JP2017530154A5 - - Google Patents
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- JP2017530154A5 JP2017530154A5 JP2017517705A JP2017517705A JP2017530154A5 JP 2017530154 A5 JP2017530154 A5 JP 2017530154A5 JP 2017517705 A JP2017517705 A JP 2017517705A JP 2017517705 A JP2017517705 A JP 2017517705A JP 2017530154 A5 JP2017530154 A5 JP 2017530154A5
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- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- ring
- hydroxy
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims description 226
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 104
- 125000005842 heteroatom Chemical group 0.000 claims description 88
- 229910052760 oxygen Inorganic materials 0.000 claims description 88
- 229910052717 sulfur Inorganic materials 0.000 claims description 88
- 229910052739 hydrogen Inorganic materials 0.000 claims description 77
- 229910052799 carbon Inorganic materials 0.000 claims description 72
- 125000000623 heterocyclic group Chemical group 0.000 claims description 61
- 125000004432 carbon atom Chemical group C* 0.000 claims description 55
- 239000001257 hydrogen Substances 0.000 claims description 55
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 55
- 125000005843 halogen group Chemical group 0.000 claims description 49
- 102100027844 Fibroblast growth factor receptor 4 Human genes 0.000 claims description 46
- 101000917134 Homo sapiens Fibroblast growth factor receptor 4 Proteins 0.000 claims description 46
- -1 haloC 1 -C 3 alkyl Chemical group 0.000 claims description 44
- 150000002431 hydrogen Chemical group 0.000 claims description 38
- 229910052736 halogen Inorganic materials 0.000 claims description 33
- 150000002367 halogens Chemical group 0.000 claims description 33
- 125000004043 oxo group Chemical group O=* 0.000 claims description 33
- 229920006395 saturated elastomer Polymers 0.000 claims description 33
- 150000001875 compounds Chemical class 0.000 claims description 32
- 102100020683 Beta-klotho Human genes 0.000 claims description 31
- 102100031734 Fibroblast growth factor 19 Human genes 0.000 claims description 31
- 101001139095 Homo sapiens Beta-klotho Proteins 0.000 claims description 31
- 101000846394 Homo sapiens Fibroblast growth factor 19 Proteins 0.000 claims description 31
- 150000003839 salts Chemical class 0.000 claims description 30
- 125000003118 aryl group Chemical group 0.000 claims description 22
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 22
- 229910052757 nitrogen Inorganic materials 0.000 claims description 22
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 22
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 17
- 239000007787 solid Substances 0.000 claims description 15
- 150000001204 N-oxides Chemical class 0.000 claims description 11
- 125000002619 bicyclic group Chemical group 0.000 claims description 11
- 125000004122 cyclic group Chemical group 0.000 claims description 11
- 125000001475 halogen functional group Chemical group 0.000 claims description 11
- 125000003566 oxetanyl group Chemical group 0.000 claims description 11
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
- 125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 claims description 11
- 125000006413 ring segment Chemical group 0.000 claims description 11
- 206010028980 Neoplasm Diseases 0.000 claims description 10
- 239000012472 biological sample Substances 0.000 claims description 10
- 201000011510 cancer Diseases 0.000 claims description 9
- 230000036210 malignancy Effects 0.000 claims description 9
- WWXYIWRCALKTTD-UHFFFAOYSA-N 6-[[acetyl(methyl)amino]methyl]-N-(5-cyanopyridin-2-yl)-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide Chemical compound CN(Cc1cc2CCCN(C(=O)Nc3ccc(cn3)C#N)c2nc1C=O)C(C)=O WWXYIWRCALKTTD-UHFFFAOYSA-N 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- DNJLKERWZGKXBF-UHFFFAOYSA-N N-(5-cyanopyridin-2-yl)-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide Chemical compound O=Cc1ccc2CCCN(C(=O)Nc3ccc(cn3)C#N)c2n1 DNJLKERWZGKXBF-UHFFFAOYSA-N 0.000 claims description 2
- HXNZAVZZAPTZBP-UHFFFAOYSA-N N-(5-cyanopyridin-2-yl)-7-formyl-6-(hydroxymethyl)-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide Chemical compound OCc1cc2CCCN(C(=O)Nc3ccc(cn3)C#N)c2nc1C=O HXNZAVZZAPTZBP-UHFFFAOYSA-N 0.000 claims description 2
- GBJIYJAVKBUOHN-UHFFFAOYSA-N N-[5-cyano-4-(2-methoxyethoxy)pyridin-2-yl]-6-(difluoromethyl)-7-formyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide Chemical compound COCCOc1cc(NC(=O)N2CCCc3cc(C(F)F)c(C=O)nc23)ncc1C#N GBJIYJAVKBUOHN-UHFFFAOYSA-N 0.000 claims description 2
- RVTLBVODLXUYNU-UHFFFAOYSA-N N-[5-cyano-4-(2-methoxyethoxy)pyridin-2-yl]-7-formyl-6-(hydroxymethyl)-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide Chemical compound COCCOc1cc(NC(=O)N2CCCc3cc(CO)c(C=O)nc23)ncc1C#N RVTLBVODLXUYNU-UHFFFAOYSA-N 0.000 claims description 2
- LGFNXKJQQVMYQI-UHFFFAOYSA-N N-[5-cyano-4-(2-methoxyethoxy)pyridin-2-yl]-7-formyl-6-[(4-methyl-2-oxopiperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide Chemical compound COCCOc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc23)ncc1C#N LGFNXKJQQVMYQI-UHFFFAOYSA-N 0.000 claims description 2
- SYRAVIOIIKVUFT-UHFFFAOYSA-N N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-formyl-6-(hydroxymethyl)-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide Chemical compound COCCNc1cc(NC(=O)N2CCCc3cc(CO)c(C=O)nc23)ncc1C#N SYRAVIOIIKVUFT-UHFFFAOYSA-N 0.000 claims description 2
- BHKDKKZMPODMIQ-UHFFFAOYSA-N N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-formyl-6-[(4-methyl-2-oxopiperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide Chemical compound COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc23)ncc1C#N BHKDKKZMPODMIQ-UHFFFAOYSA-N 0.000 claims description 2
- JDSIDNMVOWOKBD-MRXNPFEDSA-N N-[5-cyano-4-[(3R)-oxolan-3-yl]oxypyridin-2-yl]-7-formyl-6-(hydroxymethyl)-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide Chemical compound C(#N)C=1C(=CC(=NC1)NC(=O)N1CCCC2=CC(=C(N=C12)C=O)CO)O[C@H]1COCC1 JDSIDNMVOWOKBD-MRXNPFEDSA-N 0.000 claims description 2
- JDSIDNMVOWOKBD-INIZCTEOSA-N N-[5-cyano-4-[(3S)-oxolan-3-yl]oxypyridin-2-yl]-7-formyl-6-(hydroxymethyl)-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide Chemical compound C(#N)C=1C(=CC(=NC1)NC(=O)N1CCCC2=CC(=C(N=C12)C=O)CO)O[C@@H]1COCC1 JDSIDNMVOWOKBD-INIZCTEOSA-N 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 206010017758 gastric cancer Diseases 0.000 claims description 2
- 208000005017 glioblastoma Diseases 0.000 claims description 2
- 201000007270 liver cancer Diseases 0.000 claims description 2
- 208000014018 liver neoplasm Diseases 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims description 2
- 201000011549 stomach cancer Diseases 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 206010073069 Hepatic cancer Diseases 0.000 claims 1
- 229940001468 citrate Drugs 0.000 claims 1
- 150000001860 citric acid derivatives Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 229940049920 malate Drugs 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 description 66
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 6
- BVCRERJDOOBZOH-UHFFFAOYSA-N bicyclo[2.2.1]heptanyl Chemical group C1C[C+]2CC[C-]1C2 BVCRERJDOOBZOH-UHFFFAOYSA-N 0.000 description 6
- 125000000753 cycloalkyl group Chemical group 0.000 description 6
- KVIZTDNKHOCNAM-UHFFFAOYSA-N 4-methylpiperazin-2-one Chemical compound CN1CCNC(=O)C1 KVIZTDNKHOCNAM-UHFFFAOYSA-N 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000001516 cell proliferation assay Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2014/088094 | 2014-10-03 | ||
| CN2014088094 | 2014-10-03 | ||
| PCT/US2015/053677 WO2016054483A1 (en) | 2014-10-03 | 2015-10-02 | Use of ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019161051A Division JP6794514B2 (ja) | 2014-10-03 | 2019-09-04 | Ｆｇｆｒ４阻害剤としての縮環二環式ピリジル誘導体の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017530154A JP2017530154A (ja) | 2017-10-12 |
| JP2017530154A5 true JP2017530154A5 (enExample) | 2018-11-15 |
| JP6585167B2 JP6585167B2 (ja) | 2019-10-02 |
Family
ID=54330059
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017517705A Active JP6585167B2 (ja) | 2014-10-03 | 2015-10-02 | Ｆｇｆｒ４阻害剤としての縮環二環式ピリジル誘導体の使用 |
| JP2019161051A Active JP6794514B2 (ja) | 2014-10-03 | 2019-09-04 | Ｆｇｆｒ４阻害剤としての縮環二環式ピリジル誘導体の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019161051A Active JP6794514B2 (ja) | 2014-10-03 | 2019-09-04 | Ｆｇｆｒ４阻害剤としての縮環二環式ピリジル誘導体の使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20180185341A1 (enExample) |
| EP (1) | EP3200786B1 (enExample) |
| JP (2) | JP6585167B2 (enExample) |
| ES (1) | ES2756748T3 (enExample) |
| PL (1) | PL3200786T3 (enExample) |
| WO (1) | WO2016054483A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016054483A1 (en) * | 2014-10-03 | 2016-04-07 | Novartis Ag | Use of ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors |
| CN113105454B (zh) * | 2016-05-20 | 2022-10-11 | 江苏豪森药业集团有限公司 | Fgfr4抑制剂、其制备方法和应用 |
| WO2018055503A1 (en) | 2016-09-20 | 2018-03-29 | Novartis Ag | Combination comprising a pd-1 antagonist and an fgfr4 inhibitor |
| US11229643B2 (en) * | 2016-11-02 | 2022-01-25 | Novartis Ag | Combinations of FGFR4 inhibitors and bile acid sequestrants |
| TWI723480B (zh) * | 2018-07-27 | 2021-04-01 | 大陸商北京加科思新藥研發有限公司 | 用作fgfr4抑制劑的稠環衍生物 |
| EP3942045A1 (en) | 2019-03-21 | 2022-01-26 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
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| DK3395814T3 (da) | 2013-10-25 | 2022-07-04 | Blueprint Medicines Corp | Hæmmere af fibroblastvækstfaktorreceptoren |
| BR112016008276B1 (pt) * | 2013-10-25 | 2021-03-02 | Novartis Ag | derivados bicíclicos de piridila fundidos ao anel, seus usos e seu intermediário, e composição farmacêutica |
| WO2015195509A2 (en) | 2014-06-16 | 2015-12-23 | Ngm Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| WO2016054483A1 (en) * | 2014-10-03 | 2016-04-07 | Novartis Ag | Use of ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors |
| CN107787226A (zh) * | 2015-03-25 | 2018-03-09 | 诺华股份有限公司 | 药物组合 |
| US9802917B2 (en) * | 2015-03-25 | 2017-10-31 | Novartis Ag | Particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide |
| US11229643B2 (en) | 2016-11-02 | 2022-01-25 | Novartis Ag | Combinations of FGFR4 inhibitors and bile acid sequestrants |
-
2015
- 2015-10-02 WO PCT/US2015/053677 patent/WO2016054483A1/en not_active Ceased
- 2015-10-02 JP JP2017517705A patent/JP6585167B2/ja active Active
- 2015-10-02 EP EP15781518.4A patent/EP3200786B1/en active Active
- 2015-10-02 ES ES15781518T patent/ES2756748T3/es active Active
- 2015-10-02 US US15/516,443 patent/US20180185341A1/en not_active Abandoned
- 2015-10-02 PL PL15781518T patent/PL3200786T3/pl unknown
-
2018
- 2018-11-13 US US16/190,087 patent/US10463653B2/en active Active
-
2019
- 2019-02-28 US US16/289,612 patent/US10507201B2/en active Active
- 2019-09-04 JP JP2019161051A patent/JP6794514B2/ja active Active
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