JP2005513052A5 - - Google Patents
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- JP2005513052A5 JP2005513052A5 JP2003551141A JP2003551141A JP2005513052A5 JP 2005513052 A5 JP2005513052 A5 JP 2005513052A5 JP 2003551141 A JP2003551141 A JP 2003551141A JP 2003551141 A JP2003551141 A JP 2003551141A JP 2005513052 A5 JP2005513052 A5 JP 2005513052A5
- Authority
- JP
- Japan
- Prior art keywords
- imidazo
- pyridin
- amino
- ethoxymethyl
- butyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000000217 alkyl group Chemical group 0.000 claims 26
- -1 4-amino-2-butyl-6,7-dimethyl-1H-imidazo [4,5-c] pyridin-1-yl Chemical group 0.000 claims 21
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 19
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 10
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 9
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- NUKYPUAOHBNCPY-UHFFFAOYSA-N 4-aminopyridine Chemical compound NC1=CC=NC=C1 NUKYPUAOHBNCPY-UHFFFAOYSA-N 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- 229940124530 sulfonamide Drugs 0.000 claims 2
- XLLFMFAAILQGBO-FMIVXFBMSA-N (e)-n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-2-phenylethenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)\C=C\C1=CC=CC=C1 XLLFMFAAILQGBO-FMIVXFBMSA-N 0.000 claims 1
- AYUINKIDLBLXIR-SDNWHVSQSA-N (e)-n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]-2-phenylethenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)\C=C\C1=CC=CC=C1 AYUINKIDLBLXIR-SDNWHVSQSA-N 0.000 claims 1
- ZQFVHILXTVZLDV-UHFFFAOYSA-N 1-[2-(1-butylsulfonylpiperidin-4-yl)ethyl]-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-4-amine Chemical compound C1CN(S(=O)(=O)CCCC)CCC1CCN1C2=C(C)C(C)=NC(N)=C2N=C1COCC ZQFVHILXTVZLDV-UHFFFAOYSA-N 0.000 claims 1
- BFCUTJOHOPUWGQ-UHFFFAOYSA-N 2-(ethoxymethyl)-1-[2-(1-ethylsulfonylpiperidin-4-yl)ethyl]-6,7-dimethylimidazo[4,5-c]pyridin-4-amine Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCC1CCN(S(=O)(=O)CC)CC1 BFCUTJOHOPUWGQ-UHFFFAOYSA-N 0.000 claims 1
- GNXMSXQEEFMDPJ-UHFFFAOYSA-N 2-(ethoxymethyl)-6,7-dimethyl-1-[2-(1-methylsulfonylpiperidin-4-yl)ethyl]imidazo[4,5-c]pyridin-4-amine Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCC1CCN(S(C)(=O)=O)CC1 GNXMSXQEEFMDPJ-UHFFFAOYSA-N 0.000 claims 1
- VEXBNBISUFJIKZ-UHFFFAOYSA-N 2-(ethoxymethyl)-6,7-dimethyl-1-[2-(1-naphthalen-2-ylsulfonylpiperidin-4-yl)ethyl]imidazo[4,5-c]pyridin-4-amine Chemical class C1=CC=CC2=CC(S(=O)(=O)N3CCC(CC3)CCN3C4=C(C)C(C)=NC(N)=C4N=C3COCC)=CC=C21 VEXBNBISUFJIKZ-UHFFFAOYSA-N 0.000 claims 1
- YQHJWQMJJQCVKL-UHFFFAOYSA-N 2-(ethoxymethyl)-6,7-dimethyl-1-[2-(1-propan-2-ylsulfonylpiperidin-4-yl)ethyl]imidazo[4,5-c]pyridin-4-amine Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCC1CCN(S(=O)(=O)C(C)C)CC1 YQHJWQMJJQCVKL-UHFFFAOYSA-N 0.000 claims 1
- QNRLLBCZBABYEU-UHFFFAOYSA-N 2-(ethoxymethyl)-6,7-dimethyl-1-[2-[1-(4-methylsulfonylphenyl)sulfonylpiperidin-4-yl]ethyl]imidazo[4,5-c]pyridin-4-amine Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCC(CC1)CCN1S(=O)(=O)C1=CC=C(S(C)(=O)=O)C=C1 QNRLLBCZBABYEU-UHFFFAOYSA-N 0.000 claims 1
- QHHRGOALWBPDRC-UHFFFAOYSA-N 2-(ethoxymethyl)-6,7-dimethyl-1-[2-[1-(4-phenylphenyl)sulfonylpiperidin-4-yl]ethyl]imidazo[4,5-c]pyridin-4-amine Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCC(CC1)CCN1S(=O)(=O)C(C=C1)=CC=C1C1=CC=CC=C1 QHHRGOALWBPDRC-UHFFFAOYSA-N 0.000 claims 1
- KTFDYVNEGTXQCV-UHFFFAOYSA-N 2-Thiophenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CS1 KTFDYVNEGTXQCV-UHFFFAOYSA-N 0.000 claims 1
- BEHSXHFKMDXZOR-UHFFFAOYSA-N 4-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethylsulfamoyl]benzoic acid Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C1=CC=C(C(O)=O)C=C1 BEHSXHFKMDXZOR-UHFFFAOYSA-N 0.000 claims 1
- HESNGHFXTBCTNA-UHFFFAOYSA-N 4-[2-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]ethyl]-n,n-dimethylpiperidine-1-sulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCC1CCN(S(=O)(=O)N(C)C)CC1 HESNGHFXTBCTNA-UHFFFAOYSA-N 0.000 claims 1
- WXPSOLDEAMAJPP-UHFFFAOYSA-N 4-amino-1-[4-(dimethylsulfamoylamino)butyl]-2-(ethoxymethyl)-7-methylimidazo[4,5-c]pyridine Chemical compound N1=CC(C)=C2N(CCCCNS(=O)(=O)N(C)C)C(COCC)=NC2=C1N WXPSOLDEAMAJPP-UHFFFAOYSA-N 0.000 claims 1
- DIKNMAGLRNPLCD-UHFFFAOYSA-N 4-amino-1-[4-(dimethylsulfamoylamino)butyl]-6,7-dimethylimidazo[4,5-c]pyridine Chemical compound N1=C(C)C(C)=C2N(CCCCNS(=O)(=O)N(C)C)C=NC2=C1N DIKNMAGLRNPLCD-UHFFFAOYSA-N 0.000 claims 1
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- QMHAHUAQAJVBIW-UHFFFAOYSA-N [methyl(sulfamoyl)amino]methane Chemical compound CN(C)S(N)(=O)=O QMHAHUAQAJVBIW-UHFFFAOYSA-N 0.000 claims 1
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000003178 carboxy group Chemical class [H]OC(*)=O 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960004979 fampridine Drugs 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- PMPGNVBILGZNKR-UHFFFAOYSA-N n-[1-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]-2-methylpropan-2-yl]methanesulfonamide Chemical compound N1=C(C)C(C)=C2N(CC(C)(C)NS(C)(=O)=O)C(COCC)=NC2=C1N PMPGNVBILGZNKR-UHFFFAOYSA-N 0.000 claims 1
- SZRXVUJCEOXNOU-UHFFFAOYSA-N n-[1-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]-2-methylpropan-2-yl]propane-2-sulfonamide Chemical compound N1=C(C)C(C)=C2N(CC(C)(C)NS(=O)(=O)C(C)C)C(COCC)=NC2=C1N SZRXVUJCEOXNOU-UHFFFAOYSA-N 0.000 claims 1
- WABQHXXEEYRFFS-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-1-methylimidazole-4-sulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C1=CN(C)C=N1 WABQHXXEEYRFFS-UHFFFAOYSA-N 0.000 claims 1
- OSOXBFCRCUBBEY-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-2,4-difluorobenzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C1=CC=C(F)C=C1F OSOXBFCRCUBBEY-UHFFFAOYSA-N 0.000 claims 1
- XRIYPXXGMFEJGD-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-3,5-dimethyl-1,2-oxazole-4-sulfonamide Chemical compound CC1=NOC(C)=C1S(=O)(=O)NCCN1C2=C(C)C(C)=NC(N)=C2N=C1C XRIYPXXGMFEJGD-UHFFFAOYSA-N 0.000 claims 1
- RHDARXLPLTTWPE-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-3-cyanobenzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C1=CC=CC(C#N)=C1 RHDARXLPLTTWPE-UHFFFAOYSA-N 0.000 claims 1
- QHQNIVIUXKXEFI-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-3-fluorobenzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C1=CC=CC(F)=C1 QHQNIVIUXKXEFI-UHFFFAOYSA-N 0.000 claims 1
- WQTJKIUMGBOIHW-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-4-cyanobenzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C1=CC=C(C#N)C=C1 WQTJKIUMGBOIHW-UHFFFAOYSA-N 0.000 claims 1
- RBFMOELWXHMFGN-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-4-methoxybenzenesulfonamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)NCCN1C2=C(C)C(C)=NC(N)=C2N=C1C RBFMOELWXHMFGN-UHFFFAOYSA-N 0.000 claims 1
- UWYXZBFTFOCGCT-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-4-phenylbenzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C(C=C1)=CC=C1C1=CC=CC=C1 UWYXZBFTFOCGCT-UHFFFAOYSA-N 0.000 claims 1
- XNVXGXRWEXOWLG-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]-5-chlorothiophene-2-sulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C1=CC=C(Cl)S1 XNVXGXRWEXOWLG-UHFFFAOYSA-N 0.000 claims 1
- IQRIJRLKAATYNY-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]butane-1-sulfonamide Chemical compound N1=C(C)C(C)=C2N(CCNS(=O)(=O)CCCC)C(C)=NC2=C1N IQRIJRLKAATYNY-UHFFFAOYSA-N 0.000 claims 1
- PJSNKWBCIWHBCH-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]ethanesulfonamide Chemical compound N1=C(C)C(C)=C2N(CCNS(=O)(=O)CC)C(C)=NC2=C1N PJSNKWBCIWHBCH-UHFFFAOYSA-N 0.000 claims 1
- HRGCOYSKRWDVEN-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]naphthalene-1-sulfonamide Chemical compound C1=CC=C2C(S(=O)(=O)NCCN3C4=C(C)C(C)=NC(N)=C4N=C3C)=CC=CC2=C1 HRGCOYSKRWDVEN-UHFFFAOYSA-N 0.000 claims 1
- YPILHWLBRDFQPN-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]naphthalene-2-sulfonamide Chemical compound C1=CC=CC2=CC(S(=O)(=O)NCCN3C4=C(C)C(C)=NC(N)=C4N=C3C)=CC=C21 YPILHWLBRDFQPN-UHFFFAOYSA-N 0.000 claims 1
- PFWMIXCFNONSOZ-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]propane-2-sulfonamide Chemical compound N1=C(C)C(C)=C2N(CCNS(=O)(=O)C(C)C)C(C)=NC2=C1N PFWMIXCFNONSOZ-UHFFFAOYSA-N 0.000 claims 1
- ZZAQZZVHOYMVDF-UHFFFAOYSA-N n-[2-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)ethyl]thiophene-2-sulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCNS(=O)(=O)C1=CC=CS1 ZZAQZZVHOYMVDF-UHFFFAOYSA-N 0.000 claims 1
- NTHGPCKAQKTLFS-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]-3-cyanobenzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=CC(C#N)=C1 NTHGPCKAQKTLFS-UHFFFAOYSA-N 0.000 claims 1
- GUVQSOIOPJRLFW-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]-3-fluorobenzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=CC(F)=C1 GUVQSOIOPJRLFW-UHFFFAOYSA-N 0.000 claims 1
- TVKYJLLAHVDEBY-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]-4-phenylbenzenesulfonamide Chemical compound CC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C(C=C1)=CC=C1C1=CC=CC=C1 TVKYJLLAHVDEBY-UHFFFAOYSA-N 0.000 claims 1
- VFIUUEZDQAZHOH-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]butane-1-sulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCNS(=O)(=O)CCCC)C(C)=NC2=C1N VFIUUEZDQAZHOH-UHFFFAOYSA-N 0.000 claims 1
- VKPBLRKAERQXDD-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]ethanesulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCNS(=O)(=O)CC)C(C)=NC2=C1N VKPBLRKAERQXDD-UHFFFAOYSA-N 0.000 claims 1
- DYVTWANBKVYOQI-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]methanesulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCNS(C)(=O)=O)C(C)=NC2=C1N DYVTWANBKVYOQI-UHFFFAOYSA-N 0.000 claims 1
- ZDOVJTNMWDBXGR-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]naphthalene-1-sulfonamide Chemical compound C1=CC=C2C(S(=O)(=O)NCCCN3C4=C(C)C(C)=NC(N)=C4N=C3C)=CC=CC2=C1 ZDOVJTNMWDBXGR-UHFFFAOYSA-N 0.000 claims 1
- IMTHIUDVPIQGQW-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]naphthalene-2-sulfonamide Chemical compound C1=CC=CC2=CC(S(=O)(=O)NCCCN3C4=C(C)C(C)=NC(N)=C4N=C3C)=CC=C21 IMTHIUDVPIQGQW-UHFFFAOYSA-N 0.000 claims 1
- SLAQMZWVGJCNMY-UHFFFAOYSA-N n-[3-(4-amino-2,6,7-trimethylimidazo[4,5-c]pyridin-1-yl)propyl]propane-2-sulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCNS(=O)(=O)C(C)C)C(C)=NC2=C1N SLAQMZWVGJCNMY-UHFFFAOYSA-N 0.000 claims 1
- ZWRQTDAJYKXNQQ-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]-2,4-difluorobenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=C(F)C=C1F ZWRQTDAJYKXNQQ-UHFFFAOYSA-N 0.000 claims 1
- YHQUGQRPEUNTAM-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]-3-cyanobenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=CC(C#N)=C1 YHQUGQRPEUNTAM-UHFFFAOYSA-N 0.000 claims 1
- QTDWPMAYCVQJIY-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]-3-fluorobenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=CC(F)=C1 QTDWPMAYCVQJIY-UHFFFAOYSA-N 0.000 claims 1
- RAEFMLIDYZOPRW-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]-4-cyanobenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=C(C#N)C=C1 RAEFMLIDYZOPRW-UHFFFAOYSA-N 0.000 claims 1
- VGSSAWOLIAZAJC-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]-4-methoxybenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=C(OC)C=C1 VGSSAWOLIAZAJC-UHFFFAOYSA-N 0.000 claims 1
- QSTQQGMYOSAJBU-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]-4-phenylbenzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C(C=C1)=CC=C1C1=CC=CC=C1 QSTQQGMYOSAJBU-UHFFFAOYSA-N 0.000 claims 1
- NGSMWLVYTPXGSG-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]benzenesulfonamide Chemical compound CCOCC1=NC2=C(N)N=C(C)C(C)=C2N1CCCNS(=O)(=O)C1=CC=CC=C1 NGSMWLVYTPXGSG-UHFFFAOYSA-N 0.000 claims 1
- PPLLORMLEVBKNC-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]butane-1-sulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCNS(=O)(=O)CCCC)C(COCC)=NC2=C1N PPLLORMLEVBKNC-UHFFFAOYSA-N 0.000 claims 1
- KUNYIPMHHNIRKX-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]ethanesulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCNS(=O)(=O)CC)C(COCC)=NC2=C1N KUNYIPMHHNIRKX-UHFFFAOYSA-N 0.000 claims 1
- AOZMNNYIOVPNHJ-UHFFFAOYSA-N n-[3-[4-amino-2-(ethoxymethyl)-6,7-dimethylimidazo[4,5-c]pyridin-1-yl]propyl]methanesulfonamide Chemical compound N1=C(C)C(C)=C2N(CCCNS(C)(=O)=O)C(COCC)=NC2=C1N AOZMNNYIOVPNHJ-UHFFFAOYSA-N 0.000 claims 1
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- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
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| MXPA05007485A (es) | 2003-01-14 | 2006-01-30 | Arena Pharm Inc | Derivados de arilo y heteroarilo 1,2,3-trisubstituidos como moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con ello tales como diabetes e hiperglicemia. |
| US20040265351A1 (en) | 2003-04-10 | 2004-12-30 | Miller Richard L. | Methods and compositions for enhancing immune response |
| AU2004244962A1 (en) * | 2003-04-10 | 2004-12-16 | 3M Innovative Properties Company | Delivery of immune response modifier compounds using metal-containing particulate support materials |
| AR045047A1 (es) | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| BRPI0413558A (pt) * | 2003-08-12 | 2006-10-17 | 3M Innovative Properties Co | compostos contendo imidazo substituìdo por hidroxilamina |
| EP2939693A1 (en) * | 2003-08-14 | 2015-11-04 | 3M Innovative Properties Company | Lipid-modified immune response modifiers |
| MXPA06002199A (es) | 2003-08-27 | 2006-05-22 | 3M Innovative Properties Co | Imidazoquinolinas sustituidas con grupos ariloxi o arilalquilenoxi. |
| CA2537763A1 (en) | 2003-09-05 | 2005-03-17 | 3M Innovative Properties Company | Treatment for cd5+ b cell lymphoma |
| CA2540541C (en) | 2003-10-03 | 2012-03-27 | 3M Innovative Properties Company | Alkoxy substituted imidazoquinolines |
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| EP0708772B1 (en) * | 1993-07-15 | 2000-08-23 | Minnesota Mining And Manufacturing Company | IMIDAZO [4,5-c]PYRIDIN-4-AMINES |
| KR100518903B1 (ko) * | 1996-10-25 | 2005-10-06 | 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 | Ｔｈ2 매개 질병 및 관련 질병의 치료용 면역 반응 조절 화합물 |
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| US6376669B1 (en) * | 1999-11-05 | 2002-04-23 | 3M Innovative Properties Company | Dye labeled imidazoquinoline compounds |
| UA74593C2 (en) * | 2000-12-08 | 2006-01-16 | 3M Innovative Properties Co | Substituted imidazopyridines |
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