HK1120273A1 - 抗體及其使用方法 - Google Patents
抗體及其使用方法Info
- Publication number
- HK1120273A1 HK1120273A1 HK09100473.7A HK09100473A HK1120273A1 HK 1120273 A1 HK1120273 A1 HK 1120273A1 HK 09100473 A HK09100473 A HK 09100473A HK 1120273 A1 HK1120273 A1 HK 1120273A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- fgf19
- methods
- same
- antibodies
- fgf19 antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77231006P | 2006-02-10 | 2006-02-10 | |
US78060806P | 2006-03-09 | 2006-03-09 | |
US88586607P | 2007-01-19 | 2007-01-19 | |
PCT/US2007/061936 WO2007136893A2 (en) | 2006-02-10 | 2007-02-09 | Anti-fgf19 antibodies and methods using same |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1120273A1 true HK1120273A1 (zh) | 2009-03-27 |
Family
ID=38723925
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK09100473.7A HK1120273A1 (zh) | 2006-02-10 | 2009-01-16 | 抗體及其使用方法 |
Country Status (11)
Country | Link |
---|---|
US (4) | US7678373B2 (zh) |
EP (1) | EP1989230B1 (zh) |
JP (1) | JP5209505B2 (zh) |
AR (1) | AR059432A1 (zh) |
AU (1) | AU2007254005B2 (zh) |
CA (1) | CA2637988A1 (zh) |
ES (1) | ES2582652T3 (zh) |
HK (1) | HK1120273A1 (zh) |
NZ (1) | NZ569957A (zh) |
TW (1) | TWI388568B (zh) |
WO (1) | WO2007136893A2 (zh) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
ATE450615T1 (de) | 2005-07-22 | 2009-12-15 | Five Prime Therapeutics Inc | Zusammensetzungen und verfahren zur behandlung von krankheiten mit fgfr-fusionsproteinen |
TWI388568B (zh) * | 2006-02-10 | 2013-03-11 | Genentech Inc | 抗fgf19抗體及其使用方法 |
US20100267145A1 (en) * | 2006-06-05 | 2010-10-21 | Hiroshima University | Immunocompetent cell having anti-cd38 antibody on its cell surface |
EP1918376A1 (en) * | 2006-11-03 | 2008-05-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | FGFR4 promotes cancer cell resistance in response to chemotherapeutic drugs |
NO2550972T3 (zh) * | 2007-04-02 | 2018-07-21 | ||
US8236307B2 (en) | 2007-08-03 | 2012-08-07 | Genentech, Inc. | Humanized anti-FGF19 antagonists and methods using same |
US20090309617A1 (en) * | 2007-08-24 | 2009-12-17 | Ye Fang | Biosensor antibody functional mapping |
US20090226459A1 (en) * | 2008-01-29 | 2009-09-10 | Cold Spring Harbor Laboratory | Role of fgf-19 in cancer diagnosis and treatment |
RU2010147806A (ru) * | 2008-04-30 | 2012-06-10 | Внтрисерч Аб (Se) | Восстановление активности a-рецептора эстрогена |
SG191679A1 (en) | 2008-06-16 | 2013-07-31 | Immunogen Inc | Novel synergistic effects |
FR2933702A1 (fr) * | 2008-07-08 | 2010-01-15 | Sanofi Aventis | Antagonistes specifiques du recepteur fgf-r4 |
WO2010006214A1 (en) * | 2008-07-09 | 2010-01-14 | Ambrx, Inc. | Fgf-21 neutralizing antibodies and their uses |
RU2509774C2 (ru) | 2008-08-04 | 2014-03-20 | Файв Прайм Терапьютикс, Инк. | Мутеины кислотной зоны внеклеточного домена рецептора фактора роста фибробластов |
US20100092470A1 (en) * | 2008-09-22 | 2010-04-15 | Icb International, Inc. | Antibodies, analogs and uses thereof |
US20100136584A1 (en) * | 2008-09-22 | 2010-06-03 | Icb International, Inc. | Methods for using antibodies and analogs thereof |
WO2011034940A1 (en) | 2009-09-15 | 2011-03-24 | Five Prime Therapeutics, Inc. | Hair growth methods using fgfr4 extracellular domains |
MX368790B (es) * | 2009-10-15 | 2019-10-16 | Genentech Inc | Factores de crecimiento de fibroblasto quimericos con especificidad de receptor alterada. |
CA2780457A1 (en) | 2009-11-13 | 2011-05-19 | Five Prime Therapeutics, Inc. | Use of fgfr1 extra cellular domain proteins to treat cancers characterized by ligand-dependent activating mutations in fgfr2 |
JP6184695B2 (ja) | 2009-12-04 | 2017-08-23 | ジェネンテック, インコーポレイテッド | 多重特異性抗体、抗体アナログ、組成物、及び方法 |
WO2011084711A2 (en) | 2009-12-17 | 2011-07-14 | Five Prime Therapeutics, Inc. | Hair growth methods using fgfr3 extracellular domains |
JP4881428B2 (ja) * | 2009-12-25 | 2012-02-22 | 株式会社東芝 | 電子機器 |
US8481038B2 (en) | 2010-11-15 | 2013-07-09 | Five Prime Therapeutics, Inc. | Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins |
US8951972B2 (en) | 2010-12-09 | 2015-02-10 | Five Prime Therapeutics, Inc. | FGFR1 extracellular domain combination therapies for lung cancer |
EP2683736B1 (en) | 2011-03-09 | 2018-01-17 | Cell Signaling Technology, Inc. | Methods and reagents for creating monoclonal antibodies |
EP2723391B1 (en) * | 2011-06-24 | 2018-06-13 | University of Miami | Fibroblast growth factor receptor inhibition for the treatment of disease |
JP2015505818A (ja) | 2011-11-14 | 2015-02-26 | ファイブ プライム セラピューティックス インコーポレイテッド | 癌を治療する方法 |
US10112988B2 (en) | 2012-01-09 | 2018-10-30 | Icb International, Inc. | Methods of assessing amyloid-beta peptides in the central nervous system by blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an anti-amyloid-beta peptide |
US10112987B2 (en) | 2012-01-09 | 2018-10-30 | Icb International, Inc. | Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide |
EP2804630B1 (en) * | 2012-01-18 | 2017-10-18 | F. Hoffmann-La Roche AG | Methods of using fgf19 modulators |
WO2013167153A1 (en) * | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Antibodies useful in cancer diagnosis |
CN104428315B (zh) | 2012-07-13 | 2017-09-29 | 罗氏格黎卡特股份公司 | 双特异性抗‑vegf/抗‑ang‑2抗体及其在治疗眼血管疾病中的应用 |
JP6499079B2 (ja) | 2012-11-13 | 2019-04-10 | バイオエヌテック アーゲーBioNTech AG | クローディンを発現するガン疾患を処置するための剤 |
AU2014338549B2 (en) | 2013-10-25 | 2017-05-25 | Novartis Ag | Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors |
US10793626B2 (en) * | 2013-12-20 | 2020-10-06 | Angiobiomed Gmbh | Adrenomedullin binder for use in therapy of cancer |
TWI728373B (zh) | 2013-12-23 | 2021-05-21 | 美商建南德克公司 | 抗體及使用方法 |
PL3200786T3 (pl) | 2014-10-03 | 2020-03-31 | Novartis Ag | Zastosowanie pochodnych pirydylowych o skondensowanym układzie bicyklicznym jako inhibitorów fgfr4 |
AU2015335844B2 (en) * | 2014-10-23 | 2020-09-03 | Ngm Biopharmaceuticals, Inc. | Pharmaceutical compositions comprising peptide variants and methods of use thereof |
WO2016151499A1 (en) | 2015-03-25 | 2016-09-29 | Novartis Ag | Formylated n-heterocyclic derivatives as fgfr4 inhibitors |
EP3414267B1 (en) * | 2016-02-10 | 2023-12-27 | BioInvent International AB | Combination of human anti-fgfr4 antibody and sorafenib |
EP3453392A4 (en) * | 2016-05-17 | 2020-03-04 | Japanese Foundation For Cancer Research | THERAPEUTIC FOR LUNG CANCER THAT HAS OBTAINED EGFR-TKI RESISTANCE |
WO2018055503A1 (en) | 2016-09-20 | 2018-03-29 | Novartis Ag | Combination comprising a pd-1 antagonist and an fgfr4 inhibitor |
JP7394623B2 (ja) | 2016-11-02 | 2023-12-08 | ノバルティス アーゲー | Fgfr4インヒビターおよび胆汁酸捕捉薬の組合せ |
CN109251983B (zh) * | 2018-08-15 | 2022-03-25 | 深圳市罗湖区人民医院 | Frs2基因的拷贝数扩增及其应用、检测拷贝数扩增的特异性引物对 |
CN113710701A (zh) * | 2019-02-02 | 2021-11-26 | 华辉安健(北京)生物科技有限公司 | 抗fgf19抗体 |
PL3865155T3 (pl) * | 2020-02-13 | 2023-01-30 | Orano Med | Sposób miejscowo-specyficznego modyfikowania przeciwciała |
WO2023225334A1 (en) | 2022-05-19 | 2023-11-23 | Tyra Biosciences, Inc. | Therapies with ppar agonists and fgfr4 inhibitors |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
US20020012961A1 (en) * | 1999-04-15 | 2002-01-31 | Genentech, Inc. | Fibroblast growth factor- 19 |
US20020042367A1 (en) * | 1997-11-25 | 2002-04-11 | Genentech, Inc. | Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders |
US20040126852A1 (en) * | 1997-11-25 | 2004-07-01 | Genentech, Inc. | Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity |
US20020155543A1 (en) * | 1997-11-25 | 2002-10-24 | Genentech, Inc. | Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders |
CA2309783C (en) | 1997-11-25 | 2011-06-28 | Genentech, Inc. | Fibroblast growth factor-19 |
US20050026832A1 (en) * | 1997-11-25 | 2005-02-03 | Genentech, Inc. | Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders |
US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
ES2264929T3 (es) | 1999-09-08 | 2007-02-01 | Genentech, Inc. | Acidos nucleicos y polipeptidos del factor 19 de crecimiento fibroblastico (fgf-19) y procedimientos de utilizacion para el tratamiento de la obesidad. |
US7348162B2 (en) | 2000-03-22 | 2008-03-25 | Amgen Inc. | Nucleic acids encoding fibroblast growth factor receptor-like proteins and uses thereof |
EP1353947A2 (en) | 2000-12-08 | 2003-10-22 | Ipsogen | Gene expression profiling of primary breast carcinomas using arrays of candidate genes |
JP2005518782A (ja) | 2001-09-17 | 2005-06-30 | プロテイン デザイン ラブス, インコーポレイテッド | ガンの診断方法、ガンのモジュレータのスクリーニング組成物及び方法 |
WO2003065006A2 (en) | 2002-01-31 | 2003-08-07 | Millennium Pharmaceuticals, Inc. | Methods and compositions for treating cancer |
AU2003243400B2 (en) * | 2002-06-07 | 2009-10-29 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
US20050198642A1 (en) * | 2004-03-04 | 2005-09-08 | International Business Machines Corporation | Mechanism for assigning home nodes to newly created threads |
US7837626B2 (en) * | 2005-08-05 | 2010-11-23 | Siemens Medical Solutions Usa, Inc. | Contrast agent manipulation with medical ultrasound imaging |
TWI388568B (zh) | 2006-02-10 | 2013-03-11 | Genentech Inc | 抗fgf19抗體及其使用方法 |
-
2007
- 2007-02-09 TW TW096104900A patent/TWI388568B/zh not_active IP Right Cessation
- 2007-02-09 CA CA002637988A patent/CA2637988A1/en not_active Abandoned
- 2007-02-09 EP EP07797128.1A patent/EP1989230B1/en active Active
- 2007-02-09 JP JP2008554523A patent/JP5209505B2/ja not_active Expired - Fee Related
- 2007-02-09 AR ARP070100563A patent/AR059432A1/es not_active Application Discontinuation
- 2007-02-09 WO PCT/US2007/061936 patent/WO2007136893A2/en active Application Filing
- 2007-02-09 US US11/673,411 patent/US7678373B2/en not_active Expired - Fee Related
- 2007-02-09 NZ NZ569957A patent/NZ569957A/en not_active IP Right Cessation
- 2007-02-09 AU AU2007254005A patent/AU2007254005B2/en not_active Ceased
- 2007-02-09 ES ES07797128.1T patent/ES2582652T3/es active Active
-
2009
- 2009-01-16 HK HK09100473.7A patent/HK1120273A1/zh not_active IP Right Cessation
-
2010
- 2010-01-22 US US12/692,468 patent/US7846691B2/en not_active Expired - Fee Related
- 2010-10-27 US US12/913,660 patent/US8241633B2/en not_active Expired - Fee Related
-
2011
- 2011-12-08 US US13/315,220 patent/US8293241B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NZ569957A (en) | 2012-03-30 |
US20110086032A1 (en) | 2011-04-14 |
AR059432A1 (es) | 2008-04-09 |
US20100129381A1 (en) | 2010-05-27 |
US20070248604A1 (en) | 2007-10-25 |
AU2007254005B2 (en) | 2012-11-29 |
JP5209505B2 (ja) | 2013-06-12 |
US7678373B2 (en) | 2010-03-16 |
EP1989230A2 (en) | 2008-11-12 |
AU2007254005A1 (en) | 2007-11-29 |
US7846691B2 (en) | 2010-12-07 |
CA2637988A1 (en) | 2007-11-29 |
EP1989230B1 (en) | 2016-06-01 |
TWI388568B (zh) | 2013-03-11 |
WO2007136893A2 (en) | 2007-11-29 |
US8293241B2 (en) | 2012-10-23 |
TW200808827A (en) | 2008-02-16 |
JP2009525764A (ja) | 2009-07-16 |
US8241633B2 (en) | 2012-08-14 |
US20120128675A1 (en) | 2012-05-24 |
WO2007136893A3 (en) | 2008-05-15 |
ES2582652T3 (es) | 2016-09-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1120273A1 (zh) | 抗體及其使用方法 | |
IL192419A0 (en) | Anti-ephb4 antibodies and methods using same | |
IL194787A0 (en) | Anti-dll4 antibodies and methods using same | |
IL240245A0 (en) | Antibodies against 5t4 and their uses | |
IL195658A0 (en) | Anti-nkg2a antibodies and uses thereof | |
ZA200804868B (en) | Anti-OX40L antibodies and methods using same | |
HK1194395A1 (zh) | 抗體及其製備和使用方法 | |
IL196397A0 (en) | Prlr-specific antibody and uses thereof | |
IL222922A (en) | Antibodies against neurophilin-1 and their use | |
ZA200900395B (en) | Antibodies directed to +-Vß6 and uses thereof | |
AP2008004471A0 (en) | Anti-Alpha2 Intergin antibodies and their uses | |
EP2094307A4 (en) | TES7 AND THEREO BINDING ANTIBODIES | |
IL184024A0 (en) | Irta-5 antibodies and their uses | |
IL231891A (en) | Anti-ephrinb2 antibodies and methods for their use | |
ZA200809100B (en) | Anti-DLL4 antibodies and methods using same | |
ZA200806053B (en) | Anti-EphB4 antibodies and methods using same | |
EP1996938A4 (en) | IMMOBILIZED PROTEINS AND USE METHOD THEREFOR | |
GB0610059D0 (en) | Uses and methods | |
GB0621272D0 (en) | Assay and method | |
AU2006903659A0 (en) | Antibodies and related methods | |
ZA200705716B (en) | IRTA-2 antibodies and their uses | |
GB0606794D0 (en) | Methods and uses | |
GB0611806D0 (en) | Materials and methods |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20210209 |