JP5209505B2 - 抗ｆｇｆ１９抗体およびその使用方法 - Google Patents
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| US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| EP1910542B1 (en) | 2005-07-22 | 2009-12-02 | Five Prime Therapeutics, Inc. | Compositions and methods of treating disease with fgfr fusion proteins |
| CA2637988A1 (en) | 2006-02-10 | 2007-11-29 | Genentech, Inc. | Anti-fgf19 antibodies and methods using same |
| EP2039766A4 (en) * | 2006-06-05 | 2010-06-16 | Univ Hiroshima | Immunocompetent cell with anti-CD38 antibody on its surface |
| EP1918376A1 (en) * | 2006-11-03 | 2008-05-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | FGFR4 promotes cancer cell resistance in response to chemotherapeutic drugs |
| SI2550972T1 (en) * | 2007-04-02 | 2018-05-31 | Genentech, Inc. | An antibody called Klotho-beta agonist for use in the treatment of diabetes mellitus or insulin resistance |
| EP2188310B1 (en) | 2007-08-03 | 2017-02-08 | Genentech, Inc. | Humanized anti-fgf19 antagonists and methods using same |
| US20090309617A1 (en) * | 2007-08-24 | 2009-12-17 | Ye Fang | Biosensor antibody functional mapping |
| US20090226459A1 (en) * | 2008-01-29 | 2009-09-10 | Cold Spring Harbor Laboratory | Role of fgf-19 in cancer diagnosis and treatment |
| WO2009134204A1 (en) * | 2008-04-30 | 2009-11-05 | Forskarpatent I Syd Ab | RESTORATION OF ESTROGEN RECEPTOR-α ACTIVITY |
| AU2009271401A1 (en) * | 2008-06-16 | 2010-01-21 | Immunogen Inc. | Novel synergistic effects |
| FR2933702A1 (fr) * | 2008-07-08 | 2010-01-15 | Sanofi Aventis | Antagonistes specifiques du recepteur fgf-r4 |
| WO2010006214A1 (en) * | 2008-07-09 | 2010-01-14 | Ambrx, Inc. | Fgf-21 neutralizing antibodies and their uses |
| BRPI0916904A2 (pt) | 2008-08-04 | 2016-10-11 | Fiveprime Therapeutics Inc | polipeptídeos, moléculares de fusão ecd fgfr4, composições farmacêuticas, polinucleotídio e métodos de tratamento de desordem angiogênica, câncer em paciente e degeneração macular em paciente e respectivos usos |
| US20100092470A1 (en) * | 2008-09-22 | 2010-04-15 | Icb International, Inc. | Antibodies, analogs and uses thereof |
| US20100136584A1 (en) * | 2008-09-22 | 2010-06-03 | Icb International, Inc. | Methods for using antibodies and analogs thereof |
| EP2478003A4 (en) | 2009-09-15 | 2013-05-29 | Five Prime Therapeutics Inc | HAIR GROWTH METHODS USING THE EXTRACELLULAR DOMAINS OF FGFR4 |
| MX2012004303A (es) * | 2009-10-15 | 2012-06-25 | Genentech Inc | Factores de crecimiento de fibroblasto quimericos con especificacion de receptor alterada. |
| PL2498799T3 (pl) | 2009-11-13 | 2017-03-31 | Five Prime Therapeutics, Inc. | Zastosowanie białek domeny zewnątrzkomórkowej FGFR1 do leczenia nowotworów charakteryzujących się mutacjami aktywującymi zależnymi od ligandów w FGFR2 |
| JP6184695B2 (ja) | 2009-12-04 | 2017-08-23 | ジェネンテック， インコーポレイテッド | 多重特異性抗体、抗体アナログ、組成物、及び方法 |
| US8685931B2 (en) | 2009-12-17 | 2014-04-01 | Five Prime Therapeutics, Inc. | Hair growth methods using FGFR3 extracellular domains |
| JP4881428B2 (ja) * | 2009-12-25 | 2012-02-22 | 株式会社東芝 | 電子機器 |
| US8481038B2 (en) | 2010-11-15 | 2013-07-09 | Five Prime Therapeutics, Inc. | Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins |
| US8951972B2 (en) | 2010-12-09 | 2015-02-10 | Five Prime Therapeutics, Inc. | FGFR1 extracellular domain combination therapies for lung cancer |
| KR20190107761A (ko) | 2011-03-09 | 2019-09-20 | 셀 시그널링 테크놀러지, 인크. | 모노클로날 항체를 생성하는 방법 및 시약 |
| EP2723391B1 (en) * | 2011-06-24 | 2018-06-13 | University of Miami | Fibroblast growth factor receptor inhibition for the treatment of disease |
| US10016484B2 (en) | 2011-11-14 | 2018-07-10 | Five Prime Therapeutics, Inc. | Methods of treating lung cancer |
| US10112987B2 (en) | 2012-01-09 | 2018-10-30 | Icb International, Inc. | Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide |
| US10112988B2 (en) | 2012-01-09 | 2018-10-30 | Icb International, Inc. | Methods of assessing amyloid-beta peptides in the central nervous system by blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an anti-amyloid-beta peptide |
| CA2862424A1 (en) * | 2012-01-18 | 2013-07-25 | Genentech, Inc. | Methods of using fgf19 modulators |
| WO2013167153A1 (en) * | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Antibodies useful in cancer diagnosis |
| UA120029C2 (uk) | 2012-07-13 | 2019-09-25 | Рош Глікарт Аг | Спосіб зниження в'язкості біспецифічного антитіла до vegf/ang-2 та застосування такого антитіла для лікування судинних очних захворювань |
| HK1209434A1 (en) | 2012-11-13 | 2016-04-01 | Astellas Pharma Inc. | Agents for treatment of claudin expressing cancer diseases |
| EP3060563B1 (en) | 2013-10-25 | 2018-05-02 | Novartis AG | Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors |
| PL3082858T3 (pl) * | 2013-12-20 | 2021-09-27 | Angiobiomed Gmbh | Środek wiążący adrenomedulinę do zastosowania w terapii nowotworu |
| TWI728373B (zh) | 2013-12-23 | 2021-05-21 | 美商建南德克公司 | 抗體及使用方法 |
| PL3200786T3 (pl) | 2014-10-03 | 2020-03-31 | Novartis Ag | Zastosowanie pochodnych pirydylowych o skondensowanym układzie bicyklicznym jako inhibitorów fgfr4 |
| CN114129709A (zh) * | 2014-10-23 | 2022-03-04 | 恩格姆生物制药公司 | 包含肽变异体的药物组合物及其使用方法 |
| RU2017134379A (ru) | 2015-03-25 | 2019-04-03 | Новартис Аг | Формилированные n-гетероциклические производные в качестве ингибиторов fgfr4 |
| EP3414267B1 (en) * | 2016-02-10 | 2023-12-27 | BioInvent International AB | Combination of human anti-fgfr4 antibody and sorafenib |
| US10813933B2 (en) * | 2016-05-17 | 2020-10-27 | Japanese Foundation For Cancer Research | Therapeutic agent for lung cancer that has acquired EGFR-TKI resistance |
| WO2018055503A1 (en) | 2016-09-20 | 2018-03-29 | Novartis Ag | Combination comprising a pd-1 antagonist and an fgfr4 inhibitor |
| PT3534902T (pt) | 2016-11-02 | 2022-12-07 | Novartis Ag | Combinações de inibidores de fgfr4 e quelantes de ácidos biliares |
| EP3514171A1 (en) * | 2018-01-18 | 2019-07-24 | Molecular Cloning Laboratories (MCLAB) LLC | Long-acting therapeutic fusion proteins |
| CN109251983B (zh) * | 2018-08-15 | 2022-03-25 | 深圳市罗湖区人民医院 | Frs2基因的拷贝数扩增及其应用、检测拷贝数扩增的特异性引物对 |
| WO2020156539A1 (en) * | 2019-02-02 | 2020-08-06 | Huahui Health Ltd. | Anti-fgf19 antibodies |
| EP3865155B1 (en) * | 2020-02-13 | 2022-11-30 | Orano Med | Process for site-specific modification of an antibody |
| CN116726005A (zh) * | 2022-03-03 | 2023-09-12 | 上海市第六人民医院 | 一种治疗运动损伤的药物及筛选方法和应用 |
| IL316411A (en) | 2022-05-19 | 2024-12-01 | Tyra Biosciences Inc | Therapies with PPAR agonists and FGFR4 inhibitors |
| EP4509142A1 (en) | 2023-08-16 | 2025-02-19 | Ona Therapeutics S.L. | Fgfr4 as target in cancer treatment |
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| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US20020012961A1 (en) * | 1999-04-15 | 2002-01-31 | Genentech, Inc. | Fibroblast growth factor- 19 |
| US20020042367A1 (en) * | 1997-11-25 | 2002-04-11 | Genentech, Inc. | Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders |
| US20020155543A1 (en) * | 1997-11-25 | 2002-10-24 | Genentech, Inc. | Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders |
| AU733222B2 (en) | 1997-11-25 | 2001-05-10 | Genentech Inc. | Fibroblast growth factor-19 |
| US20040126852A1 (en) * | 1997-11-25 | 2004-07-01 | Genentech, Inc. | Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity |
| US20050026832A1 (en) * | 1997-11-25 | 2005-02-03 | Genentech, Inc. | Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders |
| US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
| EP1214409B1 (en) | 1999-09-08 | 2006-05-17 | Genentech, Inc. | Fibroblast growth factor-19 (fgf-19) nucleic acids and polypeptides and methods of use for the treatment of obesity |
| US7348162B2 (en) | 2000-03-22 | 2008-03-25 | Amgen Inc. | Nucleic acids encoding fibroblast growth factor receptor-like proteins and uses thereof |
| WO2002046467A2 (en) | 2000-12-08 | 2002-06-13 | Ipsogen | Gene expression profiling of primary breast carcinomas using arrays of candidate genes |
| JP2005518782A (ja) | 2001-09-17 | 2005-06-30 | プロテイン デザイン ラブス， インコーポレイテッド | ガンの診断方法、ガンのモジュレータのスクリーニング組成物及び方法 |
| WO2003065006A2 (en) | 2002-01-31 | 2003-08-07 | Millennium Pharmaceuticals, Inc. | Methods and compositions for treating cancer |
| JP2005528905A (ja) * | 2002-06-07 | 2005-09-29 | ジェネンテック・インコーポレーテッド | 腫瘍の診断と治療のための組成物と方法 |
| US20050198642A1 (en) * | 2004-03-04 | 2005-09-08 | International Business Machines Corporation | Mechanism for assigning home nodes to newly created threads |
| US7837626B2 (en) * | 2005-08-05 | 2010-11-23 | Siemens Medical Solutions Usa, Inc. | Contrast agent manipulation with medical ultrasound imaging |
| CA2637988A1 (en) | 2006-02-10 | 2007-11-29 | Genentech, Inc. | Anti-fgf19 antibodies and methods using same |
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- 2007-02-09 AU AU2007254005A patent/AU2007254005B2/en not_active Ceased
- 2007-02-09 US US11/673,411 patent/US7678373B2/en not_active Expired - Fee Related
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2010
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| US7846691B2 (en) | 2010-12-07 |
| AR059432A1 (es) | 2008-04-09 |
| TWI388568B (zh) | 2013-03-11 |
| US7678373B2 (en) | 2010-03-16 |
| US20120128675A1 (en) | 2012-05-24 |
| JP2009525764A (ja) | 2009-07-16 |
| WO2007136893A2 (en) | 2007-11-29 |
| US20070248604A1 (en) | 2007-10-25 |
| TW200808827A (en) | 2008-02-16 |
| CA2637988A1 (en) | 2007-11-29 |
| HK1120273A1 (zh) | 2009-03-27 |
| EP1989230A2 (en) | 2008-11-12 |
| US8241633B2 (en) | 2012-08-14 |
| US20100129381A1 (en) | 2010-05-27 |
| WO2007136893A3 (en) | 2008-05-15 |
| AU2007254005B2 (en) | 2012-11-29 |
| US20110086032A1 (en) | 2011-04-14 |
| AU2007254005A1 (en) | 2007-11-29 |
| US8293241B2 (en) | 2012-10-23 |
| EP1989230B1 (en) | 2016-06-01 |
| ES2582652T3 (es) | 2016-09-14 |
| NZ569957A (en) | 2012-03-30 |
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