JP2006519258A - ピリジン、ピリミジン、キノリン、キナゾリンおよびナフタレン系のウロテンシン−ｉｉ受容体拮抗薬 - Google Patents
ピリジン、ピリミジン、キノリン、キナゾリンおよびナフタレン系のウロテンシン−ｉｉ受容体拮抗薬 Download PDFInfo
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- JP2006519258A JP2006519258A JP2006508787A JP2006508787A JP2006519258A JP 2006519258 A JP2006519258 A JP 2006519258A JP 2006508787 A JP2006508787 A JP 2006508787A JP 2006508787 A JP2006508787 A JP 2006508787A JP 2006519258 A JP2006519258 A JP 2006519258A
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- Prior art keywords
- methylquinolin
- compound
- ethyl
- ylamino
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108050002984 Urotensin II receptors Proteins 0.000 title claims description 11
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title description 5
- 239000002464 receptor antagonist Substances 0.000 title description 3
- 229940044551 receptor antagonist Drugs 0.000 title description 3
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- RJUCSJZWSQCMNR-UHFFFAOYSA-N 1-[1-[2-[3-[(2-methylquinolin-4-yl)amino]phenoxy]ethyl]-4-phenylpiperidin-4-yl]ethanone Chemical compound C1CN(CCOC=2C=C(NC=3C4=CC=CC=C4N=C(C)C=3)C=CC=2)CCC1(C(=O)C)C1=CC=CC=C1 RJUCSJZWSQCMNR-UHFFFAOYSA-N 0.000 claims description 2
- 125000004898 2,2-dimethylpropylamino group Chemical group CC(CN*)(C)C 0.000 claims description 2
- MUEUNYKUKXVLEE-UHFFFAOYSA-N 4-[[2-[[3-[(2-methylquinolin-4-yl)amino]benzoyl]amino]ethylamino]methyl]benzoic acid Chemical compound C=12C=CC=CC2=NC(C)=CC=1NC(C=1)=CC=CC=1C(=O)NCCNCC1=CC=C(C(O)=O)C=C1 MUEUNYKUKXVLEE-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A61P9/06—Antiarrhythmics
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- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45108903P | 2003-02-28 | 2003-02-28 | |
| PCT/US2004/005150 WO2004078114A2 (en) | 2003-02-28 | 2004-02-20 | Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-ii receptor antagonists. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006519258A true JP2006519258A (ja) | 2006-08-24 |
| JP2006519258A5 JP2006519258A5 (https=) | 2007-03-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2006508787A Withdrawn JP2006519258A (ja) | 2003-02-28 | 2004-02-20 | ピリジン、ピリミジン、キノリン、キナゾリンおよびナフタレン系のウロテンシン−ｉｉ受容体拮抗薬 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7265122B2 (https=) |
| EP (1) | EP1603884A4 (https=) |
| JP (1) | JP2006519258A (https=) |
| AU (1) | AU2004218456A1 (https=) |
| CA (1) | CA2517166A1 (https=) |
| WO (1) | WO2004078114A2 (https=) |
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| JP2010529126A (ja) * | 2007-06-07 | 2010-08-26 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ウロテンシンｉｉ受容体拮抗薬 |
| JP2011511046A (ja) * | 2008-02-07 | 2011-04-07 | サノフイ−アベンテイス | ５，６−ビスアリール−２−ピリジン−カルボキシアミド誘導体、この調製、およびウロテンシンｉｉ受容体の拮抗剤としてのこの治療的用途 |
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| JP2004529170A (ja) | 2001-05-07 | 2004-09-24 | スミスクライン・ビーチャム・コーポレイション | スルホンアミド |
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| CN1627944A (zh) * | 2002-01-17 | 2005-06-15 | 神经能质公司 | 取代的喹唑啉－4－基胺类似物作为辣椒辣素调节剂 |
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2004
- 2004-02-20 EP EP04713383A patent/EP1603884A4/en not_active Withdrawn
- 2004-02-20 AU AU2004218456A patent/AU2004218456A1/en not_active Abandoned
- 2004-02-20 CA CA002517166A patent/CA2517166A1/en not_active Abandoned
- 2004-02-20 JP JP2006508787A patent/JP2006519258A/ja not_active Withdrawn
- 2004-02-20 US US10/783,916 patent/US7265122B2/en not_active Expired - Fee Related
- 2004-02-20 WO PCT/US2004/005150 patent/WO2004078114A2/en not_active Ceased
-
2007
- 2007-05-25 US US11/807,047 patent/US20080004312A1/en not_active Abandoned
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2013060473A (ja) * | 2006-01-10 | 2013-04-04 | Janssen Pharmaceutica Nv | ウロテンシンｉｉ受容体拮抗薬 |
| JP2009544623A (ja) * | 2006-07-20 | 2009-12-17 | スミスクライン・ビーチャム・コーポレイション | モルホリニルおよびピロリジニル類似体 |
| JP2010529126A (ja) * | 2007-06-07 | 2010-08-26 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ウロテンシンｉｉ受容体拮抗薬 |
| JP2011511046A (ja) * | 2008-02-07 | 2011-04-07 | サノフイ−アベンテイス | ５，６−ビスアリール−２−ピリジン−カルボキシアミド誘導体、この調製、およびウロテンシンｉｉ受容体の拮抗剤としてのこの治療的用途 |
| JP2015127304A (ja) * | 2013-12-27 | 2015-07-09 | 日本サプリメント株式会社 | 糖取り込み促進剤 |
| JP2017501205A (ja) * | 2013-12-30 | 2017-01-12 | ライフサイ ファーマシューティカルズ，インク． | 治療用阻害化合物 |
| JP2020509088A (ja) * | 2017-02-24 | 2020-03-26 | 深▲チェン▼市霊蘭生物医薬科技有限公司Ｓｈｅｎｚｈｅｎ Ｌｉｎｇｌａｎ Ｂｉｏ−Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ | 新規なドーパミンｄ３受容体選択的リガンド及びびその調製方法並びに医薬使用 |
| JP7017797B2 (ja) | 2017-02-24 | 2022-02-09 | 深▲チェン▼市霊蘭生物医薬科技有限公司 | 新規なドーパミンｄ３受容体選択的リガンド及びびその調製方法並びに医薬使用 |
| JP2023542541A (ja) * | 2020-09-25 | 2023-10-10 | エサイエント ファーマシューティカルズ，インコーポレイティド | Ｍａｓ関連ｇタンパク質受容体ｘ２のモジュレーター、並びに関連製品及び方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004078114A2 (en) | 2004-09-16 |
| US20080004312A1 (en) | 2008-01-03 |
| EP1603884A2 (en) | 2005-12-14 |
| WO2004078114A3 (en) | 2005-02-17 |
| CA2517166A1 (en) | 2004-09-16 |
| US20040186102A1 (en) | 2004-09-23 |
| US7265122B2 (en) | 2007-09-04 |
| AU2004218456A1 (en) | 2004-09-16 |
| EP1603884A4 (en) | 2008-05-28 |
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