JP2014526441A5 - - Google Patents
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- Publication number
- JP2014526441A5 JP2014526441A5 JP2014528614A JP2014528614A JP2014526441A5 JP 2014526441 A5 JP2014526441 A5 JP 2014526441A5 JP 2014528614 A JP2014528614 A JP 2014528614A JP 2014528614 A JP2014528614 A JP 2014528614A JP 2014526441 A5 JP2014526441 A5 JP 2014526441A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- subject
- fgf21
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 32
- 208000030159 metabolic disease Diseases 0.000 claims 12
- 101000846529 Homo sapiens Fibroblast growth factor 21 Proteins 0.000 claims 10
- 102000056713 human FGF21 Human genes 0.000 claims 10
- 108090000376 Fibroblast growth factor 21 Proteins 0.000 claims 9
- 102000003973 Fibroblast growth factor 21 Human genes 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 4
- 239000008280 blood Substances 0.000 claims 4
- 239000008103 glucose Substances 0.000 claims 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
- 230000035772 mutation Effects 0.000 claims 4
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims 2
- 102000004877 Insulin Human genes 0.000 claims 2
- 108090001061 Insulin Proteins 0.000 claims 2
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 208000033679 diabetic kidney disease Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229940125396 insulin Drugs 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 150000001413 amino acids Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161529641P | 2011-08-31 | 2011-08-31 | |
| US61/529,641 | 2011-08-31 | ||
| PCT/US2012/053216 WO2013033452A2 (en) | 2011-08-31 | 2012-08-30 | Method of treating or ameliorating type 1 diabetes using fgf21 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017132449A Division JP2017226665A (ja) | 2011-08-31 | 2017-07-06 | １型糖尿病の治療における使用のためのｆｇｆ２１ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014526441A JP2014526441A (ja) | 2014-10-06 |
| JP2014526441A5 true JP2014526441A5 (enExample) | 2015-10-29 |
Family
ID=46964016
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014528614A Pending JP2014526441A (ja) | 2011-08-31 | 2012-08-30 | １型糖尿病の治療における使用のためのｆｇｆ２１ |
| JP2017132449A Pending JP2017226665A (ja) | 2011-08-31 | 2017-07-06 | １型糖尿病の治療における使用のためのｆｇｆ２１ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017132449A Pending JP2017226665A (ja) | 2011-08-31 | 2017-07-06 | １型糖尿病の治療における使用のためのｆｇｆ２１ |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20140213512A1 (enExample) |
| EP (1) | EP2750695A2 (enExample) |
| JP (2) | JP2014526441A (enExample) |
| AU (1) | AU2012301769B2 (enExample) |
| CA (1) | CA2845357A1 (enExample) |
| MX (1) | MX2014002260A (enExample) |
| WO (1) | WO2013033452A2 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA024751B8 (ru) | 2008-06-04 | 2020-01-31 | Амген Инк. | Мутанты fgf21 и их применение |
| CA2796459C (en) | 2010-04-16 | 2016-05-24 | Salk Institute For Biological Studies | Methods for treating metabolic disorders using fgf-1 |
| PL2726511T3 (pl) | 2011-07-01 | 2019-12-31 | Ngm Biopharmaceuticals, Inc. | Kompozycje, zastosowania i sposoby leczenia zaburzeń oraz chorób metabolicznych |
| WO2013172967A1 (en) | 2012-05-17 | 2013-11-21 | Extend Biosciences, Inc | Carriers for improved drug delivery |
| US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
| EP3798228A1 (en) | 2012-11-28 | 2021-03-31 | NGM Biopharmaceuticals, Inc. | Compositions and methods for treatment of metabolic disorders and diseases |
| US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| SG11201504815QA (en) | 2012-12-27 | 2015-07-30 | Ngm Biopharmaceuticals Inc | Methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| WO2015061331A1 (en) | 2013-10-21 | 2015-04-30 | Salk Institute For Biological Studies | Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use |
| CA2928135A1 (en) | 2013-10-21 | 2015-04-30 | Salk Institute For Biological Studies | Mutated fibroblast growth factor (fgf) 1 and methods of use |
| NZ718962A (en) | 2013-10-28 | 2019-12-20 | Ngm Biopharmaceuticals Inc | Cancer models and associated methods |
| AU2015209131B2 (en) | 2014-01-24 | 2020-06-25 | Ngm Biopharmaceuticals, Inc. | Binding proteins and methods of use thereof |
| WO2015138278A1 (en) * | 2014-03-11 | 2015-09-17 | Novartis Ag | Methods of treating metabolic disorders associated with lipodystrophies and defects in insulin production or signaling |
| US10519240B2 (en) | 2014-03-25 | 2019-12-31 | Regeneron Pharmaceuticals, Inc. | Anti-FGFR1c antibody-FGF21 fusion proteins |
| WO2015183890A2 (en) | 2014-05-28 | 2015-12-03 | Ngm Biopharmaceuticals, Inc. | Methods and compositions for the treatment of metabolic disorders and diseases |
| EP3155005A4 (en) | 2014-06-16 | 2018-07-11 | NGM Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
| US10293026B2 (en) | 2014-09-08 | 2019-05-21 | Osaka University | Agent for preventing or treating demyelinating disease |
| CA2960912A1 (en) | 2014-09-16 | 2016-03-24 | Universitat Autonoma De Barcelona | Adeno-associated viral vectors for the gene therapy of metabolic diseases |
| WO2016048999A2 (en) * | 2014-09-23 | 2016-03-31 | Salk Institute For Biological Studies | Fgf21 truncations and mutants and uses thereof |
| US9585934B2 (en) | 2014-10-22 | 2017-03-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| CN114129709A (zh) | 2014-10-23 | 2022-03-04 | 恩格姆生物制药公司 | 包含肽变异体的药物组合物及其使用方法 |
| US10434144B2 (en) | 2014-11-07 | 2019-10-08 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
| HUE044783T2 (hu) * | 2014-12-23 | 2019-11-28 | Novo Nordisk As | FGF21 származékok és alkalmazásaik |
| EP3242945B1 (en) | 2015-01-07 | 2021-09-01 | Universitat Autònoma de Barcelona | Single-vector gene construct comprising insulin and glucokinase genes |
| KR20160088656A (ko) * | 2015-01-16 | 2016-07-26 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
| WO2017019957A2 (en) | 2015-07-29 | 2017-02-02 | Ngm Biopharmaceuticals, Inc. | Binding proteins and methods of use thereof |
| JP2018529729A (ja) * | 2015-10-01 | 2018-10-11 | アムジエン・インコーポレーテツド | 胆汁酸障害の処置 |
| KR102668200B1 (ko) * | 2015-10-28 | 2024-05-23 | 주식회사유한양행 | 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물 |
| KR102670157B1 (ko) | 2015-10-28 | 2024-05-29 | 주식회사유한양행 | 이중 작용 단백질 및 이를 포함하는 약학적 조성물 |
| AU2016344134A1 (en) | 2015-10-30 | 2018-05-31 | Salk Institute For Biological Studies | Treatment of steroid-induced hyperglycemia with fibroblast growth factor (FGF) 1 analogs |
| CA3003616C (en) * | 2015-11-09 | 2020-07-28 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders |
| WO2017180988A2 (en) * | 2016-04-15 | 2017-10-19 | Indiana University Research And Technology Corporation | Fgf21 c-terminal peptide optimization |
| JP7632835B2 (ja) * | 2016-05-20 | 2025-02-19 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 加齢関連疾患及び症状の遺伝子治療法 |
| CA3034399A1 (en) | 2016-08-26 | 2018-03-01 | Ngm Biopharmaceuticals, Inc. | Methods of treating fibroblast growth factor 19-mediated cancers and tumors |
| CN110121355B (zh) | 2016-11-10 | 2023-09-12 | 株式会社柳韩洋行 | 用于预防或治疗肝炎、肝纤维化和肝硬化的包含融合蛋白的药物组合物 |
| CN108570109B (zh) | 2017-03-14 | 2022-04-26 | 广东东阳光药业有限公司 | 包含免疫球蛋白Fc部分的双靶点融合蛋白 |
| AU2018256256B2 (en) | 2017-04-21 | 2023-02-23 | Yuhan Corporation | Method for producing dual function proteins and its derivatives |
| CN107056925B (zh) * | 2017-04-28 | 2022-01-14 | 中国科学院合肥物质科学研究院 | 人fgf21突变体、其制备方法及用途 |
| WO2018215613A1 (en) * | 2017-05-24 | 2018-11-29 | Universitat Autonoma De Barcelona | Viral expression construct comprising a fibroblast growth factor 21 (fgf21) coding sequence |
| IL306098A (en) * | 2017-05-24 | 2023-11-01 | Univ Barcelona Autonoma | Viral expression vectors containing the coding sequence for FIBROBLAST GROWTH FACTOR 21 (FGF21) |
| IL275499B2 (en) | 2017-12-22 | 2024-03-01 | Novartis Ag | Methods of treating metabolic disorders with fgf21 variants |
| AU2019218147B2 (en) | 2018-02-08 | 2023-06-08 | Sunshine Lake Pharma Co., Ltd. | FGF21 variant, fusion protein and application thereof |
| CN111944055B (zh) | 2019-05-16 | 2022-08-02 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的融合蛋白 |
| US11542309B2 (en) | 2019-07-31 | 2023-01-03 | Salk Institute For Biological Studies | Fibroblast growth factor 1 (FGF1) mutant proteins that selectively activate FGFR1B to reduce blood glucose |
| WO2021139763A1 (zh) * | 2020-01-08 | 2021-07-15 | 上海翰森生物医药科技有限公司 | Fgf21突变体蛋白及其融合蛋白 |
| CN115322794B (zh) | 2020-01-11 | 2025-09-19 | 北京质肽生物医药科技有限公司 | Glp-1和fgf21的融合蛋白的缀合物 |
| CA3224743A1 (en) | 2021-07-14 | 2023-01-19 | Beijing Ql Biopharmaceutical Co., Ltd. | Fusion polypeptides for metabolic disorders |
| CN113980147B (zh) * | 2021-11-26 | 2023-07-28 | 中国药科大学 | 一种聚多肽与fgf21融合蛋白突变体及其应用 |
| AU2023343076A1 (en) * | 2022-09-12 | 2025-03-27 | Akero Therapeutics, Inc. | Fgf21 mutant polypeptides |
| US12233115B2 (en) | 2022-09-30 | 2025-02-25 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
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| PL2068909T3 (pl) * | 2007-03-30 | 2012-09-28 | Ambrx Inc | Modyfikowane polipeptydy fgf-21 i ich zastosowanie |
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| UA109888C2 (uk) | 2009-12-07 | 2015-10-26 | ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ | |
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-
2012
- 2012-08-30 CA CA2845357A patent/CA2845357A1/en not_active Abandoned
- 2012-08-30 MX MX2014002260A patent/MX2014002260A/es unknown
- 2012-08-30 US US14/241,848 patent/US20140213512A1/en not_active Abandoned
- 2012-08-30 JP JP2014528614A patent/JP2014526441A/ja active Pending
- 2012-08-30 EP EP12766746.7A patent/EP2750695A2/en not_active Withdrawn
- 2012-08-30 WO PCT/US2012/053216 patent/WO2013033452A2/en not_active Ceased
- 2012-08-30 AU AU2012301769A patent/AU2012301769B2/en active Active
-
2017
- 2017-07-06 JP JP2017132449A patent/JP2017226665A/ja active Pending
- 2017-08-08 US US15/671,923 patent/US20180000898A1/en not_active Abandoned
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