AR248044A1 - Una secuencia de adn que codifica anticuerpos monoclonales humanizados contra interleuquinas humanas, metodo de obtencion y de seleccion de dichos anticuerpos, vector recombinante y celula huesped. - Google Patents
Una secuencia de adn que codifica anticuerpos monoclonales humanizados contra interleuquinas humanas, metodo de obtencion y de seleccion de dichos anticuerpos, vector recombinante y celula huesped.Info
- Publication number
- AR248044A1 AR248044A1 AR93324239A AR32423993A AR248044A1 AR 248044 A1 AR248044 A1 AR 248044A1 AR 93324239 A AR93324239 A AR 93324239A AR 32423993 A AR32423993 A AR 32423993A AR 248044 A1 AR248044 A1 AR 248044A1
- Authority
- AR
- Argentina
- Prior art keywords
- cloning
- expression
- design
- monoclonal antibodies
- antibodies against
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
- C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
UNA SECUENCIA DE ADN QUE CODIFICA UNA SECUENCIA DE AMINOACIDOS DONDE UNA SECUENCIA DE UN ANTICUERPO MONOCLONAL PRODUCIDO POR UN HIBRIDOMA QUE TIENE LAS CARACTERISTICAS IDENTIFICADORAS DE UNA LINEA CELULAR DE ACCESION ATC HB 10959, CUYA SECUENCIA DE ADN COMPRENDE DESDE APROXIMADAMENTE 12 HASTA 333 BASES DE UNA SECUENCIA NUCLEOTIDICA DEFINIDA POR SEC ID NO:1 O DESDE APROXIMADAMENTE 9 A 384 BASES DE UNA SECUENCIA NUCLEOTIDICA DEFINIDA POR SEC ID NO:2, O QUE ES UN EQUIVALENTE FUNCIONAL DE DICHAS SECUENCIAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83284292A | 1992-02-06 | 1992-02-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR248044A1 true AR248044A1 (es) | 1995-05-31 |
Family
ID=25262763
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR93324239A AR248044A1 (es) | 1992-02-06 | 1993-02-04 | Una secuencia de adn que codifica anticuerpos monoclonales humanizados contra interleuquinas humanas, metodo de obtencion y de seleccion de dichos anticuerpos, vector recombinante y celula huesped. |
Country Status (21)
Country | Link |
---|---|
US (1) | US6451982B1 (es) |
EP (1) | EP0625201A1 (es) |
JP (2) | JPH07505767A (es) |
KR (2) | KR0150060B1 (es) |
CN (1) | CN1077991A (es) |
AR (1) | AR248044A1 (es) |
AU (1) | AU683836B2 (es) |
CA (1) | CA2129445A1 (es) |
CZ (1) | CZ291039B6 (es) |
FI (1) | FI943635A (es) |
HU (1) | HUT67943A (es) |
IL (1) | IL104620A (es) |
NO (1) | NO942912L (es) |
NZ (1) | NZ249633A (es) |
PL (1) | PL176393B1 (es) |
RU (1) | RU94045919A (es) |
SG (1) | SG49597A1 (es) |
SK (1) | SK280610B6 (es) |
TN (1) | TNSN93012A1 (es) |
WO (1) | WO1993016184A1 (es) |
ZA (1) | ZA93779B (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2129445A1 (en) | 1992-02-06 | 1993-08-07 | Chuan-Chu Chou | Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5 |
USRE39548E1 (en) * | 1994-06-17 | 2007-04-03 | Celltech R&D Limited | Interleukin-5 specific recombinant antibodies |
GB9412230D0 (en) * | 1994-06-17 | 1994-08-10 | Celltech Ltd | Interleukin-5 specific recombiant antibodies |
US6056957A (en) * | 1994-08-04 | 2000-05-02 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-5 |
US5693323A (en) | 1994-12-23 | 1997-12-02 | Smithkline Beecham Corporation | Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders |
CN100391977C (zh) * | 1994-12-23 | 2008-06-04 | 史密丝克莱恩比彻姆公司 | 用于治疗il-5介导的疾病的重组il-5拮抗剂 |
US7399837B2 (en) | 1995-12-22 | 2008-07-15 | Smithkline Beecham Corporation | Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders |
US5677280A (en) * | 1995-06-07 | 1997-10-14 | Glaxo Group Limited | Peptides and compounds that bind to the IL-5 receptor |
US5668110A (en) * | 1995-06-07 | 1997-09-16 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-5 receptor |
US5683983A (en) * | 1995-06-07 | 1997-11-04 | Glaxo Group Limited | Peptides and compounds that bind to the IL-5 receptor |
US5654276A (en) * | 1995-06-07 | 1997-08-05 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-5 receptor |
AU690474B2 (en) | 1995-09-11 | 1998-04-23 | Kyowa Hakko Kirin Co., Ltd. | Antibody againts alpha-chain of human interleukin 5 receptor |
US6228360B1 (en) * | 1998-08-19 | 2001-05-08 | Ajinomoto Co., Inc. | Antithrombotic agent and humanized anti-von Willebrand factor monoclonal antibody |
US7109299B1 (en) | 1999-12-16 | 2006-09-19 | Affymax, Inc. | Peptides and compounds that bind to the IL-5 receptor |
KR100453877B1 (ko) | 2001-07-26 | 2004-10-20 | 메덱스젠 주식회사 | 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 TNFR/Fc 융합 단백질, 상기 단백질을 코딩하는 DNA, 상기 DNA를 포함하는벡터, 및 상기 벡터에 의한 형질전환체 |
MXPA04009418A (es) * | 2002-03-29 | 2005-06-08 | Schering Corp | Anticuerpos monoclonales humanos par interleucina-5, y metodos y composiciones que comprenden los mismos. |
US7927840B2 (en) * | 2006-09-11 | 2011-04-19 | Gen Probe Incorporated | Method for detecting West Nile Virus nucleic acids in the 3′ non-coding region |
CA3081071A1 (en) * | 2002-10-16 | 2004-04-29 | Gen-Probe Incorporated | Compositions and methods for detecting west nile virus |
US7169904B2 (en) | 2002-12-17 | 2007-01-30 | Emd Lexigen Research Center Corp. | Immunocytokine sequences and uses thereof |
ITRM20030601A1 (it) | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
AU2005297803B2 (en) | 2004-10-28 | 2011-06-16 | Kyowa Hakko Kirin Co., Ltd. | Remedy for endometriosis |
US20090196850A1 (en) | 2005-01-06 | 2009-08-06 | Novo Nordisk A/S | Anti-Kir Combination Treatments and Methods |
CN112480257A (zh) | 2005-03-23 | 2021-03-12 | 根马布股份公司 | 用于治疗多发性骨髓瘤的cd38抗体 |
ITRM20050290A1 (it) | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
PT2152290E (pt) | 2007-04-30 | 2014-09-03 | Glaxosmithkline Llc | Métodos para administrar anticorpos anti-il-5 |
AU2009228163B2 (en) | 2008-03-28 | 2012-08-30 | Glaxosmithkline Llc | Methods of treatment |
CN102203286B (zh) * | 2008-10-23 | 2013-07-17 | 弗·哈夫曼-拉罗切有限公司 | 免疫球蛋白编码核酸的测定 |
PT2654790T (pt) * | 2010-12-22 | 2019-05-16 | Teva Pharmaceuticals Australia Pty Ltd | Anticorpo modificado com semivida melhorada |
US9580501B2 (en) | 2011-12-16 | 2017-02-28 | Synthon Biopharmaceuticals B.V. | Anti-TNF alpha monoclonal secretory IgA antibodies and methods for treating inflammatory diseases |
US9677018B2 (en) | 2013-01-09 | 2017-06-13 | Thyssenkrupp Industrial Solutions Ag | Process for the production of synthesis gas from hard coal |
SI3191513T1 (sl) | 2014-09-08 | 2020-12-31 | Cephalon, Inc. | Uporaba reslizumaba za zdravljenje zmerne do hude eozinofilne astme |
KR20180037275A (ko) | 2015-08-24 | 2018-04-11 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | 생물제약 조성물 |
JP7295038B2 (ja) | 2017-06-06 | 2023-06-20 | グラクソスミスクライン エルエルシー | 小児患者のための生物薬剤組成物及び方法 |
JP2019026625A (ja) * | 2017-08-03 | 2019-02-21 | 日本全薬工業株式会社 | 抗イヌcd20モノクローナル抗体 |
US11224653B2 (en) | 2017-08-24 | 2022-01-18 | Cephalon, Inc. | Treatment strategy for non-responders to 100MG subcutaneous mepolizumab |
MX2020003034A (es) * | 2017-09-29 | 2020-07-22 | Jiangsu Hengrui Medicine Co | Anticuerpo il-5, fragmento de union a antigeno del mismo y su aplicacion medica. |
CN109942706A (zh) * | 2017-12-21 | 2019-06-28 | 三生国健药业(上海)股份有限公司 | 结合人il-5的单克隆抗体、其制备方法和用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
GB8720833D0 (en) | 1987-09-04 | 1987-10-14 | Celltech Ltd | Recombinant dna product |
US5096704A (en) | 1988-11-03 | 1992-03-17 | Schering Corporation | Method of treating eosinophilia |
EP0441891A1 (en) * | 1988-11-03 | 1991-08-21 | Schering Corporation | Method of preventing or reducing eosinophilia |
JP2919890B2 (ja) | 1988-11-11 | 1999-07-19 | メディカル リサーチ カウンスル | 単一ドメインリガンド、そのリガンドからなる受容体、その製造方法、ならびにそのリガンドおよび受容体の使用 |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
CA2041271A1 (en) * | 1990-04-30 | 1991-10-31 | Bradford A. Jameson | Peptide analogs to proteins of the immunoglobin superfamily |
CA2129445A1 (en) | 1992-02-06 | 1993-08-07 | Chuan-Chu Chou | Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5 |
-
1993
- 1993-02-04 CA CA002129445A patent/CA2129445A1/en not_active Abandoned
- 1993-02-04 SG SG1996000571A patent/SG49597A1/en unknown
- 1993-02-04 NZ NZ249633A patent/NZ249633A/en unknown
- 1993-02-04 HU HU9402293A patent/HUT67943A/hu unknown
- 1993-02-04 AR AR93324239A patent/AR248044A1/es active
- 1993-02-04 PL PL93304715A patent/PL176393B1/pl unknown
- 1993-02-04 SK SK918-94A patent/SK280610B6/sk unknown
- 1993-02-04 EP EP93905764A patent/EP0625201A1/en not_active Withdrawn
- 1993-02-04 IL IL10462093A patent/IL104620A/xx not_active IP Right Cessation
- 1993-02-04 KR KR1019940702711A patent/KR0150060B1/ko active
- 1993-02-04 RU RU94045919/13A patent/RU94045919A/ru unknown
- 1993-02-04 CZ CZ19941910A patent/CZ291039B6/cs not_active IP Right Cessation
- 1993-02-04 WO PCT/US1993/000759 patent/WO1993016184A1/en not_active Application Discontinuation
- 1993-02-04 ZA ZA93779A patent/ZA93779B/xx unknown
- 1993-02-04 AU AU36560/93A patent/AU683836B2/en not_active Ceased
- 1993-02-04 JP JP5514104A patent/JPH07505767A/ja active Pending
- 1993-02-05 TN TNTNSN93012A patent/TNSN93012A1/fr unknown
- 1993-02-05 CN CN93102685A patent/CN1077991A/zh active Pending
-
1994
- 1994-08-05 NO NO942912A patent/NO942912L/no not_active Application Discontinuation
- 1994-08-05 FI FI943635A patent/FI943635A/fi unknown
- 1994-08-06 KR KR1019940702711A patent/KR950700413A/ko not_active IP Right Cessation
-
1999
- 1999-11-11 JP JP11321698A patent/JP2000210097A/ja active Pending
-
2000
- 2000-03-28 US US09/537,911 patent/US6451982B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
SK280610B6 (sk) | 2000-05-16 |
RU94045919A (ru) | 1996-11-10 |
AU683836B2 (en) | 1997-11-27 |
AU3656093A (en) | 1993-09-03 |
HU9402293D0 (en) | 1994-10-28 |
NZ249633A (en) | 1995-12-21 |
FI943635A0 (fi) | 1994-08-05 |
HUT67943A (en) | 1995-05-29 |
SG49597A1 (en) | 1998-06-15 |
TNSN93012A1 (fr) | 1994-03-17 |
JP2000210097A (ja) | 2000-08-02 |
ZA93779B (en) | 1993-08-05 |
JPH07505767A (ja) | 1995-06-29 |
EP0625201A1 (en) | 1994-11-23 |
KR0150060B1 (ko) | 1998-08-17 |
CZ291039B6 (cs) | 2002-12-11 |
NO942912L (no) | 1994-10-06 |
KR950700413A (ko) | 1995-01-16 |
PL176393B1 (pl) | 1999-05-31 |
WO1993016184A1 (en) | 1993-08-19 |
IL104620A (en) | 2000-02-29 |
CA2129445A1 (en) | 1993-08-07 |
SK91894A3 (en) | 1995-02-08 |
CN1077991A (zh) | 1993-11-03 |
US6451982B1 (en) | 2002-09-17 |
NO942912D0 (es) | 1994-08-05 |
CZ191094A3 (en) | 1994-12-15 |
FI943635A (fi) | 1994-08-05 |
IL104620A0 (en) | 1993-06-10 |
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