JP2005534616A5 - - Google Patents
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- JP2005534616A5 JP2005534616A5 JP2003571403A JP2003571403A JP2005534616A5 JP 2005534616 A5 JP2005534616 A5 JP 2005534616A5 JP 2003571403 A JP2003571403 A JP 2003571403A JP 2003571403 A JP2003571403 A JP 2003571403A JP 2005534616 A5 JP2005534616 A5 JP 2005534616A5
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- Prior art keywords
- composition
- gasp1
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- modification
- seq
- Prior art date
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- 239000000203 mixture Substances 0.000 claims 51
- 102100036001 G-protein coupled receptor-associated sorting protein 1 Human genes 0.000 claims 23
- 101001021410 Homo sapiens G-protein coupled receptor-associated sorting protein 1 Proteins 0.000 claims 18
- 230000004048 modification Effects 0.000 claims 15
- 238000012986 modification Methods 0.000 claims 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 13
- 208000035475 disorder Diseases 0.000 claims 11
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 101710142641 G-protein coupled receptor-associated sorting protein 1 Proteins 0.000 claims 5
- 101710160038 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 Proteins 0.000 claims 5
- 210000003205 muscle Anatomy 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 102000009027 Albumins Human genes 0.000 claims 4
- 108010088751 Albumins Proteins 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 102000016970 Follistatin Human genes 0.000 claims 4
- 108010014612 Follistatin Proteins 0.000 claims 4
- 208000021642 Muscular disease Diseases 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 238000012217 deletion Methods 0.000 claims 4
- 230000037430 deletion Effects 0.000 claims 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
- 201000000585 muscular atrophy Diseases 0.000 claims 4
- 201000006938 muscular dystrophy Diseases 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 206010003694 Atrophy Diseases 0.000 claims 3
- 206010028289 Muscle atrophy Diseases 0.000 claims 3
- 102000004472 Myostatin Human genes 0.000 claims 3
- 108010056852 Myostatin Proteins 0.000 claims 3
- 208000001132 Osteoporosis Diseases 0.000 claims 3
- 230000037444 atrophy Effects 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 230000000087 stabilizing effect Effects 0.000 claims 3
- 238000009007 Diagnostic Kit Methods 0.000 claims 2
- 102000004877 Insulin Human genes 0.000 claims 2
- 108090001061 Insulin Proteins 0.000 claims 2
- 208000010316 Myotonia congenita Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 150000001720 carbohydrates Chemical group 0.000 claims 2
- 208000003295 carpal tunnel syndrome Diseases 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 201000009338 distal myopathy Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 230000013595 glycosylation Effects 0.000 claims 2
- 238000006206 glycosylation reaction Methods 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 229940125396 insulin Drugs 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 230000020763 muscle atrophy Effects 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 230000001314 paroxysmal effect Effects 0.000 claims 2
- 230000006320 pegylation Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 230000002028 premature Effects 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 230000008733 trauma Effects 0.000 claims 2
- 102100021277 Beta-secretase 2 Human genes 0.000 claims 1
- 101710150190 Beta-secretase 2 Proteins 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- 208000037141 Congenital muscular dystrophy, Fukuyama type Diseases 0.000 claims 1
- 208000029323 Congenital myotonia Diseases 0.000 claims 1
- 208000035810 Denervation atrophy Diseases 0.000 claims 1
- 208000001441 Familial Periodic Paralyses Diseases 0.000 claims 1
- 208000036119 Frailty Diseases 0.000 claims 1
- 201000006813 Fukuyama congenital muscular dystrophy Diseases 0.000 claims 1
- 208000002705 Glucose Intolerance Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 201000010743 Lambert-Eaton myasthenic syndrome Diseases 0.000 claims 1
- 208000002720 Malnutrition Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 208000029725 Metabolic bone disease Diseases 0.000 claims 1
- 206010028372 Muscular weakness Diseases 0.000 claims 1
- 206010028424 Myasthenic syndrome Diseases 0.000 claims 1
- 206010028629 Myoglobinuria Diseases 0.000 claims 1
- 201000009623 Myopathy Diseases 0.000 claims 1
- 208000011623 Obstructive Lung disease Diseases 0.000 claims 1
- 206010049088 Osteopenia Diseases 0.000 claims 1
- 108010077895 Sarcosine Proteins 0.000 claims 1
- 208000005770 Secondary Hyperparathyroidism Diseases 0.000 claims 1
- 208000026062 Tissue disease Diseases 0.000 claims 1
- 206010047626 Vitamin D Deficiency Diseases 0.000 claims 1
- 201000006793 Walker-Warburg syndrome Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- 239000003098 androgen Substances 0.000 claims 1
- 208000022531 anorexia Diseases 0.000 claims 1
- 206010003549 asthenia Diseases 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 230000009693 chronic damage Effects 0.000 claims 1
- 201000011474 congenital myopathy Diseases 0.000 claims 1
- 206010061428 decreased appetite Diseases 0.000 claims 1
- 208000016097 disease of metabolism Diseases 0.000 claims 1
- 230000001815 facial effect Effects 0.000 claims 1
- 206010016208 familial periodic paralysis Diseases 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 210000002149 gonad Anatomy 0.000 claims 1
- 230000002710 gonadal effect Effects 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 230000001969 hypertrophic effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000004118 muscle contraction Effects 0.000 claims 1
- 208000025855 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 4 Diseases 0.000 claims 1
- 230000036473 myasthenia Effects 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 235000018343 nutrient deficiency Nutrition 0.000 claims 1
- 206010030875 ophthalmoplegia Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 201000009104 prediabetes syndrome Diseases 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- 208000001076 sarcopenia Diseases 0.000 claims 1
- 229940043230 sarcosine Drugs 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 230000003442 weekly effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35784502P | 2002-02-21 | 2002-02-21 | |
| US43464402P | 2002-12-20 | 2002-12-20 | |
| PCT/US2003/005151 WO2003072715A2 (en) | 2002-02-21 | 2003-02-21 | Gasp1: a follistatin domain containing protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009212565A Division JP2010031018A (ja) | 2002-02-21 | 2009-09-14 | Ｇａｓｐ１；フォリスタチンドメイン含有タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005534616A JP2005534616A (ja) | 2005-11-17 |
| JP2005534616A5 true JP2005534616A5 (enExample) | 2006-03-23 |
| JP4429729B2 JP4429729B2 (ja) | 2010-03-10 |
Family
ID=27767536
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003571403A Expired - Fee Related JP4429729B2 (ja) | 2002-02-21 | 2003-02-21 | Ｇａｓｐ１；フォリスタチンドメイン含有タンパク質 |
| JP2009212565A Withdrawn JP2010031018A (ja) | 2002-02-21 | 2009-09-14 | Ｇａｓｐ１；フォリスタチンドメイン含有タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009212565A Withdrawn JP2010031018A (ja) | 2002-02-21 | 2009-09-14 | Ｇａｓｐ１；フォリスタチンドメイン含有タンパク質 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US7192717B2 (enExample) |
| EP (1) | EP1572909A4 (enExample) |
| JP (2) | JP4429729B2 (enExample) |
| KR (1) | KR20040094709A (enExample) |
| AU (1) | AU2003217612A1 (enExample) |
| BR (1) | BR0307907A2 (enExample) |
| CA (1) | CA2476887A1 (enExample) |
| IL (1) | IL163525A0 (enExample) |
| MX (1) | MXPA04008150A (enExample) |
| NO (1) | NO20043886L (enExample) |
| PL (1) | PL375045A1 (enExample) |
| WO (1) | WO2003072715A2 (enExample) |
Families Citing this family (137)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200526779A (en) | 2001-02-08 | 2005-08-16 | Wyeth Corp | Modified and stabilized GDF propeptides and uses thereof |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| MXPA04008149A (es) | 2002-02-21 | 2005-06-17 | Wyeth Corp | Proteinas que contienen dominios de folistatina. |
| MXPA04008150A (es) * | 2002-02-21 | 2005-06-17 | Wyeth Corp | Gasp1: una proteina que contiene dominio de folistatina. |
| BR0314270A (pt) * | 2002-09-16 | 2005-08-02 | Univ Johns Hopkins | Ativação de miostatina com metaloprotease e processos de modulação da atividade da miostatina |
| US7261893B2 (en) | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
| US20040223966A1 (en) * | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
| US7785587B2 (en) * | 2003-06-02 | 2010-08-31 | Wyeth | Therapeutic methods for muscular or neuromuscular disorders |
| ES2564694T3 (es) | 2003-09-12 | 2016-03-28 | Vessix Vascular, Inc. | Sistema de remodelación y / o ablación excéntrica seleccionable de material ateroesclerótico |
| JP4688483B2 (ja) * | 2004-04-15 | 2011-05-25 | 株式会社テクノネットワーク四国 | フォリスタチン変異体ポリペプチド |
| US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
| ES2551852T3 (es) * | 2004-07-23 | 2015-11-24 | Acceleron Pharma Inc. | Polipéptidos del receptor ActRII |
| US20060034831A1 (en) * | 2004-08-12 | 2006-02-16 | Wyeth | Combination therapy for diabetes, obesity and cardiovascular diseases using GDF-8 inhibitors |
| US7300773B2 (en) | 2004-08-27 | 2007-11-27 | Wyeth Research Ireland Limited | Production of TNFR-Ig |
| US7294484B2 (en) | 2004-08-27 | 2007-11-13 | Wyeth Research Ireland Limited | Production of polypeptides |
| TWI374935B (en) | 2004-08-27 | 2012-10-21 | Pfizer Ireland Pharmaceuticals | Production of α-abeta |
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| US9713730B2 (en) | 2004-09-10 | 2017-07-25 | Boston Scientific Scimed, Inc. | Apparatus and method for treatment of in-stent restenosis |
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| PT2407486T (pt) | 2005-08-19 | 2018-02-21 | Univ Pennsylvania | Anticorpos antagonistas contra gdf-8 e utilizações no tratamento de ela e outros distúrbios associados a gdf-8 |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| EA201692543A1 (ru) | 2005-11-23 | 2017-08-31 | Акселерон Фарма Инк. | Антагонисты активина-actriia и их применение для стимулирования роста кости |
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| EP2076193A4 (en) | 2006-10-18 | 2010-02-03 | Minnow Medical Inc | MATCHED RF-ENERGY AND ELECTRO-TISSUE CHARACTERIZATION FOR THE SELECTIVE TREATMENT OF TARGET TISSUE |
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| TWI782836B (zh) | 2007-02-02 | 2022-11-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
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| US8236751B2 (en) | 2007-03-07 | 2012-08-07 | The Johns Hopkins University | Methods of increasing muscle mass using follistatin-like related gene (FLRG) |
| CN103877564A (zh) | 2007-09-18 | 2014-06-25 | 阿塞勒隆制药公司 | 活化素-actriia拮抗剂和减少或抑制fsh分泌的用途 |
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2003
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- 2003-02-21 BR BRPI0307907-4A patent/BR0307907A2/pt not_active IP Right Cessation
- 2003-02-21 PL PL03375045A patent/PL375045A1/xx not_active Application Discontinuation
- 2003-02-21 KR KR10-2004-7012977A patent/KR20040094709A/ko not_active Withdrawn
- 2003-02-21 CA CA002476887A patent/CA2476887A1/en not_active Abandoned
- 2003-02-21 WO PCT/US2003/005151 patent/WO2003072715A2/en not_active Ceased
- 2003-02-21 JP JP2003571403A patent/JP4429729B2/ja not_active Expired - Fee Related
- 2003-02-21 IL IL16352503A patent/IL163525A0/xx unknown
- 2003-02-21 EP EP03713568A patent/EP1572909A4/en not_active Withdrawn
- 2003-02-21 US US10/369,736 patent/US7192717B2/en not_active Expired - Fee Related
- 2003-02-21 AU AU2003217612A patent/AU2003217612A1/en not_active Withdrawn
-
2004
- 2004-09-16 NO NO20043886A patent/NO20043886L/no not_active Application Discontinuation
-
2005
- 2005-01-04 US US11/028,058 patent/US7585835B2/en not_active Expired - Fee Related
-
2007
- 2007-01-31 US US11/669,531 patent/US7541154B2/en not_active Expired - Fee Related
-
2009
- 2009-08-13 US US12/540,606 patent/US7956038B2/en not_active Expired - Fee Related
- 2009-09-14 JP JP2009212565A patent/JP2010031018A/ja not_active Withdrawn
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