JP2005507637A5 - - Google Patents
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- Publication number
- JP2005507637A5 JP2005507637A5 JP2002568744A JP2002568744A JP2005507637A5 JP 2005507637 A5 JP2005507637 A5 JP 2005507637A5 JP 2002568744 A JP2002568744 A JP 2002568744A JP 2002568744 A JP2002568744 A JP 2002568744A JP 2005507637 A5 JP2005507637 A5 JP 2005507637A5
- Authority
- JP
- Japan
- Prior art keywords
- propeptide
- modified
- gdf
- pharmaceutical composition
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 claims 73
- 108010056852 Myostatin Proteins 0.000 claims 73
- 239000008194 pharmaceutical composition Substances 0.000 claims 54
- 102100040898 Growth/differentiation factor 11 Human genes 0.000 claims 53
- 101710194452 Growth/differentiation factor 11 Proteins 0.000 claims 53
- 150000007523 nucleic acids Chemical class 0.000 claims 39
- 108020004707 nucleic acids Proteins 0.000 claims 36
- 102000039446 nucleic acids Human genes 0.000 claims 36
- 125000003275 alpha amino acid group Chemical group 0.000 claims 27
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 21
- 208000035475 disorder Diseases 0.000 claims 21
- 230000000087 stabilizing effect Effects 0.000 claims 21
- 102000009027 Albumins Human genes 0.000 claims 14
- 108010088751 Albumins Proteins 0.000 claims 14
- 238000000034 method Methods 0.000 claims 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- 239000002299 complementary DNA Substances 0.000 claims 12
- 230000035772 mutation Effects 0.000 claims 12
- 239000002773 nucleotide Substances 0.000 claims 12
- 125000003729 nucleotide group Chemical group 0.000 claims 12
- 230000006337 proteolytic cleavage Effects 0.000 claims 12
- 238000000338 in vitro Methods 0.000 claims 8
- 238000001727 in vivo Methods 0.000 claims 8
- 125000000837 carbohydrate group Chemical group 0.000 claims 7
- 230000013595 glycosylation Effects 0.000 claims 7
- 238000006206 glycosylation reaction Methods 0.000 claims 7
- 235000018102 proteins Nutrition 0.000 claims 7
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 108091034117 Oligonucleotide Proteins 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 6
- 208000021642 Muscular disease Diseases 0.000 claims 5
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 5
- 208000030159 metabolic disease Diseases 0.000 claims 5
- 201000006938 muscular dystrophy Diseases 0.000 claims 5
- 208000018360 neuromuscular disease Diseases 0.000 claims 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims 5
- 229920000642 polymer Polymers 0.000 claims 5
- 238000002360 preparation method Methods 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 206010002329 Aneurysm Diseases 0.000 claims 3
- 206010006895 Cachexia Diseases 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 208000008589 Obesity Diseases 0.000 claims 3
- 208000011623 Obstructive Lung disease Diseases 0.000 claims 3
- 208000001132 Osteoporosis Diseases 0.000 claims 3
- 208000026062 Tissue disease Diseases 0.000 claims 3
- 210000000577 adipose tissue Anatomy 0.000 claims 3
- 210000000988 bone and bone Anatomy 0.000 claims 3
- 230000003412 degenerative effect Effects 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000003387 muscular Effects 0.000 claims 3
- 201000000585 muscular atrophy Diseases 0.000 claims 3
- 235000020824 obesity Nutrition 0.000 claims 3
- 238000000746 purification Methods 0.000 claims 3
- 208000001076 sarcopenia Diseases 0.000 claims 3
- 208000011580 syndromic disease Diseases 0.000 claims 3
- 201000009623 Myopathy Diseases 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26750901P | 2001-02-08 | 2001-02-08 | |
| PCT/US2002/003467 WO2002068650A2 (en) | 2001-02-08 | 2002-02-08 | Modified and stabilized gdf propeptides and uses thereof |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005209321A Division JP2006001938A (ja) | 2001-02-08 | 2005-07-19 | 改変され安定化されたｇｄｆプロペプチドおよびその使用 |
| JP2008298812A Division JP5013618B2 (ja) | 2001-02-08 | 2008-11-21 | 改変され安定化されたｇｄｆプロペプチドおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005507637A JP2005507637A (ja) | 2005-03-24 |
| JP2005507637A5 true JP2005507637A5 (enExample) | 2006-01-05 |
| JP4280071B2 JP4280071B2 (ja) | 2009-06-17 |
Family
ID=23019083
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002568744A Expired - Fee Related JP4280071B2 (ja) | 2001-02-08 | 2002-02-08 | 改変され安定化されたｇｄｆプロペプチドおよびその使用 |
| JP2005209321A Withdrawn JP2006001938A (ja) | 2001-02-08 | 2005-07-19 | 改変され安定化されたｇｄｆプロペプチドおよびその使用 |
| JP2008298812A Expired - Fee Related JP5013618B2 (ja) | 2001-02-08 | 2008-11-21 | 改変され安定化されたｇｄｆプロペプチドおよびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005209321A Withdrawn JP2006001938A (ja) | 2001-02-08 | 2005-07-19 | 改変され安定化されたｇｄｆプロペプチドおよびその使用 |
| JP2008298812A Expired - Fee Related JP5013618B2 (ja) | 2001-02-08 | 2008-11-21 | 改変され安定化されたｇｄｆプロペプチドおよびその使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (6) | US7202210B2 (enExample) |
| EP (1) | EP1397492B1 (enExample) |
| JP (3) | JP4280071B2 (enExample) |
| AR (1) | AR032567A1 (enExample) |
| AT (1) | ATE357519T1 (enExample) |
| AU (1) | AU2002243852B2 (enExample) |
| BR (1) | BR0207110A (enExample) |
| CA (2) | CA2674673A1 (enExample) |
| CL (1) | CL2009000648A1 (enExample) |
| CY (1) | CY1106629T1 (enExample) |
| DE (1) | DE60219006T2 (enExample) |
| DK (1) | DK1397492T3 (enExample) |
| ES (1) | ES2284828T3 (enExample) |
| MX (1) | MXPA03007063A (enExample) |
| NO (1) | NO333427B1 (enExample) |
| NZ (2) | NZ527286A (enExample) |
| PL (2) | PL212078B1 (enExample) |
| PT (1) | PT1397492E (enExample) |
| SG (2) | SG165982A1 (enExample) |
| TW (2) | TWI329129B (enExample) |
| WO (1) | WO2002068650A2 (enExample) |
| ZA (2) | ZA200508954B (enExample) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI329129B (en) | 2001-02-08 | 2010-08-21 | Wyeth Corp | Modified and stabilized gdf propeptides and uses thereof |
| US7320789B2 (en) * | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| JP4429728B2 (ja) * | 2002-02-21 | 2010-03-10 | ワイス エルエルシー | フォリスタチン（ｆｏｌｌｉｓｔａｔｉｎ）ドメイン含有タンパク質 |
| BR0307907A2 (pt) * | 2002-02-21 | 2011-07-05 | Wyeth Corp | gasp1: proteìna contendo domìnio de folistatina |
| EP1578928B1 (en) * | 2002-09-16 | 2010-03-17 | The Johns Hopkins University | Metalloprotease activation of myostatin, and methods of modulating myostatin activity |
| US7261893B2 (en) | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
| US20040223966A1 (en) * | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
| AU2003225410A1 (en) * | 2003-03-21 | 2004-10-11 | Academisch Ziekenhuis Leiden | Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure |
| JP5110877B2 (ja) | 2003-06-02 | 2012-12-26 | ワイス・エルエルシー | 神経筋障害を処置するための、コルチコステロイドと組み合わせたミオスタチン（ｇｄｆ８）インヒビターの使用 |
| EP3489257A1 (en) | 2004-07-23 | 2019-05-29 | Acceleron Pharma Inc. | Actrii receptor polypeptides, methods and compositions |
| MX2007000976A (es) * | 2004-08-12 | 2007-04-10 | Wyeth Corp | Tratamiento combinado para diabetes, obesidad y enfermedades cardiovasculares utilizando inhibidores del factor 8 de crecimiento y diferenciacion. |
| TWI384069B (zh) | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
| US7300773B2 (en) | 2004-08-27 | 2007-11-27 | Wyeth Research Ireland Limited | Production of TNFR-Ig |
| TWI374935B (en) | 2004-08-27 | 2012-10-21 | Pfizer Ireland Pharmaceuticals | Production of α-abeta |
| US8088508B2 (en) | 2005-01-31 | 2012-01-03 | Panasonic Corporation | Thermal battery |
| US20060216279A1 (en) * | 2005-03-22 | 2006-09-28 | Glass David J | Myostatin inhibiting fusion polypeptides and therapeutic methods thereof |
| EP1864138A2 (en) * | 2005-03-23 | 2007-12-12 | Wyeth | Detection of gdf-8 modulating agents |
| CN101137906A (zh) * | 2005-03-23 | 2008-03-05 | 惠氏公司 | 对gdf-8调节剂的免疫应答的检测 |
| EP2781222B1 (en) | 2005-11-23 | 2017-08-02 | Acceleron Pharma, Inc. | Activin-actriia antagonists in use for promoting bone growth |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| US20070190056A1 (en) * | 2006-02-07 | 2007-08-16 | Ravi Kambadur | Muscle regeneration compositions and uses therefor |
| JP5564249B2 (ja) * | 2006-06-23 | 2014-07-30 | アレシア・バイオセラピューティクス・インコーポレーテッド | 癌に関与するポリヌクレオチド配列およびポリペプチド配列 |
| JP6047270B2 (ja) | 2006-08-11 | 2016-12-21 | バイオマリン テクノロジーズ ベー．フェー． | Ｄｎａリピートの不安定性に関連した遺伝的障害を治療するための方法及び手段 |
| US20100028332A1 (en) * | 2006-12-18 | 2010-02-04 | Acceleron Pharma Inc. | Antagonists of actriib and uses for increasing red blood cell levels |
| WO2008076437A2 (en) * | 2006-12-18 | 2008-06-26 | Acceleron Pharma Inc. | Activin-actrii antagonists and uses for increasing red blood cell levels |
| US8895016B2 (en) * | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
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| JP2010539236A (ja) | 2007-09-18 | 2010-12-16 | アクセルロン ファーマ， インコーポレイテッド | アクチビン−ＡｃｔＲＩＩａ拮抗薬およびＦＳＨ分泌を低減または阻害するための使用 |
| EP2203173B1 (en) | 2007-10-26 | 2015-12-23 | Academisch Ziekenhuis Leiden | Means and methods for counteracting muscle disorders |
| USRE48468E1 (en) | 2007-10-26 | 2021-03-16 | Biomarin Technologies B.V. | Means and methods for counteracting muscle disorders |
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