors
|
|
CA3141826A1
(en)
|
2019-05-31 |
2020-12-03 |
Ikena Oncology, Inc. |
Tead inhibitors and uses thereof
|
|
US11161846B2
(en)
|
2019-06-14 |
2021-11-02 |
Janssen Pharmaceutica Nv |
Substituted pyrazolo[4,3-b]pyridines and their use as GluN2B receptor modulators
|
|
BR112021025141A2
(pt)
|
2019-06-14 |
2022-01-25 |
Janssen Pharmaceutica Nv |
Pirazolo-piridinas heteroaromáticas substituídas e seu uso como moduladores do receptor glun2b
|
|
BR112021023562A2
(pt)
|
2019-06-14 |
2022-01-04 |
Janssen Pharmaceutica Nv |
Carbamatos de pirazina e seus usos como moduladores do receptor de glun2b
|
|
BR112021025132A2
(pt)
|
2019-06-14 |
2022-01-25 |
Janssen Pharmaceutica Nv |
Carbamatos de piridina e seu uso como moduladores do receptor glun2b
|
|
JP7667097B2
(ja)
|
2019-06-14 |
2025-04-22 |
ヤンセン ファーマシューティカ エヌ.ベー. |
置換ピラゾロ-ピリジンアミド及びglun2b受容体調節因子としてのその使用
|
|
CA3143105A1
(en)
|
2019-06-14 |
2020-12-17 |
Janssen Pharmaceutica Nv |
Substituted pyrazolo-pyrazines and their use as glun2b receptor modulators
|
|
WO2020249792A1
(en)
|
2019-06-14 |
2020-12-17 |
Janssen Pharmaceutica Nv |
Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulators
|
|
TWI862640B
(zh)
|
2019-07-30 |
2024-11-21 |
英商拜西可泰克斯有限公司 |
異質雙環肽複合物
|
|
CA3150492A1
(en)
|
2019-09-11 |
2021-03-18 |
Donna L. Romero |
USP30 INHIBITORS AND USES THEREOF
|
|
MX2022002877A
(es)
|
2019-09-13 |
2022-08-08 |
Nimbus Saturn Inc |
Antagonistas de cinasa progenitora hematopoyetica 1 (hpk1) y sus usos.
|
|
CN114786660A
(zh)
|
2019-11-01 |
2022-07-22 |
纳维托制药有限公司 |
使用mtorc1调节剂的治疗方法
|
|
KR20220128345A
(ko)
|
2019-12-05 |
2022-09-20 |
아나쿠리아 테라퓨틱스, 인코포레이티드 |
라파마이신 유사체 및 이의 용도
|
|
WO2021127283A2
(en)
|
2019-12-17 |
2021-06-24 |
Kymera Therapeutics, Inc. |
Irak degraders and uses thereof
|
|
EP4076520A4
(en)
|
2019-12-17 |
2024-03-27 |
Kymera Therapeutics, Inc. |
Irak degraders and uses thereof
|
|
WO2021133920A1
(en)
|
2019-12-23 |
2021-07-01 |
Kymera Therapeutics, Inc. |
Smarca degraders and uses thereof
|
|
AU2021217172A1
(en)
|
2020-02-05 |
2022-09-22 |
Monash University |
Lipid prodrugs of neurosteroids
|
|
TW202146393A
(zh)
|
2020-03-03 |
2021-12-16 |
美商皮克醫療公司 |
Eif4e抑制劑及其用途
|
|
IL296451A
(en)
|
2020-03-19 |
2022-11-01 |
Kymera Therapeutics Inc |
Mdm2 degraders and uses thereof
|
|
WO2021202731A1
(en)
|
2020-03-31 |
2021-10-07 |
Chemocentryx, Inc. |
Compositions and methods for treating inflammatory bowel disease using ccr9 inhibitor and anti-il-23 blocking antibodies
|
|
EP4161521A4
(en)
|
2020-06-03 |
2024-07-10 |
Kymera Therapeutics, Inc. |
DEUTERED IRAQ DEGRADERS AND USES THEREOF
|
|
TW202210483A
(zh)
|
2020-06-03 |
2022-03-16 |
美商凱麥拉醫療公司 |
Irak降解劑之結晶型
|
|
IL300450A
(en)
|
2020-08-17 |
2023-04-01 |
Bicycletx Ltd |
Bicyclic conjugates specific to nectin-4 and uses thereof
|
|
JP2023546996A
(ja)
|
2020-10-23 |
2023-11-08 |
ニンバス クロソー, インコーポレイテッド |
Ctps1阻害剤およびその使用
|
|
WO2022120353A1
(en)
|
2020-12-02 |
2022-06-09 |
Ikena Oncology, Inc. |
Tead inhibitors and uses thereof
|
|
KR20230131189A
(ko)
|
2020-12-02 |
2023-09-12 |
이케나 온콜로지, 인코포레이티드 |
Tead 억제제 및 이의 용도
|
|
CN116867758A
(zh)
|
2020-12-30 |
2023-10-10 |
凯麦拉医疗公司 |
Irak降解剂和其用途
|
|
EP4288430A1
(en)
|
2021-02-02 |
2023-12-13 |
Liminal Biosciences Limited |
Gpr84 antagonists and uses thereof
|
|
CA3206501A1
(en)
|
2021-02-02 |
2022-08-11 |
Shaun Abbott |
Gpr84 antagonists and uses thereof
|
|
US12252488B2
(en)
|
2021-02-12 |
2025-03-18 |
Nimbus Saturn, Inc. |
HPK1 antagonists and uses thereof
|
|
MX2023009527A
(es)
|
2021-02-15 |
2023-08-24 |
Kymera Therapeutics Inc |
Degradadores de la cinasa 4 asociada al receptor de interleucina 1 (irak4) y usos de los mismos.
|
|
TW202245789A
(zh)
|
2021-02-15 |
2022-12-01 |
美商凱麥拉醫療公司 |
Irak4降解劑及其用途
|
|
US20240139183A1
(en)
|
2021-02-16 |
2024-05-02 |
Ribotech Co., Ltd. |
Compound for suppressing nonsense-mediated mrna decay
|
|
US11926625B2
(en)
|
2021-03-05 |
2024-03-12 |
Nimbus Saturn, Inc. |
HPK1 antagonists and uses thereof
|
|
JP7710756B2
(ja)
*
|
2021-03-18 |
2025-07-22 |
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|
|
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|
|
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(en)
|
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|
|
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|
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|
|
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|
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|
|
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(zh)
*
|
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|
|
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*
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(zh)
*
|
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|
|
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|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(en)
|
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|
|
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(zh)
*
|
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|
|
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|
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|
|
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(en)
|
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|
|
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|
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|
|
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(en)
*
|
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|
|
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(en)
|
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|
|
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*
|
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|
|
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|
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|
|
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|
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|
|
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(en)
|
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|
|
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*
|
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|