JP2005530490A5 - - Google Patents
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- JP2005530490A5 JP2005530490A5 JP2003582268A JP2003582268A JP2005530490A5 JP 2005530490 A5 JP2005530490 A5 JP 2005530490A5 JP 2003582268 A JP2003582268 A JP 2003582268A JP 2003582268 A JP2003582268 A JP 2003582268A JP 2005530490 A5 JP2005530490 A5 JP 2005530490A5
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- amino acid
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- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 239000002773 nucleotide Substances 0.000 claims 20
- 125000003729 nucleotide group Chemical group 0.000 claims 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims 19
- 239000012634 fragment Substances 0.000 claims 15
- 108020004707 nucleic acids Proteins 0.000 claims 13
- 150000007523 nucleic acids Chemical class 0.000 claims 13
- 102000039446 nucleic acids Human genes 0.000 claims 13
- 239000000427 antigen Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- 102000000743 Interleukin-5 Human genes 0.000 claims 7
- 108010002616 Interleukin-5 Proteins 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 102000010786 Interleukin-5 Receptors Human genes 0.000 claims 4
- 108010038484 Interleukin-5 Receptors Proteins 0.000 claims 4
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
- 230000002452 interceptive effect Effects 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 206010014950 Eosinophilia Diseases 0.000 claims 2
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000003979 eosinophil Anatomy 0.000 claims 2
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 2
- 230000008595 infiltration Effects 0.000 claims 2
- 238000001764 infiltration Methods 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 208000032671 Allergic granulomatous angiitis Diseases 0.000 claims 1
- 208000037874 Asthma exacerbation Diseases 0.000 claims 1
- 206010006474 Bronchopulmonary aspergillosis allergic Diseases 0.000 claims 1
- 206010006482 Bronchospasm Diseases 0.000 claims 1
- 206010009137 Chronic sinusitis Diseases 0.000 claims 1
- 208000006344 Churg-Strauss Syndrome Diseases 0.000 claims 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010065563 Eosinophilic bronchitis Diseases 0.000 claims 1
- 208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 claims 1
- 208000006968 Helminthiasis Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- 208000000112 Myalgia Diseases 0.000 claims 1
- 208000000592 Nasal Polyps Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 241000243981 Onchocerca Species 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 206010037423 Pulmonary oedema Diseases 0.000 claims 1
- 208000002200 Respiratory Hypersensitivity Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010039094 Rhinitis perennial Diseases 0.000 claims 1
- 208000024780 Urticaria Diseases 0.000 claims 1
- 230000009471 action Effects 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000010085 airway hyperresponsiveness Effects 0.000 claims 1
- 208000006778 allergic bronchopulmonary aspergillosis Diseases 0.000 claims 1
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 206010003230 arteritis Diseases 0.000 claims 1
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 230000007885 bronchoconstriction Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000027157 chronic rhinosinusitis Diseases 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000003038 endothelium Anatomy 0.000 claims 1
- 230000002327 eosinophilic effect Effects 0.000 claims 1
- 201000001564 eosinophilic gastroenteritis Diseases 0.000 claims 1
- 230000001667 episodic effect Effects 0.000 claims 1
- 230000008378 epithelial damage Effects 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035800 maturation Effects 0.000 claims 1
- 210000003716 mesoderm Anatomy 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 208000016366 nasal cavity polyp Diseases 0.000 claims 1
- 208000004235 neutropenia Diseases 0.000 claims 1
- 208000014837 parasitic helminthiasis infectious disease Diseases 0.000 claims 1
- 208000022719 perennial allergic rhinitis Diseases 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 208000005333 pulmonary edema Diseases 0.000 claims 1
- 201000009732 pulmonary eosinophilia Diseases 0.000 claims 1
- 230000011514 reflex Effects 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36904402P | 2002-03-29 | 2002-03-29 | |
| PCT/US2003/009260 WO2003085089A2 (en) | 2002-03-29 | 2003-03-27 | Human monoclonal antibodies to interleukin-5 and methods and compositions comprising same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009243925A Division JP2010011874A (ja) | 2002-03-29 | 2009-10-22 | インターロイキン−５に対するヒトモノクローナル抗体および方法およびこれを含む組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005530490A JP2005530490A (ja) | 2005-10-13 |
| JP2005530490A5 true JP2005530490A5 (enExample) | 2006-04-20 |
Family
ID=28791919
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003582268A Ceased JP2005530490A (ja) | 2002-03-29 | 2003-03-27 | インターロイキン−５に対するヒトモノクローナル抗体および方法およびこれを含む組成物 |
| JP2009243925A Pending JP2010011874A (ja) | 2002-03-29 | 2009-10-22 | インターロイキン−５に対するヒトモノクローナル抗体および方法およびこれを含む組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009243925A Pending JP2010011874A (ja) | 2002-03-29 | 2009-10-22 | インターロイキン−５に対するヒトモノクローナル抗体および方法およびこれを含む組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7141653B2 (enExample) |
| EP (1) | EP1527100B1 (enExample) |
| JP (2) | JP2005530490A (enExample) |
| CN (1) | CN1326879C (enExample) |
| AT (1) | ATE435239T1 (enExample) |
| AU (1) | AU2003220525A1 (enExample) |
| CA (1) | CA2479927C (enExample) |
| CY (1) | CY1109423T1 (enExample) |
| DE (1) | DE60328195D1 (enExample) |
| DK (1) | DK1527100T3 (enExample) |
| ES (1) | ES2327830T3 (enExample) |
| MX (1) | MXPA04009418A (enExample) |
| PT (1) | PT1527100E (enExample) |
| SI (1) | SI1527100T1 (enExample) |
| WO (1) | WO2003085089A2 (enExample) |
Families Citing this family (128)
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| EP2275540B1 (en) | 1999-04-09 | 2016-03-23 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
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| AU2003291002A1 (en) | 2002-11-15 | 2004-06-15 | Chiron Corporation | Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis |
| PE20090047A1 (es) | 2003-11-10 | 2009-01-26 | Schering Corp | Anticuerpo recombinante humanizado anti-interleuquina 10 |
| ES2689328T3 (es) | 2004-01-07 | 2018-11-13 | Novartis Vaccines And Diagnostics, Inc. | Anticuerpo monoclonal M-CSF-específico y usos del mismo |
| ES2395404T3 (es) * | 2004-05-14 | 2013-02-12 | Optimer Pharmaceuticals, Inc. | Tratamiento de las enfermedades asociadas al uso de antibióticos |
| KR101206318B1 (ko) | 2004-10-28 | 2012-11-29 | 교와 핫꼬 기린 가부시키가이샤 | 자궁 내막증 치료제 |
| WO2006083390A2 (en) | 2004-12-07 | 2006-08-10 | Children's Hospital Medical Center | Eotaxin-3 in eosinophilic esophagitis |
| US8652469B2 (en) * | 2005-07-28 | 2014-02-18 | Novartis Ag | M-CSF-specific monoclonal antibody and uses thereof |
| EP2277916A3 (en) * | 2005-07-28 | 2011-04-27 | Novartis AG | Use of antibody to M-CSF |
| US9062126B2 (en) | 2005-09-16 | 2015-06-23 | Raptor Pharmaceuticals Inc. | Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof |
| SI3045182T1 (en) | 2005-11-14 | 2018-08-31 | Teva Pharmaceuticals International Gmbh | An antibody to a peptide-associated peptide antagonist to calcitonin for treating a headache in aggregates |
| US20090286962A1 (en) * | 2005-12-20 | 2009-11-19 | Woolven Benjamin P | Chimeric antibodies with part new world primate binding regions |
| NZ569988A (en) | 2006-02-01 | 2011-09-30 | Cephalon Australia Pty Ltd | Domain antibody construct which binds to human TNF-alpha and contains a modified hinge region sequence and a truncated CH1 domain |
| JP2009529915A (ja) | 2006-03-20 | 2009-08-27 | ゾーマ テクノロジー リミテッド | ガストリン物質に対して特異的なヒト抗体および方法 |
| US20080038258A1 (en) * | 2006-07-21 | 2008-02-14 | Amgen Inc. | Polypeptides with Reduced Susceptibility to Oxidation and Methods of Making |
| JP4842040B2 (ja) | 2006-07-25 | 2011-12-21 | 富士通株式会社 | 電子機器 |
| JP2008027370A (ja) | 2006-07-25 | 2008-02-07 | Fujitsu Ltd | 電子機器 |
| JP4781929B2 (ja) | 2006-07-25 | 2011-09-28 | 富士通株式会社 | 電子機器 |
| JP5148079B2 (ja) | 2006-07-25 | 2013-02-20 | 富士通株式会社 | 液冷ユニット用熱交換器および液冷ユニット並びに電子機器 |
| RU2009107707A (ru) | 2006-08-04 | 2010-09-10 | Новартис АГ (CH) | СПЕЦИФИЧНОЕ К EphB3 АНТИТЕЛО И ЕГО ПРИМЕНЕНИЕ |
| CA2661023C (en) | 2006-08-18 | 2017-08-15 | Novartis Ag | Prlr-specific antibody and uses thereof |
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| CA2663536A1 (en) * | 2006-10-24 | 2008-05-02 | Trubion Pharmaceuticals, Inc. | Materials and methods for improved immunoglycoproteins |
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| BR112013007616B1 (pt) | 2010-09-29 | 2023-01-24 | Oxyrane Uk Limited | Métodos para retirar o cap ("uncapping") de porções de manose-1- fosfo-6-manose e desmanosilar n-glicanos fosforilados em uma glicoproteína, para direcionar uma glicoproteína para o interior de uma célula de mamífero, e para converter uma glicoproteína de uma primeira forma que não se liga substancialmente a um receptor de manose-6-fosfato em uma segunda forma que se liga substancialmente a um receptor de manose-6-fosfato em uma célula de mamífero |
| JP6131190B2 (ja) | 2010-09-29 | 2017-05-17 | オキシレイン ユーケー リミテッド | リン酸化ｎ−グリカンの脱マンノシル化 |
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| US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
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| PT3110848T (pt) | 2014-09-24 | 2024-03-05 | Regeneron Pharma | Métodos para tratamento de infeção cutânea por administração de um antagonista do il-4r |
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- 2003-03-27 MX MXPA04009418A patent/MXPA04009418A/es active IP Right Grant
- 2003-03-27 AU AU2003220525A patent/AU2003220525A1/en not_active Abandoned
- 2003-03-27 EP EP03716836A patent/EP1527100B1/en not_active Expired - Lifetime
- 2003-03-27 PT PT03716836T patent/PT1527100E/pt unknown
- 2003-03-27 CA CA2479927A patent/CA2479927C/en not_active Expired - Fee Related
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- 2003-03-27 SI SI200331661T patent/SI1527100T1/sl unknown
- 2003-03-27 DK DK03716836T patent/DK1527100T3/da active
- 2003-03-27 AT AT03716836T patent/ATE435239T1/de active
- 2003-03-27 US US10/401,344 patent/US7141653B2/en not_active Expired - Lifetime
- 2003-03-27 DE DE60328195T patent/DE60328195D1/de not_active Expired - Lifetime
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2006
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