JP2010532982A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010532982A5 JP2010532982A5 JP2010515513A JP2010515513A JP2010532982A5 JP 2010532982 A5 JP2010532982 A5 JP 2010532982A5 JP 2010515513 A JP2010515513 A JP 2010515513A JP 2010515513 A JP2010515513 A JP 2010515513A JP 2010532982 A5 JP2010532982 A5 JP 2010532982A5
- Authority
- JP
- Japan
- Prior art keywords
- cdr
- seq
- amino acid
- acid sequence
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92978907P | 2007-07-12 | 2007-07-12 | |
| EP07301231.2 | 2007-07-12 | ||
| EP07301231A EP2014681A1 (en) | 2007-07-12 | 2007-07-12 | Novel antibodies inhibiting c-met dimerization, and uses thereof |
| US60/929,789 | 2007-07-12 | ||
| US2063908P | 2008-01-11 | 2008-01-11 | |
| US61/020,639 | 2008-01-11 | ||
| PCT/EP2008/059026 WO2009007427A2 (en) | 2007-07-12 | 2008-07-10 | Novel antibodies inhibiting c-met dimerization, and uses thereof |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014000616A Division JP5889923B2 (ja) | 2007-07-12 | 2014-01-06 | ｃ−ＭＥＴの二量体化を阻害する新規な抗体およびその使用 |
| JP2014000617A Division JP5889924B2 (ja) | 2007-07-12 | 2014-01-06 | ｃ−ＭＥＴの二量体化を阻害する新規な抗体およびその使用 |
| JP2014000618A Division JP5889925B2 (ja) | 2007-07-12 | 2014-01-06 | ｃ−ＭＥＴの二量体化を阻害する新規な抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010532982A JP2010532982A (ja) | 2010-10-21 |
| JP2010532982A5 true JP2010532982A5 (enExample) | 2012-08-09 |
| JP5562844B2 JP5562844B2 (ja) | 2014-07-30 |
Family
ID=38871713
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010515513A Active JP5562844B2 (ja) | 2007-07-12 | 2008-07-10 | ｃ−ＭＥＴの二量体化を阻害する新規な抗体およびその使用 |
| JP2014000618A Active JP5889925B2 (ja) | 2007-07-12 | 2014-01-06 | ｃ−ＭＥＴの二量体化を阻害する新規な抗体およびその使用 |
| JP2014000616A Active JP5889923B2 (ja) | 2007-07-12 | 2014-01-06 | ｃ−ＭＥＴの二量体化を阻害する新規な抗体およびその使用 |
| JP2014000617A Active JP5889924B2 (ja) | 2007-07-12 | 2014-01-06 | ｃ−ＭＥＴの二量体化を阻害する新規な抗体およびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014000618A Active JP5889925B2 (ja) | 2007-07-12 | 2014-01-06 | ｃ−ＭＥＴの二量体化を阻害する新規な抗体およびその使用 |
| JP2014000616A Active JP5889923B2 (ja) | 2007-07-12 | 2014-01-06 | ｃ−ＭＥＴの二量体化を阻害する新規な抗体およびその使用 |
| JP2014000617A Active JP5889924B2 (ja) | 2007-07-12 | 2014-01-06 | ｃ−ＭＥＴの二量体化を阻害する新規な抗体およびその使用 |
Country Status (35)
Families Citing this family (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2143441A1 (en) | 2008-07-08 | 2010-01-13 | Pierre Fabre Medicament | Combination of a c-Met antagonist and an aminoheteroaryl compound for the treatment of cancer |
| PA8849001A1 (es) | 2008-11-21 | 2010-06-28 | Lilly Co Eli | Anticuerpos de c-met |
| AR074439A1 (es) * | 2008-12-02 | 2011-01-19 | Pf Medicament | Anticuerpo anti-cmet (receptor c-met) |
| US20140112911A9 (en) * | 2008-12-02 | 2014-04-24 | Liliane Goetsch | Novel anti-cmet antibody |
| US8545839B2 (en) * | 2008-12-02 | 2013-10-01 | Pierre Fabre Medicament | Anti-c-Met antibody |
| US9469691B2 (en) | 2008-12-02 | 2016-10-18 | Pierre Fabre Medicament | Anti-cMET antibody |
| PE20120550A1 (es) | 2009-04-07 | 2012-05-21 | Roche Glycart Ag | ANTICUERPOS BIESPECIFICOS ANTI-ErbB-3/ANTI-C-MET |
| EP2417164A1 (en) | 2009-04-07 | 2012-02-15 | Roche Glycart AG | Bispecific anti-erbb-2/anti-c-met antibodies |
| EP2287197A1 (en) | 2009-08-21 | 2011-02-23 | Pierre Fabre Medicament | Anti-cMET antibody and its use for the detection and the diagnosis of cancer |
| KR101671378B1 (ko) | 2009-10-30 | 2016-11-01 | 삼성전자 주식회사 | ｃ-Ｍｅｔ에 특이적으로 결합하는 항체 및 그의 용도 |
| KR101748707B1 (ko) | 2009-11-27 | 2017-06-20 | 삼성전자주식회사 | ｃ-Ｍｅｔ에 특이적으로 결합하는 항체 및 그를 이용한 암 진단용 키트 |
| DK3904391T3 (en) * | 2010-03-10 | 2024-10-14 | Genmab As | Monoclonal antibodies against c-met |
| AU2011261161A1 (en) * | 2010-06-01 | 2013-01-10 | Ludwig Institute For Cancer Research Limited | Antibodies directed to the unprocessed receptor tyrosine kinase c-Met |
| EP2402370A1 (en) * | 2010-06-29 | 2012-01-04 | Pierre Fabre Médicament | Novel antibody for the diagnosis and/or prognosis of cancer |
| US20130315895A1 (en) | 2010-07-01 | 2013-11-28 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| US20120089541A1 (en) | 2010-08-31 | 2012-04-12 | Genentech, Inc. | Biomarkers and methods of treatment |
| SG188324A1 (en) | 2010-09-03 | 2013-04-30 | Academia Sinica | Anti-c-met antibody and methods of use thereof |
| US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| WO2012042026A1 (en) | 2010-09-30 | 2012-04-05 | Ablynx Nv | Biological materials related to c-met |
| US9688773B2 (en) | 2010-11-03 | 2017-06-27 | Argen-X N.V. | C-Met antibody combinations |
| WO2012069557A1 (en) | 2010-11-24 | 2012-05-31 | Glaxo Group Limited | Multispecific antigen binding proteins targeting hgf |
| KR101444837B1 (ko) * | 2011-06-03 | 2014-09-30 | 한국생명공학연구원 | ＨＧＦ 활성을 가지는 ｃ-Ｍｅｔ에 대한 인간항체 및 이의 용도 |
| PT2723771T (pt) * | 2011-06-23 | 2019-12-11 | Ablynx Nv | Proteínas de ligação à albumina sérica |
| KR101965462B1 (ko) | 2011-06-23 | 2019-04-04 | 아블린쓰 엔.브이. | 면역글로불린 단일 가변 도메인을 수반하는 어세이에서 비특이적 단백질 간섭을 예측하고 검출하고 감소시키는 기법 |
| TW201306866A (zh) * | 2011-06-30 | 2013-02-16 | Genentech Inc | 抗－ｃ－ｍｅｔ抗體調配物 |
| CA2843158A1 (en) | 2011-08-26 | 2013-03-07 | Merrimack Pharmaceuticals, Inc. | Tandem fc bispecific antibodies |
| BR112014006419A2 (pt) | 2011-09-19 | 2018-08-07 | Genentech Inc | métodos para tratar um paciente com câncer, kit e artigo |
| CA2843771A1 (en) | 2011-09-20 | 2013-03-28 | Eli Lilly And Company | Anti-c-met antibodies |
| CN103889451B (zh) * | 2011-09-30 | 2016-06-29 | 埃博灵克斯股份有限公司 | 与C-Met相关的生物物质 |
| US9346884B2 (en) | 2011-09-30 | 2016-05-24 | Ablynx N.V. | Biological materials related to c-Met |
| KR20130036993A (ko) | 2011-10-05 | 2013-04-15 | 삼성전자주식회사 | ｃ-Ｍｅｔ의 ＳＥＭＡ 도메인 내의 에피토프에 특이적으로 결합하는 항체 |
| KR101865223B1 (ko) * | 2011-10-05 | 2018-06-08 | 삼성전자주식회사 | 항 ｃ-Ｍｅｔ 인간화 항체 및 그의 용도 |
| KR20130037153A (ko) * | 2011-10-05 | 2013-04-15 | 삼성전자주식회사 | 항 ｃ-Ｍｅｔ 항체 및 그의 용도 |
| EP2773660A2 (en) | 2011-11-03 | 2014-09-10 | Argen-X B.V. | Chimeric human-camel antigens and their use |
| BR112014012005A2 (pt) | 2011-11-21 | 2017-12-19 | Genentech Inc | composições, métodos, formulação farmacêutica e artigo |
| US20150147274A1 (en) | 2011-12-02 | 2015-05-28 | Cancer Research Technology Limited | Antibodies against hgf - receptor and uses |
| KR101910601B1 (ko) | 2011-12-22 | 2018-10-23 | 삼성전자주식회사 | 면역원성이 제거된 항 ｃ-Ｍｅｔ 인간화 항체 및 그의 용도 |
| US9376485B2 (en) | 2012-02-29 | 2016-06-28 | The Brigham And Women's Hospital, Inc. | Neutralizing antibody for epstein barr virus-associated disease |
| WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| CN109503714A (zh) | 2012-06-21 | 2019-03-22 | 索伦托治疗有限公司 | 与c-Met结合的抗原结合蛋白 |
| KR101938698B1 (ko) | 2012-07-23 | 2019-01-16 | 삼성전자주식회사 | Ｃｂｌ의 항 ｃ－ｍｅｔ 항체 적용 대상 환자 선별을 위한 바이오마커로서의 용도 |
| KR101938699B1 (ko) | 2012-07-23 | 2019-01-16 | 삼성전자주식회사 | Ｌｒｉｇ１의 항 ｃ―ｍｅｔ 항체 적용 대상 환자 선별을 위한 용도 |
| US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
| WO2014028865A1 (en) | 2012-08-17 | 2014-02-20 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for detecting complement activation |
| WO2014038025A1 (ja) * | 2012-09-05 | 2014-03-13 | Ｓｃｉｖａｘ株式会社 | 細胞の上皮性維持に作用する物質のスクリーニング方法 |
| CA2885340C (en) | 2012-10-12 | 2016-11-08 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| EP2914629A1 (en) | 2012-11-05 | 2015-09-09 | MAB Discovery GmbH | Method for the production of multispecific antibodies |
| EP2727941A1 (en) | 2012-11-05 | 2014-05-07 | MAB Discovery GmbH | Method for the production of multispecific antibodies |
| WO2014074907A1 (en) * | 2012-11-09 | 2014-05-15 | Indi Molecular, Inc. | C-met-specific capture agents, compositions, and methods of using and making |
| KR101911048B1 (ko) | 2013-01-29 | 2018-10-24 | 삼성전자주식회사 | ｐ５３ 활성화제 및 ｃ－Ｍｅｔ 억제제를 포함하는 병용 투여용 약학 조성물 |
| CN104994879A (zh) | 2013-02-22 | 2015-10-21 | 霍夫曼-拉罗奇有限公司 | 治疗癌症和预防药物抗性的方法 |
| CA2902505A1 (en) | 2013-03-06 | 2014-09-12 | Merrimack Pharmaceuticals, Inc. | Anti-c-met tandem fc bispecific antibodies |
| NZ712035A (en) | 2013-03-13 | 2019-06-28 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| KR102049990B1 (ko) * | 2013-03-28 | 2019-12-03 | 삼성전자주식회사 | c-Met 항체 및 VEGF 결합 단편이 연결된 융합 단백질 |
| KR102139607B1 (ko) * | 2013-04-01 | 2020-07-30 | 삼성전자주식회사 | 항 c-Met 항체 및 FGFR 저해제를 포함하는 병용 투여용 약학 조성물 |
| KR102089591B1 (ko) | 2013-07-29 | 2020-03-18 | 삼성전자주식회사 | 항 EGFR scFv 단편 및 이를 포함하는 항 c-Met/항 EGFR 이중 특이 항체 |
| WO2015031614A1 (en) * | 2013-08-28 | 2015-03-05 | Abbvie Inc. | Soluble cmet assay |
| WO2015031626A1 (en) | 2013-08-28 | 2015-03-05 | Abbvie Inc. | Soluble cmet assay |
| US10035847B2 (en) | 2013-10-02 | 2018-07-31 | The Rockefeller University | Amyloid protofibril antibodies and methods of use thereof |
| US9717715B2 (en) | 2013-11-15 | 2017-08-01 | Samsung Electronics Co., Ltd. | Method of combination therapy using an anti-C-Met antibody |
| WO2015148531A1 (en) | 2014-03-24 | 2015-10-01 | Genentech, Inc. | Cancer treatment with c-met antagonists and correlation of the latter with hgf expression |
| RU2016144405A (ru) | 2014-05-23 | 2018-06-26 | Дженентек, Инк. | MiT БИОМАРКЕРЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| US10188746B2 (en) | 2014-09-10 | 2019-01-29 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| CA2961323C (en) | 2014-09-16 | 2021-11-30 | Symphogen A/S | Anti-met antibodies and compositions |
| JP2018503596A (ja) | 2014-10-03 | 2018-02-08 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | Ｔｄｐ−４３の病理学的形態に対する抗体及びその使用 |
| WO2016053610A1 (en) * | 2014-10-03 | 2016-04-07 | Academia Sinica | Antibodies against pathological forms of tdp-43 and uses thereof |
| WO2016079194A1 (en) * | 2014-11-20 | 2016-05-26 | Stichting Katholieke Universiteit | A novel auto-active and intracellular mutant of met |
| JP6864953B2 (ja) | 2014-12-09 | 2021-04-28 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Ａｘｌに対するヒトモノクローナル抗体 |
| CN107406497A (zh) | 2014-12-19 | 2017-11-28 | 埃博灵克斯股份有限公司 | 半胱氨酸连接的纳米抗体二聚体 |
| WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
| CN113150147A (zh) * | 2015-03-16 | 2021-07-23 | 塞尔德克斯医疗公司 | 抗-met抗体及其使用方法 |
| EP3277316B1 (en) | 2015-04-02 | 2025-03-05 | Ablynx N.V. | Bispecific cxcr4-cd-4 polypeptides with potent anti-hiv activity |
| TW201709932A (zh) | 2015-06-12 | 2017-03-16 | 西雅圖遺傳學公司 | Ｃｄ１２３抗體及其共軛物 |
| US20190194345A1 (en) * | 2015-10-05 | 2019-06-27 | University Of Virginia Patent Foundation | Anti-sas1b antibodies, associated methods of use, and compositions and methods for detecting and treating cancer |
| ES2875757T3 (es) | 2015-11-03 | 2021-11-11 | Merck Patent Gmbh | Anticuerpos biespecíficos para potenciar la selectividad e inhibición tumorales y sus usos. |
| EP3436480A4 (en) | 2016-03-30 | 2019-11-27 | Musc Foundation for Research Development | METHOD FOR THE TREATMENT AND DIAGNOSIS OF CANCER BY TARGETING GLYCOPROTEIN A REPETITION PREDOMINANT (GARP) AND FOR EFFECTIVE IMMUNOTHERAPY ALONE OR IN COMBINATION |
| IL262869B (en) | 2016-05-17 | 2022-07-01 | Abbvie Biotherapeutics Inc | Anti-cmet antibody drug conjugates and methods for their use |
| EA201990218A1 (ru) * | 2016-07-06 | 2019-07-31 | Селджин Корпорейшн | Антитела с низкой иммуногенностью и их применения |
| US20200023072A1 (en) | 2016-10-11 | 2020-01-23 | Medimmune Limited | Antibody-drug conjugates with immune-mediated therapy agents |
| US20180128545A1 (en) | 2016-11-08 | 2018-05-10 | Berry Metal Company | Modular furnace cooling wall |
| TWI782930B (zh) | 2016-11-16 | 2022-11-11 | 美商再生元醫藥公司 | 抗ｍｅｔ抗體，結合ｍｅｔ之雙特異性抗原結合分子及其使用方法 |
| US20180230218A1 (en) | 2017-01-04 | 2018-08-16 | Immunogen, Inc. | Met antibodies and immunoconjugates and uses thereof |
| WO2019018538A1 (en) * | 2017-07-20 | 2019-01-24 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | RECOMBINANT ANTIBODIES BINDING TO CD123 |
| WO2019117691A1 (ko) * | 2017-12-15 | 2019-06-20 | 경북대학교 산학협력단 | CD44v6에 결합하는 펩타이드 및 이의 용도 |
| KR102194025B1 (ko) | 2017-12-15 | 2020-12-22 | 경북대학교 산학협력단 | CD44v6에 결합하는 펩타이드 및 이의 용도 |
| US20210051929A1 (en) * | 2018-03-24 | 2021-02-25 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof |
| CA3098103A1 (en) | 2018-05-23 | 2019-11-28 | Adc Therapeutics Sa | Molecular adjuvant |
| WO2020014306A1 (en) | 2018-07-10 | 2020-01-16 | Immunogen, Inc. | Met antibodies and immunoconjugates and uses thereof |
| CN109541221B (zh) * | 2018-10-24 | 2022-03-22 | 益善生物技术股份有限公司 | 一种c-Met特异性抗体、组合物及试剂盒 |
| EP3947406A4 (en) | 2019-04-05 | 2022-12-28 | Academia Sinica | SIALIDASE RESISTANT SACCHARIDE, METHOD FOR PRODUCTION AND USE |
| US11896682B2 (en) | 2019-09-16 | 2024-02-13 | Regeneron Pharmaceuticals, Inc. | Radiolabeled MET binding proteins for immuno-PET imaging and methods of use thereof |
| EP4146241A4 (en) | 2020-05-08 | 2024-06-05 | Academia Sinica | CHIMERIC INFLUENZA VACCINES |
| WO2022079211A1 (en) | 2020-10-16 | 2022-04-21 | Adc Therapeutics Sa | Glycoconjugates |
| WO2022126416A1 (zh) * | 2020-12-16 | 2022-06-23 | 武汉友芝友生物制药股份有限公司 | 抗bcma抗体及其制备方法和应用 |
| CN112679614B (zh) * | 2021-01-15 | 2022-08-16 | 广东安普泽生物医药股份有限公司 | 用于特异性结合rankl靶向治疗药物的抗体及其用途 |
| GB202102396D0 (en) | 2021-02-19 | 2021-04-07 | Adc Therapeutics Sa | Molecular adjuvant |
| CN112946279A (zh) * | 2021-03-17 | 2021-06-11 | 扬州大学 | 一种基于油水界面自组装的三明治sers免疫传感器检测宫颈癌患者血清生物标志物方法 |
| JP2024514506A (ja) | 2021-04-06 | 2024-04-02 | アッヴィ・バイオセラピューティクス・インコーポレイテッド | テリソツズマブベドチンを使用した非小細胞肺がんの治療方法 |
| IL318755A (en) | 2021-04-12 | 2025-04-01 | Academia Sinica | Improved vaccine for the coronavirus |
| AR125473A1 (es) | 2021-04-29 | 2023-07-19 | Abbvie Inc | Conjugados de anticuerpo anti-c-met y fármaco |
| TW202334429A (zh) | 2021-10-01 | 2023-09-01 | 中央研究院 | Sars-cov-2棘蛋白特異性抗體及其用途 |
| KR20240095442A (ko) | 2021-11-03 | 2024-06-25 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 항체의 특이적 접합 |
| EP4457243A4 (en) * | 2021-12-27 | 2025-12-17 | Academia Sinica | ANTIBODIES AGAINST THE SPIKE PROTEIN OF SARS-CoV-2 AND USES THEREOF |
| TW202434637A (zh) * | 2022-12-20 | 2024-09-01 | 美商翰森生物有限責任公司 | 抗體、抗原結合片段及其醫藥用途 |
| US12508235B2 (en) | 2023-04-08 | 2025-12-30 | Rock Biomedical, Inc. | Methods and compositions for dendritic cell targeting nano-delivery |
| JP2025536873A (ja) | 2023-04-08 | 2025-11-12 | ロック・バイオメディカル・インコーポレイテッド | ポリマーソームによる標的化送達のための方法及び組成物 |
| WO2025025434A1 (zh) * | 2023-08-02 | 2025-02-06 | 百泰生物药业有限公司 | EGFR/c-Met双特异性抗体及其应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2840250C2 (de) | 1978-09-15 | 1983-01-20 | Siemens AG, 1000 Berlin und 8000 München | Schaltungsanordnung für eine leitungsgespeiste Lautfernsprechstation |
| US4424200A (en) | 1979-05-14 | 1984-01-03 | Nuc Med Inc. | Method for radiolabeling proteins with technetium-99m |
| US4479930A (en) | 1982-07-26 | 1984-10-30 | Trustees Of The University Of Massachusetts | Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4831175A (en) | 1986-09-05 | 1989-05-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8924581D0 (en) | 1989-11-01 | 1989-12-20 | Pa Consulting Services | Bleaching of hair |
| GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| JPH05244982A (ja) | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化ｂ−ｂ１０ |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US6214344B1 (en) | 1995-06-02 | 2001-04-10 | Genetech, Inc. | Hepatocyte growth factor receptor antagonists and uses thereof |
| US5686292A (en) * | 1995-06-02 | 1997-11-11 | Genentech, Inc. | Hepatocyte growth factor receptor antagonist antibodies and uses thereof |
| ATE200679T1 (de) * | 1997-04-14 | 2001-05-15 | Micromet Ag | Neues verfahren zur herstellung von anti-humanen antigenrezeptoren und deren verwendungen |
| US7563874B2 (en) * | 1998-08-31 | 2009-07-21 | The Regents Of The University Of California | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
| US20060057651A1 (en) * | 2000-12-08 | 2006-03-16 | Bowdish Katherine S | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| DE60334364D1 (de) * | 2002-02-21 | 2010-11-11 | Univ California | Behandlungsverfahren unter verwendung von anti-cd22-antikörpern |
| BRPI0407446A (pt) * | 2003-02-13 | 2006-01-31 | Pharmacia Corp | Anticorpos para c-met para o tratamento de cânceres |
| CA2897608C (en) * | 2003-05-09 | 2018-07-31 | Duke University | Cd20-specific antibodies and methods employing same |
| HN2004000285A (es) | 2003-08-04 | 2006-04-27 | Pfizer Prod Inc | ANTICUERPOS DIRIGIDOS A c-MET |
| KR101195291B1 (ko) | 2003-12-11 | 2012-10-26 | 제넨테크, 인크. | Ｃ－ｍｅｔ 이량체화 및 활성화를 억제하는 방법 및조성물 |
| WO2006015371A2 (en) * | 2004-08-05 | 2006-02-09 | Genentech, Inc. | Humanized anti-cmet antagonists |
| US20060094059A1 (en) | 2004-09-22 | 2006-05-04 | Odyssey Thera, Inc. | Methods for identifying new drug leads and new therapeutic uses for known drugs |
| EP1851248B1 (en) * | 2005-02-10 | 2016-08-10 | Baylor Research Institute | Anti-interferon alpha monoclonal antibodies and methods for use |
| US8008443B2 (en) | 2005-04-26 | 2011-08-30 | Medimmune, Llc | Modulation of antibody effector function by hinge domain engineering |
| HRP20160875T1 (hr) | 2005-07-18 | 2016-09-23 | Amgen Inc. | Humana anti-b7rp1 neutralizirajuća antitijela |
| EP1913027B1 (en) | 2005-07-28 | 2015-03-04 | Novartis AG | M-csf specific monoclonal antibody and uses thereof |
| EP1981981B1 (en) | 2006-02-06 | 2011-06-29 | Metheresis Translational Research SA | Anti-met monoclonal antibody, fragments and vectors thereof, for the treatment of tumors and corresponding products |
| WO2007126799A2 (en) | 2006-03-30 | 2007-11-08 | Novartis Ag | Compositions and methods of use for antibodies of c-met |
| EP2143441A1 (en) * | 2008-07-08 | 2010-01-13 | Pierre Fabre Medicament | Combination of a c-Met antagonist and an aminoheteroaryl compound for the treatment of cancer |
| AR074439A1 (es) | 2008-12-02 | 2011-01-19 | Pf Medicament | Anticuerpo anti-cmet (receptor c-met) |
| WO2010064089A1 (en) | 2008-12-02 | 2010-06-10 | Pierre Fabre Medicament | Novel anti-cmet antibody |
-
2007
- 2007-07-12 EP EP07301231A patent/EP2014681A1/en not_active Withdrawn
-
2008
- 2008-07-10 EP EP08786050.8A patent/EP2188312B1/en active Active
- 2008-07-10 CN CN201310073997.9A patent/CN103183739B/zh active Active
- 2008-07-10 EP EP11162720.4A patent/EP2415785B1/en active Active
- 2008-07-10 HR HRP20150887TT patent/HRP20150887T1/hr unknown
- 2008-07-10 CN CN201310478556.7A patent/CN103509113B/zh active Active
- 2008-07-10 EP EP11162718.8A patent/EP2415784B1/en active Active
- 2008-07-10 RS RS20150560A patent/RS54197B1/sr unknown
- 2008-07-10 NZ NZ599959A patent/NZ599959A/xx unknown
- 2008-07-10 KR KR1020157015922A patent/KR101719084B1/ko active Active
- 2008-07-10 CA CA2888691A patent/CA2888691C/en active Active
- 2008-07-10 PL PL08786050T patent/PL2188312T3/pl unknown
- 2008-07-10 KR KR1020167002898A patent/KR101701685B1/ko active Active
- 2008-07-10 CN CN200880024368.4A patent/CN101981054B/zh active Active
- 2008-07-10 ES ES08786050.8T patent/ES2542059T3/es active Active
- 2008-07-10 CL CL2008002015A patent/CL2008002015A1/es unknown
- 2008-07-10 ES ES11162720.4T patent/ES2678495T3/es active Active
- 2008-07-10 SI SI200831467T patent/SI2188312T1/sl unknown
- 2008-07-10 AU AU2008274171A patent/AU2008274171B2/en active Active
- 2008-07-10 CN CN201310478511.XA patent/CN103509112B/zh active Active
- 2008-07-10 MX MX2014007693A patent/MX353449B/es unknown
- 2008-07-10 NZ NZ599958A patent/NZ599958A/xx not_active IP Right Cessation
- 2008-07-10 MY MYPI2010000127A patent/MY158756A/en unknown
- 2008-07-10 WO PCT/EP2008/059026 patent/WO2009007427A2/en not_active Ceased
- 2008-07-10 SG SG2012050837A patent/SG183015A1/en unknown
- 2008-07-10 CA CA2982484A patent/CA2982484C/en active Active
- 2008-07-10 JP JP2010515513A patent/JP5562844B2/ja active Active
- 2008-07-10 CA CA2694418A patent/CA2694418C/en active Active
- 2008-07-10 KR KR1020167002899A patent/KR101701686B1/ko active Active
- 2008-07-10 RU RU2010104633/10A patent/RU2552161C2/ru active
- 2008-07-10 ES ES12183763.7T patent/ES2693542T3/es active Active
- 2008-07-10 HU HUE08786050A patent/HUE026026T2/en unknown
- 2008-07-10 KR KR1020107003216A patent/KR101625234B1/ko active Active
- 2008-07-10 NZ NZ583041A patent/NZ583041A/en unknown
- 2008-07-10 US US12/440,571 patent/US8329173B2/en active Active
- 2008-07-10 ES ES11162718.8T patent/ES2686335T3/es active Active
- 2008-07-10 EP EP12183763.7A patent/EP2535357B1/en active Active
- 2008-07-10 BR BRPI0815564A patent/BRPI0815564B8/pt active IP Right Grant
- 2008-07-10 MX MX2014008274A patent/MX345391B/es unknown
- 2008-07-10 NZ NZ613716A patent/NZ613716A/en not_active IP Right Cessation
- 2008-07-10 ME MEP-2016-197A patent/ME02341B/me unknown
- 2008-07-10 EP EP12183761.1A patent/EP2535356B1/en active Active
- 2008-07-10 PA PA20088789201A patent/PA8789201A1/es unknown
- 2008-07-10 CA CA2981821A patent/CA2981821C/en active Active
- 2008-07-10 PT PT87860508T patent/PT2188312E/pt unknown
- 2008-07-10 ES ES12183761.1T patent/ES2686693T3/es active Active
- 2008-07-10 DK DK08786050.8T patent/DK2188312T3/en active
- 2008-07-11 AR ARP080102991A patent/AR067517A1/es active IP Right Grant
- 2008-07-11 TW TW104114444A patent/TWI602829B/zh active
- 2008-07-11 TW TW103121603A patent/TWI592427B/zh active
- 2008-07-11 TW TW097126356A patent/TWI549965B/zh active
- 2008-07-11 TW TW104114445A patent/TWI602830B/zh active
- 2008-07-12 SA SA08290423A patent/SA08290423B1/ar unknown
-
2010
- 2010-01-03 IL IL203114A patent/IL203114A/en active IP Right Grant
- 2010-01-08 TN TNP2010000016A patent/TN2010000016A1/fr unknown
- 2010-01-08 MX MX2013010752A patent/MX341012B/es unknown
- 2010-02-10 MA MA32608A patent/MA31977B1/fr unknown
- 2010-02-10 ZA ZA2010/00966A patent/ZA201000966B/en unknown
- 2010-02-12 CO CO10016035A patent/CO6170364A2/es active IP Right Grant
-
2012
- 2012-11-09 US US13/673,752 patent/US9107907B2/en active Active
- 2012-11-09 US US13/673,690 patent/US8871909B2/en active Active
- 2012-11-09 US US13/673,726 patent/US8889832B2/en active Active
- 2012-11-09 US US13/673,716 patent/US8871910B2/en active Active
- 2012-11-18 IL IL223106A patent/IL223106B/en active IP Right Grant
- 2012-11-18 IL IL223109A patent/IL223109B/en active IP Right Grant
- 2012-11-18 IL IL223108A patent/IL223108B/en active IP Right Grant
- 2012-11-18 IL IL223105A patent/IL223105B/en active IP Right Grant
-
2014
- 2014-01-06 JP JP2014000618A patent/JP5889925B2/ja active Active
- 2014-01-06 JP JP2014000616A patent/JP5889923B2/ja active Active
- 2014-01-06 JP JP2014000617A patent/JP5889924B2/ja active Active
-
2015
- 2015-03-17 US US14/660,046 patent/US20150252114A1/en not_active Abandoned
- 2015-08-04 CY CY20151100680T patent/CY1116608T1/el unknown
-
2017
- 2017-09-15 AR ARP170102559A patent/AR109660A2/es unknown
- 2017-09-15 AR ARP170102558A patent/AR109659A2/es unknown
- 2017-09-15 AR ARP170102560A patent/AR109535A2/es unknown
-
2018
- 2018-09-24 PH PH12018502040A patent/PH12018502040A1/en unknown
- 2018-09-24 PH PH12018502038A patent/PH12018502038A1/en unknown
- 2018-09-24 PH PH12018502039A patent/PH12018502039A1/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010532982A5 (enExample) | ||
| US20230295300A1 (en) | Antibodies specific to delta 1 chain of t cell receptor | |
| RU2010104633A (ru) | НОВЫЕ АНТИТЕЛА, ИНГИБИРУЮЩИЕ ДИМЕРИЗАЦИЮ c-МЕТ, И ИХ ПРИМЕНЕНИЯ | |
| CN110914306B (zh) | 检查点抑制物双特异性抗体 | |
| TWI769537B (zh) | 標靶ｂｃｍａ的抗體、雙專一性抗體及其用途 | |
| JP2012504401A5 (enExample) | ||
| RU2011124751A (ru) | Антитело против смет | |
| RU2011115559A (ru) | Антитела к cxcr4 и их применение для лечения рака | |
| RU2451689C2 (ru) | Новые антипролиферативные антитела | |
| JP2010509931A5 (enExample) | ||
| JP2012510280A5 (enExample) | ||
| JP2020536118A (ja) | Ｇｍ−ｃｓｆアンタゴニストを使用した免疫療法関連毒性の治療方法 | |
| EP2430050A1 (en) | Humanized axl antibodies | |
| JP2009525764A5 (enExample) | ||
| WO2020168555A1 (zh) | Cd3抗原结合片段及其应用 | |
| HRP20140502T1 (hr) | Humanizirana anti-cxcr4 antitijela za lijeäśenje karcinoma | |
| CN112638946A (zh) | 抗il1rap抗体组合物 | |
| CN111344014A (zh) | 使用cd137配体作为抗cd137抗体治疗的生物标志物的方法 | |
| KR20240144422A (ko) | 암 치료의 단독치료법 및 병용치료법에서 il-18bp 길항제 항체 및 이의 용도 | |
| KR20230132544A (ko) | 신규한 항-그렘린1 항체 | |
| CN112638945A (zh) | 人白介素18受体α和β的人抗体 | |
| US20250333506A1 (en) | Antibodies specific to delta 1 chain of t cell receptor | |
| CN114450305A (zh) | 抗cd137l抗体及其使用方法 | |
| JP2022502079A (ja) | がん関連抗体組成物および使用方法 | |
| JP2022534624A (ja) | 活性化抗ｇａｌ９結合分子 |