TWI388568B - 抗ｆｇｆ１９抗體及其使用方法 - Google Patents
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- TWI388568B TWI388568B TW096104900A TW96104900A TWI388568B TW I388568 B TWI388568 B TW I388568B TW 096104900 A TW096104900 A TW 096104900A TW 96104900 A TW96104900 A TW 96104900A TW I388568 B TWI388568 B TW I388568B
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Landscapes
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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| US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| CA2614039C (en) | 2005-07-22 | 2015-10-13 | Five Prime Therapeutics, Inc. | Compositions and methods of treating disease with fgfr fusion proteins |
| AU2007254005B2 (en) | 2006-02-10 | 2012-11-29 | Genentech, Inc. | Anti-FGF19 antibodies and methods using same |
| JP5328018B2 (ja) * | 2006-06-05 | 2013-10-30 | 国立大学法人広島大学 | 抗ｃｄ３８抗体を細胞表面に有する免疫担当細胞 |
| EP1918376A1 (en) * | 2006-11-03 | 2008-05-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | FGFR4 promotes cancer cell resistance in response to chemotherapeutic drugs |
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| ES2622107T3 (es) * | 2007-08-03 | 2017-07-05 | Genentech, Inc. | Antagonistas anti-FGF19 humanizados y métodos de uso de los mismos |
| US20090309617A1 (en) * | 2007-08-24 | 2009-12-17 | Ye Fang | Biosensor antibody functional mapping |
| US20090226459A1 (en) * | 2008-01-29 | 2009-09-10 | Cold Spring Harbor Laboratory | Role of fgf-19 in cancer diagnosis and treatment |
| US20110124574A1 (en) * | 2008-04-30 | 2011-05-26 | Tommy Andersson | Restoration of estrogen receptor-(alpha) activity |
| CA2727278A1 (en) * | 2008-06-16 | 2010-01-21 | Immunogen, Inc. | Novel synergistic effects |
| FR2933702A1 (fr) * | 2008-07-08 | 2010-01-15 | Sanofi Aventis | Antagonistes specifiques du recepteur fgf-r4 |
| WO2010006214A1 (en) * | 2008-07-09 | 2010-01-14 | Ambrx, Inc. | Fgf-21 neutralizing antibodies and their uses |
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| US20070248604A1 (en) | 2007-10-25 |
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| HK1120273A1 (zh) | 2009-03-27 |
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| EP1989230B1 (en) | 2016-06-01 |
| CA2637988A1 (en) | 2007-11-29 |
| JP2009525764A (ja) | 2009-07-16 |
| EP1989230A2 (en) | 2008-11-12 |
| WO2007136893A3 (en) | 2008-05-15 |
| US20100129381A1 (en) | 2010-05-27 |
| JP5209505B2 (ja) | 2013-06-12 |
| NZ569957A (en) | 2012-03-30 |
| US7678373B2 (en) | 2010-03-16 |
| US8293241B2 (en) | 2012-10-23 |
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