JP2006519258A5 - - Google Patents

Download PDF

Info

Publication number
JP2006519258A5
JP2006519258A5 JP2006508787A JP2006508787A JP2006519258A5 JP 2006519258 A5 JP2006519258 A5 JP 2006519258A5 JP 2006508787 A JP2006508787 A JP 2006508787A JP 2006508787 A JP2006508787 A JP 2006508787A JP 2006519258 A5 JP2006519258 A5 JP 2006519258A5
Authority
JP
Japan
Prior art keywords
methylquinolin
ylamino
amine
ethyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2006508787A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006519258A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2004/005150 external-priority patent/WO2004078114A2/en
Publication of JP2006519258A publication Critical patent/JP2006519258A/ja
Publication of JP2006519258A5 publication Critical patent/JP2006519258A5/ja
Withdrawn legal-status Critical Current

Links

JP2006508787A 2003-02-28 2004-02-20 ピリジン、ピリミジン、キノリン、キナゾリンおよびナフタレン系のウロテンシン−ii受容体拮抗薬 Withdrawn JP2006519258A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45108903P 2003-02-28 2003-02-28
PCT/US2004/005150 WO2004078114A2 (en) 2003-02-28 2004-02-20 Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-ii receptor antagonists.

Publications (2)

Publication Number Publication Date
JP2006519258A JP2006519258A (ja) 2006-08-24
JP2006519258A5 true JP2006519258A5 (https=) 2007-03-29

Family

ID=32962557

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006508787A Withdrawn JP2006519258A (ja) 2003-02-28 2004-02-20 ピリジン、ピリミジン、キノリン、キナゾリンおよびナフタレン系のウロテンシン−ii受容体拮抗薬

Country Status (6)

Country Link
US (2) US7265122B2 (https=)
EP (1) EP1603884A4 (https=)
JP (1) JP2006519258A (https=)
AU (1) AU2004218456A1 (https=)
CA (1) CA2517166A1 (https=)
WO (1) WO2004078114A2 (https=)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8309562B2 (en) 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
NZ544472A (en) 2003-07-03 2009-04-30 Myriad Genetics Inc Compounds and therapeutical use thereof
JP4932495B2 (ja) 2004-01-23 2012-05-16 アムゲン インコーポレイテッド 化合物及び使用方法
WO2005073224A2 (en) 2004-01-23 2005-08-11 Amgen Inc Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer
EA011671B1 (ru) * 2004-06-04 2009-04-28 Арена Фармасьютикалз, Инк. Замещенные производные арила и гетероарила в качестве модуляторов метаболизма и для профилактики и лечения связанных с ним расстройств
WO2006040329A1 (en) * 2004-10-12 2006-04-20 Novo Nordisk A/S 1 ibeta- hydroxysteroid dehydrogenase type 1 active spiro compounds
MX2007006230A (es) 2004-11-30 2007-07-25 Amgen Inc Quinolinas y analogos de quinazolinas y su uso como medicamentos para tratar cancer.
US20060167044A1 (en) * 2004-12-20 2006-07-27 Arnaiz Damian O Piperidine derivatives and their use as anti-inflammatory agents
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
JO2787B1 (en) 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
US7709516B2 (en) * 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
BRPI0618051A2 (pt) * 2005-11-01 2011-08-16 Transtech Pharma Inc uso farmacêutico de amidas substituìdas
KR20080076916A (ko) * 2005-11-01 2008-08-20 트랜스테크 파르마, 인크. 치환된 아미드의 약학적 사용
AU2006332694A1 (en) * 2005-12-30 2007-07-12 Alantos Pharmaceuticals, Holding, Inc. Substituted bis-amide metalloprotease inhibitors
TW200804347A (en) * 2006-01-10 2008-01-16 Janssen Pharmaceutica Nv Urotensin II receptor antagonists
EP2007722A1 (en) * 2006-03-21 2008-12-31 High Point Pharmaceuticals, LLC Adamantane derivatives for the treatment of the metabolic syndrome
KR20090014347A (ko) 2006-04-07 2009-02-10 하이 포인트 파마슈티칼스, 엘엘씨 11β-히드록시스테로이드 탈수소효소 타입 1 활성 화합물
EP2038255A2 (en) * 2006-06-16 2009-03-25 High Point Pharmaceuticals, LLC Pharmaceutical use of substituted piperidine carboxamides
EP1878721A1 (en) * 2006-07-13 2008-01-16 Novo Nordisk A/S 4-Piperidylbenzamides as 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
US8048908B2 (en) * 2006-07-13 2011-11-01 High Point Pharmaceuticals, Llc 11β-hydroxysteroid dehydrogenase type 1 active compounds
CL2007002097A1 (es) * 2006-07-20 2008-01-18 Smithkline Beecham Corp Compuestos derivados de pirrolidina o morfolina antagonistas de urotensina ii; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar insuficiencia cardiaca congestiva, insuficiencia cardiaca isquemica, angina, isquemia del miocardio, vejiga hiperactiva, asma y/o copd, entre otras.
EP2049120A4 (en) 2006-07-31 2011-09-07 Janssen Pharmaceutica Nv UROTENSIN II RECEPTOR ANTAGONISTS
FR2904827B1 (fr) * 2006-08-11 2008-09-19 Sanofi Aventis Sa Derives de 5,6-bisaryl-2-pyridine-carboxamide, leur preparation et leur application en therapeutique comme antiganistes des recepteurs a l'urotensine ii
JP2010510202A (ja) 2006-11-17 2010-04-02 ファイザー株式会社 置換ビシクロカルボキシアミド化合物
ZA200904916B (en) 2007-02-23 2010-09-29 High Point Pharmaceuticals Llc N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
WO2008101907A2 (en) * 2007-02-23 2008-08-28 High Point Pharmaceuticals, Llc N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
JP2010519239A (ja) * 2007-02-23 2010-06-03 ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー 11−ベータ−ヒドロキシステロイドデヒドロゲナーゼの阻害因子としてのn−アドマンチルベンザミド
EP2125704A1 (en) * 2007-02-23 2009-12-02 High Point Pharmaceuticals, LLC N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
CN101652359A (zh) * 2007-03-09 2010-02-17 高点制药有限责任公司 作为羟类固醇脱氢酶抑制剂的吲哚-和苯并咪唑酰胺类
EP2141990A4 (en) * 2007-03-28 2011-07-06 High Point Pharmaceuticals Llc ACTIVE COMPOUNDS ON 11BETA-HSD1
CN101677562A (zh) * 2007-04-11 2010-03-24 高点制药有限责任公司 新化合物
JP2010526777A (ja) * 2007-04-24 2010-08-05 ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー 置換アミドの医薬用途
PA8782701A1 (es) * 2007-06-07 2009-01-23 Janssen Pharmaceutica Nv Antagonistas del receptor de urotensina ii
WO2008156828A2 (en) * 2007-06-20 2008-12-24 Vitae Pharmaceuticals, Inc. Renin inhibitors
WO2009058267A2 (en) * 2007-10-29 2009-05-07 Amgen Inc. Benzomorpholine derivatives and methods of use
WO2009063364A2 (en) * 2007-11-13 2009-05-22 Encysive Pharmaceuticals Inc. Modulators of urotensin receptor and methods of use thereof
FR2927330B1 (fr) 2008-02-07 2010-02-19 Sanofi Aventis Derives de 5,6-bisaryl-2-pyridine-carboxamide, leur preparation et leur application en therapeutique comme antagonistes des recepteurs a l'urotensine ii
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
ATE546448T1 (de) 2008-08-02 2012-03-15 Janssen Pharmaceutica Nv Urotensin-ii-rezeptorantagonisten
EP2632461A4 (en) * 2010-10-29 2014-04-02 Merck Sharp & Dohme Isoindolinone PDE10 INHIBITORS
CN102060811A (zh) * 2011-01-19 2011-05-18 山西大学 单磺酰哌嗪的合成方法
JP2016505000A (ja) 2012-12-21 2016-02-18 エピザイム,インコーポレイティド Prmt5阻害剤およびその使用
EP3406607A1 (en) 2012-12-21 2018-11-28 Epizyme, Inc. Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
JP2016511744A (ja) * 2012-12-21 2016-04-21 エピザイム,インコーポレイティド Prmt5を阻害する方法
UA118548C2 (uk) 2012-12-21 2019-02-11 Епізайм, Інк. Тетрагідро- та дигідроізохіноліни як інгібітори prmt5 та їх застосування
CA2894157A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
US9611257B2 (en) 2012-12-21 2017-04-04 Epizyme, Inc. PRMT5 inhibitors and uses thereof
EP2970266B1 (en) 2013-03-15 2018-01-31 Epizyme, Inc. 1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof
CA2903813C (en) 2013-03-15 2023-08-29 Epizyme, Inc. Carm1 inhibitors and uses thereof
DK3054936T5 (da) 2013-10-10 2024-03-18 Eastern Virginia Medical School 4-((2-hydroxy-3-methoxybenzyl)amino) benzensulfonamid derivater som 12-lipoxygenase inhibitorer
JP6272604B2 (ja) * 2013-12-27 2018-01-31 日本サプリメント株式会社 糖取り込み促進剤
BR112016015449A8 (pt) * 2013-12-30 2020-06-09 Lifesci Pharmaceuticals Inc compostos inibidores terapêuticos, composição farmacêutica os compreendendo e uso dos mesmos
EP3177288A4 (en) 2014-08-04 2018-04-04 Epizyme, Inc. Prmt5 inhibitors and uses thereof
MA41051B1 (fr) 2014-10-06 2020-11-30 Vertex Pharma Modulateurs du régulateur de conductance transmembranaire de la mucoviscidose
WO2016100940A1 (en) 2014-12-19 2016-06-23 The Broad Institute, Inc. Dopamine d2 receptor ligands
US10752588B2 (en) 2014-12-19 2020-08-25 The Broad Institute, Inc. Dopamine D2 receptor ligands
CA3019380A1 (en) 2016-03-31 2017-10-05 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
EP3241874B1 (en) 2016-05-04 2019-08-14 Agfa Nv Acylphosphine oxide photoinitiators
CN109803962B (zh) 2016-09-30 2022-04-29 弗特克斯药品有限公司 囊性纤维化跨膜传导调控蛋白的调节剂、以及药物组合物
MD3551622T2 (ro) 2016-12-09 2021-03-31 Vertex Pharma Modulator al regulatorului conductanței transmembranare în fibroză chistică, compoziții farmaceutice, metode de tratament și procedeu pentru fabricarea modulatorului
CN110494432B (zh) 2016-12-28 2022-08-12 米尼奥尔克斯治疗有限公司 异喹啉化合物,其制备方法及其在与β-半乳糖苷酶活性改变相关的病症中的治疗用途
US12319659B2 (en) 2017-02-24 2025-06-03 Shenzhen Linglan Bio-Pharmaceutical Technology Co., Ltd Selective ligand for dopamine D3 receptor, preparation method therefor, and pharmaceutical application thereof
US11253509B2 (en) 2017-06-08 2022-02-22 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
MA49631A (fr) 2017-07-17 2020-05-27 Vertex Pharma Méthodes de traitement de la fibrose kystique
JP7121794B2 (ja) 2017-08-02 2022-08-18 バーテックス ファーマシューティカルズ インコーポレイテッド ピロリジン化合物を調製するためのプロセス
WO2019079760A1 (en) 2017-10-19 2019-04-25 Vertex Pharmaceuticals Incorporated CRYSTALLINE FORMS AND COMPOSITIONS OF CFTR MODULATORS
EP3720849A2 (en) 2017-12-08 2020-10-14 Vertex Pharmaceuticals Incorporated Processes for making modulators of cystic fibrosis transmembrane conductance regulator
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
EP3774825A1 (en) 2018-04-13 2021-02-17 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
CN110938021A (zh) * 2019-12-18 2020-03-31 荆门市丽康源纺织科技有限公司 一种染料中间体3-(β-羟乙基砜基)苯胺的制备方法
CN111170897A (zh) * 2019-12-18 2020-05-19 荆门市丽康源纺织科技有限公司 一种间位酯的制备方法及间位酯
JP2023542541A (ja) * 2020-09-25 2023-10-10 エサイエント ファーマシューティカルズ,インコーポレイティド Mas関連gタンパク質受容体x2のモジュレーター、並びに関連製品及び方法
CN114890946B (zh) * 2022-05-20 2023-10-27 沈阳药科大学 含有吗啉丙基的[(喹啉-4-基)氨基]苯甲酰胺类化合物及其制备与应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2419199A (en) * 1945-02-09 1947-04-22 Parke Davis & Co Quinoline compounds and process of making same
GB974348A (en) * 1961-01-25 1964-11-04 Parke Davis & Co Basic 7-chloroquinoline-1-oxide derivatives and methods for their production
BE687335A (https=) 1965-12-10 1967-03-01
US3919238A (en) * 1973-06-06 1975-11-11 Morton Norwich Products Inc 9-(Substituted amino)imidazo(4,5-f) quinolines
CH593266A5 (https=) * 1973-09-20 1977-11-30 Delalande Sa
EP0982300A3 (en) * 1998-07-29 2000-03-08 Societe Civile Bioprojet Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications
WO2002062787A1 (en) 2001-02-02 2002-08-15 Glaxo Group Limited Pyrazoles as tgf inhibitors
EP1385495A4 (en) 2001-05-07 2005-12-21 Smithkline Beecham Corp SULPHONAMIDES
WO2002089793A1 (en) 2001-05-07 2002-11-14 Smithkline Beecham Corporation Sulfonamides
AR033879A1 (es) 2001-05-07 2004-01-07 Smithkline Beecham Corp Compuesto sulfonamida, composicion farmaceutica que lo comprende, su uso para preparar dicha composicion y procedimiento para la obtencion de dicho compuesto
JP2004529168A (ja) 2001-05-07 2004-09-24 スミスクライン・ビーチャム・コーポレイション スルホンアミド
JP2004529170A (ja) 2001-05-07 2004-09-24 スミスクライン・ビーチャム・コーポレイション スルホンアミド
JP2004535390A (ja) 2001-05-07 2004-11-25 スミスクライン・ビーチャム・コーポレイション スルホンアミド
CN1627944A (zh) * 2002-01-17 2005-06-15 神经能质公司 取代的喹唑啉-4-基胺类似物作为辣椒辣素调节剂
EP2399903A1 (en) 2002-05-24 2011-12-28 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof
JP2006505533A (ja) 2002-09-17 2006-02-16 アクテリオン ファマシューティカルズ リミテッド 1−ピリジン−4−イル−尿素誘導体

Similar Documents

Publication Publication Date Title
JP2006519258A5 (https=)
JP2013517283A5 (https=)
US6552022B1 (en) Benzamide derivatives and their use as ApoB-100 secretion inhibitors
US7915443B2 (en) Sulfoximines as kinase inhibitors
US20090163482A1 (en) Tetralines antagonists of the h-3 receptor
JP4216196B2 (ja) Npyアンタゴニストとしてのキノリン誘導体
AU2001260310B2 (en) Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists
JP2007509117A5 (https=)
JP2015517981A5 (https=)
AU782191B2 (en) Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists
JP2010506918A5 (https=)
JP2007530459A5 (https=)
EP1305304A1 (en) Carboxamide compounds and their use as antagonists of a human 11cby receptor
JP2007505901A5 (https=)
JP2018522823A5 (https=)
KR20070030271A (ko) 2-카르바미드-4-페닐티아졸 유도체, 그의 제조방법 및 그의치료적 용도
RU2012129737A (ru) Замещенные бензамидные производные
RU95118133A (ru) Гетероциклические соединения, способы их получения и фармацевтическая композиция
CA2473892A1 (en) Novel quinoline derivatives
JP2007519754A5 (https=)
JPWO2005037269A1 (ja) 新規ピペリジン誘導体
RU2009138219A (ru) Новые бензамидные производные и способ их получения
JP2011500697A5 (https=)
JP2005508923A5 (https=)
JPWO2005097738A1 (ja) 新規スルホンアミド誘導体