JP2009286804A5 - - Google Patents
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- JP2009286804A5 JP2009286804A5 JP2009212564A JP2009212564A JP2009286804A5 JP 2009286804 A5 JP2009286804 A5 JP 2009286804A5 JP 2009212564 A JP2009212564 A JP 2009212564A JP 2009212564 A JP2009212564 A JP 2009212564A JP 2009286804 A5 JP2009286804 A5 JP 2009286804A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- protein
- follistatin
- muscular dystrophy
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 claims 25
- 102000016970 Follistatin Human genes 0.000 claims 18
- 108010014612 Follistatin Proteins 0.000 claims 18
- 102000004169 proteins and genes Human genes 0.000 claims 17
- 108090000623 proteins and genes Proteins 0.000 claims 17
- 230000004048 modification Effects 0.000 claims 7
- 238000012986 modification Methods 0.000 claims 7
- 102000019203 Follistatin-Related Proteins Human genes 0.000 claims 6
- 108010012820 Follistatin-Related Proteins Proteins 0.000 claims 6
- 208000021642 Muscular disease Diseases 0.000 claims 6
- 208000030159 metabolic disease Diseases 0.000 claims 6
- 239000003937 drug carrier Substances 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
- 201000006938 muscular dystrophy Diseases 0.000 claims 4
- 206010028289 Muscle atrophy Diseases 0.000 claims 3
- 208000016097 disease of metabolism Diseases 0.000 claims 3
- 201000000585 muscular atrophy Diseases 0.000 claims 3
- 102000009027 Albumins Human genes 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 206010010356 Congenital anomaly Diseases 0.000 claims 2
- 102000004877 Insulin Human genes 0.000 claims 2
- 108090001061 Insulin Proteins 0.000 claims 2
- 102000004472 Myostatin Human genes 0.000 claims 2
- 108010056852 Myostatin Proteins 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 229940125396 insulin Drugs 0.000 claims 2
- 210000003205 muscle Anatomy 0.000 claims 2
- 230000020763 muscle atrophy Effects 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 206010003694 Atrophy Diseases 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- 208000035810 Denervation atrophy Diseases 0.000 claims 1
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims 1
- 208000001441 Familial Periodic Paralyses Diseases 0.000 claims 1
- 208000002705 Glucose Intolerance Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 201000010743 Lambert-Eaton myasthenic syndrome Diseases 0.000 claims 1
- 201000009342 Limb-girdle muscular dystrophy Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 206010028372 Muscular weakness Diseases 0.000 claims 1
- 206010028424 Myasthenic syndrome Diseases 0.000 claims 1
- 206010028629 Myoglobinuria Diseases 0.000 claims 1
- 201000009623 Myopathy Diseases 0.000 claims 1
- 208000010316 Myotonia congenita Diseases 0.000 claims 1
- 206010068871 Myotonic dystrophy Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000011623 Obstructive Lung disease Diseases 0.000 claims 1
- 201000006793 Walker-Warburg syndrome Diseases 0.000 claims 1
- 210000001766 X chromosome Anatomy 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 claims 1
- 150000001720 carbohydrates Chemical group 0.000 claims 1
- 208000003295 carpal tunnel syndrome Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 201000011474 congenital myopathy Diseases 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 201000009338 distal myopathy Diseases 0.000 claims 1
- 230000001815 facial effect Effects 0.000 claims 1
- 206010016208 familial periodic paralysis Diseases 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 208000025855 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 4 Diseases 0.000 claims 1
- 230000036473 myasthenia Effects 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 206010030875 ophthalmoplegia Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000001314 paroxysmal effect Effects 0.000 claims 1
- 230000006320 pegylation Effects 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 201000009104 prediabetes syndrome Diseases 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
- 230000017854 proteolysis Effects 0.000 claims 1
- 208000001076 sarcopenia Diseases 0.000 claims 1
- 208000000943 scapulohumeral muscular dystrophy Diseases 0.000 claims 1
- 230000001148 spastic effect Effects 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 230000003442 weekly effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35784602P | 2002-02-21 | 2002-02-21 | |
| US43464502P | 2002-12-20 | 2002-12-20 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003571402A Division JP4429728B2 (ja) | 2002-02-21 | 2003-02-21 | フォリスタチン（ｆｏｌｌｉｓｔａｔｉｎ）ドメイン含有タンパク質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009286804A JP2009286804A (ja) | 2009-12-10 |
| JP2009286804A5 true JP2009286804A5 (enExample) | 2010-10-21 |
Family
ID=27767537
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003571402A Expired - Fee Related JP4429728B2 (ja) | 2002-02-21 | 2003-02-21 | フォリスタチン（ｆｏｌｌｉｓｔａｔｉｎ）ドメイン含有タンパク質 |
| JP2009212564A Pending JP2009286804A (ja) | 2002-02-21 | 2009-09-14 | フォリスタチン（ｆｏｌｌｉｓｔａｔｉｎ）ドメイン含有タンパク質 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003571402A Expired - Fee Related JP4429728B2 (ja) | 2002-02-21 | 2003-02-21 | フォリスタチン（ｆｏｌｌｉｓｔａｔｉｎ）ドメイン含有タンパク質 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7572763B2 (enExample) |
| EP (1) | EP1572934A4 (enExample) |
| JP (2) | JP4429728B2 (enExample) |
| KR (1) | KR20040096592A (enExample) |
| AU (1) | AU2003216345A1 (enExample) |
| BR (1) | BR0307871A (enExample) |
| CA (1) | CA2476654A1 (enExample) |
| MX (1) | MXPA04008149A (enExample) |
| NO (1) | NO20043564L (enExample) |
| PL (1) | PL374966A1 (enExample) |
| WO (1) | WO2003072714A2 (enExample) |
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| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| JP4429728B2 (ja) * | 2002-02-21 | 2010-03-10 | ワイス エルエルシー | フォリスタチン（ｆｏｌｌｉｓｔａｔｉｎ）ドメイン含有タンパク質 |
| BR0307907A2 (pt) * | 2002-02-21 | 2011-07-05 | Wyeth Corp | gasp1: proteìna contendo domìnio de folistatina |
| US7193069B2 (en) | 2002-03-22 | 2007-03-20 | Research Association For Biotechnology | Full-length cDNA |
| EP1578928B1 (en) * | 2002-09-16 | 2010-03-17 | The Johns Hopkins University | Metalloprotease activation of myostatin, and methods of modulating myostatin activity |
| US7261893B2 (en) | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
| US20040223966A1 (en) * | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
| WO2004064785A2 (en) * | 2003-01-14 | 2004-08-05 | Dana Farber Cancer Institute | Cancer therapy sensitizer |
| JP5110877B2 (ja) | 2003-06-02 | 2012-12-26 | ワイス・エルエルシー | 神経筋障害を処置するための、コルチコステロイドと組み合わせたミオスタチン（ｇｄｆ８）インヒビターの使用 |
| WO2005005471A2 (en) * | 2003-07-11 | 2005-01-20 | Develogen Aktiengesellschaft | Use of dg153 secreted protein products for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome |
| US7456149B2 (en) | 2004-03-02 | 2008-11-25 | Acceleron Pharma, Inc. | ALK7 and myostatin inhibitors and uses thereof |
| AU2006249235B2 (en) | 2004-05-14 | 2010-11-11 | Abraxis Bioscience, Llc | Sparc and methods of use thereof |
| US8420603B2 (en) * | 2004-05-14 | 2013-04-16 | Abraxis Bioscience, Llc | SPARC and methods of use thereof |
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| AU1356401A (en) * | 1999-11-03 | 2001-05-14 | Zymogenetics Inc. | Follistatin-related protein zfsta4 |
| AU2001241817A1 (en) | 2000-02-29 | 2001-09-12 | Zymogenetics Inc. | Kunitz domain polypeptide zkun8 |
| DE60125148T2 (de) * | 2000-03-03 | 2007-09-27 | Curagen Corp., New Haven | Fctrx genannte proteine und dafür kodierende nuklein säure |
| EP1274720A4 (en) * | 2000-04-12 | 2004-08-18 | Human Genome Sciences Inc | FUSION PROTEINS CONTAINING ALBUMIN |
| US7037501B2 (en) * | 2001-01-04 | 2006-05-02 | Regents Of The University Of Minnesota | Myostatin immnoconjugate |
| TWI329129B (en) | 2001-02-08 | 2010-08-21 | Wyeth Corp | Modified and stabilized gdf propeptides and uses thereof |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| JP4429728B2 (ja) * | 2002-02-21 | 2010-03-10 | ワイス エルエルシー | フォリスタチン（ｆｏｌｌｉｓｔａｔｉｎ）ドメイン含有タンパク質 |
| BR0307907A2 (pt) | 2002-02-21 | 2011-07-05 | Wyeth Corp | gasp1: proteìna contendo domìnio de folistatina |
| EP1578928B1 (en) | 2002-09-16 | 2010-03-17 | The Johns Hopkins University | Metalloprotease activation of myostatin, and methods of modulating myostatin activity |
| US7261893B2 (en) | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
| US20040223966A1 (en) | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
| KR20110086881A (ko) | 2002-12-20 | 2011-08-01 | 암겐 인코포레이티드 | 미오스타틴을 저해하는 결합제 |
| EP1864138A2 (en) * | 2005-03-23 | 2007-12-12 | Wyeth | Detection of gdf-8 modulating agents |
| CN101137906A (zh) * | 2005-03-23 | 2008-03-05 | 惠氏公司 | 对gdf-8调节剂的免疫应答的检测 |
-
2003
- 2003-02-21 JP JP2003571402A patent/JP4429728B2/ja not_active Expired - Fee Related
- 2003-02-21 US US10/369,738 patent/US7572763B2/en not_active Expired - Fee Related
- 2003-02-21 AU AU2003216345A patent/AU2003216345A1/en not_active Withdrawn
- 2003-02-21 WO PCT/US2003/005150 patent/WO2003072714A2/en not_active Ceased
- 2003-02-21 BR BR0307871-0A patent/BR0307871A/pt not_active IP Right Cessation
- 2003-02-21 CA CA002476654A patent/CA2476654A1/en not_active Abandoned
- 2003-02-21 EP EP03743174A patent/EP1572934A4/en not_active Withdrawn
- 2003-02-21 MX MXPA04008149A patent/MXPA04008149A/es active IP Right Grant
- 2003-02-21 PL PL03374966A patent/PL374966A1/xx not_active Application Discontinuation
- 2003-02-21 KR KR10-2004-7012978A patent/KR20040096592A/ko not_active Withdrawn
-
2004
- 2004-08-26 NO NO20043564A patent/NO20043564L/no not_active Application Discontinuation
-
2009
- 2009-06-02 US US12/476,489 patent/US20100047259A1/en not_active Abandoned
- 2009-09-14 JP JP2009212564A patent/JP2009286804A/ja active Pending
-
2010
- 2010-09-17 US US12/884,371 patent/US20110020372A1/en not_active Abandoned
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