AR015514A1 - Compuesto de amida, proceso para su preparacion y composicion farmaceutica que lo contiene - Google Patents
Compuesto de amida, proceso para su preparacion y composicion farmaceutica que lo contieneInfo
- Publication number
- AR015514A1 AR015514A1 ARP990100525A ARP990100525A AR015514A1 AR 015514 A1 AR015514 A1 AR 015514A1 AR P990100525 A ARP990100525 A AR P990100525A AR P990100525 A ARP990100525 A AR P990100525A AR 015514 A1 AR015514 A1 AR 015514A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- halogen
- nr7r8
- alkoxy
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un compuesto de amida inhibidor de células B que tiene la formula (A). En donde cualquiera de: 1) Z es O; n es 0 o 1; T es un residuo de formula (I), endonde R6 es H; alquilo C1-6 opcionalmente sustituido en la posicion terminal por halogeno, OH, NR7R8, COOH, CO-O-alquilo C1-4, o CO-NR7R8; alquilo C1-6interrumpido por uno o más heteroátomos seleccionados a partir de N, O o S, y sustituido en la posicion terminal por halogeno, OH, NR7R8, COOH, CO-O-alquiloC1-4, o CO-NR7R8; OR9; NHR10; ciano; o formilo; cada uno de R7 y R8 es independientemente H, alquilo C1-4, omega-HO-alquilo C1-4, CHO o heterocicloalquiloC1-4, o R7 y R8 forman junto con el átomo de nitrogeno con el que están enlazados, un anillo heterocíclico; R9 es alquilo C1-6 sustituidoen la posicionterminal por OH o NR7R8; R10 es alquilo C1-6 sustituido en la posicion terminal por OH o NR7R8; y W es un residuo de formula (II) en donde: i) X es -CR1=, endonde R1 es H, F, CF3, alquilo C1-4, o NH2; y R2 es H, F, OH, alcoxi C1-4, CN,NO2, CF3 o NHCO-alquilo C1-4; R3 es H, halogeno, CN, NO2, CF3, NH2 u OH; R4 esH, halogeno, CF3, o alcoxi C1-4; y R5 es H, halogeno, alcoxi C1-4, tioalquilo C1-4, CF3, NH2, alquilo C1-4, o un grupo heterocíclico; o ii) X es -N=; y R3 esH, halogeno, NH2, alcoxi C1-4, OH, -O(CH2)3-NH2, piperidino, o CF3; R4 es H, F, CF3, CN o NO2; y cada uno de R2 y R5 es H; 2) Z es O o S; n es 0 o 1; T es unresiduo de formula (III), en donde: R11 es H, CH3 o C2H5; R12 es H, halogeno, alquilo C1-4, o cicloalquiloC3-6; R13 es H, halogeno, hidroxi, alcoxi C1-2,fenilalcoxi C1-2, o alquilo C1-2 sustituido por NH2, NH(alquilo C1-5), NH-SO2-alquilo C1-2, o NH-CO-alcoxi C1-4; y W es un residuo de formula (IV) en donde:uno de R14, R15 y R16 es F, CF3, OCF3, CN, alquilo C2-4, di-(alquilo C1-2)amino o carbamoílo, y los otros dos símbolos son H; o uno de R14, R15 y R16 es H, ylos otros 2 símbolos son cada uno CF3, cada uno de R14, R15 y R16 es H; o cada uno de R14, R15 y R16 es halogeno; el grupo fenil-amida o tiamida está unido acualquiera de los átomos de C libres del anillo de indol; en el entendido de que, cuando R13 es H, cuando menos uno de R14, R15 y R16 sea diferente de H, en
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9802842.6A GB9802842D0 (en) | 1998-02-10 | 1998-02-10 | Organic compounds |
GBGB9810688.3A GB9810688D0 (en) | 1998-05-19 | 1998-05-19 | Organic compounds |
GBGB9826553.1A GB9826553D0 (en) | 1998-12-02 | 1998-12-02 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
AR015514A1 true AR015514A1 (es) | 2001-05-02 |
Family
ID=27269204
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990100525A AR015514A1 (es) | 1998-02-10 | 1999-02-08 | Compuesto de amida, proceso para su preparacion y composicion farmaceutica que lo contiene |
Country Status (5)
Country | Link |
---|---|
AR (1) | AR015514A1 (es) |
AU (1) | AU2832399A (es) |
CO (1) | CO4980854A1 (es) |
PE (1) | PE20000281A1 (es) |
WO (1) | WO1999041239A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7112594B2 (en) | 2000-08-09 | 2006-09-26 | Mitsubishi Pharma Corporation | Fused bicyclic amide compounds and medicinal use thereof |
CA2430951A1 (en) * | 2000-12-07 | 2002-06-13 | Cv Therapeutics, Inc. | Substituted 1, 3, 5-triazines and pyrimidines as abca-1 elevating compounds against coronary artery disease or atherosclerosis |
EP1377549A1 (en) * | 2001-03-12 | 2004-01-07 | Millennium Pharmaceuticals, Inc. | Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor |
MXPA04001286A (es) * | 2001-08-15 | 2004-05-27 | Du Pont | Arilamidas orto-heterociclicas sustituidas para controlar plagas de invertebrados. |
JP4361800B2 (ja) | 2001-12-21 | 2009-11-11 | サイトキネティックス, インコーポレイテッド | 心不全を処置するための組成物および方法 |
WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
US8686048B2 (en) | 2010-05-06 | 2014-04-01 | Rhizen Pharmaceuticals Sa | Immunomodulator and anti-inflammatory compounds |
CA2804225C (en) * | 2010-07-02 | 2018-05-01 | Aska Pharmaceutical Co., Ltd. | Heterocyclic compound and p27kip1 degradation inhibitor |
EP2672963A4 (en) | 2011-02-08 | 2015-06-24 | Childrens Medical Center | METHOD FOR THE TREATMENT OF MELANOMA |
US9499484B2 (en) * | 2012-04-02 | 2016-11-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Indole, indoline derivatives, compositions comprising them and uses thereof |
ES2682493T3 (es) | 2013-10-25 | 2018-09-20 | Novartis Ag | Compuestos derivados de piridilo bicíclicos fusionados a anillo como inhibidores de FGFR4 |
US20180185341A1 (en) | 2014-10-03 | 2018-07-05 | Novartis Ag | Use of ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors |
US9802917B2 (en) | 2015-03-25 | 2017-10-31 | Novartis Ag | Particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide |
US10730839B2 (en) * | 2016-11-27 | 2020-08-04 | Russell Dahl | Quinolines as cytoprotective agents |
CN111164075A (zh) * | 2017-09-20 | 2020-05-15 | 北京加科思新药研发有限公司 | 用作fgfr4抑制剂的稠环衍生物 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1305458A (es) * | 1969-02-26 | 1973-01-31 | ||
US3699123A (en) * | 1970-03-24 | 1972-10-17 | Sandoz Ltd | 4-(3-amino-2-hydroxy-propoxy) indole derivatives |
FR2121394A1 (fr) * | 1971-01-08 | 1972-08-25 | Anvar | Procédé d'obtention de dérivés d'acides indole carboxyliques et produits préparables par ce procédé. |
US5484944A (en) * | 1993-10-27 | 1996-01-16 | Neurogen Corporation | Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands |
-
1999
- 1999-02-08 WO PCT/EP1999/000817 patent/WO1999041239A1/en active Application Filing
- 1999-02-08 AU AU28323/99A patent/AU2832399A/en not_active Abandoned
- 1999-02-08 AR ARP990100525A patent/AR015514A1/es unknown
- 1999-02-08 CO CO99007017A patent/CO4980854A1/es unknown
- 1999-02-09 PE PE1999000110A patent/PE20000281A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PE20000281A1 (es) | 2000-05-15 |
CO4980854A1 (es) | 2000-11-27 |
AU2832399A (en) | 1999-08-30 |
WO1999041239A1 (en) | 1999-08-19 |
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