DE69725007D1 - Delta 1,6 bicyclo (4,4,0) basierte farbstoffe zur kontrastverstaerkung in der optischen bilderzeugung - Google Patents
Delta 1,6 bicyclo (4,4,0) basierte farbstoffe zur kontrastverstaerkung in der optischen bilderzeugungInfo
- Publication number
- DE69725007D1 DE69725007D1 DE69725007T DE69725007T DE69725007D1 DE 69725007 D1 DE69725007 D1 DE 69725007D1 DE 69725007 T DE69725007 T DE 69725007T DE 69725007 T DE69725007 T DE 69725007T DE 69725007 D1 DE69725007 D1 DE 69725007D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- group
- bicyclo
- delta
- carboxylalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000003287 optical effect Effects 0.000 title 1
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 5
- 239000000975 dye Substances 0.000 abstract 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 3
- 125000005358 mercaptoalkyl group Chemical group 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 abstract 1
- 125000003396 thiol group Chemical class [H]S* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Indole Compounds (AREA)
- Developing Agents For Electrophotography (AREA)
- Silver Salt Photography Or Processing Solution Therefor (AREA)
- Optical Filters (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Liquid Crystal (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US649850 | 1996-05-13 | ||
| US08/649,850 US5672333A (en) | 1996-05-13 | 1996-05-13 | Delta1,6 bicyclo 4,4,0! functional dyes for contrast enhancement in optical imaging |
| PCT/US1997/007864 WO1997042977A1 (en) | 1996-05-13 | 1997-05-09 | Δ1,6 bicyclo [4,4,0] functional dyes for contrast enhancement in optical imaging |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69725007D1 true DE69725007D1 (de) | 2003-10-23 |
| DE69725007T2 DE69725007T2 (de) | 2004-07-08 |
Family
ID=24606485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69725007T Expired - Lifetime DE69725007T2 (de) | 1996-05-13 | 1997-05-09 | Delta 1,6 bicyclo (4,4,0) basierte farbstoffe zur kontrastverstaerkung in der optischen bilderzeugung |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5672333A (de) |
| EP (1) | EP0959906B1 (de) |
| JP (1) | JP2000510147A (de) |
| AT (1) | ATE249843T1 (de) |
| CA (1) | CA2254900A1 (de) |
| DE (1) | DE69725007T2 (de) |
| DK (1) | DK0959906T3 (de) |
| ES (1) | ES2202619T3 (de) |
| PT (1) | PT959906E (de) |
| WO (1) | WO1997042977A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7547721B1 (en) | 1998-09-18 | 2009-06-16 | Bayer Schering Pharma Ag | Near infrared fluorescent contrast agent and fluorescence imaging |
| JP2000095758A (ja) | 1998-09-18 | 2000-04-04 | Schering Ag | 近赤外蛍光造影剤および蛍光造影方法 |
| US20030180221A1 (en) * | 1998-09-18 | 2003-09-25 | Schering Ag | Near infrared fluorescent contrast agent and fluorescence imaging |
| US6167297A (en) | 1999-05-05 | 2000-12-26 | Benaron; David A. | Detecting, localizing, and targeting internal sites in vivo using optical contrast agents |
| US6180086B1 (en) | 2000-01-18 | 2001-01-30 | Mallinckrodt Inc. | Hydrophilic cyanine dyes |
| US6939532B2 (en) | 2000-01-18 | 2005-09-06 | Mallinckrodt, Inc. | Versatile hydrophilic dyes |
| US6395257B1 (en) * | 2000-01-18 | 2002-05-28 | Mallinckrodt Inc. | Dendrimer precursor dyes for imaging |
| US7198778B2 (en) * | 2000-01-18 | 2007-04-03 | Mallinckrodt Inc. | Tumor-targeted optical contrast agents |
| US6180087B1 (en) | 2000-01-18 | 2001-01-30 | Mallinckrodt Inc. | Tunable indocyanine dyes for biomedical applications |
| US7790144B2 (en) * | 2000-01-18 | 2010-09-07 | Mallinckrodt Inc. | Receptor-avid exogenous optical contrast and therapeutic agents |
| US20080233050A1 (en) * | 2000-01-18 | 2008-09-25 | Mallinckrodt Inc. | Diagnostic and therapeutic optical agents |
| US6748259B1 (en) | 2000-06-15 | 2004-06-08 | Spectros Corporation | Optical imaging of induced signals in vivo under ambient light conditions |
| US20040180809A1 (en) * | 2000-10-16 | 2004-09-16 | Mallinckrodt Inc. | Tissue-specific exogenous optical agents |
| US20070092450A1 (en) * | 2000-10-16 | 2007-04-26 | Mallinckrodt Inc. | Tissue-specific exogenous optical agents |
| US20040143190A1 (en) * | 2003-01-22 | 2004-07-22 | Schnitzer Mark J. | Mapping neural and muscular electrical activity |
| US20100022449A1 (en) * | 2006-03-09 | 2010-01-28 | Mallinckrodt Inc. | Receptor-avid exogenous optical contrast and therapeutic agents |
| US20110177006A1 (en) * | 2008-09-29 | 2011-07-21 | Raghavan Rajagopalan | Dithienofuran Dyes for Imaging and Therapy |
| EP2350206A2 (de) * | 2008-09-29 | 2011-08-03 | Mallinckrodt Inc. | Dithienpyrrolfarbstoffe für bildgebung und therapie |
| CA2737912A1 (en) * | 2008-09-29 | 2010-04-01 | Mallinckrodt Inc. | Fused ring thiophene dyes for imaging and therapy |
| WO2010121003A1 (en) | 2009-04-16 | 2010-10-21 | Mallinckrodt Inc. | Pyrazine derivatives for optical imaging and therapy |
| WO2010132554A2 (en) | 2009-05-12 | 2010-11-18 | Mallinckrodt Inc. | Diaza heterocyclic compounds for phototherapy |
| WO2010132515A1 (en) | 2009-05-12 | 2010-11-18 | Mallinckrodt Inc. | Compounds containing acyclic n-n bonds for phototherapy |
| WO2011031955A2 (en) | 2009-09-11 | 2011-03-17 | Mallinckrodt Inc. | Optical monitoring of leukemia |
| WO2011035140A1 (en) | 2009-09-18 | 2011-03-24 | Paka Pulmonary Pharmaceuticals, Inc. | Methods and compositions for delivery of contrast moieties to the lungs |
| WO2011060113A1 (en) | 2009-11-11 | 2011-05-19 | Mallinckrodt Inc. | Sulfenamide compounds for phototherapy |
| WO2011084571A2 (en) | 2009-12-16 | 2011-07-14 | Mallinckrodt Inc. | Azide derivatives for phototherapy |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4762701A (en) * | 1986-10-31 | 1988-08-09 | Smithkline Beckman Corporation | In vivo cellular tracking |
| FR2682498A1 (fr) * | 1991-10-15 | 1993-04-16 | Kodak Pathe | Colorants comprenant des macrocycles thioethers. |
| EP0565121B1 (de) * | 1992-04-09 | 1999-07-14 | Fuji Photo Film Co., Ltd. | Photographisches lichtempfindliches Silberhalogenidmaterial |
| DE4301106A1 (de) * | 1993-01-18 | 1994-07-21 | Agfa Gevaert Ag | Farbfotografisches Aufzeichnungsmaterial |
| BR9506899A (pt) * | 1994-02-28 | 1997-09-09 | Imation Corp | Elemento fototermográfico revelável a quente |
-
1996
- 1996-05-13 US US08/649,850 patent/US5672333A/en not_active Expired - Lifetime
-
1997
- 1997-05-09 ES ES97924641T patent/ES2202619T3/es not_active Expired - Lifetime
- 1997-05-09 JP JP09540962A patent/JP2000510147A/ja not_active Withdrawn
- 1997-05-09 DK DK97924641T patent/DK0959906T3/da active
- 1997-05-09 EP EP97924641A patent/EP0959906B1/de not_active Expired - Lifetime
- 1997-05-09 DE DE69725007T patent/DE69725007T2/de not_active Expired - Lifetime
- 1997-05-09 PT PT97924641T patent/PT959906E/pt unknown
- 1997-05-09 CA CA002254900A patent/CA2254900A1/en not_active Abandoned
- 1997-05-09 AT AT97924641T patent/ATE249843T1/de not_active IP Right Cessation
- 1997-05-09 WO PCT/US1997/007864 patent/WO1997042977A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP0959906B1 (de) | 2003-09-17 |
| EP0959906A4 (de) | 1999-12-22 |
| DK0959906T3 (da) | 2003-12-08 |
| PT959906E (pt) | 2004-01-30 |
| ATE249843T1 (de) | 2003-10-15 |
| CA2254900A1 (en) | 1997-11-20 |
| EP0959906A1 (de) | 1999-12-01 |
| WO1997042977A1 (en) | 1997-11-20 |
| JP2000510147A (ja) | 2000-08-08 |
| ES2202619T3 (es) | 2004-04-01 |
| DE69725007T2 (de) | 2004-07-08 |
| US5672333A (en) | 1997-09-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69725007D1 (de) | Delta 1,6 bicyclo (4,4,0) basierte farbstoffe zur kontrastverstaerkung in der optischen bilderzeugung | |
| ATE220925T1 (de) | Trizyklische funktional farbstoffe zur verbesserung von kontrast und optische bilderzeugung | |
| ES481549A1 (es) | Un procedimiento para la producicion de un derivado de feni-letanolamina. | |
| LU92544I2 (fr) | Ezetimibe en combinaison avec rosuvastatine ou luers sels pharmaceutiquement acceptées, y compris rosuvastatine sous forme de sel de zinc | |
| PE20212302A1 (es) | Inhibidores de apol1 y sus metodos de uso | |
| DE3673094D1 (de) | (meth)-acrylsaeure-derivate von tricyclodecanen und ihre verwendung. | |
| ES2057809T5 (es) | Composicion tintorea a base de 5,6-dihidroxiindolinas y procedimiento para la tincion de fibras queratinicas. | |
| DE69202286D1 (de) | Verfahren zur Färbung keratinischer Fasern mit Isatin oder Isatinderivaten zusammen mit Aminopyrimidin oder Aminopyridin und Färbemittel. | |
| DE69723880D1 (de) | Delta 1,2 bicyclo 4,4,0] basierte farbstoffe zur kontrastverstärkung in der optischen bilderzeugung | |
| AR015514A1 (es) | Compuesto de amida, proceso para su preparacion y composicion farmaceutica que lo contiene | |
| ATE44648T1 (de) | Antihypertensives kombinationspraeparat. | |
| ATE375348T1 (de) | Analoge von n-acetylardeemin, verfahren zur herstellung und verwendung dieser analogen | |
| ES402638A1 (es) | Procedimiento para la preparacion de fenilaminoalcanos. | |
| DE68902627D1 (de) | Verwendung von chromanderivaten zur herstellung eines medikamentes zur behandlung von depressiven zustaenden. | |
| TR199801683A2 (xx) | Yeni �re t�revleri. | |
| DK272482A (da) | Tricykliske forbindelser | |
| ES528460A0 (es) | Procedimiento de preparacion de nuevos deridados de alfa-etibenzol con un grupo amino propanolico sustituido y sus sales de adicion acidas y amonicas cuaternarias. | |
| ATE272384T1 (de) | Verwendung von 2-nitro-p-phenylendiaminderivaten als direktziehende farbstoffe | |
| ATE53839T1 (de) | 2,3-dihydro-3-phenyl-benzofuran-2-onacetamidderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |