JP2005534616A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005534616A5 JP2005534616A5 JP2003571403A JP2003571403A JP2005534616A5 JP 2005534616 A5 JP2005534616 A5 JP 2005534616A5 JP 2003571403 A JP2003571403 A JP 2003571403A JP 2003571403 A JP2003571403 A JP 2003571403A JP 2005534616 A5 JP2005534616 A5 JP 2005534616A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- gasp1
- disorder
- modification
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 51
- 102100036001 G-protein coupled receptor-associated sorting protein 1 Human genes 0.000 claims 23
- 101001021410 Homo sapiens G-protein coupled receptor-associated sorting protein 1 Proteins 0.000 claims 18
- 230000004048 modification Effects 0.000 claims 15
- 238000012986 modification Methods 0.000 claims 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 13
- 208000035475 disorder Diseases 0.000 claims 11
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 101710142641 G-protein coupled receptor-associated sorting protein 1 Proteins 0.000 claims 5
- 101710160038 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 Proteins 0.000 claims 5
- 210000003205 muscle Anatomy 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 102000009027 Albumins Human genes 0.000 claims 4
- 108010088751 Albumins Proteins 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 102000016970 Follistatin Human genes 0.000 claims 4
- 108010014612 Follistatin Proteins 0.000 claims 4
- 208000021642 Muscular disease Diseases 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 238000012217 deletion Methods 0.000 claims 4
- 230000037430 deletion Effects 0.000 claims 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
- 201000000585 muscular atrophy Diseases 0.000 claims 4
- 201000006938 muscular dystrophy Diseases 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 206010003694 Atrophy Diseases 0.000 claims 3
- 206010028289 Muscle atrophy Diseases 0.000 claims 3
- 102000004472 Myostatin Human genes 0.000 claims 3
- 108010056852 Myostatin Proteins 0.000 claims 3
- 208000001132 Osteoporosis Diseases 0.000 claims 3
- 230000037444 atrophy Effects 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 230000000087 stabilizing effect Effects 0.000 claims 3
- 238000009007 Diagnostic Kit Methods 0.000 claims 2
- 102000004877 Insulin Human genes 0.000 claims 2
- 108090001061 Insulin Proteins 0.000 claims 2
- 208000010316 Myotonia congenita Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 150000001720 carbohydrates Chemical group 0.000 claims 2
- 208000003295 carpal tunnel syndrome Diseases 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 201000009338 distal myopathy Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 230000013595 glycosylation Effects 0.000 claims 2
- 238000006206 glycosylation reaction Methods 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 229940125396 insulin Drugs 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 230000020763 muscle atrophy Effects 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 230000001314 paroxysmal effect Effects 0.000 claims 2
- 230000006320 pegylation Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 230000002028 premature Effects 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 230000008733 trauma Effects 0.000 claims 2
- 102100021277 Beta-secretase 2 Human genes 0.000 claims 1
- 101710150190 Beta-secretase 2 Proteins 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- 208000037141 Congenital muscular dystrophy, Fukuyama type Diseases 0.000 claims 1
- 208000029323 Congenital myotonia Diseases 0.000 claims 1
- 208000035810 Denervation atrophy Diseases 0.000 claims 1
- 208000001441 Familial Periodic Paralyses Diseases 0.000 claims 1
- 208000036119 Frailty Diseases 0.000 claims 1
- 201000006813 Fukuyama congenital muscular dystrophy Diseases 0.000 claims 1
- 208000002705 Glucose Intolerance Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 201000010743 Lambert-Eaton myasthenic syndrome Diseases 0.000 claims 1
- 208000002720 Malnutrition Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 208000029725 Metabolic bone disease Diseases 0.000 claims 1
- 206010028372 Muscular weakness Diseases 0.000 claims 1
- 206010028424 Myasthenic syndrome Diseases 0.000 claims 1
- 206010028629 Myoglobinuria Diseases 0.000 claims 1
- 201000009623 Myopathy Diseases 0.000 claims 1
- 208000011623 Obstructive Lung disease Diseases 0.000 claims 1
- 206010049088 Osteopenia Diseases 0.000 claims 1
- 108010077895 Sarcosine Proteins 0.000 claims 1
- 208000005770 Secondary Hyperparathyroidism Diseases 0.000 claims 1
- 208000026062 Tissue disease Diseases 0.000 claims 1
- 206010047626 Vitamin D Deficiency Diseases 0.000 claims 1
- 201000006793 Walker-Warburg syndrome Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- 239000003098 androgen Substances 0.000 claims 1
- 208000022531 anorexia Diseases 0.000 claims 1
- 206010003549 asthenia Diseases 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 230000009693 chronic damage Effects 0.000 claims 1
- 201000011474 congenital myopathy Diseases 0.000 claims 1
- 206010061428 decreased appetite Diseases 0.000 claims 1
- 208000016097 disease of metabolism Diseases 0.000 claims 1
- 230000001815 facial effect Effects 0.000 claims 1
- 206010016208 familial periodic paralysis Diseases 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 210000002149 gonad Anatomy 0.000 claims 1
- 230000002710 gonadal effect Effects 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 230000001969 hypertrophic effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000004118 muscle contraction Effects 0.000 claims 1
- 208000025855 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 4 Diseases 0.000 claims 1
- 230000036473 myasthenia Effects 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 235000018343 nutrient deficiency Nutrition 0.000 claims 1
- 206010030875 ophthalmoplegia Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 201000009104 prediabetes syndrome Diseases 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- 208000001076 sarcopenia Diseases 0.000 claims 1
- 229940043230 sarcosine Drugs 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 230000003442 weekly effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35784502P | 2002-02-21 | 2002-02-21 | |
| US43464402P | 2002-12-20 | 2002-12-20 | |
| PCT/US2003/005151 WO2003072715A2 (en) | 2002-02-21 | 2003-02-21 | Gasp1: a follistatin domain containing protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009212565A Division JP2010031018A (ja) | 2002-02-21 | 2009-09-14 | Ｇａｓｐ１；フォリスタチンドメイン含有タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005534616A JP2005534616A (ja) | 2005-11-17 |
| JP2005534616A5 true JP2005534616A5 (enExample) | 2006-03-23 |
| JP4429729B2 JP4429729B2 (ja) | 2010-03-10 |
Family
ID=27767536
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003571403A Expired - Fee Related JP4429729B2 (ja) | 2002-02-21 | 2003-02-21 | Ｇａｓｐ１；フォリスタチンドメイン含有タンパク質 |
| JP2009212565A Withdrawn JP2010031018A (ja) | 2002-02-21 | 2009-09-14 | Ｇａｓｐ１；フォリスタチンドメイン含有タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009212565A Withdrawn JP2010031018A (ja) | 2002-02-21 | 2009-09-14 | Ｇａｓｐ１；フォリスタチンドメイン含有タンパク質 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US7192717B2 (enExample) |
| EP (1) | EP1572909A4 (enExample) |
| JP (2) | JP4429729B2 (enExample) |
| KR (1) | KR20040094709A (enExample) |
| AU (1) | AU2003217612A1 (enExample) |
| BR (1) | BR0307907A2 (enExample) |
| CA (1) | CA2476887A1 (enExample) |
| IL (1) | IL163525A0 (enExample) |
| MX (1) | MXPA04008150A (enExample) |
| NO (1) | NO20043886L (enExample) |
| PL (1) | PL375045A1 (enExample) |
| WO (1) | WO2003072715A2 (enExample) |
Families Citing this family (137)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200526779A (en) * | 2001-02-08 | 2005-08-16 | Wyeth Corp | Modified and stabilized GDF propeptides and uses thereof |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| WO2003072715A2 (en) * | 2002-02-21 | 2003-09-04 | Wyeth | Gasp1: a follistatin domain containing protein |
| AU2003216345A1 (en) * | 2002-02-21 | 2003-09-09 | Wyeth | Follistatin domain containing proteins |
| US7572599B2 (en) * | 2002-09-16 | 2009-08-11 | The Johns Hopkins University School Of Medicine | Metalloprotease activation of myostatin, and methods of modulating myostatin activity |
| US7261893B2 (en) | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
| US20040223966A1 (en) * | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
| KR20060026860A (ko) * | 2003-06-02 | 2006-03-24 | 와이어쓰 | 신경근 장애의 치료를 위한, 코르티코스테로이드와 조합된미오스타틴 (ｇｄｆ８) 저해제의 용도 |
| US7291146B2 (en) | 2003-09-12 | 2007-11-06 | Minnow Medical, Inc. | Selectable eccentric remodeling and/or ablation of atherosclerotic material |
| JP4688483B2 (ja) * | 2004-04-15 | 2011-05-25 | 株式会社テクノネットワーク四国 | フォリスタチン変異体ポリペプチド |
| US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
| EP1771470B1 (en) | 2004-07-23 | 2013-06-26 | Acceleron Pharma Inc. | Actrii receptor polypeptides, methods and compositions |
| WO2006020884A2 (en) * | 2004-08-12 | 2006-02-23 | Wyeth | Combination therapy for diabetes, obesity, and cardiovascular diseases using gdf-8 inhibitors |
| TWI384069B (zh) | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
| US7335491B2 (en) | 2004-08-27 | 2008-02-26 | Wyeth Research Ireland Limited | Production of anti-abeta |
| US7300773B2 (en) | 2004-08-27 | 2007-11-27 | Wyeth Research Ireland Limited | Production of TNFR-Ig |
| US8396548B2 (en) | 2008-11-14 | 2013-03-12 | Vessix Vascular, Inc. | Selective drug delivery in a lumen |
| US9713730B2 (en) | 2004-09-10 | 2017-07-25 | Boston Scientific Scimed, Inc. | Apparatus and method for treatment of in-stent restenosis |
| BRPI0609449A2 (pt) * | 2005-03-23 | 2010-04-06 | Wyeth Corp | detecção de agentes de modulação de gdf-8 |
| WO2006107611A2 (en) * | 2005-03-23 | 2006-10-12 | Wyeth | Detection of an immune response to gdf-8 modulating agents |
| EP3327033A1 (en) | 2005-08-19 | 2018-05-30 | Wyeth LLC | Antagonist antibodies against gdf-8 and uses in treatment of als and other gdf-8-associated disorders |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| RS58231B1 (sr) | 2005-11-23 | 2019-03-29 | Acceleron Pharma Inc | Antagonisti aktivin-actriia i primene za stimulaciju rasta kostiju |
| US7790161B2 (en) * | 2006-03-28 | 2010-09-07 | Wyeth Llc | GDF-9/BMP-15 modulators for the treatment of bone disorders |
| US8019435B2 (en) | 2006-05-02 | 2011-09-13 | Boston Scientific Scimed, Inc. | Control of arterial smooth muscle tone |
| CA2666660C (en) | 2006-10-18 | 2015-06-02 | Minnow Medical, Inc. | Inducing desirable temperature effects on body tissue |
| AU2007310991B2 (en) | 2006-10-18 | 2013-06-20 | Boston Scientific Scimed, Inc. | System for inducing desirable temperature effects on body tissue |
| ES2546773T3 (es) | 2006-10-18 | 2015-09-28 | Vessix Vascular, Inc. | Energía de RF sintonizada y caracterización eléctrica de tejido para el tratamiento selectivo de tejidos diana |
| US20100028332A1 (en) * | 2006-12-18 | 2010-02-04 | Acceleron Pharma Inc. | Antagonists of actriib and uses for increasing red blood cell levels |
| MX2009006651A (es) * | 2006-12-18 | 2009-08-26 | Acceleron Pharma Inc | Antagonistas de activina-actrii y usos para incrementar los niveles de globulos rojo. |
| US8895016B2 (en) * | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| KR101526613B1 (ko) * | 2007-02-01 | 2015-06-26 | 악셀레론 파마 인코포레이티드 | 액티빈-ａｃｔｒⅱａ 길항제 및 유방암을 치료 또는 예방하기 위한 이들의 용도 |
| TW201940502A (zh) | 2007-02-02 | 2019-10-16 | 美商艾瑟勒朗法瑪公司 | 衍生自ＡｃｔＲＩＩＢ的變體與其用途 |
| TW201808334A (zh) * | 2007-02-09 | 2018-03-16 | 艾瑟勒朗法瑪公司 | 包含ＡｃｔＲＩＩａ-Ｆｃ融合蛋白的醫藥組合物；ＡｃｔＲＩＩａ-Ｆｃ融合蛋白於治療或預防與癌症相關的骨質流失之用途；ＡｃｔＲＩＩａ-Ｆｃ融合蛋白於治療或預防多發性骨髓瘤之用途 |
| WO2008109779A2 (en) * | 2007-03-07 | 2008-09-12 | The Johns Hopkins University | Use of follistatin-like related gene (flrg) to increase muscle mass |
| EP2207562B1 (en) * | 2007-09-18 | 2017-05-31 | Acceleron Pharma, Inc. | Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion |
| US8637455B2 (en) * | 2007-10-22 | 2014-01-28 | Affinergy, Llc | Compositions and methods for delivery of glycopeptide antibiotics to medical device surfaces |
| WO2009054967A2 (en) * | 2007-10-22 | 2009-04-30 | Synthes (U.S.A.) | Compositions for delivery of glycopeptide antibiotics |
| PE20091163A1 (es) | 2007-11-01 | 2009-08-09 | Wyeth Corp | Anticuerpos para gdf8 |
| EP3415161A1 (en) | 2008-06-26 | 2018-12-19 | Acceleron Pharma Inc. | The use of an actriib antagonist for the treatment of anemia |
| HUE063136T2 (hu) | 2008-08-14 | 2023-12-28 | Acceleron Pharma Inc | GDF-Csapdák |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| CA2743992A1 (en) | 2008-11-17 | 2010-05-20 | Minnow Medical, Inc. | Selective accumulation of energy with or without knowledge of tissue topography |
| CA2749544A1 (en) | 2009-01-13 | 2010-07-22 | Acceleron Pharma Inc. | Methods for increasing adiponectin |
| KR20120049214A (ko) | 2009-06-08 | 2012-05-16 | 악셀레론 파마 인코포레이티드 | 발열성 지방세포를 증가시키는 방법 |
| US8293881B2 (en) | 2009-06-12 | 2012-10-23 | Acceleron Pharma Inc. | Isolated nucleic acid encoding a truncated ActRIIB fusion protein |
| BR112012005225B8 (pt) * | 2009-09-09 | 2023-01-10 | Acceleron Pharma Inc | Uso de uma proteína de fusão actriib-fc para o tratamento de um transtorno relacionado ao osso ou associado à perda de músculo por crescimento muscular insuficiente |
| EP2496247B1 (en) * | 2009-11-03 | 2017-08-23 | Acceleron Pharma, Inc. | Methods for treating fatty liver disease |
| WO2011063018A1 (en) * | 2009-11-17 | 2011-05-26 | Acceleron Pharma Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
| CA2795229A1 (en) | 2010-04-09 | 2011-10-13 | Vessix Vascular, Inc. | Power generating and control apparatus for the treatment of tissue |
| US9192790B2 (en) | 2010-04-14 | 2015-11-24 | Boston Scientific Scimed, Inc. | Focused ultrasonic renal denervation |
| US8895011B2 (en) * | 2010-05-27 | 2014-11-25 | The University Of Tokyo | Insulin-resistance-improving drug |
| US8473067B2 (en) | 2010-06-11 | 2013-06-25 | Boston Scientific Scimed, Inc. | Renal denervation and stimulation employing wireless vascular energy transfer arrangement |
| US9463062B2 (en) | 2010-07-30 | 2016-10-11 | Boston Scientific Scimed, Inc. | Cooled conductive balloon RF catheter for renal nerve ablation |
| US9358365B2 (en) | 2010-07-30 | 2016-06-07 | Boston Scientific Scimed, Inc. | Precision electrode movement control for renal nerve ablation |
| US9408661B2 (en) | 2010-07-30 | 2016-08-09 | Patrick A. Haverkost | RF electrodes on multiple flexible wires for renal nerve ablation |
| US9084609B2 (en) | 2010-07-30 | 2015-07-21 | Boston Scientific Scime, Inc. | Spiral balloon catheter for renal nerve ablation |
| US9155589B2 (en) | 2010-07-30 | 2015-10-13 | Boston Scientific Scimed, Inc. | Sequential activation RF electrode set for renal nerve ablation |
| CA2807607A1 (en) | 2010-08-20 | 2012-02-23 | Wyeth Llc | Cell culture of growth factor-free adapted cells |
| US8974451B2 (en) | 2010-10-25 | 2015-03-10 | Boston Scientific Scimed, Inc. | Renal nerve ablation using conductive fluid jet and RF energy |
| US9220558B2 (en) | 2010-10-27 | 2015-12-29 | Boston Scientific Scimed, Inc. | RF renal denervation catheter with multiple independent electrodes |
| CN103298832A (zh) | 2010-11-08 | 2013-09-11 | 阿塞勒隆制药公司 | Actriia结合剂及其用途 |
| US9028485B2 (en) | 2010-11-15 | 2015-05-12 | Boston Scientific Scimed, Inc. | Self-expanding cooling electrode for renal nerve ablation |
| US9668811B2 (en) | 2010-11-16 | 2017-06-06 | Boston Scientific Scimed, Inc. | Minimally invasive access for renal nerve ablation |
| US9089350B2 (en) | 2010-11-16 | 2015-07-28 | Boston Scientific Scimed, Inc. | Renal denervation catheter with RF electrode and integral contrast dye injection arrangement |
| US9326751B2 (en) | 2010-11-17 | 2016-05-03 | Boston Scientific Scimed, Inc. | Catheter guidance of external energy for renal denervation |
| US9060761B2 (en) | 2010-11-18 | 2015-06-23 | Boston Scientific Scime, Inc. | Catheter-focused magnetic field induced renal nerve ablation |
| US9023034B2 (en) | 2010-11-22 | 2015-05-05 | Boston Scientific Scimed, Inc. | Renal ablation electrode with force-activatable conduction apparatus |
| US9192435B2 (en) | 2010-11-22 | 2015-11-24 | Boston Scientific Scimed, Inc. | Renal denervation catheter with cooled RF electrode |
| US20120157993A1 (en) | 2010-12-15 | 2012-06-21 | Jenson Mark L | Bipolar Off-Wall Electrode Device for Renal Nerve Ablation |
| WO2012100095A1 (en) | 2011-01-19 | 2012-07-26 | Boston Scientific Scimed, Inc. | Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury |
| AU2012283908B2 (en) | 2011-07-20 | 2017-02-16 | Boston Scientific Scimed, Inc. | Percutaneous devices and methods to visualize, target and ablate nerves |
| WO2013016203A1 (en) | 2011-07-22 | 2013-01-31 | Boston Scientific Scimed, Inc. | Nerve modulation system with a nerve modulation element positionable in a helical guide |
| EP2765942B1 (en) | 2011-10-10 | 2016-02-24 | Boston Scientific Scimed, Inc. | Medical devices including ablation electrodes |
| US9420955B2 (en) | 2011-10-11 | 2016-08-23 | Boston Scientific Scimed, Inc. | Intravascular temperature monitoring system and method |
| US10085799B2 (en) | 2011-10-11 | 2018-10-02 | Boston Scientific Scimed, Inc. | Off-wall electrode device and methods for nerve modulation |
| US9364284B2 (en) | 2011-10-12 | 2016-06-14 | Boston Scientific Scimed, Inc. | Method of making an off-wall spacer cage |
| WO2013059202A1 (en) | 2011-10-18 | 2013-04-25 | Boston Scientific Scimed, Inc. | Integrated crossing balloon catheter |
| WO2013058962A1 (en) | 2011-10-18 | 2013-04-25 | Boston Scientific Scimed, Inc. | Deflectable medical devices |
| US20140322758A1 (en) | 2011-10-21 | 2014-10-30 | Pfizer Inc. | Addition of iron to improve cell culture |
| CN108095821B (zh) | 2011-11-08 | 2021-05-25 | 波士顿科学西美德公司 | 孔部肾神经消融 |
| US9119600B2 (en) | 2011-11-15 | 2015-09-01 | Boston Scientific Scimed, Inc. | Device and methods for renal nerve modulation monitoring |
| US9119632B2 (en) | 2011-11-21 | 2015-09-01 | Boston Scientific Scimed, Inc. | Deflectable renal nerve ablation catheter |
| US9265969B2 (en) | 2011-12-21 | 2016-02-23 | Cardiac Pacemakers, Inc. | Methods for modulating cell function |
| WO2013096920A1 (en) | 2011-12-23 | 2013-06-27 | Vessix Vascular, Inc. | Methods and apparatuses for remodeling tissue of or adjacent to a body passage |
| WO2013101452A1 (en) | 2011-12-28 | 2013-07-04 | Boston Scientific Scimed, Inc. | Device and methods for nerve modulation using a novel ablation catheter with polymeric ablative elements |
| US9050106B2 (en) | 2011-12-29 | 2015-06-09 | Boston Scientific Scimed, Inc. | Off-wall electrode device and methods for nerve modulation |
| US10660703B2 (en) | 2012-05-08 | 2020-05-26 | Boston Scientific Scimed, Inc. | Renal nerve modulation devices |
| KR101704893B1 (ko) | 2012-06-15 | 2017-02-08 | 화이자 인코포레이티드 | Gdf-8에 대한 개선된 길항물질 항체 및 그의 용도 |
| US9873739B2 (en) | 2012-08-01 | 2018-01-23 | Ikaika Therapeutics, Llc | Mitigating tissue damage and fibrosis via latent transforming growth factor beta binding protein (LTBP4) |
| CN104540465A (zh) | 2012-08-24 | 2015-04-22 | 波士顿科学西美德公司 | 带有含单独微孔隙区域的球囊的血管内导管 |
| EP2895095A2 (en) | 2012-09-17 | 2015-07-22 | Boston Scientific Scimed, Inc. | Self-positioning electrode system and method for renal nerve modulation |
| WO2014047411A1 (en) | 2012-09-21 | 2014-03-27 | Boston Scientific Scimed, Inc. | System for nerve modulation and innocuous thermal gradient nerve block |
| US10549127B2 (en) | 2012-09-21 | 2020-02-04 | Boston Scientific Scimed, Inc. | Self-cooling ultrasound ablation catheter |
| WO2014059165A2 (en) | 2012-10-10 | 2014-04-17 | Boston Scientific Scimed, Inc. | Renal nerve modulation devices and methods |
| MX366336B (es) | 2012-11-02 | 2019-07-05 | Celgene Corp | Antagonistas de activina - actrii y usos para el tratar trastornos oseos y otros. |
| WO2014163987A1 (en) | 2013-03-11 | 2014-10-09 | Boston Scientific Scimed, Inc. | Medical devices for modulating nerves |
| US9693821B2 (en) | 2013-03-11 | 2017-07-04 | Boston Scientific Scimed, Inc. | Medical devices for modulating nerves |
| US9808311B2 (en) | 2013-03-13 | 2017-11-07 | Boston Scientific Scimed, Inc. | Deflectable medical devices |
| EP2967734B1 (en) | 2013-03-15 | 2019-05-15 | Boston Scientific Scimed, Inc. | Methods and apparatuses for remodeling tissue of or adjacent to a body passage |
| US10265122B2 (en) | 2013-03-15 | 2019-04-23 | Boston Scientific Scimed, Inc. | Nerve ablation devices and related methods of use |
| JP6139772B2 (ja) | 2013-03-15 | 2017-05-31 | ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． | 電極パッドと共に使用するための制御ユニットおよび漏電を推定するための方法 |
| JP2016523147A (ja) | 2013-06-21 | 2016-08-08 | ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． | 同乗型電極支持体を備えた腎除神経バルーンカテーテル |
| JP2016524949A (ja) | 2013-06-21 | 2016-08-22 | ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． | 回転可能シャフトを有する腎神経アブレーション用医療装置 |
| US9707036B2 (en) | 2013-06-25 | 2017-07-18 | Boston Scientific Scimed, Inc. | Devices and methods for nerve modulation using localized indifferent electrodes |
| JP6204579B2 (ja) | 2013-07-01 | 2017-09-27 | ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． | 腎神経アブレーション用医療器具 |
| WO2015006573A1 (en) | 2013-07-11 | 2015-01-15 | Boston Scientific Scimed, Inc. | Medical device with stretchable electrode assemblies |
| US10660698B2 (en) | 2013-07-11 | 2020-05-26 | Boston Scientific Scimed, Inc. | Devices and methods for nerve modulation |
| WO2015010074A1 (en) | 2013-07-19 | 2015-01-22 | Boston Scientific Scimed, Inc. | Spiral bipolar electrode renal denervation balloon |
| US10342609B2 (en) | 2013-07-22 | 2019-07-09 | Boston Scientific Scimed, Inc. | Medical devices for renal nerve ablation |
| JP6122217B2 (ja) | 2013-07-22 | 2017-04-26 | ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． | 腎神経アブレーション用医療器具 |
| EP4049605A1 (en) | 2013-08-22 | 2022-08-31 | Boston Scientific Scimed Inc. | Flexible circuit having improved adhesion to a renal nerve modulation balloon |
| US9895194B2 (en) | 2013-09-04 | 2018-02-20 | Boston Scientific Scimed, Inc. | Radio frequency (RF) balloon catheter having flushing and cooling capability |
| CN105530885B (zh) | 2013-09-13 | 2020-09-22 | 波士顿科学国际有限公司 | 具有气相沉积覆盖层的消融球囊 |
| US11246654B2 (en) | 2013-10-14 | 2022-02-15 | Boston Scientific Scimed, Inc. | Flexible renal nerve ablation devices and related methods of use and manufacture |
| WO2015057521A1 (en) | 2013-10-14 | 2015-04-23 | Boston Scientific Scimed, Inc. | High resolution cardiac mapping electrode array catheter |
| US9770606B2 (en) | 2013-10-15 | 2017-09-26 | Boston Scientific Scimed, Inc. | Ultrasound ablation catheter with cooling infusion and centering basket |
| CN105636537B (zh) | 2013-10-15 | 2018-08-17 | 波士顿科学国际有限公司 | 医疗器械球囊 |
| EP3057521B1 (en) | 2013-10-18 | 2020-03-25 | Boston Scientific Scimed, Inc. | Balloon catheters with flexible conducting wires |
| CN105658163B (zh) | 2013-10-25 | 2020-08-18 | 波士顿科学国际有限公司 | 去神经柔性电路中的嵌入式热电偶 |
| WO2015103617A1 (en) | 2014-01-06 | 2015-07-09 | Boston Scientific Scimed, Inc. | Tear resistant flex circuit assembly |
| US9907609B2 (en) | 2014-02-04 | 2018-03-06 | Boston Scientific Scimed, Inc. | Alternative placement of thermal sensors on bipolar electrode |
| US11000679B2 (en) | 2014-02-04 | 2021-05-11 | Boston Scientific Scimed, Inc. | Balloon protection and rewrapping devices and related methods of use |
| US10010498B2 (en) | 2014-06-04 | 2018-07-03 | Acceleron Pharma Inc. | Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins |
| AU2015269333B2 (en) | 2014-06-04 | 2020-05-07 | Acceleron Pharma, Inc. | Methods and compositions for treatment of disorders with follistatin polypeptides |
| TN2016000553A1 (en) | 2014-06-13 | 2018-04-04 | Acceleron Pharma Inc | Methods and compositions for treating ulcers |
| MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
| IL252631B2 (en) | 2014-12-03 | 2024-06-01 | Celgene Corp | ACTIVIN-ACTRII antagonists and uses for the treatment of anemia |
| WO2016120647A2 (en) | 2015-01-30 | 2016-08-04 | Debreceni Egyetem | Muscle regeneration |
| EP3274457A4 (en) * | 2015-03-26 | 2018-08-08 | Acceleron Pharma Inc. | Follistatin-related fusion proteins and uses thereof |
| HU230620B1 (hu) | 2015-05-14 | 2017-04-28 | ALU-ÖNTŐ Fémöntő és Fémmegmunkáló Ipari | Eljárás vékonyfalú, tagolt, részletgazdag alumínium öntvények homokformázásos technológiával, gravitációs öntéssel történő előállítására |
| JP2019509735A (ja) * | 2016-03-04 | 2019-04-11 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | デュシェンヌ型筋ジストロフィー治療における組換えフォリスタチン−Ｆｃ融合タンパク質及び使用 |
| US12253490B2 (en) | 2018-03-19 | 2025-03-18 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| MY202358A (en) * | 2018-03-19 | 2024-04-24 | Regeneron Pharma | Microchip capillary electrophoresis assays and reagents |
| US12259355B2 (en) | 2018-03-19 | 2025-03-25 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| CN113347990A (zh) | 2018-12-21 | 2021-09-03 | 西北大学 | 膜联蛋白在预防和治疗肌膜损伤中的用途 |
| US20220062299A1 (en) | 2018-12-26 | 2022-03-03 | Northwestern University | Use of glucocorticoid steroids in preventing and treating conditions of muscle wasting, aging and metabolic disorder |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US223966A (en) * | 1880-01-27 | Vapor-burner | ||
| US181033A (en) * | 1876-08-15 | Improvement in fire-kindlers | ||
| US162714A (en) * | 1875-04-27 | Improvement in balanced and cut-off valves | ||
| US43232A (en) * | 1864-06-21 | Improvement in preserving fruits | ||
| US150577A (en) * | 1874-05-05 | Improvement in grain-separators | ||
| US77053A (en) * | 1868-04-21 | Improvement in mitre-gauges | ||
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US6162896A (en) | 1991-05-10 | 2000-12-19 | The Salk Institute For Biological Studies | Recombinant vertebrate activin receptors |
| DE69432815T2 (de) | 1993-03-19 | 2003-12-11 | The Johns Hopkins University School Of Medicine, Baltimore | Wachstumsfaktor-8 |
| US7393682B1 (en) | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
| US5994618A (en) | 1997-02-05 | 1999-11-30 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 transgenic mice |
| DE69433530T2 (de) | 1993-05-12 | 2005-01-05 | Genetics Institute, LLC, Cambridge | Bmp-11 zusammensetzungen |
| CA2169191C (en) | 1993-08-26 | 2008-01-15 | Elizabeth A. Wang | Neural regeneration using human bone morphogenetic proteins |
| US6008434A (en) | 1994-07-08 | 1999-12-28 | Johns Hopkins University School Of Medicine | Growth differentiation factor-11 transgenic mice |
| CA2194660C (en) | 1994-07-08 | 2009-09-29 | Se-Jin Lee | Growth differentiation factor-11 |
| US5723125A (en) | 1995-12-28 | 1998-03-03 | Tanox Biosystems, Inc. | Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide |
| WO1998033887A1 (en) | 1997-02-05 | 1998-08-06 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-8 |
| US6656475B1 (en) | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| US6696260B1 (en) | 1997-08-01 | 2004-02-24 | The Johns Hopkins University School Of Medicine | Methods to identify growth differentiation factor (GDF) binding proteins |
| EP1015468A4 (en) | 1997-08-29 | 2000-09-06 | Human Genome Sciences Inc | FOLLISTATINE-3 |
| AU1276399A (en) | 1997-11-07 | 1999-05-31 | Genetics Institute Inc. | Neuronal uses of bmp-11 |
| US5942420A (en) | 1997-11-17 | 1999-08-24 | Millennium Biotherapeutics, Inc. | Molecules of the follistatin-related protein family and uses therefor |
| US6369201B1 (en) | 1998-02-19 | 2002-04-09 | Metamorphix International, Inc. | Myostatin multimers |
| US6004937A (en) | 1998-03-09 | 1999-12-21 | Genetics Institute, Inc. | Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11] |
| CA2331410C (en) | 1998-05-06 | 2009-07-14 | Metamorphix, Inc. | Methods for treating diabetes by inhibiting gdf-8 |
| WO2000011163A1 (en) | 1998-08-20 | 2000-03-02 | Regeneron Pharmaceuticals, Inc. | Dcr5, a bmp-binding protein, and applications thereof |
| ATE322681T1 (de) | 1999-01-21 | 2006-04-15 | Metamorphix Inc | Inhibitoren für wachstumdifferenzierungsfaktor und ihre anwendungen |
| US20020004224A1 (en) * | 2000-02-29 | 2002-01-10 | Sheppard Paul O. | Kunitz domain polypeptide zkun8 |
| AU2001241817A1 (en) * | 2000-02-29 | 2001-09-12 | Zymogenetics Inc. | Kunitz domain polypeptide zkun8 |
| US7037501B2 (en) * | 2001-01-04 | 2006-05-02 | Regents Of The University Of Minnesota | Myostatin immnoconjugate |
| TW200526779A (en) | 2001-02-08 | 2005-08-16 | Wyeth Corp | Modified and stabilized GDF propeptides and uses thereof |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| WO2003072715A2 (en) | 2002-02-21 | 2003-09-04 | Wyeth | Gasp1: a follistatin domain containing protein |
| AU2003216345A1 (en) * | 2002-02-21 | 2003-09-09 | Wyeth | Follistatin domain containing proteins |
| US7572599B2 (en) | 2002-09-16 | 2009-08-11 | The Johns Hopkins University School Of Medicine | Metalloprotease activation of myostatin, and methods of modulating myostatin activity |
| US7261893B2 (en) | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
| US20040223966A1 (en) | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
| RS52815B (sr) | 2002-12-20 | 2013-10-31 | Amgen Inc. | Vezivna sredstva koja inhibiraju miostatin |
-
2003
- 2003-02-21 WO PCT/US2003/005151 patent/WO2003072715A2/en not_active Ceased
- 2003-02-21 KR KR10-2004-7012977A patent/KR20040094709A/ko not_active Withdrawn
- 2003-02-21 US US10/369,736 patent/US7192717B2/en not_active Expired - Fee Related
- 2003-02-21 MX MXPA04008150A patent/MXPA04008150A/es not_active Application Discontinuation
- 2003-02-21 BR BRPI0307907-4A patent/BR0307907A2/pt not_active IP Right Cessation
- 2003-02-21 JP JP2003571403A patent/JP4429729B2/ja not_active Expired - Fee Related
- 2003-02-21 PL PL03375045A patent/PL375045A1/xx not_active Application Discontinuation
- 2003-02-21 IL IL16352503A patent/IL163525A0/xx unknown
- 2003-02-21 AU AU2003217612A patent/AU2003217612A1/en not_active Withdrawn
- 2003-02-21 EP EP03713568A patent/EP1572909A4/en not_active Withdrawn
- 2003-02-21 CA CA002476887A patent/CA2476887A1/en not_active Abandoned
-
2004
- 2004-09-16 NO NO20043886A patent/NO20043886L/no not_active Application Discontinuation
-
2005
- 2005-01-04 US US11/028,058 patent/US7585835B2/en not_active Expired - Fee Related
-
2007
- 2007-01-31 US US11/669,531 patent/US7541154B2/en not_active Expired - Fee Related
-
2009
- 2009-08-13 US US12/540,606 patent/US7956038B2/en not_active Expired - Fee Related
- 2009-09-14 JP JP2009212565A patent/JP2010031018A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005534616A5 (enExample) | ||
| JP2005531505A5 (enExample) | ||
| JP2005507637A5 (enExample) | ||
| JP2009286804A5 (enExample) | ||
| JP2010031018A5 (enExample) | ||
| JP6379300B2 (ja) | ＧＬＰ及び免疫グロブリンハイブリッドＦｃ融合ポリペプチド及びその用途 | |
| EP3241558B1 (en) | Highly soluble leptins | |
| JP6058646B2 (ja) | 多置換インスリン | |
| JP2019527200A (ja) | Ｉｌ−１０の免疫刺激特性および抗炎症特性を調節するための組成物および方法 | |
| JP2010512399A (ja) | 医薬製剤及びその調製方法 | |
| JP6680758B2 (ja) | 上昇したトリグリセリドと関連する状態の治療のための方法及び組成物 | |
| RU2015136440A (ru) | Композиции и способы применения для лечения метаболических расстройств | |
| JP2010535781A (ja) | 肥満に対する処置 | |
| JP2014504597A (ja) | アシル化グルカゴン類似体とインスリン類似体の組合せ物 | |
| JP2017538395A (ja) | 代謝障害を処置するための組成物及びその使用方法 | |
| PT1831252E (pt) | Formulações de proteínas de fusão de análogos de glp-1 | |
| EP3934679A1 (en) | Growth differentiation factor 15 combination therapy | |
| US12018060B2 (en) | Glucagon derivatives | |
| BR112021005419A2 (pt) | conjugado que compreende um ou mais polímeros hidrofílicos, uso do mesmo e composição farmacêutica | |
| JP2009510999A (ja) | キメラ治療剤 | |
| EP1575531B1 (en) | Therapies for chronic inflammatory demyelinating polyneuropathy using interferon-beta | |
| TW202140074A (zh) | Fgf-21結合物調配物 | |
| JP5647609B2 (ja) | 経粘膜吸収性を付与したモチリン類似ペプチド化合物 | |
| AU2014362992A1 (en) | A process for preparing a composition of pegylated proteins | |
| JP2025539794A (ja) | 二重機能タンパク質およびその使用 |