JP2015517981A5 - - Google Patents

Download PDF

Info

Publication number
JP2015517981A5
JP2015517981A5 JP2014560012A JP2014560012A JP2015517981A5 JP 2015517981 A5 JP2015517981 A5 JP 2015517981A5 JP 2014560012 A JP2014560012 A JP 2014560012A JP 2014560012 A JP2014560012 A JP 2014560012A JP 2015517981 A5 JP2015517981 A5 JP 2015517981A5
Authority
JP
Japan
Prior art keywords
phenyl
trifluoromethyl
chloro
optionally substituted
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014560012A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015517981A (ja
JP6134338B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2013/028150 external-priority patent/WO2013130703A2/en
Publication of JP2015517981A publication Critical patent/JP2015517981A/ja
Publication of JP2015517981A5 publication Critical patent/JP2015517981A5/ja
Application granted granted Critical
Publication of JP6134338B2 publication Critical patent/JP6134338B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014560012A 2012-02-29 2013-02-28 B型肝炎ウイルス共有結合閉環状dna形成の阻害剤およびそれらの使用方法 Expired - Fee Related JP6134338B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261605071P 2012-02-29 2012-02-29
US201261605059P 2012-02-29 2012-02-29
US61/605,071 2012-02-29
US61/605,059 2012-02-29
PCT/US2013/028150 WO2013130703A2 (en) 2012-02-29 2013-02-28 Binhibitors of hepatitis b virus convalently closed circular dna formation and their method of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017083672A Division JP2017165751A (ja) 2012-02-29 2017-04-20 B型肝炎ウイルス共有結合閉環状dna形成の阻害剤およびそれらの使用方法

Publications (3)

Publication Number Publication Date
JP2015517981A JP2015517981A (ja) 2015-06-25
JP2015517981A5 true JP2015517981A5 (https=) 2016-06-16
JP6134338B2 JP6134338B2 (ja) 2017-05-24

Family

ID=49083449

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014560012A Expired - Fee Related JP6134338B2 (ja) 2012-02-29 2013-02-28 B型肝炎ウイルス共有結合閉環状dna形成の阻害剤およびそれらの使用方法
JP2017083672A Pending JP2017165751A (ja) 2012-02-29 2017-04-20 B型肝炎ウイルス共有結合閉環状dna形成の阻害剤およびそれらの使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017083672A Pending JP2017165751A (ja) 2012-02-29 2017-04-20 B型肝炎ウイルス共有結合閉環状dna形成の阻害剤およびそれらの使用方法

Country Status (10)

Country Link
US (1) US9657013B2 (https=)
EP (1) EP2819671A4 (https=)
JP (2) JP6134338B2 (https=)
CN (1) CN104822267B (https=)
AU (2) AU2013226013B2 (https=)
BR (1) BR112014021498A2 (https=)
CA (1) CA2865962A1 (https=)
NZ (1) NZ631419A (https=)
WO (1) WO2013130703A2 (https=)
ZA (1) ZA201407798B (https=)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5977347B2 (ja) 2011-07-01 2016-08-24 バルーク エス.ブルームバーグ インスティテュート Hbv感染に対する抗ウイルス剤としてのスルファモイルベンズアミド誘導体
BR112014015197A8 (pt) 2011-12-21 2017-06-13 Novira Therapeutics Inc agentes antivirais de hepatite b
KR102271574B1 (ko) 2012-08-28 2021-07-01 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 설파모일-아릴아미드 및 b형 간염 치료제로서의 그 용도
EP2900642B1 (en) * 2012-09-27 2018-02-28 F. Hoffmann-La Roche AG Substituted sulfonamide compounds
BR112015015584A2 (pt) 2012-12-27 2017-12-12 Baruch S Blumberg Inst novos agentes antivirais contra infecção por hbv
WO2014131847A1 (en) 2013-02-28 2014-09-04 Janssen R&D Ireland Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b
US8993771B2 (en) 2013-03-12 2015-03-31 Novira Therapeutics, Inc. Hepatitis B antiviral agents
MX353412B (es) 2013-04-03 2018-01-10 Janssen Sciences Ireland Uc Derivados de n-fenil-carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b.
TWI733288B (zh) 2013-05-17 2021-07-11 愛爾蘭商健生科學愛爾蘭無限公司 胺磺醯基吡咯醯胺衍生物及其作為用於治療b型肝炎藥物的用途
HRP20180791T1 (hr) 2013-07-25 2018-09-07 Janssen Sciences Ireland Uc Glioksamid supstituirani derivati pirolamida i njihova uporaba kao lijekova za liječenje hepatitisa b
CA2923712C (en) 2013-10-23 2021-11-02 Janssen Sciences Ireland Uc Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US9181288B2 (en) 2014-01-16 2015-11-10 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US10392349B2 (en) 2014-01-16 2019-08-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
CA2936947A1 (en) 2014-02-05 2015-08-13 Novira Therapeutics, Inc. Combination therapy for treatment of hbv infections
TW201620893A (zh) 2014-02-06 2016-06-16 健生科學愛爾蘭無限公司 磺醯胺基吡咯醯胺衍生物及其用作治療b型肝炎之醫藥品的用途
US9400280B2 (en) 2014-03-27 2016-07-26 Novira Therapeutics, Inc. Piperidine derivatives and methods of treating hepatitis B infections
JP2018510159A (ja) 2015-03-19 2018-04-12 ノヴィラ・セラピューティクス・インコーポレイテッド アゾカン及びアゾナン誘導体及びb型肝炎感染症の治療法
US10442788B2 (en) 2015-04-01 2019-10-15 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2016183266A1 (en) 2015-05-13 2016-11-17 Enanta Pharmaceuticals, Inc. Ehpatitis b antiviral agents
US10875876B2 (en) 2015-07-02 2020-12-29 Janssen Sciences Ireland Uc Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
US10179131B2 (en) 2015-07-13 2019-01-15 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10301255B2 (en) 2015-07-22 2019-05-28 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
TW201718496A (zh) 2015-09-29 2017-06-01 諾維拉治療公司 B型肝炎抗病毒劑之晶型
WO2017136403A1 (en) 2016-02-02 2017-08-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
KR102398439B1 (ko) 2016-03-07 2022-05-16 이난타 파마슈티칼스, 인코포레이티드 B형 간염 항바이러스제
AU2017248828A1 (en) 2016-04-15 2018-11-01 Janssen Sciences Ireland Uc Combinations and methods comprising a capsid assembly inhibitor
CA3028228A1 (en) 2016-06-10 2017-12-14 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
EP3500294A4 (en) 2016-08-22 2020-07-29 Arbutus Biopharma Corporation ANTI-PD-1 ANTIBODIES, OR THEIR FRAGMENTS, FOR THE TREATMENT OF HEPATITIS B
SG11201902944TA (en) 2016-11-07 2019-05-30 Arbutus Biopharma Corp Substituted pyridinone-containing tricyclic compounds, and methods using same
WO2018086530A1 (zh) * 2016-11-08 2018-05-17 正大天晴药业集团股份有限公司 作为cccDNA抑制剂的磺酰胺类化合物
WO2018086531A1 (zh) * 2016-11-08 2018-05-17 正大天晴药业集团股份有限公司 作为cccDNA抑制剂的磺酰胺类化合物
MA49014A (fr) 2017-03-21 2020-02-05 Arbutus Biopharma Corp Dihydroindène-4-carboxamides substitués, leurs analogues et procédés d'utilisation correspondant
SG11202001685TA (en) 2017-08-28 2020-03-30 Enanta Pharm Inc Hepatitis b antiviral agents
WO2019113175A1 (en) 2017-12-06 2019-06-13 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
WO2019113173A1 (en) 2017-12-06 2019-06-13 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
US11058678B2 (en) 2018-01-22 2021-07-13 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
MX2020009531A (es) 2018-03-14 2020-10-05 Janssen Sciences Ireland Unlimited Co Regimen posologico del modulador del ensamblaje de la capside.
WO2019191166A1 (en) 2018-03-29 2019-10-03 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
TWI826492B (zh) 2018-07-27 2023-12-21 加拿大商愛彼特生物製藥公司 經取代四氫環戊[c]吡咯、經取代二氫吡咯,其類似物及使用其之方法
JP2022500466A (ja) 2018-09-21 2022-01-04 エナンタ ファーマシューティカルズ インコーポレイテッド 抗ウイルス剤としての官能化複素環
IL283190B2 (en) 2018-11-21 2025-08-01 Enanta Pharm Inc Functionalized heterocycles as antiviral agents
TW202415643A (zh) 2018-12-12 2024-04-16 加拿大商愛彼特生物製藥公司 經取代之芳基甲基脲類及雜芳基甲基脲類、其類似物及其使用方法
WO2020169784A1 (en) 2019-02-22 2020-08-27 Janssen Sciences Ireland Unlimited Company Amide derivatives useful in the treatment of hbv infection or hbv-induced diseases
AR119732A1 (es) 2019-05-06 2022-01-05 Janssen Sciences Ireland Unlimited Co Derivados de amida útiles en el tratamiento de la infección por vhb o de enfermedades inducidas por vhb
WO2020247444A1 (en) 2019-06-03 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
WO2020247575A1 (en) * 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
WO2020247561A1 (en) * 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
US11738019B2 (en) 2019-07-11 2023-08-29 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
US11236108B2 (en) 2019-09-17 2022-02-01 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
WO2021188414A1 (en) 2020-03-16 2021-09-23 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
JP2024508817A (ja) * 2021-02-24 2024-02-28 エフ. ホフマン-ラ ロシュ アーゲー B型肝炎ウイルス感染症の処置および予防のためのベンゾチアゾリルビシクロ[1.1.1]ペンタン誘導体

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU567140B2 (en) 1984-01-06 1987-11-12 Shionogi & Co., Ltd. Sulphonamido-benzamide derivatives
FR2743073B1 (fr) * 1995-12-29 1998-02-20 Fournier Ind & Sante Nouveaux composes de 1-benzenesulfonylpyrrolidine, procede de preparation et utilisation en therapeutique
JP4467648B2 (ja) * 1997-03-14 2010-05-26 スミスクライン・ビーチャム・コーポレイション 新規インドールカルボキサミド、医薬組成物およびカルパインの阻害方法
JPH11292840A (ja) * 1998-04-06 1999-10-26 Soyaku Gijutsu Kenkyusho:Kk ノルスタチン誘導体又はその塩
DE19907532A1 (de) 1999-02-22 2000-08-31 Basf Ag Verfahren zur Herstellung von Acetylenalkoholen und deren Folgeprodukten
FR2790260B1 (fr) * 1999-02-26 2001-05-04 Fournier Ind & Sante Nouveaux composes de n-(benzenesulfonamide), procede de preparation et utilisation en therapeutique
NZ514453A (en) * 1999-02-26 2003-04-29 Merck & Co Inc Novel sulfonamide compounds and uses thereof
EP1314733A1 (en) * 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
US6759428B2 (en) * 2001-12-04 2004-07-06 Roche Palo Alto Llc Indole nitriles
EP1680431A1 (en) * 2003-10-17 2006-07-19 Rigel Pharmaceuticals, Inc. Benzothiazole and thiazole'5,5-b!pyridine compositions and their use as ubiquitin ligase inhibitors
WO2006004622A2 (en) 2004-06-25 2006-01-12 The Burnham Institute Inhibition of bid-induced cell-death using small organic molecules
US20070225322A1 (en) 2005-05-25 2007-09-27 Transoral Pharmaceuticals, Inc. Compositions and methods for treating middle-of-the night insomnia
US8143288B2 (en) * 2005-06-06 2012-03-27 Bristol-Myers Squibb Company Inhibitors of HCV replication
EP1981845A2 (en) * 2006-02-08 2008-10-22 Wyeth Sulfonamide derivatives to treat infection with hepatitis c virus
TW200817319A (en) * 2006-08-10 2008-04-16 Astellas Pharma Inc Sulfonamide compound or salt thereof
CN101134769A (zh) * 2006-08-28 2008-03-05 曾昭斌 熊去氧胆酸恩替卡韦酰胺及其制法和用途
JP2010520200A (ja) * 2007-02-28 2010-06-10 クオナトウス ファーマシューティカルズ,インコーポレイテッド 特定のマトリックスメタロプロテイナーゼ(mmp)阻害剤を使用する肝疾患を治療する方法
JP5383484B2 (ja) * 2007-04-24 2014-01-08 塩野義製薬株式会社 環式基で置換されたアミノジヒドロチアジン誘導体
WO2009032116A1 (en) 2007-08-29 2009-03-12 Schering Corporation 2, 3-substituted indole derivatives for treating viral infections
WO2009086303A2 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
ES2527589T3 (es) * 2008-04-24 2015-01-27 Msd K.K. Inhibidor de la enzima de elongación de ácidos grasos de cadena larga que comprende un derivado de arilsulfonilo como principio activo
JPWO2009133863A1 (ja) * 2008-04-28 2011-09-01 国立大学法人浜松医科大学 Ep1アゴニストを含有してなる免疫増強剤
DE102008061214A1 (de) * 2008-12-09 2010-06-10 Merck Patent Gmbh Chinazolinamidderivate
WO2010141805A1 (en) * 2009-06-05 2010-12-09 Janssen Pharmaceutica Nv Heterocyclic amides as modulators of trpa1
WO2011041713A2 (en) 2009-10-02 2011-04-07 Glaxosmithkline Llc Piperazinyl antiviral agents
WO2011050284A1 (en) * 2009-10-23 2011-04-28 Glaxosmithkline Llc Pyrazolylpyridine antiviral agents
EA201200823A1 (ru) * 2009-12-08 2013-02-28 Новартис Аг Гетероциклические производные сульфонамидов
CA2798330A1 (en) * 2010-05-05 2011-11-10 Infinity Pharmaceuticals, Inc. Tetrazolones as inhibitors of fatty acid synthase
WO2012037108A1 (en) 2010-09-13 2012-03-22 Glaxosmithkline Llc Aminoquinoline derivatives as antiviral agents

Similar Documents

Publication Publication Date Title
JP2015517981A5 (https=)
JP2018522823A5 (https=)
RU2264389C2 (ru) Азотсодержащие ароматические производные, их применение, лекарственное средство на их основе и способ лечения
RU2201927C2 (ru) Амидиновые соединения и фармацевтическая композиция, обладающая фактор ха ингибирующим действием
RU2010101633A (ru) Новое сульфонамидное производное малоновой кислоты и его фармацевтическое применение
JP2004504301A5 (https=)
HRP20181076T1 (hr) Pirazolski derivati kao modulatori kalcijevih kanala aktiviranih oslobađanjem kalcija
JP2013505903A5 (https=)
RU2013130925A (ru) Оксимовые соединения в качестве средств для повышения уровня холестерина высокой плотности
RU2009148673A (ru) Производные пиразинона и их применение для лечения легочных заболеваний
JP2010505881A5 (https=)
JP2009526072A5 (https=)
RU2017145650A (ru) Ингибиторы тирозинкиназы брутона
JP2017530185A5 (https=)
JP2017533968A5 (https=)
JP2016503786A5 (https=)
RU2009140465A (ru) Имидазохинолины с иммуномодулирующими свойствами
JP2011529037A5 (https=)
JP2012510989A5 (https=)
JP2006519258A5 (https=)
JP2017525757A5 (https=)
JP2017511794A5 (https=)
JP2005526723A5 (https=)
JP2012525336A5 (https=)
JP2016534134A5 (https=)