JP2009525764A5 - - Google Patents

Download PDF

Info

Publication number
JP2009525764A5
JP2009525764A5 JP2008554523A JP2008554523A JP2009525764A5 JP 2009525764 A5 JP2009525764 A5 JP 2009525764A5 JP 2008554523 A JP2008554523 A JP 2008554523A JP 2008554523 A JP2008554523 A JP 2008554523A JP 2009525764 A5 JP2009525764 A5 JP 2009525764A5
Authority
JP
Japan
Prior art keywords
antibody
composition
cancer
fgf19
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008554523A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009525764A (ja
JP5209505B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/061936 external-priority patent/WO2007136893A2/en
Publication of JP2009525764A publication Critical patent/JP2009525764A/ja
Publication of JP2009525764A5 publication Critical patent/JP2009525764A5/ja
Application granted granted Critical
Publication of JP5209505B2 publication Critical patent/JP5209505B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2008554523A 2006-02-10 2007-02-09 抗fgf19抗体およびその使用方法 Expired - Fee Related JP5209505B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US77231006P 2006-02-10 2006-02-10
US60/772,310 2006-02-10
US78060806P 2006-03-09 2006-03-09
US60/780,608 2006-03-09
US88586607P 2007-01-19 2007-01-19
US60/885,866 2007-01-19
PCT/US2007/061936 WO2007136893A2 (en) 2006-02-10 2007-02-09 Anti-fgf19 antibodies and methods using same

Publications (3)

Publication Number Publication Date
JP2009525764A JP2009525764A (ja) 2009-07-16
JP2009525764A5 true JP2009525764A5 (enExample) 2010-03-18
JP5209505B2 JP5209505B2 (ja) 2013-06-12

Family

ID=38723925

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008554523A Expired - Fee Related JP5209505B2 (ja) 2006-02-10 2007-02-09 抗fgf19抗体およびその使用方法

Country Status (10)

Country Link
US (4) US7678373B2 (enExample)
EP (1) EP1989230B1 (enExample)
JP (1) JP5209505B2 (enExample)
AR (1) AR059432A1 (enExample)
AU (1) AU2007254005B2 (enExample)
CA (1) CA2637988A1 (enExample)
ES (1) ES2582652T3 (enExample)
NZ (1) NZ569957A (enExample)
TW (1) TWI388568B (enExample)
WO (1) WO2007136893A2 (enExample)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6737056B1 (en) * 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
DE10254601A1 (de) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
EP1910542B1 (en) 2005-07-22 2009-12-02 Five Prime Therapeutics, Inc. Compositions and methods of treating disease with fgfr fusion proteins
CA2637988A1 (en) 2006-02-10 2007-11-29 Genentech, Inc. Anti-fgf19 antibodies and methods using same
EP2039766A4 (en) * 2006-06-05 2010-06-16 Univ Hiroshima Immunocompetent cell with anti-CD38 antibody on its surface
EP1918376A1 (en) * 2006-11-03 2008-05-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. FGFR4 promotes cancer cell resistance in response to chemotherapeutic drugs
SI2550972T1 (en) * 2007-04-02 2018-05-31 Genentech, Inc. An antibody called Klotho-beta agonist for use in the treatment of diabetes mellitus or insulin resistance
EP2188310B1 (en) 2007-08-03 2017-02-08 Genentech, Inc. Humanized anti-fgf19 antagonists and methods using same
US20090309617A1 (en) * 2007-08-24 2009-12-17 Ye Fang Biosensor antibody functional mapping
US20090226459A1 (en) * 2008-01-29 2009-09-10 Cold Spring Harbor Laboratory Role of fgf-19 in cancer diagnosis and treatment
WO2009134204A1 (en) * 2008-04-30 2009-11-05 Forskarpatent I Syd Ab RESTORATION OF ESTROGEN RECEPTOR-α ACTIVITY
AU2009271401A1 (en) * 2008-06-16 2010-01-21 Immunogen Inc. Novel synergistic effects
FR2933702A1 (fr) * 2008-07-08 2010-01-15 Sanofi Aventis Antagonistes specifiques du recepteur fgf-r4
WO2010006214A1 (en) * 2008-07-09 2010-01-14 Ambrx, Inc. Fgf-21 neutralizing antibodies and their uses
BRPI0916904A2 (pt) 2008-08-04 2016-10-11 Fiveprime Therapeutics Inc polipeptídeos, moléculares de fusão ecd fgfr4, composições farmacêuticas, polinucleotídio e métodos de tratamento de desordem angiogênica, câncer em paciente e degeneração macular em paciente e respectivos usos
US20100092470A1 (en) * 2008-09-22 2010-04-15 Icb International, Inc. Antibodies, analogs and uses thereof
US20100136584A1 (en) * 2008-09-22 2010-06-03 Icb International, Inc. Methods for using antibodies and analogs thereof
EP2478003A4 (en) 2009-09-15 2013-05-29 Five Prime Therapeutics Inc HAIR GROWTH METHODS USING THE EXTRACELLULAR DOMAINS OF FGFR4
MX2012004303A (es) * 2009-10-15 2012-06-25 Genentech Inc Factores de crecimiento de fibroblasto quimericos con especificacion de receptor alterada.
PL2498799T3 (pl) 2009-11-13 2017-03-31 Five Prime Therapeutics, Inc. Zastosowanie białek domeny zewnątrzkomórkowej FGFR1 do leczenia nowotworów charakteryzujących się mutacjami aktywującymi zależnymi od ligandów w FGFR2
JP6184695B2 (ja) 2009-12-04 2017-08-23 ジェネンテック, インコーポレイテッド 多重特異性抗体、抗体アナログ、組成物、及び方法
US8685931B2 (en) 2009-12-17 2014-04-01 Five Prime Therapeutics, Inc. Hair growth methods using FGFR3 extracellular domains
JP4881428B2 (ja) * 2009-12-25 2012-02-22 株式会社東芝 電子機器
US8481038B2 (en) 2010-11-15 2013-07-09 Five Prime Therapeutics, Inc. Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins
US8951972B2 (en) 2010-12-09 2015-02-10 Five Prime Therapeutics, Inc. FGFR1 extracellular domain combination therapies for lung cancer
KR20190107761A (ko) 2011-03-09 2019-09-20 셀 시그널링 테크놀러지, 인크. 모노클로날 항체를 생성하는 방법 및 시약
EP2723391B1 (en) * 2011-06-24 2018-06-13 University of Miami Fibroblast growth factor receptor inhibition for the treatment of disease
US10016484B2 (en) 2011-11-14 2018-07-10 Five Prime Therapeutics, Inc. Methods of treating lung cancer
US10112987B2 (en) 2012-01-09 2018-10-30 Icb International, Inc. Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide
US10112988B2 (en) 2012-01-09 2018-10-30 Icb International, Inc. Methods of assessing amyloid-beta peptides in the central nervous system by blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an anti-amyloid-beta peptide
CA2862424A1 (en) * 2012-01-18 2013-07-25 Genentech, Inc. Methods of using fgf19 modulators
WO2013167153A1 (en) * 2012-05-09 2013-11-14 Ganymed Pharmaceuticals Ag Antibodies useful in cancer diagnosis
UA120029C2 (uk) 2012-07-13 2019-09-25 Рош Глікарт Аг Спосіб зниження в'язкості біспецифічного антитіла до vegf/ang-2 та застосування такого антитіла для лікування судинних очних захворювань
HK1209434A1 (en) 2012-11-13 2016-04-01 Astellas Pharma Inc. Agents for treatment of claudin expressing cancer diseases
EP3060563B1 (en) 2013-10-25 2018-05-02 Novartis AG Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors
PL3082858T3 (pl) * 2013-12-20 2021-09-27 Angiobiomed Gmbh Środek wiążący adrenomedulinę do zastosowania w terapii nowotworu
TWI728373B (zh) 2013-12-23 2021-05-21 美商建南德克公司 抗體及使用方法
PL3200786T3 (pl) 2014-10-03 2020-03-31 Novartis Ag Zastosowanie pochodnych pirydylowych o skondensowanym układzie bicyklicznym jako inhibitorów fgfr4
CN114129709A (zh) * 2014-10-23 2022-03-04 恩格姆生物制药公司 包含肽变异体的药物组合物及其使用方法
RU2017134379A (ru) 2015-03-25 2019-04-03 Новартис Аг Формилированные n-гетероциклические производные в качестве ингибиторов fgfr4
EP3414267B1 (en) * 2016-02-10 2023-12-27 BioInvent International AB Combination of human anti-fgfr4 antibody and sorafenib
US10813933B2 (en) * 2016-05-17 2020-10-27 Japanese Foundation For Cancer Research Therapeutic agent for lung cancer that has acquired EGFR-TKI resistance
WO2018055503A1 (en) 2016-09-20 2018-03-29 Novartis Ag Combination comprising a pd-1 antagonist and an fgfr4 inhibitor
PT3534902T (pt) 2016-11-02 2022-12-07 Novartis Ag Combinações de inibidores de fgfr4 e quelantes de ácidos biliares
EP3514171A1 (en) * 2018-01-18 2019-07-24 Molecular Cloning Laboratories (MCLAB) LLC Long-acting therapeutic fusion proteins
CN109251983B (zh) * 2018-08-15 2022-03-25 深圳市罗湖区人民医院 Frs2基因的拷贝数扩增及其应用、检测拷贝数扩增的特异性引物对
WO2020156539A1 (en) * 2019-02-02 2020-08-06 Huahui Health Ltd. Anti-fgf19 antibodies
EP3865155B1 (en) * 2020-02-13 2022-11-30 Orano Med Process for site-specific modification of an antibody
CN116726005A (zh) * 2022-03-03 2023-09-12 上海市第六人民医院 一种治疗运动损伤的药物及筛选方法和应用
IL316411A (en) 2022-05-19 2024-12-01 Tyra Biosciences Inc Therapies with PPAR agonists and FGFR4 inhibitors
EP4509142A1 (en) 2023-08-16 2025-02-19 Ona Therapeutics S.L. Fgfr4 as target in cancer treatment

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US20020012961A1 (en) * 1999-04-15 2002-01-31 Genentech, Inc. Fibroblast growth factor- 19
US20020042367A1 (en) * 1997-11-25 2002-04-11 Genentech, Inc. Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders
US20020155543A1 (en) * 1997-11-25 2002-10-24 Genentech, Inc. Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders
AU733222B2 (en) 1997-11-25 2001-05-10 Genentech Inc. Fibroblast growth factor-19
US20040126852A1 (en) * 1997-11-25 2004-07-01 Genentech, Inc. Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity
US20050026832A1 (en) * 1997-11-25 2005-02-03 Genentech, Inc. Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders
US7459540B1 (en) 1999-09-07 2008-12-02 Amgen Inc. Fibroblast growth factor-like polypeptides
EP1214409B1 (en) 1999-09-08 2006-05-17 Genentech, Inc. Fibroblast growth factor-19 (fgf-19) nucleic acids and polypeptides and methods of use for the treatment of obesity
US7348162B2 (en) 2000-03-22 2008-03-25 Amgen Inc. Nucleic acids encoding fibroblast growth factor receptor-like proteins and uses thereof
WO2002046467A2 (en) 2000-12-08 2002-06-13 Ipsogen Gene expression profiling of primary breast carcinomas using arrays of candidate genes
JP2005518782A (ja) 2001-09-17 2005-06-30 プロテイン デザイン ラブス, インコーポレイテッド ガンの診断方法、ガンのモジュレータのスクリーニング組成物及び方法
WO2003065006A2 (en) 2002-01-31 2003-08-07 Millennium Pharmaceuticals, Inc. Methods and compositions for treating cancer
JP2005528905A (ja) * 2002-06-07 2005-09-29 ジェネンテック・インコーポレーテッド 腫瘍の診断と治療のための組成物と方法
US20050198642A1 (en) * 2004-03-04 2005-09-08 International Business Machines Corporation Mechanism for assigning home nodes to newly created threads
US7837626B2 (en) * 2005-08-05 2010-11-23 Siemens Medical Solutions Usa, Inc. Contrast agent manipulation with medical ultrasound imaging
CA2637988A1 (en) 2006-02-10 2007-11-29 Genentech, Inc. Anti-fgf19 antibodies and methods using same

Similar Documents

Publication Publication Date Title
JP2009525764A5 (enExample)
TWI769537B (zh) 標靶bcma的抗體、雙專一性抗體及其用途
JP2017529838A5 (enExample)
JP2010531140A5 (enExample)
JP2020517249A5 (enExample)
JP2010532982A5 (enExample)
JPWO2019129221A5 (enExample)
HRP20140244T1 (hr) Sastavi i metode za inhibiranje pdgfrbeta i vegf-a
JP2018519364A5 (enExample)
JP2009545325A5 (enExample)
HRP20131107T1 (hr) Anti-notch1 nrr-protutijela i postupak njihove uporabe
JP2017522861A5 (enExample)
JP2008529489A5 (enExample)
JP2010509931A5 (enExample)
JP2010504755A5 (enExample)
JP2017514461A5 (enExample)
JP2013538553A5 (enExample)
JP2008500815A5 (enExample)
RU2013102225A (ru) АНТИТЕЛА ПРОТИВ Axl И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
JP2011514150A5 (enExample)
JP2015517300A5 (enExample)
JP2010526028A5 (enExample)
HRP20110187T1 (hr) Multispecifične deimunizirane tvari koje vežu cd3
WO2011103700A1 (zh) 一种全人源抗her2单克隆抗体、其制备方法及用途
CN111615519B (zh) 结合人il-5的单克隆抗体、其制备方法和用途