JP2010031018A5 - - Google Patents

Info

Publication number

JP2010031018A5

JP2010031018A5 JP2009212565A JP2009212565A JP2010031018A5 JP 2010031018 A5 JP2010031018 A5 JP 2010031018A5 JP 2009212565 A JP2009212565 A JP 2009212565A JP 2009212565 A JP2009212565 A JP 2009212565A JP 2010031018 A5 JP2010031018 A5 JP 2010031018A5

Authority

JP

Japan

Prior art keywords

composition

gasp1

seq

disorder

administered

Prior art date

2009-09-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000203 mixture Substances 0.000 claims 22
• 102100036001 G-protein coupled receptor-associated sorting protein 1 Human genes 0.000 claims 14
• 101001021410 Homo sapiens G-protein coupled receptor-associated sorting protein 1 Proteins 0.000 claims 14
• 208000030159 metabolic disease Diseases 0.000 claims 8
• 230000004048 modification Effects 0.000 claims 7
• 238000012986 modification Methods 0.000 claims 7
• 239000002773 nucleotide Substances 0.000 claims 6
• 125000003729 nucleotide group Chemical group 0.000 claims 6
• 150000001413 amino acids Chemical group 0.000 claims 4
• 208000016097 disease of metabolism Diseases 0.000 claims 4
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
• 102000004169 proteins and genes Human genes 0.000 claims 3
• 108090000623 proteins and genes Proteins 0.000 claims 3
• 102000009027 Albumins Human genes 0.000 claims 2
• 108010088751 Albumins Proteins 0.000 claims 2
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
• 102000004877 Insulin Human genes 0.000 claims 2
• 108090001061 Insulin Proteins 0.000 claims 2
• 208000021642 Muscular disease Diseases 0.000 claims 2
• 208000008589 Obesity Diseases 0.000 claims 2
• 230000001419 dependent effect Effects 0.000 claims 2
• 206010012601 diabetes mellitus Diseases 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 239000012634 fragment Substances 0.000 claims 2
• 229940125396 insulin Drugs 0.000 claims 2
• 235000020824 obesity Nutrition 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 208000002705 Glucose Intolerance Diseases 0.000 claims 1
• 206010022489 Insulin Resistance Diseases 0.000 claims 1
• 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
• 208000026062 Tissue disease Diseases 0.000 claims 1
• 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
• 210000000577 adipose tissue Anatomy 0.000 claims 1
• 238000003556 assay Methods 0.000 claims 1
• 150000001720 carbohydrates Chemical group 0.000 claims 1
• 230000007423 decrease Effects 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 230000004927 fusion Effects 0.000 claims 1
• 230000013595 glycosylation Effects 0.000 claims 1
• 238000006206 glycosylation reaction Methods 0.000 claims 1
• 201000001421 hyperglycemia Diseases 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
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• 208000014674 injury Diseases 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 229910052757 nitrogen Inorganic materials 0.000 claims 1
• 230000006320 pegylation Effects 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• 201000009104 prediabetes syndrome Diseases 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 230000017854 proteolysis Effects 0.000 claims 1
• 230000000087 stabilizing effect Effects 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1
• 230000008733 trauma Effects 0.000 claims 1
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1