KR950700413A - 인간 인터루킨-5에 대한 인간화 모노클로날 항체의 고안, 클로닝 및 발현(Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5) - Google Patents

인간 인터루킨-5에 대한 인간화 모노클로날 항체의 고안, 클로닝 및 발현(Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5)

Info

Publication number
KR950700413A
KR950700413A KR1019940702711A KR19940702711A KR950700413A KR 950700413 A KR950700413 A KR 950700413A KR 1019940702711 A KR1019940702711 A KR 1019940702711A KR 19940702711 A KR19940702711 A KR 19940702711A KR 950700413 A KR950700413 A KR 950700413A
Authority
KR
South Korea
Prior art keywords
cloning
expression
design
monoclonal antibodies
antibodies against
Prior art date
Application number
KR1019940702711A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of KR950700413A publication Critical patent/KR950700413A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
KR1019940702711A 1992-02-06 1994-08-06 인간 인터루킨-5에 대한 인간화 모노클로날 항체의 고안, 클로닝 및 발현(Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5) KR950700413A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83284292A 1992-02-06 1992-02-06
PCT/US1993/000759 WO1993016184A1 (en) 1992-02-06 1993-02-04 Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5

Publications (1)

Publication Number Publication Date
KR950700413A true KR950700413A (ko) 1995-01-16

Family

ID=25262763

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019940702711A KR0150060B1 (ko) 1992-02-06 1993-02-04 사람 인터루킨-5에 대한 인간화 모노클로날 항체의 고안, 클로닝 및 발현
KR1019940702711A KR950700413A (ko) 1992-02-06 1994-08-06 인간 인터루킨-5에 대한 인간화 모노클로날 항체의 고안, 클로닝 및 발현(Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1019940702711A KR0150060B1 (ko) 1992-02-06 1993-02-04 사람 인터루킨-5에 대한 인간화 모노클로날 항체의 고안, 클로닝 및 발현

Country Status (21)

Country Link
US (1) US6451982B1 (ko)
EP (1) EP0625201A1 (ko)
JP (2) JPH07505767A (ko)
KR (2) KR0150060B1 (ko)
CN (1) CN1077991A (ko)
AR (1) AR248044A1 (ko)
AU (1) AU683836B2 (ko)
CA (1) CA2129445A1 (ko)
CZ (1) CZ291039B6 (ko)
FI (1) FI943635A0 (ko)
HU (1) HUT67943A (ko)
IL (1) IL104620A (ko)
NO (1) NO942912L (ko)
NZ (1) NZ249633A (ko)
PL (1) PL176393B1 (ko)
RU (1) RU94045919A (ko)
SG (1) SG49597A1 (ko)
SK (1) SK280610B6 (ko)
TN (1) TNSN93012A1 (ko)
WO (1) WO1993016184A1 (ko)
ZA (1) ZA93779B (ko)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ291039B6 (cs) 1992-02-06 2002-12-11 Schering Corporation Monoklonální protilátka, hybridom, polypeptid a způsob jeho přípravy, izolovaná DNA, rekombinantní vektor, hostitelská buňka, humanizovaná protilátka a farmaceutický prostředek
GB9412230D0 (en) * 1994-06-17 1994-08-10 Celltech Ltd Interleukin-5 specific recombiant antibodies
USRE39548E1 (en) * 1994-06-17 2007-04-03 Celltech R&D Limited Interleukin-5 specific recombinant antibodies
US6056957A (en) * 1994-08-04 2000-05-02 Schering Corporation Humanized monoclonal antibodies against human interleukin-5
US5693323A (en) * 1994-12-23 1997-12-02 Smithkline Beecham Corporation Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
CZ297045B6 (cs) * 1994-12-23 2006-08-16 Smithkline Beecham Corporation Hlodavcí neutralizacní monoklonální protilátka, zpusob pro její produkci, kompozice s jejím obsahema pouzití, hybridom a jím produkovaná protilátka,fab fragment, komplementaritu urcující region, molekula nukleové kyseliny a její sekvence, plasmid a
US7399837B2 (en) 1995-12-22 2008-07-15 Smithkline Beecham Corporation Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
US5683983A (en) * 1995-06-07 1997-11-04 Glaxo Group Limited Peptides and compounds that bind to the IL-5 receptor
US5677280A (en) * 1995-06-07 1997-10-14 Glaxo Group Limited Peptides and compounds that bind to the IL-5 receptor
US5654276A (en) * 1995-06-07 1997-08-05 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
US5668110A (en) * 1995-06-07 1997-09-16 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
CN1241944C (zh) 1995-09-11 2006-02-15 协和发酵工业株式会社 抗人白介素－5受体α链的抗体
US6228360B1 (en) * 1998-08-19 2001-05-08 Ajinomoto Co., Inc. Antithrombotic agent and humanized anti-von Willebrand factor monoclonal antibody
US7109299B1 (en) 1999-12-16 2006-09-19 Affymax, Inc. Peptides and compounds that bind to the IL-5 receptor
KR100453877B1 (ko) 2001-07-26 2004-10-20 메덱스젠 주식회사 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 ＴＮＦＲ/Ｆｃ 융합 단백질, 상기 단백질을 코딩하는 ＤＮＡ, 상기 ＤＮＡ를 포함하는벡터, 및 상기 벡터에 의한 형질전환체
ATE435239T1 (de) * 2002-03-29 2009-07-15 Schering Corp Menschliche monoklonale antikörper gegen interleukin-5 sowie diese umfassende verfahren und zusammensetzungen
US7927840B2 (en) 2006-09-11 2011-04-19 Gen Probe Incorporated Method for detecting West Nile Virus nucleic acids in the 3′ non-coding region
CA3081071A1 (en) * 2002-10-16 2004-04-29 Gen-Probe Incorporated Compositions and methods for detecting west nile virus
CA2510180C (en) 2002-12-17 2012-09-11 Merck Patent Gesellschaft Mit Beschraenkter Haftung Humanized antibody (h14.18) of the mouse 14.18 antibody binding to gd2 and its fusion with il-2
ITRM20030601A1 (it) * 2003-12-24 2005-06-25 Lay Line Genomics Spa Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti.
ATE541585T1 (de) 2004-10-28 2012-02-15 Kyowa Hakko Kirin Co Ltd Antikörper gegen il-5-rezeptor zur verwendung in der behandlung von endometriose.
JP5855326B2 (ja) 2005-01-06 2016-02-09 ノヴォ ノルディスク アー／エス 抗ｋｉｒ組み合わせ治療および方法
SG10201912554TA (en) 2005-03-23 2020-02-27 Genmab As Antibodies against cd38 for treatment of multiple myeloma
ITRM20050290A1 (it) 2005-06-07 2006-12-08 Lay Line Genomics Spa Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato.
ES2492943T3 (es) 2007-04-30 2014-09-10 Glaxosmithkline Llc Procedimientos de administración de anticuerpos anti-IL5
BRPI0910854A2 (pt) 2008-03-28 2015-10-06 Glaxosmithkline Llc métodos de tratamento
MX2011003601A (es) * 2008-10-23 2011-04-27 Hoffmann La Roche Determinacion de acido nucleico que codifica inmunoglobulina.
WO2012083370A1 (en) 2010-12-22 2012-06-28 Cephalon Australia Pty Ltd Modified antibody with improved half-life
US9580501B2 (en) 2011-12-16 2017-02-28 Synthon Biopharmaceuticals B.V. Anti-TNF alpha monoclonal secretory IgA antibodies and methods for treating inflammatory diseases
US9677018B2 (en) 2013-01-09 2017-06-13 Thyssenkrupp Industrial Solutions Ag Process for the production of synthesis gas from hard coal
KR102495432B1 (ko) 2014-09-08 2023-02-03 세파론 엘엘씨 중등증 내지 중증의 호산성 천식을 치료하기 위한 레슬리주맙의 용도
BR112018003741A2 (pt) 2015-08-24 2018-09-25 Glaxosmithkline Ip No 2 Ltd composições biofarmacêuticas
WO2018226339A1 (en) 2017-06-06 2018-12-13 Glaxosmithkline Llc Biopharmaceutical compositions and methods for pediatric patients
JP2019026625A (ja) * 2017-08-03 2019-02-21 日本全薬工業株式会社 抗イヌｃｄ２０モノクローナル抗体
US11224653B2 (en) 2017-08-24 2022-01-18 Cephalon, Inc. Treatment strategy for non-responders to 100MG subcutaneous mepolizumab
JP7307720B2 (ja) * 2017-09-29 2023-07-12 江蘇恒瑞医薬股▲ふん▼有限公司 Ｉｌ－５抗体、その抗原結合フラグメント、およびそれらの医薬適用
CN109942706A (zh) * 2017-12-21 2019-06-28 三生国健药业（上海）股份有限公司 结合人il-5的单克隆抗体、其制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
GB8720833D0 (en) 1987-09-04 1987-10-14 Celltech Ltd Recombinant dna product
IL92180A (en) * 1988-11-03 1997-04-15 Schering Corp Pharmaceutical composition for preventing or reducing eosinophilia
US5096704A (en) 1988-11-03 1992-03-17 Schering Corporation Method of treating eosinophilia
AU634186B2 (en) 1988-11-11 1993-02-18 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
CA2041271A1 (en) * 1990-04-30 1991-10-31 Bradford A. Jameson Peptide analogs to proteins of the immunoglobin superfamily
CZ291039B6 (cs) 1992-02-06 2002-12-11 Schering Corporation Monoklonální protilátka, hybridom, polypeptid a způsob jeho přípravy, izolovaná DNA, rekombinantní vektor, hostitelská buňka, humanizovaná protilátka a farmaceutický prostředek

Also Published As

Publication number Publication date
SK280610B6 (sk) 2000-05-16
RU94045919A (ru) 1996-11-10
JPH07505767A (ja) 1995-06-29
HUT67943A (en) 1995-05-29
SK91894A3 (en) 1995-02-08
ZA93779B (en) 1993-08-05
NZ249633A (en) 1995-12-21
AR248044A1 (es) 1995-05-31
EP0625201A1 (en) 1994-11-23
CA2129445A1 (en) 1993-08-07
IL104620A (en) 2000-02-29
KR0150060B1 (ko) 1998-08-17
CZ191094A3 (en) 1994-12-15
SG49597A1 (en) 1998-06-15
CN1077991A (zh) 1993-11-03
PL176393B1 (pl) 1999-05-31
WO1993016184A1 (en) 1993-08-19
JP2000210097A (ja) 2000-08-02
TNSN93012A1 (fr) 1994-03-17
CZ291039B6 (cs) 2002-12-11
NO942912L (no) 1994-10-06
FI943635A (fi) 1994-08-05
IL104620A0 (en) 1993-06-10
FI943635A0 (fi) 1994-08-05
US6451982B1 (en) 2002-09-17
AU3656093A (en) 1993-09-03
AU683836B2 (en) 1997-11-27
NO942912D0 (ko) 1994-08-05
HU9402293D0 (en) 1994-10-28

Similar Documents

Publication Publication Date Title
KR950700413A (ko) 인간 인터루킨-5에 대한 인간화 모노클로날 항체의 고안, 클로닝 및 발현(Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5)
DE69319662T2 (de) Monoklonale Antikörper gegen GP130-Protein
CY2006001I1 (el) Ανθρωποποιημενο heregulin αντισωμα
DE69324596D1 (de) Rekombinante humanisierte anti-cytomegalovirus antikörper
IL108199A0 (en) Monoclonal antibodies against the human il-4 receptor and hybridomas producing the same
EP0528951A4 (en) Humanized cdr-grafted anti-icam-1 antibodies, methods of preparation and usage thereof
ITRM920457A0 (it) Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteinaumana.
GB8910395D0 (en) Human monoclonal antibody and hybridoma producing the same
NO915017L (no) Monoklonale antistoffer og fremgangsmaate for deres fremstilling
FI972430A0 (fi) Immunosuppressiivista aktiivisuutta sisältäviä monoklonaalisen vasta-aineen fragmentteja
DK69690D0 (da) Humane anti-rh(d) monoklonale antistoffer
DE69322847T2 (de) Monoklonaler Antikörper gegen menschliches Ceruloplasmin
EP0498767A3 (en) Chimeric antiidiotypic monoclonal antibodies
EP0554458A4 (en) Immunoassay, monoclonal antibody and hybridoma
DE69129582D1 (de) Antikörper gegen menschlichen plasmin-alpha 2-plasmininhibitor-komplex, hybridoma und immunoassay
DE3687542D1 (de) Monoklonaler antikoerper gegen humanes protein c.
MX9202642A (es) Anticuerpos monoclonales y antigeno para melanoma humano.
DK413389A (da) Monoklonale antistoffer
NO924137D0 (no) Monoklonale anti-igm-antistoffer, deres fremstilling og anvendelse, og hybridomas for fremstilling av de samme
DE29512719U1 (de) Monoklonale Antikörper gegen humanes Interleukin-10
CS347090A3 (en) Murine lymphocyte hybridoma tsh-51 producing monoclonal antibody of the class igg 2a against human thyrostimulative hormone
CS347190A3 (en) Murine lymphocyte hybridoma tsh-116 producing monoclonal antibody of the class igg 2a against human thyrostimulative hormone
EP0520436A3 (en) Monoclonal antibody, method of production thereof and use thereof
DE69324928T2 (de) Monoklonaler antikörper
LTIP137A (en) Hybridoma which produces murine monoclonal antibodies to human angiogenin

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20020419

Year of fee payment: 5

LAPS Lapse due to unpaid annual fee