CN104822267B - 乙型肝炎病毒共价闭合环状dna形成的抑制剂及其使用方法 - Google Patents

乙型肝炎病毒共价闭合环状dna形成的抑制剂及其使用方法 Download PDF

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CN104822267B
CN104822267B CN201380011882.5A CN201380011882A CN104822267B CN 104822267 B CN104822267 B CN 104822267B CN 201380011882 A CN201380011882 A CN 201380011882A CN 104822267 B CN104822267 B CN 104822267B
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phenyl
trifluoromethyl
chloro
acetamide
ylmethyl
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CN104822267A (zh
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安德烈亚·库科纳蒂
郭海涛
蒂莫西·M·布勒克
郭巨涛
徐晓东
陆华刚
蔡大为
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Drexel University
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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CN201380011882.5A 2012-02-29 2013-02-28 乙型肝炎病毒共价闭合环状dna形成的抑制剂及其使用方法 Expired - Fee Related CN104822267B (zh)

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PCT/US2013/028150 WO2013130703A2 (en) 2012-02-29 2013-02-28 Binhibitors of hepatitis b virus convalently closed circular dna formation and their method of use

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