|
CA1202840A
(en)
|
1985-06-10 |
1986-04-08 |
Jonathan R. Kleinsasser |
Combination wet and dry feeder for animals
|
|
JPS63152393A
(ja)
|
1986-07-03 |
1988-06-24 |
Takeda Chem Ind Ltd |
グリコシル誘導体
|
|
US4965195A
(en)
|
1987-10-26 |
1990-10-23 |
Immunex Corp. |
Interleukin-7
|
|
US5714585A
(en)
|
1987-10-26 |
1998-02-03 |
Sterling Winthrop, Inc. |
Antibodies that are immunoreactive with interleukin-7
|
|
US5032396A
(en)
|
1989-02-17 |
1991-07-16 |
Immunex Corporation |
IL-7 to stimulate platelet production
|
|
US5231012A
(en)
|
1989-06-28 |
1993-07-27 |
Schering Corporation |
Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10)
|
|
US6217857B1
(en)
|
1989-06-28 |
2001-04-17 |
Schering Corporation |
Cytokine synthesis inhibitory factor (IL-10) and pharmaceutical compositions thereof
|
|
US5229115A
(en)
|
1990-07-26 |
1993-07-20 |
Immunex Corporation |
Adoptive immunotherapy with interleukin-7
|
|
US5252714A
(en)
|
1990-11-28 |
1993-10-12 |
The University Of Alabama In Huntsville |
Preparation and use of polyethylene glycol propionaldehyde
|
|
US5156301A
(en)
|
1990-12-17 |
1992-10-20 |
Imi Cornelius Inc. |
Constant ratio post-mix beverage dispensing valve
|
|
EP0567586B1
(en)
|
1991-01-16 |
1995-07-12 |
Schering Corporation |
Use of interleukin-10 in adoptive immunotherapy of cancer
|
|
ATE116550T1
(de)
|
1991-01-16 |
1995-01-15 |
Schering Corp |
Behandlung von neoplastischen krankenheiten mit interleukin-10.
|
|
US5624823A
(en)
|
1991-11-22 |
1997-04-29 |
The General Hospital Corporation |
DNA encoding procine interleukin-10
|
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
|
WO1994017773A2
(en)
|
1993-02-01 |
1994-08-18 |
Université Libre de Bruxelles |
Use of a pharmaceutical composition comprising an effective amount of interleukin-10, an analog and/or an agonist of interleukin-10
|
|
US5328989A
(en)
|
1993-03-05 |
1994-07-12 |
Schering-Plough |
Purification of human interleukin-10 from a cell culture medium
|
|
US5552303A
(en)
|
1993-03-08 |
1996-09-03 |
Immunex Corporation |
DNA encoding epithelium-derived T-cell factor
|
|
WO1994022473A1
(en)
|
1993-04-01 |
1994-10-13 |
University Of Washington |
Use of interleukin 7 to improve vaccine potency
|
|
US5665345A
(en)
|
1993-05-24 |
1997-09-09 |
The United States Of America As Represented By The Department Of Health And Human Services |
Methods of inhibiting viral replication using IL-10
|
|
CA2168110A1
(en)
|
1993-07-26 |
1995-02-02 |
Chuan-Chu Chou |
Agonists and antagonists of human interleukin-10
|
|
GB9317618D0
(en)
|
1993-08-24 |
1993-10-06 |
Royal Free Hosp School Med |
Polymer modifications
|
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5951974A
(en)
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
PL175343B1
(pl)
|
1994-01-20 |
1998-12-31 |
Schering Corp |
Sposób pozaustrojowego wytwarzania aktywowanych jednojądrzastych komórek krwi obwodowej, kompozycja farmaceutyczna do pozaustrojowego wytwarzania aktywowanych jednojądrzastych komórek krwi obwodowej i kompozycja farmaceutyczna do leczenia nowotworów
|
|
US5696234A
(en)
|
1994-08-01 |
1997-12-09 |
Schering Corporation |
Muteins of mammalian cytokine interleukin-13
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
US6410008B1
(en)
|
1994-12-12 |
2002-06-25 |
Beth Israel Hospital Association |
Chimeric IL-10 proteins and uses thereof
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
US5866134A
(en)
|
1995-03-24 |
1999-02-02 |
Schering Corporation |
Method for enhancing the antibody response to specific antigens with Interleukin-10
|
|
US5770190A
(en)
|
1995-07-14 |
1998-06-23 |
Schering Corporation |
Method of treatment of acute leukemia with inteleukin-10
|
|
GB2304047A
(en)
|
1995-08-09 |
1997-03-12 |
Univ Manchester |
Pharmaceutical compositions containing cytokines
|
|
US5744451A
(en)
|
1995-09-12 |
1998-04-28 |
Warner-Lambert Company |
N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity
|
|
US5908621A
(en)
|
1995-11-02 |
1999-06-01 |
Schering Corporation |
Polyethylene glycol modified interferon therapy
|
|
US5759859A
(en)
|
1996-07-15 |
1998-06-02 |
United States Of America As Represented By The Secretary Of The Army |
Sensor and method for detecting trace underground energetic materials
|
|
US5945097A
(en)
|
1996-09-06 |
1999-08-31 |
Schering Corporation |
Method for lowering cholesterol levels with interleukin-10
|
|
US5989867A
(en)
|
1996-09-23 |
1999-11-23 |
Knappe; Andrea |
DNA encoding IL-10-like homologue; related reagents
|
|
US6660258B1
(en)
|
1997-05-09 |
2003-12-09 |
Pharma Pacific Pty Ltd |
Oromucosal cytokine compositions and uses thereof
|
|
DE69838552T2
(de)
|
1997-07-14 |
2008-05-21 |
Bolder Biotechnology, Inc., Louisville |
Derivate des wachstumshormons und verwandte proteine
|
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
DK1053019T3
(da)
|
1998-01-07 |
2004-04-13 |
Debio Rech Pharma Sa |
Nedbrydelige heterobifunktionelle polyethylenglycolacrylater og geler og konjugater afledt derfra
|
|
US6428985B1
(en)
|
1998-12-02 |
2002-08-06 |
The Regents Of The University Of Michigan |
Immunosuppressive structural definition of IL-10
|
|
WO2000037096A2
(en)
|
1998-12-22 |
2000-06-29 |
Schering Corporation |
Treatment of hepatitis c virus infections with interleukin-10
|
|
US7666400B2
(en)
|
2005-04-06 |
2010-02-23 |
Ibc Pharmaceuticals, Inc. |
PEGylation by the dock and lock (DNL) technique
|
|
WO2001005821A2
(en)
|
1999-07-16 |
2001-01-25 |
Maria Teresa Bejarano |
Viral il-10 for the inhibition of angiogenesis, tumorigenesis and metastasis
|
|
US6989377B2
(en)
|
1999-12-21 |
2006-01-24 |
Wisconsin Alumni Research Foundation |
Treating vitamin D responsive diseases
|
|
US20030186386A1
(en)
|
2000-02-11 |
2003-10-02 |
Hansen Christian Karsten |
Interleukin 10
|
|
EP1257574A1
(en)
|
2000-02-11 |
2002-11-20 |
Maxygen Aps |
Improved interleukin 10
|
|
EP1324779B1
(en)
|
2000-09-29 |
2011-07-20 |
Schering Corporation |
Pegylated interleukin-10
|
|
JP2002142770A
(ja)
|
2000-11-08 |
2002-05-21 |
Dnavec Research Inc |
循環系への遺伝子送達用パラミクソウイルスベクター
|
|
US6838452B2
(en)
|
2000-11-24 |
2005-01-04 |
Vascular Biogenics Ltd. |
Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
|
|
EP1234583A1
(en)
|
2001-02-23 |
2002-08-28 |
F. Hoffmann-La Roche Ag |
PEG-conjugates of HGF-NK4
|
|
AU2002307497A1
(en)
|
2001-04-23 |
2002-11-05 |
The Regents Of The University Of California |
Methods of using interleukin-7 to modulate physiological processes in mammalian pulmonary fibroblasts
|
|
GB0212648D0
(en)
|
2002-05-31 |
2002-07-10 |
Immunoclin Lab Ltd |
Treatment with cytokines
|
|
EP1391513A1
(en)
|
2002-08-08 |
2004-02-25 |
Cytheris |
IL-7 drug substance, IL-7 comprising composition, preparation and uses thereof
|
|
DE60332358D1
(de)
|
2002-09-09 |
2010-06-10 |
Hanall Pharmaceutical Co Ltd |
Protease-resistente modifizierte interferon alpha polypeptide
|
|
US20040142893A1
(en)
*
|
2002-10-21 |
2004-07-22 |
Uichi Ikeda |
Methods for treating and preventing vascular disease
|
|
AU2003280315A1
(en)
|
2002-11-14 |
2004-06-03 |
Maxygen, Inc. |
Conjugates of interleukin-10 and polymers
|
|
US20060127357A1
(en)
|
2002-11-29 |
2006-06-15 |
Roncarolo Maria G |
Rapamycin and il-10 for the treatment of immune diseases
|
|
WO2004056850A2
(en)
|
2002-12-19 |
2004-07-08 |
Vib Vzw |
Mutant proteins showing increased secretion
|
|
CA2508660C
(en)
|
2002-12-23 |
2013-08-20 |
Wyeth |
Antibodies against pd-1 and uses therefor
|
|
BR0317752A
(pt)
|
2002-12-26 |
2005-11-22 |
Mountain View Pharmaceuticals |
Conjugados poliméricos de citocinas, quimiocinas, fatores do crescimento, hormÈnios polipeptìdicos e seus antagonistas com atividade de ligação a receptores conservada
|
|
US20050214859A1
(en)
|
2003-03-03 |
2005-09-29 |
Dyax Corp. |
Peptides that specifically bind HGF receptor (cMet) and uses thereof
|
|
JP4753867B2
(ja)
|
2003-04-15 |
2011-08-24 |
グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー |
ヒトｉｌ−１８を含むコンジュゲートおよびその置換変異体
|
|
US7261882B2
(en)
|
2003-06-23 |
2007-08-28 |
Reagents Of The University Of Colorado |
Methods for treating neuropathic pain by administering IL-10 polypeptides
|
|
WO2005033307A1
(ja)
|
2003-09-30 |
2005-04-14 |
Kyowa Hakko Kogyo Co., Ltd. |
新規のリフォールディング方法およびその方法によって得られたタンパク質
|
|
DE602004025509D1
(de)
|
2003-11-28 |
2010-03-25 |
Univ Sydney |
Virales latentphasen-interleukin-10-(vii-10) und verwendungen davon
|
|
CN100467488C
(zh)
|
2003-12-30 |
2009-03-11 |
默克专利有限公司 |
Il-7融合蛋白
|
|
US20060078942A1
(en)
*
|
2004-03-10 |
2006-04-13 |
Pepgen Corporation |
Method of treatment using interferon-tau
|
|
CN1946742A
(zh)
|
2004-03-11 |
2007-04-11 |
弗雷泽纽斯卡比德国有限公司 |
通过还原氨基化制备的羟烷基淀粉和蛋白质的偶联物
|
|
US20060046961A1
(en)
|
2004-09-02 |
2006-03-02 |
Mckay William F |
Controlled and directed local delivery of anti-inflammatory compositions
|
|
CN100334112C
(zh)
|
2004-10-15 |
2007-08-29 |
上海海欣生物技术有限公司 |
人白细胞介素15与Fc融合蛋白
|
|
AU2005313492B2
(en)
|
2004-12-09 |
2011-12-15 |
Merck Patent Gmbh |
IL-7 variants with reduced immunogenicity
|
|
GB0500643D0
(en)
|
2005-01-13 |
2005-02-23 |
Renovo Ltd |
Medicaments
|
|
WO2006094530A1
(en)
|
2005-03-11 |
2006-09-14 |
Siegfried Ltd. |
Di-polymer protein conjugates and processes for their preparation
|
|
AR052741A1
(es)
|
2005-04-08 |
2007-03-28 |
Noxxon Pharma Ag |
Acidos nucleicos de union a ghrelin
|
|
EP1901769A2
(en)
|
2005-05-02 |
2008-03-26 |
Avigen, Inc. |
Use of cytokine-derived peptides in treatment of pain and neurodegenerative disease
|
|
WO2006130580A2
(en)
|
2005-05-31 |
2006-12-07 |
Avigen, Inc. |
Mutant il-10
|
|
WO2007003041A1
(en)
|
2005-07-01 |
2007-01-11 |
John Schrader |
Methods of isolating cells and generating monoclonal antibodies
|
|
EP1746161A1
(en)
|
2005-07-20 |
2007-01-24 |
Cytheris |
Glycosylated IL-7, preparation and uses
|
|
SI1931704T1
(sl)
|
2005-10-04 |
2011-04-29 |
Zymogenetics L L C |
Priprava in čiščenje IL-29
|
|
WO2007061657A2
(en)
|
2005-11-14 |
2007-05-31 |
The Brigham & Women's Hospital, Inc. |
Interleukin-10 compositions for the treatment of adenocarcinomas
|
|
US7868139B2
(en)
|
2006-01-24 |
2011-01-11 |
Uab Research Foundation |
Compositions and methods for the identification and treatment of immune-mediated inflammatory diseases
|
|
AU2007314501B2
(en)
*
|
2006-09-28 |
2013-05-23 |
Merck Sharp & Dohme Corp. |
Use of pegylated IL-10 to treat cancer
|
|
WO2008041953A2
(en)
|
2006-10-05 |
2008-04-10 |
Agency For Science, Technology And Research |
Dengue diagnosis and treatment
|
|
JP5220025B2
(ja)
|
2006-12-04 |
2013-06-26 |
プロメディオール， インコーポレイテッド |
線維症疾患を処置するための併用療法
|
|
WO2008089491A2
(en)
|
2007-01-19 |
2008-07-24 |
Kai Pharmaceuticals, Inc. |
Modifications of peptide compositions to increase stability and delivery efficiency
|
|
ES2346178T3
(es)
|
2007-07-31 |
2015-11-02 |
Affibody Ab |
Nuevas composiciones, procedimientos y usos de unión de la albúmina
|
|
WO2009036568A1
(en)
|
2007-09-19 |
2009-03-26 |
University Health Network |
Methods and compositions for treating tumors and viral infections
|
|
EP2200649A4
(en)
|
2007-10-19 |
2012-09-26 |
Univ California |
COMPOSITIONS AND METHODS FOR IMPROVING INFLAMMATION OF SN, PSYCHOSIS, DELI, PTSD OR PTSD
|
|
GB0724231D0
(en)
|
2007-12-12 |
2008-01-30 |
Renono Ltd |
Methods for inhibiting scarring
|
|
JP2011525616A
(ja)
*
|
2008-05-29 |
2011-09-22 |
ブリストル−マイヤーズ スクイブ カンパニー |
共刺激経路の調節に対する患者応答を予測するための方法
|
|
WO2010022227A1
(en)
*
|
2008-08-20 |
2010-02-25 |
Schering Corporation |
Methods for monitoring il-10 therapy
|
|
EP2379115B1
(en)
|
2008-12-17 |
2017-10-25 |
Merck Sharp & Dohme Corp. |
Mono- and di-peg il-10 production; and uses
|
|
EP2488553B1
(en)
|
2009-10-12 |
2015-06-17 |
Pfizer Inc. |
Cancer treatment
|
|
WO2011051489A2
(en)
|
2009-10-30 |
2011-05-05 |
Novozymes Biopharma Dk A/S |
Albumin variants
|
|
BR112012032206A2
(pt)
|
2010-06-16 |
2016-10-04 |
Abbvie Inc |
comparações de amostras de proteínas
|
|
KR101884654B1
(ko)
|
2010-07-09 |
2018-08-02 |
애피바디 에이비 |
폴리펩타이드
|
|
US8759617B2
(en)
|
2010-09-21 |
2014-06-24 |
National Institute Of Agrobiological Sciences |
Method for extraction and purification of recombinant proteins from transgenic plants
|
|
CA2813087C
(en)
|
2010-09-28 |
2020-07-21 |
Amylin Pharmaceuticals, Llc |
Engineered polypeptides having enhanced duration of action
|
|
JP6121330B2
(ja)
|
2010-09-28 |
2017-04-26 |
アミリン・ファーマシューティカルズ, リミテッド・ライアビリティ・カンパニーAmylin Pharmaceuticals, Llc |
作用持続時間が増した改変ポリペプチド
|
|
LT3757126T
(lt)
*
|
2010-11-05 |
2025-12-10 |
Novartis Ag |
Psoriazinio artrito gydymo būdas, panaudojant il-17 antagonistus
|
|
MX359513B
(es)
|
2011-03-23 |
2018-10-01 |
Hutchinson Fred Cancer Res |
Metodo y composiciones para inmunoterapia celular.
|
|
CN102145178B
(zh)
|
2011-04-15 |
2012-09-26 |
北京凯因科技股份有限公司 |
Peg化白介素15
|
|
EP2537933A1
(en)
|
2011-06-24 |
2012-12-26 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
An IL-15 and IL-15Ralpha sushi domain based immunocytokines
|
|
WO2013074916A1
(en)
|
2011-11-18 |
2013-05-23 |
Board Of Regents, The University Of Texas System |
Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla
|
|
MX2014009129A
(es)
|
2012-01-26 |
2014-11-21 |
Amgen Inc |
Polipeptidos de factor 15 de diferenciacion de crecimiento (gdf-15).
|
|
WO2013130913A1
(en)
|
2012-02-29 |
2013-09-06 |
Ambrx, Inc. |
Interleukin-10 polypeptide conjugates and their uses
|
|
US20150118244A1
(en)
|
2012-05-10 |
2015-04-30 |
Bristol-Myers Squibb Company |
Anti-tumor antibodies as predictive or prognostic biomarkers of efficacy and survival in ipilimumab-treated patients
|
|
HK1215681A1
(zh)
*
|
2013-04-18 |
2016-09-09 |
Armo Biosciences, Inc. |
使用白细胞介素-10治疗疾病和病症的方法
|
|
CA2908208A1
(en)
|
2013-04-24 |
2014-10-30 |
Armo Biosciences, Inc. |
Interleukin-10 compositions and uses thereof
|
|
ES2688206T3
(es)
|
2013-06-17 |
2018-10-31 |
Armo Biosciences, Inc. |
Procedimiento de evaluación de la identidad y la estabilidad de proteínas
|
|
CN105658232A
(zh)
|
2013-08-30 |
2016-06-08 |
阿尔莫生物科技股份有限公司 |
使用白细胞介素-10治疗疾病和病症的方法
|
|
ES2862139T3
(es)
|
2013-11-11 |
2021-10-07 |
Armo Biosciences Inc |
Procedimientos de uso de Interleucina 10 para el tratamiento de enfermedades y trastornos
|
|
WO2015108785A1
(en)
|
2014-01-15 |
2015-07-23 |
Armo Biosciences, Inc. |
Methods of using interleukin-10 for treating diseases and disorders
|
|
EP4303229A3
(en)
|
2014-01-21 |
2024-04-17 |
Novartis AG |
Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules
|
|
MA39711A
(fr)
|
2014-04-03 |
2015-10-08 |
Nektar Therapeutics |
Conjugués d'une fraction d'il-15 et d'un polymère
|
|
US10293043B2
(en)
*
|
2014-06-02 |
2019-05-21 |
Armo Biosciences, Inc. |
Methods of lowering serum cholesterol
|
|
AU2015369808A1
(en)
|
2014-12-23 |
2017-06-29 |
Armo Biosciences, Inc. |
Methods of improving yield in recombinant protein production
|
|
CN107405384A
(zh)
|
2015-03-11 |
2017-11-28 |
尼克塔治疗公司 |
Il‑7部分与聚合物的缀合物
|
|
HK1248137A1
(zh)
|
2015-05-28 |
2018-10-12 |
阿尔莫生物科技股份有限公司 |
用於治疗癌症的聚乙二醇化白细胞介素-10
|