JP2006519258A - ピリジン、ピリミジン、キノリン、キナゾリンおよびナフタレン系のウロテンシン−ｉｉ受容体拮抗薬 - Google Patents

ピリジン、ピリミジン、キノリン、キナゾリンおよびナフタレン系のウロテンシン−ｉｉ受容体拮抗薬 Download PDF

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JP2006519258A
JP2006519258A JP2006508787A JP2006508787A JP2006519258A JP 2006519258 A JP2006519258 A JP 2006519258A JP 2006508787 A JP2006508787 A JP 2006508787A JP 2006508787 A JP2006508787 A JP 2006508787A JP 2006519258 A JP2006519258 A JP 2006519258A
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Prior art keywords
methylquinolin
compound
ethyl
ylamino
amine
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JP2006508787A
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Japanese (ja)
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JP2006519258A5 (https=
Inventor
ウー，チヨントー
アンダーソン，エリツク・シー
ブイ，ホーン
ガオー，ダシン
ホランド，ジヨージ・ダブリユ
カシル，ジヤマール
リー，ウエン
ワン，ユンメイ
デユプレ，ブライアン
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Encysive Pharmaceuticals Inc
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Encysive Pharmaceuticals Inc
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Publication of JP2006519258A publication Critical patent/JP2006519258A/ja
Publication of JP2006519258A5 publication Critical patent/JP2006519258A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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JP2006508787A 2003-02-28 2004-02-20 ピリジン、ピリミジン、キノリン、キナゾリンおよびナフタレン系のウロテンシン−ｉｉ受容体拮抗薬 Withdrawn JP2006519258A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45108903P 2003-02-28 2003-02-28
PCT/US2004/005150 WO2004078114A2 (en) 2003-02-28 2004-02-20 Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-ii receptor antagonists.

Publications (2)

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JP2006519258A true JP2006519258A (ja) 2006-08-24
JP2006519258A5 JP2006519258A5 (https=) 2007-03-29

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Country Status (6)

Country Link
US (2) US7265122B2 (https=)
EP (1) EP1603884A4 (https=)
JP (1) JP2006519258A (https=)
AU (1) AU2004218456A1 (https=)
CA (1) CA2517166A1 (https=)
WO (1) WO2004078114A2 (https=)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009544623A (ja) * 2006-07-20 2009-12-17 スミスクライン・ビーチャム・コーポレイション モルホリニルおよびピロリジニル類似体
JP2010529126A (ja) * 2007-06-07 2010-08-26 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ウロテンシンｉｉ受容体拮抗薬
JP2011511046A (ja) * 2008-02-07 2011-04-07 サノフイ−アベンテイス ５，６−ビスアリール−２−ピリジン−カルボキシアミド誘導体、この調製、およびウロテンシンｉｉ受容体の拮抗剤としてのこの治療的用途
JP2013060473A (ja) * 2006-01-10 2013-04-04 Janssen Pharmaceutica Nv ウロテンシンｉｉ受容体拮抗薬
JP2015127304A (ja) * 2013-12-27 2015-07-09 日本サプリメント株式会社 糖取り込み促進剤
JP2017501205A (ja) * 2013-12-30 2017-01-12 ライフサイ ファーマシューティカルズ，インク． 治療用阻害化合物
JP2020509088A (ja) * 2017-02-24 2020-03-26 深▲チェン▼市霊蘭生物医薬科技有限公司Ｓｈｅｎｚｈｅｎ Ｌｉｎｇｌａｎ Ｂｉｏ−Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ 新規なドーパミンｄ３受容体選択的リガンド及びびその調製方法並びに医薬使用
JP2023542541A (ja) * 2020-09-25 2023-10-10 エサイエント ファーマシューティカルズ，インコーポレイティド Ｍａｓ関連ｇタンパク質受容体ｘ２のモジュレーター、並びに関連製品及び方法

Families Citing this family (65)

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AU2004253967B2 (en) 2003-07-03 2010-02-18 Cytovia, Inc. 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis
US8309562B2 (en) 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
JP2007518823A (ja) 2004-01-23 2007-07-12 アムゲン インコーポレイテッド キノリン、キナゾリン、ピリジン、及びピリミジン化合物と炎症、血管新生、及び癌に対する治療におけるそれら化合物の用途
GEP20084439B (en) 2004-01-23 2008-07-25 Amgen Inc Nitrogen-containing heterocyclic derivatives and pharmaceutical use thereof
PL1756084T3 (pl) * 2004-06-04 2009-06-30 Arena Pharm Inc Podstawione pochodne arylowe i heteroarylowe jako modulatory metabolizmu oraz profilaktyka i leczenie zaburzeń z metabolizmem związanych
EP1802623A1 (en) * 2004-10-12 2007-07-04 Novo Nordisk A/S 11beta-hydroxysteroid dehydrogenase type 1 active spiro compounds
JP2008521900A (ja) 2004-11-30 2008-06-26 アムジエン・インコーポレーテツド キノリン及びキナゾリン類似体並びにがん治療のための医薬としてのその使用
GT200500375A (es) * 2004-12-20 2006-11-28 Derivados de piperidina y su uso como agentes antiinflamatorios
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
JO2787B1 (en) 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
US7709516B2 (en) * 2005-06-17 2010-05-04 Endorecherche, Inc. Helix 12 directed non-steroidal antiandrogens
KR20080069189A (ko) * 2005-11-01 2008-07-25 트랜스테크 파르마, 인크. 치환된 아미드의 약학적 사용
EA200801243A1 (ru) * 2005-11-01 2008-10-30 Транстек Фарма Фармацевтическое применение замещенных амидов
AU2006332694A1 (en) * 2005-12-30 2007-07-12 Alantos Pharmaceuticals, Holding, Inc. Substituted bis-amide metalloprotease inhibitors
JP2009530346A (ja) * 2006-03-21 2009-08-27 ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー メタボリックシンドロームの治療用のアダマンタン誘導体
KR20090014347A (ko) 2006-04-07 2009-02-10 하이 포인트 파마슈티칼스, 엘엘씨 11β-히드록시스테로이드 탈수소효소 타입 1 활성 화합물
EP2038255A2 (en) * 2006-06-16 2009-03-25 High Point Pharmaceuticals, LLC Pharmaceutical use of substituted piperidine carboxamides
EP1878721A1 (en) * 2006-07-13 2008-01-16 Novo Nordisk A/S 4-Piperidylbenzamides as 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
WO2008006702A1 (en) * 2006-07-13 2008-01-17 High Point Pharmaceuticals, Llc. 11beta-hydroxysteroid dehydrogenase type 1 active compounds
WO2008016534A1 (en) 2006-07-31 2008-02-07 Janssen Pharmaceutica, N.V. Urotensin ii receptor antagonists
FR2904827B1 (fr) 2006-08-11 2008-09-19 Sanofi Aventis Sa Derives de 5,6-bisaryl-2-pyridine-carboxamide, leur preparation et leur application en therapeutique comme antiganistes des recepteurs a l'urotensine ii
WO2008059370A2 (en) 2006-11-17 2008-05-22 Pfizer Japan Inc. Substituted bicyclocarboxyamide compounds
WO2008101885A1 (en) * 2007-02-23 2008-08-28 High Point Pharmaceuticals, Llc N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
EP2129652A2 (en) * 2007-02-23 2009-12-09 High Point Pharmaceuticals, LLC N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
EP2150526B1 (en) 2007-02-23 2017-09-20 vTv Therapeutics LLC N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
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