|
DE3226768A1
(de)
|
1981-11-05 |
1983-05-26 |
Hoechst Ag, 6230 Frankfurt |
Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
|
|
DE3211676A1
(de)
|
1982-03-30 |
1983-10-06 |
Hoechst Ag |
Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
|
|
US4499082A
(en)
*
|
1983-12-05 |
1985-02-12 |
E. I. Du Pont De Nemours And Company |
α-Aminoboronic acid peptides
|
|
FR2575753B1
(fr)
|
1985-01-07 |
1987-02-20 |
Adir |
Nouveaux derives peptidiques a structure polycyclique azotee, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
US5496927A
(en)
|
1985-02-04 |
1996-03-05 |
Merrell Pharmaceuticals Inc. |
Peptidase inhibitors
|
|
CA1341029C
(en)
|
1985-02-04 |
2000-06-20 |
Michael Kolb |
Peptidase inhibitors
|
|
ATE71934T1
(de)
|
1985-06-07 |
1992-02-15 |
Ici America Inc |
Selektionierte difluorverbindungen.
|
|
US5231084A
(en)
|
1986-03-27 |
1993-07-27 |
Hoechst Aktiengesellschaft |
Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
|
|
NZ223148A
(en)
|
1987-01-16 |
1989-10-27 |
Merrell Dow Pharma |
Peptide derivatives having peptidase inhibition activity
|
|
EP0356595A1
(en)
|
1988-09-01 |
1990-03-07 |
Merrell Dow Pharmaceuticals Inc. |
Novel peptidase inhibitors
|
|
US5736520A
(en)
|
1988-10-07 |
1998-04-07 |
Merrell Pharmaceuticals Inc. |
Peptidase inhibitors
|
|
ZA897515B
(en)
|
1988-10-07 |
1990-06-27 |
Merrell Dow Pharma |
Novel peptidase inhibitors
|
|
EP0371179A1
(en)
|
1988-10-28 |
1990-06-06 |
Merrell Dow Pharmaceuticals Inc. |
Novel analogs of peptidase substrates
|
|
NZ235155A
(en)
|
1989-09-11 |
1993-04-28 |
Merrell Dow Pharma |
Peptidase substrates in which the carboxy terminal group has been replaced by a tricarbonyl radical
|
|
WO1992012140A1
(en)
|
1990-12-28 |
1992-07-23 |
Georgia Tech Research Corporation |
Peptides ketoamides, ketoacids, and ketoesters
|
|
EP0644892A1
(en)
|
1992-06-12 |
1995-03-29 |
Pfizer Inc. |
Inhibitors of angiotensin i chymase(s) including human heart chymase
|
|
US5371072A
(en)
|
1992-10-16 |
1994-12-06 |
Corvas International, Inc. |
Asp-Pro-Arg α-keto-amide enzyme inhibitors
|
|
EP0604182B1
(en)
*
|
1992-12-22 |
2000-10-11 |
Eli Lilly And Company |
Inhibitors of HIV protease useful for the treatment of Aids
|
|
CA2170020C
(en)
|
1992-12-29 |
2005-08-02 |
Dale J. Kempf |
Retroviral protease inhibiting compounds
|
|
US5384410A
(en)
*
|
1993-03-24 |
1995-01-24 |
The Du Pont Merck Pharmaceutical Company |
Removal of boronic acid protecting groups by transesterification
|
|
US5656600A
(en)
|
1993-03-25 |
1997-08-12 |
Corvas International, Inc. |
α-ketoamide derivatives as inhibitors of thrombosis
|
|
US5672582A
(en)
|
1993-04-30 |
1997-09-30 |
Merck & Co., Inc. |
Thrombin inhibitors
|
|
IL110752A
(en)
*
|
1993-09-13 |
2000-07-26 |
Abbott Lab |
Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor
|
|
US5559158A
(en)
|
1993-10-01 |
1996-09-24 |
Abbott Laboratories |
Pharmaceutical composition
|
|
US5468858A
(en)
|
1993-10-28 |
1995-11-21 |
The Board Of Regents Of Oklahoma State University Physical Sciences |
N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
|
|
IL111991A
(en)
|
1994-01-28 |
2000-07-26 |
Abbott Lab |
Liquid pharmaceutical composition of HIV protease inhibitors in organic solvent
|
|
AU1615895A
(en)
|
1994-03-31 |
1995-10-12 |
Bristol-Myers Squibb Company |
Imidazole-containing inhibitors of farnesyl protein transferase
|
|
US5756466A
(en)
|
1994-06-17 |
1998-05-26 |
Vertex Pharmaceuticals, Inc. |
Inhibitors of interleukin-1β converting enzyme
|
|
US6420522B1
(en)
|
1995-06-05 |
2002-07-16 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of interleukin-1β converting enzyme
|
|
US5716929A
(en)
|
1994-06-17 |
1998-02-10 |
Vertex Pharmaceuticals, Inc. |
Inhibitors of interleukin-1β converting enzyme
|
|
US5847135A
(en)
|
1994-06-17 |
1998-12-08 |
Vertex Pharmaceuticals, Incorporated |
Inhibitors of interleukin-1β converting enzyme
|
|
US5861267A
(en)
|
1995-05-01 |
1999-01-19 |
Vertex Pharmaceuticals Incorporated |
Methods, nucleotide sequences and host cells for assaying exogenous and endogenous protease activity
|
|
US6037157A
(en)
*
|
1995-06-29 |
2000-03-14 |
Abbott Laboratories |
Method for improving pharmacokinetics
|
|
EP1019410A1
(en)
|
1995-11-23 |
2000-07-19 |
MERCK SHARP & DOHME LTD. |
Spiro-piperidine derivatives and their use as tachykinin antagonists
|
|
US6900238B1
(en)
|
1995-12-07 |
2005-05-31 |
The Scripps Research Institute |
HIV protease inhibitors
|
|
US6054472A
(en)
*
|
1996-04-23 |
2000-04-25 |
Vertex Pharmaceuticals, Incorporated |
Inhibitors of IMPDH enzyme
|
|
US5807876A
(en)
*
|
1996-04-23 |
1998-09-15 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of IMPDH enzyme
|
|
ZA972195B
(en)
|
1996-03-15 |
1998-09-14 |
Du Pont Merck Pharma |
Spirocycle integrin inhibitors
|
|
HUP0004421A3
(en)
|
1996-04-23 |
2002-10-28 |
Vertex Pharmaceuticals Inc Cam |
Urea derivatives and pharmaceutical compositions containing them, use thereof for the treatment of deseases mediated by impdh enzyme
|
|
WO1997043310A1
(en)
|
1996-05-10 |
1997-11-20 |
Schering Corporation |
Synthetic inhibitors of hepatitis c virus ns3 protease
|
|
US5990276A
(en)
*
|
1996-05-10 |
1999-11-23 |
Schering Corporation |
Synthetic inhibitors of hepatitis C virus NS3 protease
|
|
US6153579A
(en)
|
1996-09-12 |
2000-11-28 |
Vertex Pharmaceuticals, Incorporated |
Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex
|
|
EP0929554B1
(en)
|
1996-09-25 |
2006-03-15 |
MERCK SHARP & DOHME LTD. |
Spiro-azacyclic derivatives, their preparation and their use as tachykinin antagonists
|
|
WO1998015544A1
(en)
|
1996-10-08 |
1998-04-16 |
Colorado State University Research Foundation |
Catalytic asymmetric epoxidation
|
|
KR100509388B1
(ko)
*
|
1996-10-18 |
2005-08-23 |
버텍스 파마슈티칼스 인코포레이티드 |
세린 프로테아제, 특히 간염 c 바이러스 ns3 프로테아제의 저해제
|
|
GB9623908D0
(en)
*
|
1996-11-18 |
1997-01-08 |
Hoffmann La Roche |
Amino acid derivatives
|
|
DE19648011A1
(de)
|
1996-11-20 |
1998-05-28 |
Bayer Ag |
Cyclische Imine
|
|
DE19648793A1
(de)
|
1996-11-26 |
1998-05-28 |
Basf Ag |
Neue Benzamide und deren Anwendung
|
|
EP0966465B1
(en)
|
1997-03-14 |
2003-07-09 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of impdh enzyme
|
|
GB9707659D0
(en)
|
1997-04-16 |
1997-06-04 |
Peptide Therapeutics Ltd |
Hepatitis C NS3 Protease inhibitors
|
|
GB9708484D0
(en)
|
1997-04-25 |
1997-06-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9711114D0
(en)
|
1997-05-29 |
1997-07-23 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US6767991B1
(en)
|
1997-08-11 |
2004-07-27 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis C inhibitor peptides
|
|
ES2234144T3
(es)
|
1997-08-11 |
2005-06-16 |
Boehringer Ingelheim (Canada) Ltd. |
Analogos de peptidos inhibidores de la hepatitis c.
|
|
WO1999007733A2
(en)
|
1997-08-11 |
1999-02-18 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis c inhibitor peptides
|
|
US6183121B1
(en)
|
1997-08-14 |
2001-02-06 |
Vertex Pharmaceuticals Inc. |
Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets
|
|
US20040058982A1
(en)
|
1999-02-17 |
2004-03-25 |
Bioavailability System, Llc |
Pharmaceutical compositions
|
|
US20020017295A1
(en)
|
2000-07-07 |
2002-02-14 |
Weers Jeffry G. |
Phospholipid-based powders for inhalation
|
|
WO1999028482A2
(en)
*
|
1997-11-28 |
1999-06-10 |
Schering Corporation |
Single-chain recombinant complexes of hepatitis c virus ns3 protease and ns4a cofactor peptide
|
|
US6075150A
(en)
|
1998-01-26 |
2000-06-13 |
Cv Therapeutics, Inc. |
α-ketoamide inhibitors of 20S proteasome
|
|
IT1299134B1
(it)
|
1998-02-02 |
2000-02-29 |
Angeletti P Ist Richerche Bio |
Procedimento per la produzione di peptidi con proprieta' inibitrici della proteasi ns3 del virus hcv, peptidi cosi' ottenibili e peptidi
|
|
ATE346035T1
(de)
|
1998-03-31 |
2006-12-15 |
Vertex Pharma |
Inhibitoren von serin proteasen, insbesondere von hepatitis c virus ns3 protease
|
|
US6251583B1
(en)
|
1998-04-27 |
2001-06-26 |
Schering Corporation |
Peptide substrates for HCV NS3 protease assays
|
|
GB9812523D0
(en)
|
1998-06-10 |
1998-08-05 |
Angeletti P Ist Richerche Bio |
Peptide inhibitors of hepatitis c virus ns3 protease
|
|
AR022061A1
(es)
|
1998-08-10 |
2002-09-04 |
Boehringer Ingelheim Ca Ltd |
Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos.
|
|
US6323180B1
(en)
|
1998-08-10 |
2001-11-27 |
Boehringer Ingelheim (Canada) Ltd |
Hepatitis C inhibitor tri-peptides
|
|
DE19836514A1
(de)
|
1998-08-12 |
2000-02-17 |
Univ Stuttgart |
Modifikation von Engineeringpolymeren mit N-basischen Gruppe und mit Ionenaustauschergruppen in der Seitenkette
|
|
US6117639A
(en)
|
1998-08-31 |
2000-09-12 |
Vertex Pharmaceuticals Incorporated |
Fusion proteins, DNA molecules, vectors, and host cells useful for measuring protease activity
|
|
US6686335B1
(en)
|
1998-09-22 |
2004-02-03 |
Cephalon, Inc. |
Hydroxamate-containing cysteine and serine protease inhibitors
|
|
US6025516A
(en)
|
1998-10-14 |
2000-02-15 |
Chiragene, Inc. |
Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes
|
|
US6117870A
(en)
|
1998-11-12 |
2000-09-12 |
Fujirebio Kabushiki Kaisha |
Cyclic amide derivatives
|
|
GB9825946D0
(en)
|
1998-11-26 |
1999-01-20 |
Angeletti P Ist Richerche Bio |
Pharmaceutical compounds for the inhibition of hepatitis C virus NS3 protease
|
|
ATE400251T1
(de)
|
1999-02-09 |
2008-07-15 |
Pfizer Prod Inc |
Zusammensetzungen basischer arzneistoffe mit verbesserter bioverfügbarkeit
|
|
US20020042046A1
(en)
|
1999-02-25 |
2002-04-11 |
Vertex Pharmaceuticals, Incorporated |
Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex
|
|
AP1498A
(en)
*
|
1999-03-19 |
2005-11-21 |
Vertex Pharma |
Inhibitors of impdh enzyme.
|
|
UA74546C2
(en)
|
1999-04-06 |
2006-01-16 |
Boehringer Ingelheim Ca Ltd |
Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
|
|
US6608027B1
(en)
|
1999-04-06 |
2003-08-19 |
Boehringer Ingelheim (Canada) Ltd |
Macrocyclic peptides active against the hepatitis C virus
|
|
AU5920400A
(en)
*
|
1999-07-07 |
2001-01-22 |
Du Pont Pharmaceuticals Company |
Cell-based assay systems for examining hcv ns3 protease activity
|
|
AU6371900A
(en)
|
1999-07-26 |
2001-02-13 |
Du Pont Pharmaceuticals Company |
Lactam inhibitors of hepatitis c virus ns3 protease
|
|
US7122627B2
(en)
*
|
1999-07-26 |
2006-10-17 |
Bristol-Myers Squibb Company |
Lactam inhibitors of Hepatitis C virus NS3 protease
|
|
AU7077400A
(en)
|
1999-08-31 |
2001-03-26 |
Basf Aktiengesellschaft |
Method of identifying inhibitors of cdc25
|
|
US20020183249A1
(en)
|
1999-08-31 |
2002-12-05 |
Taylor Neil R. |
Method of identifying inhibitors of CDC25
|
|
GB9925955D0
(en)
|
1999-11-02 |
1999-12-29 |
Angeletti P Ist Richerche Bio |
Hcv n33 protease inhibitors
|
|
JP2003526634A
(ja)
*
|
1999-12-03 |
2003-09-09 |
ブリストル−マイヤーズ スクイブ ファーマ カンパニー |
C型肝炎ウイルスNS3プロテアーゼのα−ケトアミド阻害剤
|
|
WO2001058929A1
(en)
|
2000-02-08 |
2001-08-16 |
Schering Corporation |
Azapeptides useful in the treatment of hepatitis c
|
|
CA2396504A1
(en)
|
2000-02-29 |
2001-09-07 |
Dupont Pharmaceuticals Company |
Inhibitors of hepatitis c virus ns3 protease
|
|
ES2240446T3
(es)
*
|
2000-04-03 |
2005-10-16 |
Vertex Pharma |
Inhibidores de serina proteasas, particularmente la proteasa ns3 del virus de la hepatitis c.
|
|
AR029903A1
(es)
|
2000-04-05 |
2003-07-23 |
Schering Corp |
Inhibidores macrociclicos de la ns3-serina proteasa, del virus de la hepatitis c, que comprenden partes p2 n-ciclicas, composiciones farmaceuticas y utilizacion de los mismos para la manufactura de un medicamento
|
|
CN101580536A
(zh)
|
2000-04-19 |
2009-11-18 |
先灵公司 |
含有烷基和芳基丙氨酸p2部分的丙型肝炎病毒的大环ns3-丝氨酸蛋白酶抑制剂
|
|
AU2001267886A1
(en)
|
2000-06-30 |
2002-01-14 |
Seikagaku Corporation |
Epoxycarboxylic acid amides, azides and amino alcohols and processes for preparation of alpha-keto amides by using them
|
|
JP2004504356A
(ja)
|
2000-07-20 |
2004-02-12 |
メルク エンド カムパニー インコーポレーテッド |
C型肝炎ウイルスのプロセシングおよび複製の抑制
|
|
AR029851A1
(es)
*
|
2000-07-21 |
2003-07-16 |
Dendreon Corp |
Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c
|
|
CA2418199A1
(en)
|
2000-07-21 |
2002-01-31 |
Corvas International, Inc. |
Peptides as ns3-serine protease inhibitors of hepatitis c virus
|
|
US7244721B2
(en)
|
2000-07-21 |
2007-07-17 |
Schering Corporation |
Peptides as NS3-serine protease inhibitors of hepatitis C virus
|
|
AR034127A1
(es)
|
2000-07-21 |
2004-02-04 |
Schering Corp |
Imidazolidinonas como inhibidores de ns3-serina proteasa del virus de hepatitis c, composicion farmaceutica, un metodo para su preparacion, y el uso de las mismas para la manufactura de un medicamento
|
|
DK1385870T3
(da)
|
2000-07-21 |
2010-07-05 |
Schering Corp |
Peptider som inhibitorer af NS3-serinprotease fra hepatitis C-virus
|
|
KR20030081297A
(ko)
|
2000-07-21 |
2003-10-17 |
쉐링 코포레이션 |
C형 간염 바이러스의 ns3-세린 프로테아제억제제로서의 신규한 펩티드
|
|
US6777400B2
(en)
|
2000-08-05 |
2004-08-17 |
Smithkline Beecham Corporation |
Anti-inflammatory androstane derivative compositions
|
|
SV2003000617A
(es)
*
|
2000-08-31 |
2003-01-13 |
Lilly Co Eli |
Inhibidores de la proteasa peptidomimetica ref. x-14912m
|
|
US6939692B2
(en)
|
2000-09-12 |
2005-09-06 |
Degussa Ag |
Nucleotide sequences coding for the pknB gene
|
|
US6846806B2
(en)
|
2000-10-23 |
2005-01-25 |
Bristol-Myers Squibb Company |
Peptide inhibitors of Hepatitis C virus NS3 protein
|
|
JP2002198723A
(ja)
*
|
2000-11-02 |
2002-07-12 |
Ace Technol Co Ltd |
広帯域指向性アンテナ
|
|
US6602718B1
(en)
|
2000-11-08 |
2003-08-05 |
Becton, Dickinson And Company |
Method and device for collecting and stabilizing a biological sample
|
|
DE60119968T2
(de)
|
2000-11-20 |
2007-01-18 |
Bristol-Myers Squibb Co. |
Hepatitis c tripeptid inhibitoren
|
|
KR20030091946A
(ko)
|
2000-12-12 |
2003-12-03 |
쉐링 코포레이션 |
C형 간염 바이러스의 ns3-세린 프로테아제억제제로서의 디아릴 펩티드
|
|
AU2002230764A1
(en)
|
2000-12-13 |
2002-06-24 |
Bristol-Myers Squibb Pharma Company |
Imidazolidinones and their related derivatives as hepatitis c virus ns3 protease inhibitors
|
|
AU2002230763A1
(en)
|
2000-12-13 |
2008-01-03 |
Bristol-Myers Squibb Pharma Company |
Inhibitors of hepatitis c virus ns3 protease
|
|
US6653295B2
(en)
|
2000-12-13 |
2003-11-25 |
Bristol-Myers Squibb Company |
Inhibitors of hepatitis C virus NS3 protease
|
|
JP4848528B2
(ja)
|
2000-12-28 |
2011-12-28 |
株式会社Ihi |
イオン質量分離方法及び装置、並びにイオンドーピング装置
|
|
SK286630B6
(sk)
|
2001-01-22 |
2009-02-05 |
Merck & Co., Inc. |
Nukleozidové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie
|
|
AU2002237982A1
(en)
|
2001-01-30 |
2002-08-12 |
Vertex Pharmaceuticals Incorporated |
A quantitative assay for nucleic acids
|
|
GB0102342D0
(en)
|
2001-01-30 |
2001-03-14 |
Smithkline Beecham Plc |
Pharmaceutical formulation
|
|
MXPA03008882A
(es)
|
2001-03-27 |
2003-12-08 |
Vertex Pharma |
Composiciones y metodos utiles para la infeccion por hcv.
|
|
GB0107924D0
(en)
|
2001-03-29 |
2001-05-23 |
Angeletti P Ist Richerche Bio |
Inhibitor of hepatitis C virus NS3 protease
|
|
AU2002354739A1
(en)
|
2001-07-03 |
2003-01-21 |
Altana Pharma Ag |
Process for the production of optically active 3-phenylisoserine
|
|
CA2449504A1
(en)
*
|
2001-07-11 |
2003-01-23 |
Vertex Pharmaceuticals Incorporated |
Bridged bicyclic serine protease inhibitors
|
|
JP2003055389A
(ja)
|
2001-08-09 |
2003-02-26 |
Univ Tokyo |
錯体及びそれを用いたエポキシドの製法
|
|
US6824769B2
(en)
|
2001-08-28 |
2004-11-30 |
Vertex Pharmaceuticals Incorporated |
Optimal compositions and methods thereof for treating HCV infections
|
|
US7241796B2
(en)
*
|
2001-10-24 |
2007-07-10 |
Vertex Pharmaceuticals Inc. |
Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
|
|
ES2234451T1
(es)
|
2001-11-14 |
2005-07-01 |
Teva Pharmaceutical Industries Ltd. |
Formas cristalinas y amorfas de losartan potasio y procedimiento para su preparacion.
|
|
CA2369711A1
(en)
|
2002-01-30 |
2003-07-30 |
Boehringer Ingelheim (Canada) Ltd. |
Macrocyclic peptides active against the hepatitis c virus
|
|
US7091184B2
(en)
|
2002-02-01 |
2006-08-15 |
Boehringer Ingelheim International Gmbh |
Hepatitis C inhibitor tri-peptides
|
|
US6642204B2
(en)
|
2002-02-01 |
2003-11-04 |
Boehringer Ingelheim International Gmbh |
Hepatitis C inhibitor tri-peptides
|
|
CA2369970A1
(en)
|
2002-02-01 |
2003-08-01 |
Boehringer Ingelheim (Canada) Ltd. |
Hepatitis c inhibitor tri-peptides
|
|
AR038375A1
(es)
|
2002-02-01 |
2005-01-12 |
Pfizer Prod Inc |
Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo
|
|
KR20040099425A
(ko)
*
|
2002-04-11 |
2004-11-26 |
버텍스 파마슈티칼스 인코포레이티드 |
세린 프로테아제, 특히 c형 간염 바이러스 ns3-ns4프로테아제의 억제제
|
|
NZ536728A
(en)
|
2002-04-25 |
2006-07-28 |
Ono Pharmaceutical Co |
Diketohydrazine derivative compounds and drugs containing the compounds as the active ingredient
|
|
WO2004013300A2
(en)
|
2002-08-01 |
2004-02-12 |
Pharmasset Inc. |
Compounds with the bicyclo[4.2.1]nonane system for the treatment of flaviviridae infections
|
|
US20050075279A1
(en)
|
2002-10-25 |
2005-04-07 |
Boehringer Ingelheim International Gmbh |
Macrocyclic peptides active against the hepatitis C virus
|
|
CA2413705A1
(en)
|
2002-12-06 |
2004-06-06 |
Raul Altman |
Use of meloxicam in combination with an antiplatelet agent for treatment of acute coronary syndrome and related conditions
|
|
US7601709B2
(en)
|
2003-02-07 |
2009-10-13 |
Enanta Pharmaceuticals, Inc. |
Macrocyclic hepatitis C serine protease inhibitors
|
|
US7223785B2
(en)
|
2003-01-22 |
2007-05-29 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
|
US7098231B2
(en)
|
2003-01-22 |
2006-08-29 |
Boehringer Ingelheim International Gmbh |
Viral polymerase inhibitors
|
|
US20040180815A1
(en)
|
2003-03-07 |
2004-09-16 |
Suanne Nakajima |
Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors
|
|
BRPI0407587A
(pt)
|
2003-02-18 |
2006-02-14 |
Pfizer |
inibidores do vìrus da hepatite c, composições e tratamentos que os utilizam
|
|
CA2516016C
(en)
|
2003-03-05 |
2012-05-29 |
Boehringer Ingelheim International Gmbh |
Hepatitis c inhibiting compounds
|
|
US6908901B2
(en)
|
2003-03-05 |
2005-06-21 |
Boehringer Ingelheim International, Gmbh |
Hepatitis C inhibitor peptide analogs
|
|
JP2006526011A
(ja)
*
|
2003-04-11 |
2006-11-16 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
セリンプロテアーゼ(特に、hcvns3−ns4aプロテアーゼ)のインヒビター
|
|
WO2004092161A1
(en)
*
|
2003-04-11 |
2004-10-28 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
|
|
CL2004001161A1
(es)
|
2003-05-21 |
2005-04-08 |
Boehringer Ingelheim Int |
Compuestos describe compuestos derivados de quinolina; composicion farmaceutica; y su uso para tratar una enfermedad causada por el virus de la hepatitis c.
|
|
CN1852920B
(zh)
*
|
2003-07-18 |
2010-12-15 |
沃泰克斯药物股份有限公司 |
丝氨酸蛋白酶抑制剂、特别是hcv ns3-ns4a蛋白酶抑制剂
|
|
WO2005018330A1
(en)
|
2003-08-18 |
2005-03-03 |
Pharmasset, Inc. |
Dosing regimen for flaviviridae therapy
|
|
TWI359147B
(en)
|
2003-09-05 |
2012-03-01 |
Vertex Pharma |
Inhibitors of serine proteases, particularly hcv n
|
|
EP1670415A4
(en)
|
2003-09-12 |
2007-12-05 |
Vertex Pharma |
ANIMAL MODEL FOR STUDYING PROTEASES ACTIVITY AND HEPATIC DISORDERS
|
|
EP1664091A1
(en)
*
|
2003-09-18 |
2006-06-07 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
|
|
US6933760B2
(en)
|
2003-09-19 |
2005-08-23 |
Intel Corporation |
Reference voltage generator for hysteresis circuit
|
|
ES2361997T3
(es)
|
2003-09-22 |
2011-06-27 |
Boehringer Ingelheim International Gmbh |
Péptidos macrocíclicos activos contra el virus de la hepatitis c.
|
|
WO2005037860A2
(en)
*
|
2003-10-10 |
2005-04-28 |
Vertex Pharmaceuticals Incoporated |
Inhibitors of serine proteases, particularly hcv ns3-ns4a protease
|
|
AR045870A1
(es)
|
2003-10-11 |
2005-11-16 |
Vertex Pharma |
Terapia de combinacion para la infeccion de virus de hepatitis c
|
|
KR20060120166A
(ko)
|
2003-10-27 |
2006-11-24 |
버텍스 파마슈티칼스 인코포레이티드 |
Hcv ns3-ns4a 단백질분해효소 저항성 돌연변이
|
|
US8187874B2
(en)
|
2003-10-27 |
2012-05-29 |
Vertex Pharmaceuticals Incorporated |
Drug discovery method
|
|
JP2007509950A
(ja)
|
2003-10-27 |
2007-04-19 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Hcv処置の組合せ剤
|
|
DE602004023105D1
(de)
|
2003-10-28 |
2009-10-22 |
Vertex Pharma |
HERSTELLUNG VON 4,5-DIALKYL-3-ACYLPYRROL-2-CARBONS ANSCHLIEßENDE ACYLIERUNG
|
|
US20050119318A1
(en)
|
2003-10-31 |
2005-06-02 |
Hudyma Thomas W. |
Inhibitors of HCV replication
|
|
US7132504B2
(en)
|
2003-11-12 |
2006-11-07 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
CN1910275B
(zh)
|
2003-12-01 |
2011-04-27 |
威特克斯医药股份有限公司 |
包含胎儿肝细胞的组合物及其用于hcv感染的方法
|
|
ATE495185T1
(de)
|
2004-01-21 |
2011-01-15 |
Boehringer Ingelheim Int |
Makrocyclische peptide mit wirkung gegen das hepatitis-c-virus
|
|
CN1938332B
(zh)
|
2004-02-04 |
2011-10-19 |
沃泰克斯药物股份有限公司 |
丝氨酸蛋白酶、特别是hcv ns3-ns4a蛋白酶的抑制剂
|
|
CN102911161A
(zh)
|
2004-02-20 |
2013-02-06 |
贝林格尔.英格海姆国际有限公司 |
病毒聚合酶抑制剂
|
|
US20050187192A1
(en)
|
2004-02-20 |
2005-08-25 |
Kucera Pharmaceutical Company |
Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses
|
|
EP1737821B1
(en)
|
2004-02-27 |
2009-08-05 |
Schering Corporation |
3,4-(cyclopentyl)-fused proline compounds as inhibitors of hepatitis c virus ns3 serine protease
|
|
EP2399916B1
(en)
|
2004-03-12 |
2014-12-10 |
Vertex Pharmaceuticals Incorporated |
Process and intermediates for the preparation of aspartic acetal caspase ihnhibitors
|
|
AR049635A1
(es)
|
2004-05-06 |
2006-08-23 |
Schering Corp |
(1r,2s,5s)-n-((1s)-3-amino-1-(ciclobutilmetil)-2,3-dioxopropil)-3-((2s)-2-((((1,1-dimetiletil)amino)carbonil)amino)-3,3-dimetil-1-oxobutil)-6,6-dimetil-3-azabiciclo(3.1.0)hexan-2-carboxamida como inhibidor de la ns3/ns4a serina proteasa del virus de la hepatitis c
|
|
AR049297A1
(es)
*
|
2004-06-08 |
2006-07-12 |
Vertex Pharma |
Una composicion farmaceutica y dispersiones solidas de vx-950 (inhibidor de la proteasa de hcv ns3/4a) y proceso de obtencion
|
|
ATE513844T1
(de)
|
2004-08-27 |
2011-07-15 |
Schering Corp |
Acylsulfonamidverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus
|
|
RU2007116265A
(ru)
*
|
2004-10-01 |
2008-11-10 |
Вертекс Фармасьютикалз Инкорпорейтед (Us) |
Ингибирование протеазы ns3-ns4a вируса hcv
|
|
TW201424733A
(zh)
*
|
2004-10-29 |
2014-07-01 |
Vertex Pharma |
劑量型式
|
|
US7863274B2
(en)
|
2005-07-29 |
2011-01-04 |
Concert Pharmaceuticals Inc. |
Deuterium enriched analogues of tadalafil as PDE5 inhibitors
|
|
KR20080033481A
(ko)
*
|
2005-08-02 |
2008-04-16 |
버텍스 파마슈티칼스 인코포레이티드 |
세린 프로테아제의 억제제
|
|
PL385229A1
(pl)
*
|
2005-08-19 |
2008-09-29 |
Vertex Pharmaceuticals Incorporated |
Sposoby i związki pośrednie
|
|
US7964624B1
(en)
|
2005-08-26 |
2011-06-21 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of serine proteases
|
|
AR055395A1
(es)
*
|
2005-08-26 |
2007-08-22 |
Vertex Pharma |
Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
|
|
US7705138B2
(en)
*
|
2005-11-11 |
2010-04-27 |
Vertex Pharmaceuticals Incorporated |
Hepatitis C virus variants
|
|
EP1991229A2
(en)
|
2006-02-27 |
2008-11-19 |
Vertex Pharmaceuticals Incorporated |
Co-crystals and pharmaceutical compositions comprising the same
|
|
EP1993994A2
(en)
|
2006-03-16 |
2008-11-26 |
Vertex Pharmceuticals Incorporated |
Deuterated hepatitis c protease inhibitors
|
|
EP2295401A3
(en)
|
2006-03-16 |
2012-07-25 |
Vertex Pharmaceuticals Incorporated |
Deuterated hepatitis C protease inhibitors
|
|
CA2645566A1
(en)
|
2006-03-20 |
2007-09-27 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions
|
|
WO2007109605A2
(en)
|
2006-03-20 |
2007-09-27 |
Vertex Pharmaceuticals Incorporated |
Pharmaceutical compositions
|
|
US7651520B2
(en)
*
|
2006-05-30 |
2010-01-26 |
Ostial Solutions, Llc |
Means and method for the accurate placement of a stent at the ostium of an artery
|
|
US20080070972A1
(en)
|
2006-05-31 |
2008-03-20 |
Kadiyala Irina N |
Controlled release formulations
|
|
US7708294B2
(en)
|
2006-11-02 |
2010-05-04 |
Gm Global Technology Operations, Inc. |
Detachable dual-use platform apparatus and method
|
|
JP2010519329A
(ja)
|
2007-02-27 |
2010-06-03 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
セリンプロテアーゼ阻害剤
|
|
US7910587B2
(en)
*
|
2007-04-26 |
2011-03-22 |
Enanta Pharmaceuticals, Inc. |
Quinoxalinyl dipeptide hepatitis C virus inhibitors
|
|
US7959488B2
(en)
*
|
2007-10-15 |
2011-06-14 |
Tania Alessandra Talamo |
Brassiere pad system
|