|
US7157277B2
(en)
|
2001-11-28 |
2007-01-02 |
Neose Technologies, Inc. |
Factor VIII remodeling and glycoconjugation of Factor VIII
|
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
US7635463B2
(en)
|
2002-02-27 |
2009-12-22 |
Pharmain Corporation |
Compositions for delivery of therapeutics and other materials
|
|
ATE494010T1
(de)
|
2002-02-27 |
2011-01-15 |
Pharmain Corp |
Zusammensetzungen zur abgabe von therapeutika und anderen materialien und verfahren zu ihrer herstellung und verwendung
|
|
US20050260259A1
(en)
|
2004-04-23 |
2005-11-24 |
Bolotin Elijah M |
Compositions for treatment with glucagon-like peptide, and methods of making and using the same
|
|
CN102212019B
(zh)
|
2003-03-14 |
2015-05-27 |
蔚所番有限公司 |
支化水溶性聚合物及其缀合物
|
|
BRPI0407936A
(pt)
|
2003-03-19 |
2006-02-21 |
Lilly Co Eli |
composto de glp-1 peguilado, método de estimular o receptor de glp-1 em um indivìduo, e, uso de composto glp-1 peguilado
|
|
WO2004085471A2
(en)
*
|
2003-03-24 |
2004-10-07 |
Novo Nordisk A/S |
Glp-2 derivatives
|
|
US8791070B2
(en)
|
2003-04-09 |
2014-07-29 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
|
SG155777A1
(en)
|
2003-04-09 |
2009-10-29 |
Neose Technologies Inc |
Glycopegylation methods and proteins/peptides produced by the methods
|
|
EP1624847B1
(en)
|
2003-05-09 |
2012-01-04 |
BioGeneriX AG |
Compositions and methods for the preparation of human growth hormone glycosylation mutants
|
|
WO2005012484A2
(en)
|
2003-07-25 |
2005-02-10 |
Neose Technologies, Inc. |
Antibody-toxin conjugates
|
|
US8633157B2
(en)
|
2003-11-24 |
2014-01-21 |
Novo Nordisk A/S |
Glycopegylated erythropoietin
|
|
US20080305992A1
(en)
|
2003-11-24 |
2008-12-11 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
|
US20060040856A1
(en)
|
2003-12-03 |
2006-02-23 |
Neose Technologies, Inc. |
Glycopegylated factor IX
|
|
ATE461217T1
(de)
*
|
2003-12-18 |
2010-04-15 |
Novo Nordisk As |
Glp-1-verbindungen
|
|
JP5743368B2
(ja)
|
2004-01-08 |
2015-07-01 |
ラショファーム ゲーエムベーハー |
ペプチドのｏ結合型グリコシル化
|
|
EP1768686A4
(en)
*
|
2004-06-12 |
2007-11-14 |
Bayer Pharmaceuticals Corp |
PEGYLATION OF VASOACTIVE INTESTINAL PEPTIDE (VIP) / HYPOPHYDE-ADENYLATE CYCLASE-ACTIVATING PEPTIDE (PACAP) RECEPTOR 2 (VPAC2) AGONISTS AND METHOD OF USE
|
|
US20080300173A1
(en)
|
2004-07-13 |
2008-12-04 |
Defrees Shawn |
Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1]
|
|
US8268967B2
(en)
|
2004-09-10 |
2012-09-18 |
Novo Nordisk A/S |
Glycopegylated interferon α
|
|
HUE026826T2
(en)
|
2004-10-29 |
2016-07-28 |
Ratiopharm Gmbh |
Modeling and glycopegylation of fibroblast growth factor (FGF)
|
|
US9029331B2
(en)
|
2005-01-10 |
2015-05-12 |
Novo Nordisk A/S |
Glycopegylated granulocyte colony stimulating factor
|
|
US8716221B2
(en)
|
2005-01-14 |
2014-05-06 |
Wuxi Grandchamp Pharmaceutical Technology Co., Ltd. |
Modified exendins and uses thereof
|
|
ES2541633T3
(es)
|
2005-01-14 |
2015-07-22 |
Wuxi Grandchamp Pharmaceutical Technology Co., Ltd. |
Exendinas modificadas y usos de las mismas
|
|
EP1871795A4
(en)
|
2005-04-08 |
2010-03-31 |
Biogenerix Ag |
COMPOSITIONS AND METHOD FOR PRODUCING GLYCOSYLATION MUTANTS OF A PROTEASE-RESISTANT HUMAN GROWTH HORMONE
|
|
JP2008539735A
(ja)
*
|
2005-05-06 |
2008-11-20 |
バイエル・フアーマシユーチカルズ・コーポレーシヨン |
グルカゴン様ペプチド１（ｇｌｐ−１）受容体アンタゴニストおよびそれらの薬理学的使用方法
|
|
EP1891231A4
(en)
|
2005-05-25 |
2011-06-22 |
Novo Nordisk As |
GLYCOPEGYLATED FACTOR IX
|
|
US20070105755A1
(en)
|
2005-10-26 |
2007-05-10 |
Neose Technologies, Inc. |
One pot desialylation and glycopegylation of therapeutic peptides
|
|
ES2397289T3
(es)
|
2005-09-22 |
2013-03-06 |
Biocompatibles Uk Ltd. |
Polipéptidos de fusión de GLP-1 (péptido 1 de tipo glucagón) con resistencia a peptidasa incrementada
|
|
US8759290B2
(en)
*
|
2005-10-18 |
2014-06-24 |
Biocon Limited |
Oral glucagon-like peptide conjugates for metabolic diseases
|
|
WO2007049695A1
(ja)
*
|
2005-10-26 |
2007-05-03 |
Chugai Seiyaku Kabushiki Kaisha |
凝集性ｇｌｐ－１アナログおよび徐放性医薬組成物
|
|
US20090048440A1
(en)
|
2005-11-03 |
2009-02-19 |
Neose Technologies, Inc. |
Nucleotide Sugar Purification Using Membranes
|
|
WO2007056362A2
(en)
*
|
2005-11-07 |
2007-05-18 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting physiological solubility and stability
|
|
EP2364735A3
(en)
|
2005-12-16 |
2012-04-11 |
Nektar Therapeutics |
Branched PEG conjugates of GLP-1
|
|
JP2009520040A
(ja)
|
2005-12-19 |
2009-05-21 |
ファーマイン コーポレーション |
治療薬の送達のための疎水性コアの担体組成物、及び同担体組成物の作製法及び使用法
|
|
AU2007240313B2
(en)
|
2006-04-20 |
2012-02-02 |
Amgen Inc. |
GLP-1 compounds
|
|
EP1854455B1
(en)
*
|
2006-05-10 |
2009-10-07 |
Biocompatibles UK Limited |
Spherical microcapsules comprising GLP-1 peptides, their production and use
|
|
KR100886783B1
(ko)
|
2006-06-12 |
2009-03-04 |
성균관대학교산학협력단 |
N-말단이 수식된 peg-trail 결합체, 이의 제조방법 및 이의 용도
|
|
EP2452683A3
(en)
|
2006-06-26 |
2012-08-22 |
Amgen Inc. |
Methods for treating atherosclerosis
|
|
US20080248959A1
(en)
|
2006-07-21 |
2008-10-09 |
Neose Technologies, Inc. |
Glycosylation of peptides via o-linked glycosylation sequences
|
|
JP2010505874A
(ja)
|
2006-10-03 |
2010-02-25 |
ノヴォ ノルディスク アー／エス |
ポリペプチドコンジュゲートの精製方法
|
|
CN102827284B
(zh)
*
|
2006-11-14 |
2015-07-29 |
上海仁会生物制药股份有限公司 |
带有聚乙二醇基团的Exendin或其类似物及其制剂和用途
|
|
CA2674354A1
(en)
|
2007-01-05 |
2008-07-17 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting enhanced solubility in physiological ph buffers
|
|
EA017849B1
(ru)
|
2007-02-15 |
2013-03-29 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Соагонисты глюкагоновых/glp-1-рецепторов
|
|
RS52845B
(sr)
|
2007-04-03 |
2013-12-31 |
Biogenerix Ag |
Postupci tretmana korišćenjem glikopegiliranog g-csf
|
|
GB2448895A
(en)
*
|
2007-05-01 |
2008-11-05 |
Activotec Spp Ltd |
GLP-1 like compounds and uses thereof
|
|
JP5876649B2
(ja)
|
2007-06-12 |
2016-03-02 |
ラツィオファルム ゲーエムベーハーｒａｔｉｏｐｈａｒｍ ＧｍｂＨ |
ヌクレオチド糖の改良製造法
|
|
US7960336B2
(en)
|
2007-08-03 |
2011-06-14 |
Pharmain Corporation |
Composition for long-acting peptide analogs
|
|
US8563527B2
(en)
|
2007-08-20 |
2013-10-22 |
Pharmain Corporation |
Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same
|
|
US8207112B2
(en)
|
2007-08-29 |
2012-06-26 |
Biogenerix Ag |
Liquid formulation of G-CSF conjugate
|
|
WO2009058734A1
(en)
|
2007-10-30 |
2009-05-07 |
Indiana University Research And Technology Corporation |
Compounds exhibiting glucagon antagonist and glp-1 agonist activity
|
|
AU2008318986B2
(en)
|
2007-10-30 |
2014-12-04 |
Indiana University Research And Technology Corporation |
Glucagon antagonists
|
|
US20090176892A1
(en)
|
2008-01-09 |
2009-07-09 |
Pharmain Corporation |
Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same
|
|
GB0803352D0
(en)
|
2008-02-22 |
2008-04-02 |
Ntnu Technology Transfer As |
Oligopeptidic compounds and uses thereof
|
|
ES2476690T3
(es)
|
2008-02-27 |
2014-07-15 |
Novo Nordisk A/S |
Moléculas conjugadas del Factor VIII
|
|
PA8830501A1
(es)
|
2008-06-17 |
2010-07-27 |
Univ Indiana Res & Tech Corp |
Co-agonistas del receptor de glucagon/glp-1
|
|
EA020326B9
(ru)
|
2008-06-17 |
2015-03-31 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Агонисты смешанного действия на основе глюкозозависимого инсулинотропного пептида для лечения нарушений обмена веществ и ожирения
|
|
EP2348857B1
(en)
|
2008-10-22 |
2016-02-24 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
|
AU2009309037A1
(en)
|
2008-10-31 |
2010-05-06 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
|
CN102325539A
(zh)
|
2008-12-19 |
2012-01-18 |
印第安纳大学研究及科技有限公司 |
基于酰胺的胰高血糖素超家族肽前药
|
|
US9382525B2
(en)
*
|
2009-03-26 |
2016-07-05 |
The Hong Kong Polytechnic University |
Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents
|
|
AU2010242422B2
(en)
*
|
2009-03-26 |
2014-12-04 |
The Hong Kong Polytechnic University |
Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents
|
|
CN102459325B
(zh)
|
2009-06-16 |
2015-03-25 |
印第安纳大学科技研究有限公司 |
胃抑胜肽受体活化的胰高血糖素化合物
|
|
CA2780460C
(en)
*
|
2009-11-13 |
2018-09-04 |
Sanofi-Aventis Deutschland Gmbh |
Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine
|
|
US8703701B2
(en)
|
2009-12-18 |
2014-04-22 |
Indiana University Research And Technology Corporation |
Glucagon/GLP-1 receptor co-agonists
|
|
EP2460527A1
(en)
*
|
2010-01-21 |
2012-06-06 |
Sanofi |
Pharmaceutical composition for treating a metabolic syndrome
|
|
EP2528618A4
(en)
|
2010-01-27 |
2015-05-27 |
Univ Indiana Res & Tech Corp |
GLUCAGON ANTAGONISTE AND GIP AGONISTS CONJUGATES AND COMPOSITIONS FOR THE TREATMENT OF METABOLISM DISEASES AND ADIPOSITAS
|
|
US8895596B2
(en)
|
2010-02-25 |
2014-11-25 |
Merck Sharp & Dohme Corp |
Cyclic benzimidazole derivatives useful as anti-diabetic agents
|
|
CN103179976A
(zh)
|
2010-05-13 |
2013-06-26 |
印第安纳大学研究及科技有限公司 |
呈现g蛋白偶联受体活性的胰高血糖素超家族肽
|
|
EP2569000B1
(en)
|
2010-05-13 |
2017-09-27 |
Indiana University Research and Technology Corporation |
Glucagon superfamily peptides exhibiting nuclear hormone receptor activity
|
|
RU2580317C2
(ru)
|
2010-06-24 |
2016-04-10 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Пептидные пролекарства, принадлежащие к суперсемейству амид-содержащих глюкагонов
|
|
WO2012012352A2
(en)
*
|
2010-07-19 |
2012-01-26 |
Amidebio, Llc |
Modified peptides and proteins
|
|
BR112013015389A2
(pt)
|
2010-12-22 |
2016-11-22 |
Univ Indiana Res & Tech Corp |
análogo de glucagon exibindo atividade de receptor gip
|
|
MY159058A
(en)
|
2011-02-25 |
2016-12-15 |
Merck Sharp & Dohme |
Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agent
|
|
PE20140724A1
(es)
|
2011-06-22 |
2014-07-10 |
Univ Indiana Res & Tech Corp |
Coagonistas del receptor de glucagon/glp-1
|
|
CA2839867A1
(en)
|
2011-06-22 |
2012-12-27 |
Indiana University Research And Technology Corporation |
Glucagon/glp-1 receptor co-agonists
|
|
KR101357117B1
(ko)
*
|
2011-06-28 |
2014-02-06 |
비앤엘델리팜 주식회사 |
폴리에틸렌글라이콜 또는 이의 유도체로 페길화된 엑센딘-4 유사체, 이의 제조방법 및 이를 유효성분으로 함유하는 당뇨병 예방 또는 치료용 약학적 조성물
|
|
WO2013021377A1
(en)
*
|
2011-08-08 |
2013-02-14 |
Two To Biotech Ltd. |
Novel peptides, compositions comprising the same and uses thereof in methods for the treatment of metabolic, cardiac and immune-related disorders
|
|
US8859491B2
(en)
|
2011-11-17 |
2014-10-14 |
Indiana University Research And Technology Corporation |
Glucagon superfamily peptides exhibiting glucocorticoid receptor activity
|
|
JP6311708B2
(ja)
|
2012-06-21 |
2018-04-18 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ |
Ｇｉｐ受容体活性を示すグルカゴンアナローグ
|
|
EP2880028B1
(en)
|
2012-08-02 |
2020-09-30 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
TWI674270B
(zh)
*
|
2012-12-11 |
2019-10-11 |
英商梅迪繆思有限公司 |
用於治療肥胖之升糖素與glp-1共促效劑
|
|
JP2016516004A
(ja)
|
2013-02-22 |
2016-06-02 |
メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． |
抗糖尿病二環式化合物
|
|
WO2014139388A1
(en)
|
2013-03-14 |
2014-09-18 |
Merck Sharp & Dohme Corp. |
Novel indole derivatives useful as anti-diabetic agents
|
|
HK1220383A1
(zh)
*
|
2013-03-14 |
2017-05-05 |
Medimmune Limited |
用於治疗肥胖症的聚乙二醇化的胰高血糖素和glp-1共激动剂
|
|
WO2015051496A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
US10626156B2
(en)
|
2013-12-06 |
2020-04-21 |
Jie Han |
Bioreversable promoieties for nitrogen-containing and hydroxyl-containing drugs
|
|
US11299528B2
(en)
|
2014-03-11 |
2022-04-12 |
D&D Pharmatech Inc. |
Long acting TRAIL receptor agonists for treatment of autoimmune diseases
|
|
US10046058B2
(en)
|
2014-12-02 |
2018-08-14 |
Rezolute, Inc. |
Use of hydrophobic organic acids to increase hydrophobicity of proteins and protein conjugates
|
|
AU2016270302B2
(en)
|
2015-06-04 |
2020-09-17 |
Rezolute, Inc. |
Amine pegylation methods for the preparation of site-specific protein conjugates
|
|
TWI726889B
(zh)
|
2015-06-10 |
2021-05-11 |
英商梅迪繆思有限公司 |
蛋白酶抗性之脂化肽
|
|
CA3008392C
(en)
|
2015-12-17 |
2021-11-09 |
The Johns Hopkins University |
Ameliorating systemic sclerosis with death receptor agonists
|
|
PL3393496T3
(pl)
|
2015-12-23 |
2024-04-22 |
The Johns Hopkins University |
Długo działający agonista glp-1r jako terapia stanów neurologicznych i neurodegeneracyjnych
|
|
RU2764547C2
(ru)
*
|
2016-03-16 |
2022-01-18 |
ПРОЛИНКС ЭлЭлСи |
Конъюгаты аналогов эксенатида с замедленным высвобождением
|
|
EP3439687A1
(en)
|
2016-04-07 |
2019-02-13 |
The Johns Hopkins University |
Compositions and methods for treating pancreatitis and pain with death receptor agonists
|
|
US11072602B2
(en)
|
2016-12-06 |
2021-07-27 |
Merck Sharp & Dohme Corp. |
Antidiabetic heterocyclic compounds
|
|
US10968232B2
(en)
|
2016-12-20 |
2021-04-06 |
Merck Sharp & Dohme Corp. |
Antidiabetic spirochroman compounds
|
|
AU2020253560A1
(en)
|
2019-04-05 |
2021-11-25 |
Prolynx Llc |
Improved conjugation linkers
|
|
KR102193211B1
(ko)
*
|
2019-11-27 |
2020-12-18 |
(주)디앤디파마텍 |
비오틴 모이어티가 결합된 폴리펩티드 및 이를 포함하는 경구 투여용 약학적 조성물
|