JP2009502487A5 - - Google Patents
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- Publication number
- JP2009502487A5 JP2009502487A5 JP2008524228A JP2008524228A JP2009502487A5 JP 2009502487 A5 JP2009502487 A5 JP 2009502487A5 JP 2008524228 A JP2008524228 A JP 2008524228A JP 2008524228 A JP2008524228 A JP 2008524228A JP 2009502487 A5 JP2009502487 A5 JP 2009502487A5
- Authority
- JP
- Japan
- Prior art keywords
- solvent
- spray
- organic material
- mixture
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000002904 solvent Substances 0.000 claims 37
- 239000000203 mixture Substances 0.000 claims 29
- 238000000034 method Methods 0.000 claims 21
- 229920000642 polymer Polymers 0.000 claims 13
- 239000011368 organic material Substances 0.000 claims 12
- 239000013543 active substance Substances 0.000 claims 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 8
- 239000002245 particle Substances 0.000 claims 6
- 238000004090 dissolution Methods 0.000 claims 5
- 239000007921 spray Substances 0.000 claims 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- 239000012190 activator Substances 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 229920013820 alkyl cellulose Polymers 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 3
- 229920001519 homopolymer Polymers 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 239000011343 solid material Substances 0.000 claims 2
- 239000008247 solid mixture Substances 0.000 claims 2
- 238000001694 spray drying Methods 0.000 claims 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 239000011149 active material Substances 0.000 claims 1
- 229920003232 aliphatic polyester Polymers 0.000 claims 1
- 238000009835 boiling Methods 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 235000010980 cellulose Nutrition 0.000 claims 1
- 238000000151 deposition Methods 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 238000005469 granulation Methods 0.000 claims 1
- 230000003179 granulation Effects 0.000 claims 1
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 claims 1
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 229920000768 polyamine Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000151 polyglycol Polymers 0.000 claims 1
- 239000010695 polyglycol Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920001290 polyvinyl ester Polymers 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000013557 residual solvent Substances 0.000 claims 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical class OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims 1
- 239000007909 solid dosage form Substances 0.000 claims 1
- 239000011877 solvent mixture Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 150000005846 sugar alcohols Chemical class 0.000 claims 1
- 230000008016 vaporization Effects 0.000 claims 1
- -1 vinyl lactam Chemical class 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70337405P | 2005-07-28 | 2005-07-28 | |
| US60/703,374 | 2005-07-28 | ||
| PCT/US2006/029604 WO2007016435A2 (en) | 2005-07-28 | 2006-07-28 | Method to improve characteristics of spray dried powders and granulated materials, and the products thereby produced |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009502487A JP2009502487A (ja) | 2009-01-29 |
| JP2009502487A5 true JP2009502487A5 (enExample) | 2009-09-10 |
| JP5243247B2 JP5243247B2 (ja) | 2013-07-24 |
Family
ID=37450928
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008524271A Pending JP2009502969A (ja) | 2005-07-28 | 2006-07-28 | 非晶質エファビレンツ及びその製造 |
| JP2008524228A Active JP5243247B2 (ja) | 2005-07-28 | 2006-07-28 | スプレー乾燥された粉体及び粒状化された材料の特性の改良方法、並びにそれによって製造した製品 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008524271A Pending JP2009502969A (ja) | 2005-07-28 | 2006-07-28 | 非晶質エファビレンツ及びその製造 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10532028B2 (enExample) |
| EP (2) | EP1909762A2 (enExample) |
| JP (2) | JP2009502969A (enExample) |
| CN (3) | CN101272769B (enExample) |
| BR (1) | BRPI0614455A2 (enExample) |
| WO (2) | WO2007014393A2 (enExample) |
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| ITMI20071502A1 (it) * | 2007-07-25 | 2009-01-26 | Archimica Srl | Procedimento per la preparazione di formulazioni solide a rilascio controllato contenenti oxcarbazepina e formulazioni ottenibili con tale procedimento |
| ITMI20080807A1 (it) | 2008-05-05 | 2009-11-06 | Antibioticos Spa | Procedimento per la preparazione di tigeciclina in forma amorfa |
| US8173621B2 (en) * | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| US8883176B2 (en) * | 2008-09-25 | 2014-11-11 | Isp Investments Inc. | Smooth, high solids tablet coating composition |
| US11458105B2 (en) * | 2008-12-04 | 2022-10-04 | International Flavors & Fragrances Inc. | Hybrid fragrance encapsulate formulation and method for using the same |
| EP2355805B1 (en) * | 2008-12-10 | 2019-02-13 | Cipla Limited | Rifaximin complexes |
| AU2009329917B2 (en) | 2008-12-23 | 2016-03-31 | Gilead Pharmasset Llc | Nucleoside analogs |
| BRPI0923815A2 (pt) | 2008-12-23 | 2015-07-14 | Pharmasset Inc | Síntese de nucleosídeos de purina |
| CN102695513A (zh) | 2008-12-23 | 2012-09-26 | 吉利德制药有限责任公司 | 核苷氨基磷酸酯 |
| TWI583692B (zh) | 2009-05-20 | 2017-05-21 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
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| US8563530B2 (en) | 2010-03-31 | 2013-10-22 | Gilead Pharmassel LLC | Purine nucleoside phosphoramidate |
| SMT201700412T1 (it) | 2010-03-31 | 2017-11-15 | Gilead Pharmasset Llc | Procedimento per la cristallizzazione di (s)-isopropil 2-(((s)-(perfluorofenossi)(fenossi)fosforil)ammino)propanoato |
| WO2012063498A2 (ja) * | 2010-11-12 | 2012-05-18 | 富士化学工業株式会社 | 新規なエキセメスタン固体分散体 |
| AU2011332031B2 (en) | 2010-11-24 | 2017-01-12 | Melinta Subsidiary Corp. | Pharmaceutical compositions |
| PT3042910T (pt) | 2010-11-30 | 2019-04-16 | Gilead Pharmasset Llc | 2'-espiro-nucleósidos para utilização na terapia da hepatite c |
| TW201309346A (zh) * | 2011-01-05 | 2013-03-01 | Hospira Inc | 噴霧乾燥萬古黴素 |
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| EA033374B9 (ru) | 2012-09-11 | 2019-12-18 | Медивейшн Простейт Терапьютикс Ллк | Твердые фармацевтические композиции, содержащие энзалутамид, и способ лечения |
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| CN104043104B (zh) | 2013-03-15 | 2018-07-10 | 浙江创新生物有限公司 | 含盐酸万古霉素的喷雾干粉及其工业化制备方法 |
| CN104119209B (zh) * | 2013-04-25 | 2018-03-02 | 浙江医药股份有限公司新昌制药厂 | 一种还原型辅酶q10干粉及其组合物以及制备方法 |
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| CN105853482A (zh) * | 2015-01-21 | 2016-08-17 | 熊慧 | 人参总次苷在制备治疗和/或预防心肌缺血后脂质代谢异常的药物中的应用 |
| EP3103440A1 (en) * | 2015-06-12 | 2016-12-14 | INDENA S.p.A. | Solid dispersions of coenzyme q10 |
| CN110267706B (zh) * | 2017-02-09 | 2023-06-20 | Med-El电气医疗器械有限公司 | 与电极载体一起使用的地塞米松涂层 |
| AU2018218259B2 (en) * | 2017-02-09 | 2019-12-12 | Med-El Elektromedizinische Geraete Gmbh | Implantable electrode with dexamethasone coating |
| EP3813543A1 (en) * | 2018-06-29 | 2021-05-05 | DSM IP Assets B.V. | Fast release benzoic acid in feed |
| CN114404377B (zh) * | 2022-01-10 | 2023-07-25 | 安徽贝克生物制药有限公司 | 一种阿巴卡韦、拉米夫定、依非韦伦复方片及其制备方法 |
| WO2024092404A1 (zh) * | 2022-10-31 | 2024-05-10 | 南京百正生物医药有限公司 | 哌拉西林他唑巴坦喷雾干燥粉末的工业化生产方法 |
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| KR20120080243A (ko) | 2003-05-28 | 2012-07-16 | 노바르티스 아게 | 아미노산 및/또는 인지질로 부분 또는 완전 코팅된 수불용성 활성제 미립자의 제조를 위한 알코올성 수용액의 분무 건조법 |
| CL2004001884A1 (es) * | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
| US8377952B2 (en) * | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| US20050096365A1 (en) | 2003-11-03 | 2005-05-05 | David Fikstad | Pharmaceutical compositions with synchronized solubilizer release |
| US20050133949A1 (en) * | 2003-12-19 | 2005-06-23 | Pragtech, Inc. | Polymer solidification and coating process |
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| DE102005026755A1 (de) * | 2005-06-09 | 2006-12-14 | Basf Ag | Herstellung von festen Lösungen schwerlöslicher Wirkstoffe durch Kurzzeitüberhitzung und schnelle Trocknung |
| WO2006134610A1 (en) | 2005-06-16 | 2006-12-21 | Hetero Drugs Limited | Efavirenz pharmaceutical composition having enhanced dissolution profile |
| CA2612864A1 (en) * | 2005-07-05 | 2007-01-11 | Abbott Gmbh & Co. Kg | Composition and dosage form comprising a solid or semi-solid matrix |
| EP1912626B1 (en) * | 2005-08-08 | 2016-04-13 | AbbVie Deutschland GmbH & Co KG | Dosage forms with improved bioavailability |
| US20090011007A1 (en) * | 2006-02-03 | 2009-01-08 | Evonik Roehm Gmbh | Pharmaceutical Compositions Containing Mixtures of Polymers and Active Agents Poorly Soluble in Water |
| JP5349290B2 (ja) * | 2006-04-03 | 2013-11-20 | オディディ,イサ | 薬物送達組成物およびそれを含む医薬品、ならびにその製造方法 |
-
2006
- 2006-07-28 JP JP2008524271A patent/JP2009502969A/ja active Pending
- 2006-07-28 EP EP06789043A patent/EP1909762A2/en not_active Withdrawn
- 2006-07-28 EP EP06788904A patent/EP1912730A2/en not_active Withdrawn
- 2006-07-28 US US11/495,993 patent/US10532028B2/en active Active
- 2006-07-28 CN CN2006800353026A patent/CN101272769B/zh not_active Expired - Fee Related
- 2006-07-28 CN CN2006800355159A patent/CN101272848B/zh not_active Expired - Fee Related
- 2006-07-28 BR BRPI0614455-1A patent/BRPI0614455A2/pt not_active IP Right Cessation
- 2006-07-28 JP JP2008524228A patent/JP5243247B2/ja active Active
- 2006-07-28 WO PCT/US2006/029822 patent/WO2007014393A2/en not_active Ceased
- 2006-07-28 WO PCT/US2006/029604 patent/WO2007016435A2/en not_active Ceased
- 2006-07-28 US US11/496,030 patent/US20070026073A1/en not_active Abandoned
- 2006-07-28 CN CN200680036202.5A patent/CN101277682B/zh active Active
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