JP2009502968A5 - - Google Patents
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- Publication number
- JP2009502968A5 JP2009502968A5 JP2008524270A JP2008524270A JP2009502968A5 JP 2009502968 A5 JP2009502968 A5 JP 2009502968A5 JP 2008524270 A JP2008524270 A JP 2008524270A JP 2008524270 A JP2008524270 A JP 2008524270A JP 2009502968 A5 JP2009502968 A5 JP 2009502968A5
- Authority
- JP
- Japan
- Prior art keywords
- benzoquinone
- composition
- polymer
- group
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 40
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 claims 34
- 229920000642 polymer Polymers 0.000 claims 31
- 239000002904 solvent Substances 0.000 claims 13
- 238000000034 method Methods 0.000 claims 10
- 239000007909 solid dosage form Substances 0.000 claims 7
- 229920001577 copolymer Polymers 0.000 claims 6
- 239000000047 product Substances 0.000 claims 5
- 239000003826 tablet Substances 0.000 claims 5
- -1 vinyl lactam Chemical class 0.000 claims 5
- 229920013820 alkyl cellulose Polymers 0.000 claims 4
- 229920002678 cellulose Polymers 0.000 claims 4
- 235000010980 cellulose Nutrition 0.000 claims 4
- 239000006185 dispersion Substances 0.000 claims 4
- 239000002552 dosage form Substances 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
- 229920002554 vinyl polymer Polymers 0.000 claims 4
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 239000002775 capsule Substances 0.000 claims 3
- 239000001913 cellulose Substances 0.000 claims 3
- 239000007910 chewable tablet Substances 0.000 claims 3
- 229940068682 chewable tablet Drugs 0.000 claims 3
- 238000004090 dissolution Methods 0.000 claims 3
- 239000007903 gelatin capsule Substances 0.000 claims 3
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 3
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 3
- 239000004615 ingredient Substances 0.000 claims 3
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 2
- 150000001720 carbohydrates Chemical class 0.000 claims 2
- 235000014633 carbohydrates Nutrition 0.000 claims 2
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 2
- 235000017471 coenzyme Q10 Nutrition 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 239000006069 physical mixture Substances 0.000 claims 2
- 229920000768 polyamine Polymers 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229920000151 polyglycol Polymers 0.000 claims 2
- 239000010695 polyglycol Substances 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 229920001290 polyvinyl ester Polymers 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 2
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical class OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 239000008186 active pharmaceutical agent Substances 0.000 claims 1
- 229920003232 aliphatic polyester Polymers 0.000 claims 1
- 239000011805 ball Substances 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 235000013361 beverage Nutrition 0.000 claims 1
- 239000005515 coenzyme Substances 0.000 claims 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims 1
- 239000008139 complexing agent Substances 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 229960000913 crospovidone Drugs 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 238000005469 granulation Methods 0.000 claims 1
- 230000003179 granulation Effects 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 230000000873 masking effect Effects 0.000 claims 1
- 239000002417 nutraceutical Substances 0.000 claims 1
- 235000021436 nutraceutical agent Nutrition 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
- 239000002304 perfume Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 239000000049 pigment Substances 0.000 claims 1
- 229940023488 pill Drugs 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 239000004014 plasticizer Substances 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 1
- 239000002994 raw material Substances 0.000 claims 1
- 239000002002 slurry Substances 0.000 claims 1
- 239000007962 solid dispersion Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70337405P | 2005-07-28 | 2005-07-28 | |
| US60/703,374 | 2005-07-28 | ||
| US75645406P | 2006-01-05 | 2006-01-05 | |
| US60/756,454 | 2006-01-05 | ||
| PCT/US2006/029821 WO2007014392A2 (en) | 2005-07-28 | 2006-07-28 | Benzoquinones of enhanced bioavailability |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009502968A JP2009502968A (ja) | 2009-01-29 |
| JP2009502968A5 true JP2009502968A5 (enExample) | 2009-09-10 |
| JP5426165B2 JP5426165B2 (ja) | 2014-02-26 |
Family
ID=37499521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008524270A Active JP5426165B2 (ja) | 2005-07-28 | 2006-07-28 | 優れた生物学的利用能のベンゾキノン類 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20070026072A1 (enExample) |
| EP (1) | EP1909763A2 (enExample) |
| JP (1) | JP5426165B2 (enExample) |
| WO (1) | WO2007014392A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2631152T3 (es) | 2004-01-22 | 2017-08-28 | University Of Miami | Formulaciones de coenzima Q10 tópicas o intravenosas para su uso en el tratamiento del cáncer |
| ES2836184T3 (es) * | 2006-05-02 | 2021-06-24 | Univ Miami | Formulaciones tópicas de co-enzima Q10 y tratamiento de heridas |
| US20080085315A1 (en) * | 2006-10-10 | 2008-04-10 | John Alfred Doney | Amorphous ezetimibe and the production thereof |
| PE20081506A1 (es) * | 2006-12-12 | 2008-12-09 | Infinity Discovery Inc | Formulaciones de ansamicina |
| EP2271325A4 (en) | 2008-04-11 | 2011-11-09 | Cytotech Labs Llc | METHODS AND USE OF INDUCING APOPTOSIS IN CANCER CELLS |
| US10519504B2 (en) | 2009-05-11 | 2019-12-31 | Berg Llc | Methods for treatment of oncological disorders using epimetabolic shifters, multidimensional intracellular molecules, or environmental influencers |
| KR101944124B1 (ko) | 2010-11-24 | 2019-01-30 | 멜린타 서브시디어리 코프. | 약학 조성물 |
| EP2694463B8 (en) | 2011-04-04 | 2019-10-09 | Berg LLC | Treating central nervous system tumors with coenzyme q10 |
| JP2013032301A (ja) * | 2011-08-01 | 2013-02-14 | Shizuokaken Koritsu Daigaku Hojin | コエンザイムｑ１０含有組成物 |
| EA032775B1 (ru) | 2013-04-08 | 2019-07-31 | Берг Ллк | Способы лечения злокачественной опухоли с использованием комбинированной терапии с коферментом q10 |
| WO2015035094A1 (en) | 2013-09-04 | 2015-03-12 | Berg Llc | Methods of treatment of cancer by continuous infusion of coenzyme q10 |
| WO2016198983A1 (en) | 2015-06-09 | 2016-12-15 | Bend Research Inc. | Formulations to achieve rapid dissolution of drug from spray-dried dispersions in capsules |
| EP3103440A1 (en) * | 2015-06-12 | 2016-12-14 | INDENA S.p.A. | Solid dispersions of coenzyme q10 |
| WO2017087576A1 (en) | 2015-11-16 | 2017-05-26 | Berg Llc | Methods of treatment of temozolomide-resistant glioma using coenzyme q10 |
| KR102682716B1 (ko) | 2017-05-17 | 2024-07-08 | 비피지바이오, 인크. | 수포성 표피박리증의 치료 및 예방에서 조효소 q10 제형의 용도 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3981676A (en) * | 1970-03-03 | 1976-09-21 | L'oreal | Lyophilized dyes and the use thereof to color keratinic fibers |
| JPS5951214A (ja) * | 1982-09-16 | 1984-03-24 | Taiho Yakuhin Kogyo Kk | バイオアベイラビリテイの高い薬剤の製造方法 |
| JPS6028915A (ja) * | 1983-07-26 | 1985-02-14 | Eisai Co Ltd | ユビデカレノン高含量含有組成物 |
| US6143211A (en) * | 1995-07-21 | 2000-11-07 | Brown University Foundation | Process for preparing microparticles through phase inversion phenomena |
| IL117773A (en) * | 1996-04-02 | 2000-10-31 | Pharmos Ltd | Solid lipid compositions of coenzyme Q10 for enhanced oral bioavailability |
| US5891469A (en) * | 1997-04-02 | 1999-04-06 | Pharmos Corporation | Solid Coprecipitates for enhanced bioavailability of lipophilic substances |
| US6232346B1 (en) * | 1997-03-27 | 2001-05-15 | Michael J. Sole | Composition for improvement of cellular nutrition and mitochondrial energetics |
| DE10046541A1 (de) * | 2000-09-19 | 2002-03-28 | Knoll Ag | Mechanisch stabile darreichungsformen, enthaltend Ubichinone |
| AU2256702A (en) * | 2000-12-01 | 2002-06-11 | Kyowa Hakko Kogyo Kk | Composition improved in solubility or oral absorbability |
| KR100463167B1 (ko) * | 2001-04-13 | 2004-12-23 | 주식회사 태평양 | 고분자 나노입자를 이용한 경피흡수제 및 이를 함유한외용제 조성물 |
| EP1269994A3 (en) * | 2001-06-22 | 2003-02-12 | Pfizer Products Inc. | Pharmaceutical compositions comprising drug and concentration-enhancing polymers |
| WO2003068008A1 (en) * | 2002-02-14 | 2003-08-21 | Dsm Ip Assets B.V. | Water-dispersible coenzyme q10 dry powders |
-
2006
- 2006-07-28 US US11/495,991 patent/US20070026072A1/en not_active Abandoned
- 2006-07-28 JP JP2008524270A patent/JP5426165B2/ja active Active
- 2006-07-28 EP EP06800574A patent/EP1909763A2/en not_active Withdrawn
- 2006-07-28 WO PCT/US2006/029821 patent/WO2007014392A2/en not_active Ceased
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