JP2010215644A5 - - Google Patents
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- Publication number
- JP2010215644A5 JP2010215644A5 JP2010117814A JP2010117814A JP2010215644A5 JP 2010215644 A5 JP2010215644 A5 JP 2010215644A5 JP 2010117814 A JP2010117814 A JP 2010117814A JP 2010117814 A JP2010117814 A JP 2010117814A JP 2010215644 A5 JP2010215644 A5 JP 2010215644A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- phenyl
- trifluoromethyl
- alkyl
- pyrrolyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- -1 3,5-bis (trifluoromethyl) phenyl group Chemical group 0.000 claims 100
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000005843 halogen group Chemical group 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 5
- 125000001462 1-pyrrolyl group Chemical group [*]N1C([H])=C([H])C([H])=C1[H] 0.000 claims 4
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 4
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 4
- 125000001397 3-pyrrolyl group Chemical group [H]N1C([H])=C([*])C([H])=C1[H] 0.000 claims 4
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 4
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 4
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 3
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 claims 2
- 125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 2
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 claims 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 claims 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical group C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 206010013700 Drug hypersensitivity Diseases 0.000 claims 1
- 208000004262 Food Hypersensitivity Diseases 0.000 claims 1
- 206010016946 Food allergy Diseases 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 201000008197 Laryngitis Diseases 0.000 claims 1
- 206010029240 Neuritis Diseases 0.000 claims 1
- 206010033078 Otitis media Diseases 0.000 claims 1
- 206010037549 Purpura Diseases 0.000 claims 1
- 241001672981 Purpura Species 0.000 claims 1
- 208000024780 Urticaria Diseases 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 201000003146 cystitis Diseases 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 201000005311 drug allergy Diseases 0.000 claims 1
- 235000020932 food allergy Nutrition 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 201000005299 metal allergy Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010117814A JP2010215644A (ja) | 2002-06-06 | 2010-05-21 | 抗アレルギー薬 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002165148 | 2002-06-06 | ||
| JP2010117814A JP2010215644A (ja) | 2002-06-06 | 2010-05-21 | 抗アレルギー薬 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004510784A Division JP4660674B2 (ja) | 2002-06-06 | 2003-06-05 | 抗アレルギー薬 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010215644A JP2010215644A (ja) | 2010-09-30 |
| JP2010215644A5 true JP2010215644A5 (enExample) | 2011-03-10 |
Family
ID=29727583
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004510784A Expired - Fee Related JP4660674B2 (ja) | 2002-06-06 | 2003-06-05 | 抗アレルギー薬 |
| JP2010117814A Withdrawn JP2010215644A (ja) | 2002-06-06 | 2010-05-21 | 抗アレルギー薬 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004510784A Expired - Fee Related JP4660674B2 (ja) | 2002-06-06 | 2003-06-05 | 抗アレルギー薬 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US20060122243A1 (enExample) |
| EP (1) | EP1514544A4 (enExample) |
| JP (2) | JP4660674B2 (enExample) |
| KR (1) | KR101054562B1 (enExample) |
| CN (1) | CN1658872B (enExample) |
| AU (1) | AU2003242103A1 (enExample) |
| CA (1) | CA2488367A1 (enExample) |
| EA (1) | EA009701B1 (enExample) |
| TW (1) | TW200402291A (enExample) |
| WO (1) | WO2003103665A1 (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8263657B2 (en) * | 2000-12-18 | 2012-09-11 | Institute Of Medicinal Molecular Design, Inc. | Inhibitors against the production and release of inflammatory cytokines |
| WO2003103656A1 (ja) | 2002-06-06 | 2003-12-18 | 株式会社医薬分子設計研究所 | Ｏ−置換ヒドロキシアリール誘導体 |
| KR101054562B1 (ko) | 2002-06-06 | 2011-08-04 | 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 | 항알레르기약 |
| EP1535610A4 (en) * | 2002-06-10 | 2008-12-31 | Inst Med Molecular Design Inc | THERAPEUTIC CANCER |
| JPWO2003103654A1 (ja) * | 2002-06-10 | 2005-10-06 | 株式会社医薬分子設計研究所 | ＮＦ−κＢ活性化阻害剤 |
| CA2492593A1 (en) | 2002-07-15 | 2004-01-22 | Myriad Genetics, Inc. | Compounds, compositions, and methods employing same |
| WO2005007151A1 (ja) * | 2003-07-16 | 2005-01-27 | Institute Of Medicinal Molecular Design. Inc. | 皮膚色素沈着の治療剤 |
| US8524729B2 (en) * | 2003-09-17 | 2013-09-03 | Sumitomo Chemical Company, Limited | Cinnamoyl derivatives and use thereof |
| AU2004274328B2 (en) * | 2003-09-17 | 2011-11-10 | Sumitomo Chemical Company, Limited | Cinnamoyl compound and use of the same |
| JPWO2006013873A1 (ja) * | 2004-08-05 | 2008-05-01 | 株式会社医薬分子設計研究所 | シクロオキシゲナーゼ阻害作用を有する医薬 |
| UA90864C2 (en) * | 2004-09-09 | 2010-06-10 | Ромарк Лебораториз, Л.К. | Halogenated benzamide derivatives |
| EP1839655A1 (en) * | 2005-01-20 | 2007-10-03 | Shionogi Co., Ltd. | Ctgf expression inhibitor |
| CA2604042C (en) * | 2005-04-13 | 2016-06-21 | Astex Therapeutics Limited | Pharmaceutical compounds |
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| US7671058B2 (en) | 2006-06-21 | 2010-03-02 | Institute Of Medicinal Molecular Design, Inc. | N-(3,4-disubstituted phenyl) salicylamide derivatives |
| EP2073804B1 (en) | 2006-10-12 | 2017-09-13 | Astex Therapeutics Limited | Hydroxy-substituted benzoic acid amide compounds for use in the treatment of pain |
| GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| JP5528807B2 (ja) | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
| WO2008044029A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| US8916552B2 (en) | 2006-10-12 | 2014-12-23 | Astex Therapeutics Limited | Pharmaceutical combinations |
| WO2008044027A2 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical compounds having hsp90 inhibitory or modulating activity |
| US7737149B2 (en) * | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
| GB0806527D0 (en) | 2008-04-11 | 2008-05-14 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| BRPI0914233A2 (pt) * | 2008-06-19 | 2015-11-03 | Astrazeneca Ab | composto, uso de um composto, métodos para produzir um efeito inibidor de fgfr e para produzir um efeito anticâncer em um animal de sangue quente, composição farmacêutica, e, método para tratar uma doença |
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| KR102200176B1 (ko) | 2012-05-08 | 2021-01-11 | 에어로믹스, 인코포레이티드 | 신규 방법 |
| US20140179712A1 (en) | 2012-12-21 | 2014-06-26 | Astrazeneca Ab | Pharmaceutical formulation of n-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide |
| JP6083770B2 (ja) | 2013-09-13 | 2017-02-22 | 昭子 板井 | 水溶液製剤及びその製造方法 |
| CN106163506A (zh) | 2013-11-06 | 2016-11-23 | 埃罗米克斯公司 | 新配方 |
| AU2015314287B2 (en) | 2014-09-12 | 2019-04-18 | UNION therapeutics A/S | Antibacterial use of halogenated salicylanilides |
| GB201509326D0 (en) | 2015-05-29 | 2015-07-15 | Antibio Tx Aps | Novel use |
| WO2016210289A1 (en) | 2015-06-24 | 2016-12-29 | Duke University | Chemical modulators of signaling pathways and therapeutic use |
| GB201604484D0 (en) | 2016-03-16 | 2016-04-27 | Antibiotx Aps And Københavns Uni University Of Copenhagen | Topical antibacterial compositions |
| US11419834B2 (en) | 2019-02-25 | 2022-08-23 | Rhode Island Hospital | Methods for treating diseases or infections caused by or associated with H. pylori using a halogenated salicylanilide |
| AR126669A1 (es) * | 2021-08-02 | 2023-11-01 | Eurofarma Laboratorios S A | COMPUESTOS N-ACILIDRAZÓNICOS INHIBIDORES DE Nav 1.7 Y/O Nav 1.8, SUS PROCESOS DE OBTENCIÓN, COMPOSICIONES, USOS, MÉTODOS DE TRATAMIENTO DE ESTOS Y KITS |
| AR131658A1 (es) * | 2023-01-30 | 2025-04-16 | Eurofarma Laboratorios S A | Hidrazidas bloqueadoras de nav 1.7 y/o nav 1.8, sus procesos de obtención, composiciones, usos, métodos de tratamiento de los mismos y sus kits |
| EP4660182A1 (en) * | 2023-01-30 | 2025-12-10 | Eurofarma Laboratórios S.A. | Nav1.7- and/or nav1.8-inhibiting aryl pyridine compounds, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits |
| AR131690A1 (es) * | 2023-01-30 | 2025-04-23 | Eurofarma Laboratorios S A | COMPUESTOS FENÓLICOS BLOQUEADORES DE Nav 1.7 Y/O Nav 1.8, SUS PROCESOS DE OBTENCIÓN, SUS COMPOSICIONES, SUS USOS, LOS MÉTODOS DE TRATAMIENTO DE LOS MISMOS Y LOS KITS |
| CN117105810B (zh) * | 2023-10-23 | 2024-02-09 | 中国农业大学 | 一种具有广谱抗菌活性的化合物及其抗菌组合物 |
| KR20250064798A (ko) | 2023-11-03 | 2025-05-12 | 재단법인 대구경북첨단의료산업진흥재단 | 아릴에텐 유도체를 유효성분으로 포함하는 아토피성 피부염 치료용 조성물 |
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-
2003
- 2003-06-05 KR KR1020047019765A patent/KR101054562B1/ko not_active Expired - Fee Related
- 2003-06-05 TW TW092115270A patent/TW200402291A/zh unknown
- 2003-06-05 AU AU2003242103A patent/AU2003242103A1/en not_active Abandoned
- 2003-06-05 EP EP03730831A patent/EP1514544A4/en not_active Withdrawn
- 2003-06-05 CN CN038129264A patent/CN1658872B/zh not_active Expired - Fee Related
- 2003-06-05 JP JP2004510784A patent/JP4660674B2/ja not_active Expired - Fee Related
- 2003-06-05 EA EA200401612A patent/EA009701B1/ru not_active IP Right Cessation
- 2003-06-05 US US10/515,623 patent/US20060122243A1/en not_active Abandoned
- 2003-06-05 CA CA002488367A patent/CA2488367A1/en not_active Abandoned
- 2003-06-05 WO PCT/JP2003/007120 patent/WO2003103665A1/ja not_active Ceased
-
2007
- 2007-04-09 US US11/783,324 patent/US7700655B2/en not_active Expired - Fee Related
- 2007-04-09 US US11/783,325 patent/US20070185059A1/en not_active Abandoned
- 2007-12-07 US US11/952,686 patent/US20080090779A1/en not_active Abandoned
-
2010
- 2010-05-21 JP JP2010117814A patent/JP2010215644A/ja not_active Withdrawn
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