JP2010500882A5 - - Google Patents
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- JP2010500882A5 JP2010500882A5 JP2009524772A JP2009524772A JP2010500882A5 JP 2010500882 A5 JP2010500882 A5 JP 2010500882A5 JP 2009524772 A JP2009524772 A JP 2009524772A JP 2009524772 A JP2009524772 A JP 2009524772A JP 2010500882 A5 JP2010500882 A5 JP 2010500882A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- amino acid
- acid sequence
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 21
- 238000006467 substitution reaction Methods 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 3
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 3
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 3
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 2
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 2
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 2
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 208000025324 B-cell acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 1
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 claims 1
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 150000001720 carbohydrates Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 201000011649 lymphoblastic lymphoma Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82236206P | 2006-08-14 | 2006-08-14 | |
| US60/822,362 | 2006-08-14 | ||
| PCT/US2007/075932 WO2008022152A2 (en) | 2006-08-14 | 2007-08-14 | Optimized antibodies that target cd19 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011103488A Division JP5645747B2 (ja) | 2006-08-14 | 2011-05-06 | Ｃｄ１９を標的とする最適化抗体 |
| JP2013118273A Division JP2013177443A (ja) | 2006-08-14 | 2013-06-04 | Ｃｄ１９を標的とする最適化抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010500882A JP2010500882A (ja) | 2010-01-14 |
| JP2010500882A5 true JP2010500882A5 (enExample) | 2011-06-23 |
| JP5825756B2 JP5825756B2 (ja) | 2015-12-02 |
Family
ID=39083071
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009524772A Active JP5825756B2 (ja) | 2006-08-14 | 2007-08-14 | Ｃｄ１９を標的とする最適化抗体 |
| JP2011103488A Active JP5645747B2 (ja) | 2006-08-14 | 2011-05-06 | Ｃｄ１９を標的とする最適化抗体 |
| JP2013118273A Pending JP2013177443A (ja) | 2006-08-14 | 2013-06-04 | Ｃｄ１９を標的とする最適化抗体 |
| JP2015179854A Pending JP2015221839A (ja) | 2006-08-14 | 2015-09-11 | Ｃｄ１９を標的とする最適化抗体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011103488A Active JP5645747B2 (ja) | 2006-08-14 | 2011-05-06 | Ｃｄ１９を標的とする最適化抗体 |
| JP2013118273A Pending JP2013177443A (ja) | 2006-08-14 | 2013-06-04 | Ｃｄ１９を標的とする最適化抗体 |
| JP2015179854A Pending JP2015221839A (ja) | 2006-08-14 | 2015-09-11 | Ｃｄ１９を標的とする最適化抗体 |
Country Status (20)
| Country | Link |
|---|---|
| US (7) | US8524867B2 (enExample) |
| EP (2) | EP2059536B1 (enExample) |
| JP (4) | JP5825756B2 (enExample) |
| AU (1) | AU2007285976B2 (enExample) |
| CA (1) | CA2658557C (enExample) |
| DK (2) | DK2383297T5 (enExample) |
| ES (2) | ES2457072T3 (enExample) |
| FI (1) | FIC20220006I1 (enExample) |
| FR (1) | FR22C1007I2 (enExample) |
| HR (2) | HRP20140331T1 (enExample) |
| HU (1) | HUS2200007I1 (enExample) |
| LT (1) | LTC2383297I2 (enExample) |
| LU (1) | LUC00249I2 (enExample) |
| ME (1) | ME01786B (enExample) |
| NL (1) | NL301163I2 (enExample) |
| PL (2) | PL2383297T3 (enExample) |
| PT (2) | PT2383297E (enExample) |
| RS (2) | RS52775B9 (enExample) |
| SI (2) | SI2383297T1 (enExample) |
| WO (1) | WO2008022152A2 (enExample) |
Families Citing this family (158)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104761637B (zh) | 2006-03-31 | 2021-10-15 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
| PL2383297T3 (pl) * | 2006-08-14 | 2013-06-28 | Xencor Inc | Zoptymalizowane przeciwciała ukierunkowane na CD19 |
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| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| EP3415529B1 (en) | 2007-09-26 | 2020-11-04 | Chugai Seiyaku Kabushiki Kaisha | Modified antibody constant region |
| WO2009052431A2 (en) | 2007-10-19 | 2009-04-23 | Seattle Genetics, Inc. | Cd19 binding agents and uses thereof |
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| MX2010014574A (es) | 2008-07-08 | 2011-04-27 | Abbott Lab | Inmunoglobulinas de dominio variable dual para prostaglandina e2 y usos de las mismas. |
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| EP3539982B1 (en) | 2011-12-23 | 2025-02-19 | Pfizer Inc. | Engineered antibody constant regions for site-specific conjugation and methods and uses therefor |
| US9120870B2 (en) | 2011-12-30 | 2015-09-01 | Abbvie Inc. | Dual specific binding proteins directed against IL-13 and IL-17 |
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