HK1220207A1 - 人源化抗 抗體 - Google Patents
人源化抗 抗體Info
- Publication number
- HK1220207A1 HK1220207A1 HK16108176.1A HK16108176A HK1220207A1 HK 1220207 A1 HK1220207 A1 HK 1220207A1 HK 16108176 A HK16108176 A HK 16108176A HK 1220207 A1 HK1220207 A1 HK 1220207A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- antibodies
- humanized anti
- humanized
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39583—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials not provided for elsewhere, e.g. haptens, coenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361777647P | 2013-03-12 | 2013-03-12 | |
PCT/US2014/024445 WO2014165115A1 (en) | 2013-03-12 | 2014-03-12 | Humanized anti-n2 antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1220207A1 true HK1220207A1 (zh) | 2017-04-28 |
Family
ID=51527960
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16108176.1A HK1220207A1 (zh) | 2013-03-12 | 2016-07-12 | 人源化抗 抗體 |
Country Status (7)
Country | Link |
---|---|
US (4) | US9243059B2 (zh) |
EP (1) | EP2970445A4 (zh) |
JP (1) | JP6162319B2 (zh) |
AU (2) | AU2014248636B2 (zh) |
CA (1) | CA2905940A1 (zh) |
HK (1) | HK1220207A1 (zh) |
WO (1) | WO2014165115A1 (zh) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2010328359B2 (en) | 2009-12-07 | 2015-02-05 | Decimmune Therapeutics, Inc. | Anti-inflammatory antibodies and uses therefor |
WO2014055392A2 (en) * | 2012-10-01 | 2014-04-10 | Decimmune Therapeutics, Inc. | Method of protecting cardiac function |
JP6162319B2 (ja) | 2013-03-12 | 2017-07-12 | デシミューン セラピューティクス,インコーポレイテッド | ヒト化抗n2抗体 |
MA41867A (fr) | 2015-04-01 | 2018-02-06 | Anaptysbio Inc | Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3) |
CN107847590B (zh) | 2015-04-15 | 2022-07-26 | 安奈普泰斯生物有限公司 | 针对白细胞介素36受体(il-36r)的抗体 |
WO2018085469A2 (en) | 2016-11-01 | 2018-05-11 | Anaptysbio, Inc. | Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3) |
MX2019008208A (es) | 2017-01-09 | 2019-12-11 | Tesaro Inc | Métodos para tratar el cáncer con anticuerpos anti-tim-3. |
WO2019027635A1 (en) * | 2017-07-31 | 2019-02-07 | Dow Global Technologies Llc | DETERGENT ADDITIVE |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991008756A1 (en) | 1989-12-12 | 1991-06-27 | Biomedical Research Institute | Novel malarial sporozoite peptide antigens |
US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
DK0766745T3 (da) | 1995-04-08 | 2002-11-25 | Lg Chemical Ltd | Monoklonalt antistof, som er specifikt for humant 4-1BB samt cellelinje, som producerer dette |
JPH11505704A (ja) | 1995-05-17 | 1999-05-25 | リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミネソタ | アンチcd−19抗体の単鎖可変領域フラグメントを含む免疫コンジュゲート |
US6376653B1 (en) | 1998-09-28 | 2002-04-23 | Smithkline Beecham Plc | Tie2 antagonist antibodies |
AU774841B2 (en) | 1998-12-03 | 2004-07-08 | Targanta Therapeutics Inc. | Development of novel anti-microbial agents based on bacteriophage genomics |
WO2001064835A2 (en) | 2000-02-28 | 2001-09-07 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
US6753314B1 (en) | 1999-04-01 | 2004-06-22 | Curagen Corporation | Protein-protein complexes and methods of using same |
US20090087878A9 (en) | 1999-05-06 | 2009-04-02 | La Rosa Thomas J | Nucleic acid molecules associated with plants |
US6436703B1 (en) | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
AU2001263006A1 (en) | 2000-05-18 | 2001-11-26 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
EP1289624B1 (en) | 2000-06-09 | 2005-12-14 | Agricultural Products, Inc. | An agricultural or industrial filter and a method of operation for same |
AU8867501A (en) | 2000-09-01 | 2002-03-13 | Biogen Inc | Co-crystal structure of monoclonal antibody 5c8 and cd154, and use thereof in drug design |
BR0207068A (pt) | 2001-01-26 | 2004-12-21 | Inhibitex Inc | Anticorpo monoclonal para a protéina clfa, anti-soro isolado, anticorpo isolado e anticorpo humanizado contendo o referido anticorpo, kit diagnóstico compreendendo o referido anticorpo, método para diagnóstico de uma infecção por s.aureus, composição farmacêutica para o tratamento ou prevenção da referida infecção, método para indução de de uma resposta imunológica, método para identificação de anticorpos monoclonais para a protéina clfa e fragmento ativo isolado a partir do domìnio a da protéina clfa do s.aureus |
AU2002327164A1 (en) | 2001-01-29 | 2002-12-09 | Idec Pharmaceuticals Corporation | Engineered tetravalent antibodies and methods of use |
US20040131607A1 (en) | 2001-06-08 | 2004-07-08 | Carroll Michael C. | Methods and compositions for inhibiting immunoglobulin-mediated reperfusion injury |
AU2002364105A1 (en) | 2001-12-21 | 2003-07-15 | Diadexus, Inc. | Compositions and methods relating to endometrial specific genes and proteins |
CA2476776A1 (en) | 2002-02-21 | 2003-09-04 | Duke University | Reagents and treatment methods for autoimmune diseases |
US20080260731A1 (en) * | 2002-03-01 | 2008-10-23 | Bernett Matthew J | Optimized antibodies that target cd19 |
DE10228880B4 (de) | 2002-06-27 | 2005-09-08 | Jakob Voets Ing. Grad. Gmbh & Co. Kg Rheinische Landschaftspflege | Mähgerät zur Rasen- und Landschaftswiesenpflege mit einer Vorrichtung zur Aufnahme und Zerkleinerung von Mähgut |
US7709610B2 (en) | 2003-05-08 | 2010-05-04 | Facet Biotech Corporation | Therapeutic use of anti-CS1 antibodies |
AU2004261198A1 (en) | 2003-07-26 | 2005-02-10 | Biogen Idec Ma Inc. | Altered antibodies having improved antigen-binding affinity |
CN1871259A (zh) | 2003-08-22 | 2006-11-29 | 比奥根艾迪克Ma公司 | 具有改变的效应物功能的经改进的抗体和制备它的方法 |
US20100136684A1 (en) | 2004-03-01 | 2010-06-03 | Carroll Michael C | Natural IgM Antibodies |
ATE498010T1 (de) | 2004-03-01 | 2011-02-15 | Immune Disease Inst Inc | Natürliche igm-antikörper und inhibitoren davon |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
ES2457072T3 (es) * | 2006-08-14 | 2014-04-24 | Xencor, Inc. | Anticuerpos optimizados que seleccionan como diana CD19 |
CL2008001071A1 (es) | 2007-04-17 | 2009-05-22 | Smithkline Beecham Corp | Metodo para obtener anticuerpo penta-especifico contra il-8/cxcl8, gro-alfa/cxcl1, gro-beta/cxcl2), gro-gama/cxcl3 y ena-78/cxcl5 humanas; anticuerpo penta-especifico; proceso de produccion del mismo; vector, hbridoma o celela que lo comprende; composicion farmceutica; uso para tratar copd, otras enfermedades. |
ES2527521T3 (es) | 2008-03-17 | 2015-01-26 | Livtech Inc. | Anticuerpos antihumanos frente a Dlk-1 que tienen actividad antitumoral |
EP2135880A1 (en) | 2008-06-17 | 2009-12-23 | Heinrich-Heine-Universität Düsseldorf | Anti-prion protein antibody fragment |
AU2010328359B2 (en) * | 2009-12-07 | 2015-02-05 | Decimmune Therapeutics, Inc. | Anti-inflammatory antibodies and uses therefor |
JP6162319B2 (ja) | 2013-03-12 | 2017-07-12 | デシミューン セラピューティクス,インコーポレイテッド | ヒト化抗n2抗体 |
-
2014
- 2014-03-12 JP JP2016501538A patent/JP6162319B2/ja not_active Expired - Fee Related
- 2014-03-12 CA CA2905940A patent/CA2905940A1/en not_active Abandoned
- 2014-03-12 US US14/206,316 patent/US9243059B2/en not_active Expired - Fee Related
- 2014-03-12 US US14/206,368 patent/US9409977B2/en not_active Expired - Fee Related
- 2014-03-12 EP EP14779100.8A patent/EP2970445A4/en not_active Withdrawn
- 2014-03-12 WO PCT/US2014/024445 patent/WO2014165115A1/en active Application Filing
- 2014-03-12 AU AU2014248636A patent/AU2014248636B2/en not_active Ceased
-
2015
- 2015-12-14 US US14/967,577 patent/US20160168238A1/en not_active Abandoned
-
2016
- 2016-06-29 US US15/196,195 patent/US20160376353A1/en not_active Abandoned
- 2016-07-12 HK HK16108176.1A patent/HK1220207A1/zh unknown
-
2017
- 2017-06-29 AU AU2017204441A patent/AU2017204441A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20140271628A1 (en) | 2014-09-18 |
US20160376353A1 (en) | 2016-12-29 |
AU2014248636B2 (en) | 2017-03-30 |
AU2014248636A1 (en) | 2015-10-08 |
EP2970445A1 (en) | 2016-01-20 |
AU2017204441A1 (en) | 2017-07-20 |
US9243059B2 (en) | 2016-01-26 |
CA2905940A1 (en) | 2014-10-09 |
US20160168238A1 (en) | 2016-06-16 |
JP2016512539A (ja) | 2016-04-28 |
JP6162319B2 (ja) | 2017-07-12 |
US20140271627A1 (en) | 2014-09-18 |
EP2970445A4 (en) | 2017-02-22 |
US9409977B2 (en) | 2016-08-09 |
WO2014165115A1 (en) | 2014-10-09 |
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