|
US8309562B2
(en)
|
2003-07-03 |
2012-11-13 |
Myrexis, Inc. |
Compounds and therapeutical use thereof
|
|
NZ544472A
(en)
|
2003-07-03 |
2009-04-30 |
Myriad Genetics Inc |
Compounds and therapeutical use thereof
|
|
JP4932495B2
(ja)
|
2004-01-23 |
2012-05-16 |
アムゲン インコーポレイテッド |
化合物及び使用方法
|
|
WO2005073224A2
(en)
|
2004-01-23 |
2005-08-11 |
Amgen Inc |
Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer
|
|
EA011671B1
(ru)
*
|
2004-06-04 |
2009-04-28 |
Арена Фармасьютикалз, Инк. |
Замещенные производные арила и гетероарила в качестве модуляторов метаболизма и для профилактики и лечения связанных с ним расстройств
|
|
WO2006040329A1
(en)
*
|
2004-10-12 |
2006-04-20 |
Novo Nordisk A/S |
1 ibeta- hydroxysteroid dehydrogenase type 1 active spiro compounds
|
|
MX2007006230A
(es)
|
2004-11-30 |
2007-07-25 |
Amgen Inc |
Quinolinas y analogos de quinazolinas y su uso como medicamentos para tratar cancer.
|
|
US20060167044A1
(en)
*
|
2004-12-20 |
2006-07-27 |
Arnaiz Damian O |
Piperidine derivatives and their use as anti-inflammatory agents
|
|
US8258145B2
(en)
|
2005-01-03 |
2012-09-04 |
Myrexis, Inc. |
Method of treating brain cancer
|
|
JO2787B1
(en)
|
2005-04-27 |
2014-03-15 |
امجين إنك, |
Alternative amide derivatives and methods of use
|
|
US7709516B2
(en)
*
|
2005-06-17 |
2010-05-04 |
Endorecherche, Inc. |
Helix 12 directed non-steroidal antiandrogens
|
|
BRPI0618051A2
(pt)
*
|
2005-11-01 |
2011-08-16 |
Transtech Pharma Inc |
uso farmacêutico de amidas substituìdas
|
|
KR20080076916A
(ko)
*
|
2005-11-01 |
2008-08-20 |
트랜스테크 파르마, 인크. |
치환된 아미드의 약학적 사용
|
|
AU2006332694A1
(en)
*
|
2005-12-30 |
2007-07-12 |
Alantos Pharmaceuticals, Holding, Inc. |
Substituted bis-amide metalloprotease inhibitors
|
|
TW200804347A
(en)
*
|
2006-01-10 |
2008-01-16 |
Janssen Pharmaceutica Nv |
Urotensin II receptor antagonists
|
|
EP2007722A1
(en)
*
|
2006-03-21 |
2008-12-31 |
High Point Pharmaceuticals, LLC |
Adamantane derivatives for the treatment of the metabolic syndrome
|
|
KR20090014347A
(ko)
|
2006-04-07 |
2009-02-10 |
하이 포인트 파마슈티칼스, 엘엘씨 |
11β-히드록시스테로이드 탈수소효소 타입 1 활성 화합물
|
|
EP2038255A2
(en)
*
|
2006-06-16 |
2009-03-25 |
High Point Pharmaceuticals, LLC |
Pharmaceutical use of substituted piperidine carboxamides
|
|
EP1878721A1
(en)
*
|
2006-07-13 |
2008-01-16 |
Novo Nordisk A/S |
4-Piperidylbenzamides as 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
|
|
US8048908B2
(en)
*
|
2006-07-13 |
2011-11-01 |
High Point Pharmaceuticals, Llc |
11β-hydroxysteroid dehydrogenase type 1 active compounds
|
|
CL2007002097A1
(es)
*
|
2006-07-20 |
2008-01-18 |
Smithkline Beecham Corp |
Compuestos derivados de pirrolidina o morfolina antagonistas de urotensina ii; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar insuficiencia cardiaca congestiva, insuficiencia cardiaca isquemica, angina, isquemia del miocardio, vejiga hiperactiva, asma y/o copd, entre otras.
|
|
EP2049120A4
(en)
|
2006-07-31 |
2011-09-07 |
Janssen Pharmaceutica Nv |
UROTENSIN II RECEPTOR ANTAGONISTS
|
|
FR2904827B1
(fr)
*
|
2006-08-11 |
2008-09-19 |
Sanofi Aventis Sa |
Derives de 5,6-bisaryl-2-pyridine-carboxamide, leur preparation et leur application en therapeutique comme antiganistes des recepteurs a l'urotensine ii
|
|
JP2010510202A
(ja)
|
2006-11-17 |
2010-04-02 |
ファイザー株式会社 |
置換ビシクロカルボキシアミド化合物
|
|
ZA200904916B
(en)
|
2007-02-23 |
2010-09-29 |
High Point Pharmaceuticals Llc |
N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
|
|
WO2008101907A2
(en)
*
|
2007-02-23 |
2008-08-28 |
High Point Pharmaceuticals, Llc |
N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
|
|
JP2010519239A
(ja)
*
|
2007-02-23 |
2010-06-03 |
ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー |
11−ベータ−ヒドロキシステロイドデヒドロゲナーゼの阻害因子としてのn−アドマンチルベンザミド
|
|
EP2125704A1
(en)
*
|
2007-02-23 |
2009-12-02 |
High Point Pharmaceuticals, LLC |
N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
|
|
CN101652359A
(zh)
*
|
2007-03-09 |
2010-02-17 |
高点制药有限责任公司 |
作为羟类固醇脱氢酶抑制剂的吲哚-和苯并咪唑酰胺类
|
|
EP2141990A4
(en)
*
|
2007-03-28 |
2011-07-06 |
High Point Pharmaceuticals Llc |
ACTIVE COMPOUNDS ON 11BETA-HSD1
|
|
CN101677562A
(zh)
*
|
2007-04-11 |
2010-03-24 |
高点制药有限责任公司 |
新化合物
|
|
JP2010526777A
(ja)
*
|
2007-04-24 |
2010-08-05 |
ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー |
置換アミドの医薬用途
|
|
PA8782701A1
(es)
*
|
2007-06-07 |
2009-01-23 |
Janssen Pharmaceutica Nv |
Antagonistas del receptor de urotensina ii
|
|
WO2008156828A2
(en)
*
|
2007-06-20 |
2008-12-24 |
Vitae Pharmaceuticals, Inc. |
Renin inhibitors
|
|
WO2009058267A2
(en)
*
|
2007-10-29 |
2009-05-07 |
Amgen Inc. |
Benzomorpholine derivatives and methods of use
|
|
WO2009063364A2
(en)
*
|
2007-11-13 |
2009-05-22 |
Encysive Pharmaceuticals Inc. |
Modulators of urotensin receptor and methods of use thereof
|
|
FR2927330B1
(fr)
|
2008-02-07 |
2010-02-19 |
Sanofi Aventis |
Derives de 5,6-bisaryl-2-pyridine-carboxamide, leur preparation et leur application en therapeutique comme antagonistes des recepteurs a l'urotensine ii
|
|
UA103319C2
(en)
|
2008-05-06 |
2013-10-10 |
Глаксосмитклайн Ллк |
Thiazole- and oxazole-benzene sulfonamide compounds
|
|
ATE546448T1
(de)
|
2008-08-02 |
2012-03-15 |
Janssen Pharmaceutica Nv |
Urotensin-ii-rezeptorantagonisten
|
|
EP2632461A4
(en)
*
|
2010-10-29 |
2014-04-02 |
Merck Sharp & Dohme |
Isoindolinone PDE10 INHIBITORS
|
|
CN102060811A
(zh)
*
|
2011-01-19 |
2011-05-18 |
山西大学 |
单磺酰哌嗪的合成方法
|
|
JP2016505000A
(ja)
|
2012-12-21 |
2016-02-18 |
エピザイム,インコーポレイティド |
Prmt5阻害剤およびその使用
|
|
EP3406607A1
(en)
|
2012-12-21 |
2018-11-28 |
Epizyme, Inc. |
Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
|
|
JP2016511744A
(ja)
*
|
2012-12-21 |
2016-04-21 |
エピザイム,インコーポレイティド |
Prmt5を阻害する方法
|
|
UA118548C2
(uk)
|
2012-12-21 |
2019-02-11 |
Епізайм, Інк. |
Тетрагідро- та дигідроізохіноліни як інгібітори prmt5 та їх застосування
|
|
CA2894157A1
(en)
|
2012-12-21 |
2014-06-26 |
Epizyme, Inc. |
Prmt5 inhibitors and uses thereof
|
|
US9611257B2
(en)
|
2012-12-21 |
2017-04-04 |
Epizyme, Inc. |
PRMT5 inhibitors and uses thereof
|
|
EP2970266B1
(en)
|
2013-03-15 |
2018-01-31 |
Epizyme, Inc. |
1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof
|
|
CA2903813C
(en)
|
2013-03-15 |
2023-08-29 |
Epizyme, Inc. |
Carm1 inhibitors and uses thereof
|
|
DK3054936T5
(da)
|
2013-10-10 |
2024-03-18 |
Eastern Virginia Medical School |
4-((2-hydroxy-3-methoxybenzyl)amino) benzensulfonamid derivater som 12-lipoxygenase inhibitorer
|
|
JP6272604B2
(ja)
*
|
2013-12-27 |
2018-01-31 |
日本サプリメント株式会社 |
糖取り込み促進剤
|
|
BR112016015449A8
(pt)
*
|
2013-12-30 |
2020-06-09 |
Lifesci Pharmaceuticals Inc |
compostos inibidores terapêuticos, composição farmacêutica os compreendendo e uso dos mesmos
|
|
EP3177288A4
(en)
|
2014-08-04 |
2018-04-04 |
Epizyme, Inc. |
Prmt5 inhibitors and uses thereof
|
|
MA41051B1
(fr)
|
2014-10-06 |
2020-11-30 |
Vertex Pharma |
Modulateurs du régulateur de conductance transmembranaire de la mucoviscidose
|
|
WO2016100940A1
(en)
|
2014-12-19 |
2016-06-23 |
The Broad Institute, Inc. |
Dopamine d2 receptor ligands
|
|
US10752588B2
(en)
|
2014-12-19 |
2020-08-25 |
The Broad Institute, Inc. |
Dopamine D2 receptor ligands
|
|
CA3019380A1
(en)
|
2016-03-31 |
2017-10-05 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator
|
|
EP3241874B1
(en)
|
2016-05-04 |
2019-08-14 |
Agfa Nv |
Acylphosphine oxide photoinitiators
|
|
CN109803962B
(zh)
|
2016-09-30 |
2022-04-29 |
弗特克斯药品有限公司 |
囊性纤维化跨膜传导调控蛋白的调节剂、以及药物组合物
|
|
MD3551622T2
(ro)
|
2016-12-09 |
2021-03-31 |
Vertex Pharma |
Modulator al regulatorului conductanței transmembranare în fibroză chistică, compoziții farmaceutice, metode de tratament și procedeu pentru fabricarea modulatorului
|
|
CN110494432B
(zh)
|
2016-12-28 |
2022-08-12 |
米尼奥尔克斯治疗有限公司 |
异喹啉化合物,其制备方法及其在与β-半乳糖苷酶活性改变相关的病症中的治疗用途
|
|
US12319659B2
(en)
|
2017-02-24 |
2025-06-03 |
Shenzhen Linglan Bio-Pharmaceutical Technology Co., Ltd |
Selective ligand for dopamine D3 receptor, preparation method therefor, and pharmaceutical application thereof
|
|
US11253509B2
(en)
|
2017-06-08 |
2022-02-22 |
Vertex Pharmaceuticals Incorporated |
Methods of treatment for cystic fibrosis
|
|
MA49631A
(fr)
|
2017-07-17 |
2020-05-27 |
Vertex Pharma |
Méthodes de traitement de la fibrose kystique
|
|
JP7121794B2
(ja)
|
2017-08-02 |
2022-08-18 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
ピロリジン化合物を調製するためのプロセス
|
|
WO2019079760A1
(en)
|
2017-10-19 |
2019-04-25 |
Vertex Pharmaceuticals Incorporated |
CRYSTALLINE FORMS AND COMPOSITIONS OF CFTR MODULATORS
|
|
EP3720849A2
(en)
|
2017-12-08 |
2020-10-14 |
Vertex Pharmaceuticals Incorporated |
Processes for making modulators of cystic fibrosis transmembrane conductance regulator
|
|
TWI810243B
(zh)
|
2018-02-05 |
2023-08-01 |
美商維泰克斯製藥公司 |
用於治療囊腫纖化症之醫藥組合物
|
|
EP3774825A1
(en)
|
2018-04-13 |
2021-02-17 |
Vertex Pharmaceuticals Incorporated |
Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
|
|
CN110938021A
(zh)
*
|
2019-12-18 |
2020-03-31 |
荆门市丽康源纺织科技有限公司 |
一种染料中间体3-(β-羟乙基砜基)苯胺的制备方法
|
|
CN111170897A
(zh)
*
|
2019-12-18 |
2020-05-19 |
荆门市丽康源纺织科技有限公司 |
一种间位酯的制备方法及间位酯
|
|
JP2023542541A
(ja)
*
|
2020-09-25 |
2023-10-10 |
エサイエント ファーマシューティカルズ,インコーポレイティド |
Mas関連gタンパク質受容体x2のモジュレーター、並びに関連製品及び方法
|
|
CN114890946B
(zh)
*
|
2022-05-20 |
2023-10-27 |
沈阳药科大学 |
含有吗啉丙基的[(喹啉-4-基)氨基]苯甲酰胺类化合物及其制备与应用
|